LOCUS       NM_199103               4597 bp    mRNA    linear   ROD 05-OCT-2024
DEFINITION  Rattus norvegicus inhibitor of nuclear factor kappa B kinase
            regulatory subunit gamma (Ikbkg), mRNA.
ACCESSION   NM_199103 XM_006229584 XM_219769
VERSION     NM_199103.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4597)
  AUTHORS   Harding,O., Holzer,E., Riley,J.F., Martens,S. and Holzbaur,E.L.F.
  TITLE     Damaged mitochondria recruit the effector NEMO to activate
            NF-kappaB signaling
  JOURNAL   Mol Cell 83 (17), 3188-3204 (2023)
   PUBMED   37683611
  REMARK    GeneRIF: Damaged mitochondria recruit the effector NEMO to activate
            NF-kappaB signaling.
REFERENCE   2  (bases 1 to 4597)
  AUTHORS   Ren,Y.S., Li,H.H., Yao,J.C., Tan,Y.J., Pan,L.H., Peng,T.,
            Zhao,L.L., Zhang,G.M., Yue,J., Hu,X.M., Liu,Z. and Li,J.
  TITLE     Application quantitative proteomics approach to identify
            differentially expressed proteins associated with cardiac
            protection mediated by cycloastragenol in acute myocardial
            infarction rats
  JOURNAL   J Proteomics 222, 103691 (2020)
   PUBMED   32068187
REFERENCE   3  (bases 1 to 4597)
  AUTHORS   Van Quickelberghe,E., De Sutter,D., van Loo,G., Eyckerman,S. and
            Gevaert,K.
  TITLE     A protein-protein interaction map of the TNF-induced NF-kappaB
            signal transduction pathway
  JOURNAL   Sci Data 5, 180289 (2018)
   PUBMED   30561431
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4597)
  AUTHORS   Ehedego,H., Mohs,A., Jansen,B., Hiththetiya,K., Sicinski,P.,
            Liedtke,C. and Trautwein,C.
  TITLE     Loss of Cyclin E1 attenuates hepatitis and hepatocarcinogenesis in
            a mouse model of chronic liver injury
  JOURNAL   Oncogene 37 (25), 3329-3339 (2018)
   PUBMED   29551768
REFERENCE   5  (bases 1 to 4597)
  AUTHORS   An,J., Wu,M., Xin,X., Lin,Z., Li,X., Zheng,Q., Gui,X., Li,T.,
            Pu,H., Li,H. and Lu,D.
  TITLE     Inflammatory related gene IKKalpha, IKKbeta, IKKgamma cooperates to
            determine liver cancer stem cells progression by altering telomere
            via heterochromatin protein 1-HOTAIR axis
  JOURNAL   Oncotarget 7 (31), 50131-50149 (2016)
   PUBMED   27367027
REFERENCE   6  (bases 1 to 4597)
  AUTHORS   Saito,N., Courtois,G., Chiba,A., Yamamoto,N., Nitta,T.,
            Hironaka,N., Rowe,M., Yamamoto,N. and Yamaoka,S.
  TITLE     Two carboxyl-terminal activation regions of Epstein-Barr virus
            latent membrane protein 1 activate NF-kappaB through distinct
            signaling pathways in fibroblast cell lines
  JOURNAL   J Biol Chem 278 (47), 46565-46575 (2003)
   PUBMED   12968033
REFERENCE   7  (bases 1 to 4597)
  AUTHORS   Wajant,H., Pfizenmaier,K. and Scheurich,P.
  TITLE     Tumor necrosis factor signaling
  JOURNAL   Cell Death Differ 10 (1), 45-65 (2003)
   PUBMED   12655295
  REMARK    Review article
REFERENCE   8  (bases 1 to 4597)
  AUTHORS   Pasparakis,M., Schmidt-Supprian,M. and Rajewsky,K.
  TITLE     IkappaB kinase signaling is essential for maintenance of mature B
            cells
  JOURNAL   J Exp Med 196 (6), 743-752 (2002)
   PUBMED   12235208
REFERENCE   9  (bases 1 to 4597)
  AUTHORS   Poyet,J.L., Srinivasula,S.M. and Alnemri,E.S.
  TITLE     vCLAP, a caspase-recruitment domain-containing protein of equine
            Herpesvirus-2, persistently activates the Ikappa B kinases through
            oligomerization of IKKgamma
  JOURNAL   J Biol Chem 276 (5), 3183-3187 (2001)
   PUBMED   11113112
REFERENCE   10 (bases 1 to 4597)
  AUTHORS   Smahi,A., Courtois,G., Vabres,P., Yamaoka,S., Heuertz,S.,
            Munnich,A., Israel,A., Heiss,N.S., Klauck,S.M., Kioschis,P.,
            Wiemann,S., Poustka,A., Esposito,T., Bardaro,T., Gianfrancesco,F.,
            Ciccodicola,A., D'Urso,M., Woffendin,H., Jakins,T., Donnai,D.,
            Stewart,H., Kenwrick,S.J., Aradhya,S., Yamagata,T., Levy,M.,
            Lewis,R.A. and Nelson,D.L.
  TITLE     Genomic rearrangement in NEMO impairs NF-kappaB activation and is a
            cause of incontinentia pigmenti. The International Incontinentia
            Pigmenti (IP) Consortium
  JOURNAL   Nature 405 (6785), 466-472 (2000)
   PUBMED   10839543
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000021.1.
            
            On or before Sep 1, 2022 this sequence version replaced
            XM_006229584.4, NM_199103.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643297.55525.1,
                                           SRR26360186.1701051.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-118               JAXUCZ010000021.1  157372885-157373002
            119-158             JAXUCZ010000021.1  157375532-157375571
            159-360             JAXUCZ010000021.1  157376194-157376395
            361-572             JAXUCZ010000021.1  157377364-157377575
            573-691             JAXUCZ010000021.1  157380123-157380241
            692-844             JAXUCZ010000021.1  157381924-157382076
            845-920             JAXUCZ010000021.1  157382806-157382881
            921-1064            JAXUCZ010000021.1  157385992-157386135
            1065-1207           JAXUCZ010000021.1  157386418-157386560
            1208-1269           JAXUCZ010000021.1  157389058-157389119
            1270-4597           JAXUCZ010000021.1  157389430-157392757
FEATURES             Location/Qualifiers
     source          1..4597
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq37"
     gene            1..4597
                     /gene="Ikbkg"
                     /gene_synonym="Nemo"
                     /note="inhibitor of nuclear factor kappa B kinase
                     regulatory subunit gamma"
                     /db_xref="GeneID:309295"
                     /db_xref="RGD:735223"
     exon            1..118
                     /gene="Ikbkg"
                     /gene_synonym="Nemo"
                     /inference="alignment:Splign:2.1.0"
     exon            119..158
                     /gene="Ikbkg"
                     /gene_synonym="Nemo"
                     /inference="alignment:Splign:2.1.0"
     exon            159..360
                     /gene="Ikbkg"
                     /gene_synonym="Nemo"
                     /inference="alignment:Splign:2.1.0"
     CDS             174..1412
                     /gene="Ikbkg"
                     /gene_synonym="Nemo"
                     /note="IKKG; IKKAP1; IKK-gamma; I-kappa-B kinase gamma;
                     ikB kinase subunit gamma; NF-kappa-B essential modifier;
                     ikB kinase-associated protein 1; I-kappa-B kinase subunit
                     gamma; inhibitor of kappaB kinase gamma; inhibitor of
                     kappa light polypeptide gene enhancer in B-cells, kinase
                     gamma; inhibitor of nuclear factor kappa B kinase subunit
                     gamma"
                     /codon_start=1
                     /product="NF-kappa-B essential modulator"
                     /protein_id="NP_954534.1"
                     /db_xref="GeneID:309295"
                     /db_xref="RGD:735223"
                     /translation="MSRHLWKNQLSEMVQPSGGPAEDQDMLGEESSLGKPAMLHLPSE
                     QGTPETLQRCLEENQELRDAIRQSNQMLRERCEELLHFQVSQREEKEFLMCKFQEARK
                     LVERLSLEKLDLRRQREQALEDLEHLKKCQQQMAEDKASVKAQVTSLLGELQESQSRL
                     EAATKERQTLEGRIRAVSEQVRQLESEREVLQQQHSVQVDQLRMQNQSVEAALRMERQ
                     AASEEKRKLAQLQAAYHQLFQDYDSHIKSSKGMQLEDLRQQLQQAEEALVAKQELIDK
                     LKEEAEQHKIVMETVPVLKAQADIYKADFQAERHAREKLVERKELLQEQLEQLQREFN
                     KLKVGCHESARIEDMRKRHVETSQPPLLPAPAHHSFHLALSNQRRSPPEEPPDFCCPK
                     CQYQAPDMDTLQIHVMECIE"
     exon            361..572
                     /gene="Ikbkg"
                     /gene_synonym="Nemo"
                     /inference="alignment:Splign:2.1.0"
     exon            573..691
                     /gene="Ikbkg"
                     /gene_synonym="Nemo"
                     /inference="alignment:Splign:2.1.0"
     exon            692..844
                     /gene="Ikbkg"
                     /gene_synonym="Nemo"
                     /inference="alignment:Splign:2.1.0"
     exon            845..920
                     /gene="Ikbkg"
                     /gene_synonym="Nemo"
                     /inference="alignment:Splign:2.1.0"
     exon            921..1064
                     /gene="Ikbkg"
                     /gene_synonym="Nemo"
                     /inference="alignment:Splign:2.1.0"
     exon            1065..1207
                     /gene="Ikbkg"
                     /gene_synonym="Nemo"
                     /inference="alignment:Splign:2.1.0"
     exon            1208..1269
                     /gene="Ikbkg"
                     /gene_synonym="Nemo"
                     /inference="alignment:Splign:2.1.0"
     exon            1270..4597
                     /gene="Ikbkg"
                     /gene_synonym="Nemo"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggaagtgggg ttttccactg ctgagaaggg aagggtgacc gcctgactag gatttcctag
       61 gagctccgat tctgccgctg ctcctgccct cttcacttct gaccgactct gctgacagga
      121 ggagcttgga attgaaccaa cagtcttgtg catgctagac actgtcttgt tggatgagca
      181 ggcacctctg gaagaatcag ttgagtgaga tggtgcaacc cagtggtggc ccagcagagg
      241 accaggacat gctgggtgaa gaatcttctc tggggaagcc agcaatgcta catcttcctt
      301 cagagcaggg tactcctgag accctccagc gctgtctgga agagaatcaa gaactccgag
      361 atgctatccg gcagagcaat cagatgctga gggaacgctg tgaggagctg ctgcatttcc
      421 aggtcagcca gcgggaggag aaggagttcc tcatgtgcaa attccaggaa gccaggaagc
      481 tggtggagag actgagcttg gagaagcttg acctgcggag gcagagagaa caggccttag
      541 aggatttgga gcatctgaag aaatgccaac agcagatggc tgaggacaag gcctctgtga
      601 aagctcaggt gacatcattg ctgggggaac tccaggagag ccagagtcgt ttggaggctg
      661 ctaccaagga acgacaaact ttagagggaa ggattcgagc agttagtgag caggtcagac
      721 agctggagag tgagcgggag gtgctgcagc agcagcacag tgtccaggtg gaccaactgc
      781 gcatgcagaa ccagagtgtg gaggctgcct tgcgaatgga gcgacaggct gcttcagagg
      841 agaagcggaa gctggctcag ttgcaggcag cctatcacca actcttccaa gactatgaca
      901 gccacattaa gagcagcaag ggcatgcagc tggaagatct gaggcagcag ctccagcaag
      961 ctgaggaggc cctggtagcc aaacaggaat tgattgataa gctgaaagag gaagctgagc
     1021 agcacaagat tgtcatggag accgttccag tcttgaaagc ccaggcggac atctacaagg
     1081 ctgacttcca agctgagagg catgcccggg agaaactggt ggagaggaag gagcttttgc
     1141 aggagcagtt ggagcagctg cagcgcgagt tcaacaagtt gaaagttggc tgccatgagt
     1201 cagccaggat tgaggatatg aggaagcggc atgtagagac ttcccagccc cctttactcc
     1261 ctgctccagc tcaccactcc tttcatttgg ccttgtccaa ccagcggagg agccctcctg
     1321 aggaaccacc tgacttctgt tgtcccaagt gccagtatca ggctcctgat atggacactc
     1381 tacagataca tgtcatggag tgcatagagt aggagcagca gattcaaggc cacctgtaat
     1441 actatgtccc aatctgtgca acttatgctt tcccgtttca cctgcgtagt ccacaattaa
     1501 gtgcttaatg tcaaagagtg ggtcccagga actagcagga cccttgcttt agccctttgg
     1561 tctgctagtc ccctattagg gtagacagct ccattcaggg ctgttttttt tccctttttt
     1621 cttctgtgtg cctgagccac ttcgcctctg gtggcttctt cttccctctt ctcccatttt
     1681 cttagggagt ctagaatgga ggccaggggc tctcagggag catcccttct ccaagcaggg
     1741 ctagtgcctc tcttcagcta gtgcctttct tgccagtgaa ctgcaggctc tcctccttaa
     1801 ggcatgtggc acttaggtct ataacatgta ttacctctga tagacatgtg gaaagtattc
     1861 tgtccttgtt actagtaatg gtgcagtgaa agtacttgtg cacagatctg tatgtacctt
     1921 taggacagat gcttagatgt gacattagat atgacaaggg tcatagaaga ggtgagcaga
     1981 cctttggatt ctgctatctg ctagacatgc tattatttac taaagagttt gcttaagtgt
     2041 ctttttctgg ggtatgtggg cccttcttaa tttctctgat gtaacttgga ttttcataat
     2101 tcctacccat ttttctgttg ggtcgttgcc atttgttctt tggctttgga gagctctttg
     2161 attatcagtc aggttagctt tgactatcac agaaagggca caccttgttc cagtttgatt
     2221 gtgttactgt tttggggcct agaagctgtt atctactcca ttctttactc ctttttttgg
     2281 ctttggaatt atgactactt tgtcaacaga aaggtatttc acatatatgc ttttcttttt
     2341 ctaactccag tgtgttcttg tttttgctaa gcacattgtt gccttctgtg aatggtggta
     2401 gttcatcaca gttcaggaat ttgtgatggc ttgttctcca ccagccaatt tgtcctagca
     2461 caccatttag cagtgactga aaggttacag aaaagggaac acttcacttg ttttgcaaga
     2521 ttctagatat tttctgggac cttacagtca ttggtattag ccctgcagtt ctagtaaagg
     2581 aaagtaaact gcaattgaga aagcaataaa tgtcccttgc tcattcctca ggtttgaaat
     2641 ccttcctgcc ctcctgtaag ctttcatggt tctgagtggg atttgtgaat ccatccctgg
     2701 gcttttattc acatggcttc tatcccatta agagtgagta ggctaagtag aatttagatt
     2761 ttaaaaaagg atttaaaaag caatcctgag ctgagggctt cctcagcatt ctcaggggat
     2821 gtggaacaag ttttccattt cctaattccc tggtatctat cagacagatc tttgggaaaa
     2881 tgttaaagga acaaacaagt actttgctta tgtgttttca tttaaatacc taacctataa
     2941 ttttttcttt aggaatactg ttggtttagc ttgagtccag ttttgtggtg gtatataaga
     3001 ctgtcctata gctgctttaa aaattctttt agacttgaaa gagcaacaac aacaaaaatt
     3061 agtcttcctg tctggaagcc aaatgttaag tttttttctg gaggctctga gaatcaattc
     3121 caagcattct cttaactttt ggtggtttct ggaagtcctt ggtgttgctt gacttgtaga
     3181 ccaatcactc caatttctgg ttctagggcc tcgtggtctc ttcctctctt ctatctcata
     3241 aggaaaccaa gttgcacacg tggagtctat ttggttagat tacgaaggat ttccatttca
     3301 agacctttac ctcattccac ctatcaagac ccttttccca aataaagtca ttgtctcaca
     3361 ttctgggggt ttgggcttac acaacccaga gtagggacat cattagaacc tgagtaaatg
     3421 cagctccaaa gcaggtgcct ttttaagcct tctaattctg ctagagagac ccggtctcta
     3481 gggtgatgac cagtaggctt cagagtttgg aggctgtcaa acccttgtca gtgctccaag
     3541 ctgttagcag ggtcagtggg aatgactggg aaaggcaggt tggctatagt aggagagagc
     3601 tgttgtgatg cctgcagtgg ctgcaagagc ttcatgcttc ttggataaac agatgcatag
     3661 gtacatttct gactagtact ttctcttgaa aggggctcag aaagcaggtg tgactcaggt
     3721 tccaggttac atacgatcat ctggaagctt gaaaacatta tgtcttgggc ttcatggact
     3781 ggtcaagaca aatctgagag tggctccagg caacggttgg gacctagtac ccttctagaa
     3841 ggtgggaacc cttgccacct acttaccctg cagtatggtg tatgattaac catacatcaa
     3901 agatttgaga atctaccatc ttcctgatat gggacatgtt gttttctttt ccaggattat
     3961 tgaagctata actggaaaaa gtagttgtcc catctccctc aggaattagc ctaattgttt
     4021 ttacacaaat tttatgtggt ctctggcaga taacttctag atccatataa ctagaagcat
     4081 gtcctttcca gacgacctct tactgttact tatgtatgct ttcttcttgt tggcccatgc
     4141 ccaagagaaa accagaaagc cagtaagaca gtacagagta cttcacctac tgtagtagta
     4201 aaccataagg cagactgtaa gtagggatga tgtcaaaata ggaataattg cagccctgta
     4261 tgtgacaccc tcaggcaagg tgaggcctac ctttcagtgt tttccctttc aaggtgggag
     4321 tttggtgaga tggaacaagc actttggaag cattctcagc cctctttacc tgacagcagc
     4381 ttggtcctca cagtgattgc ctcattggag tggctgtcat ggcactgtca ccaccaaagt
     4441 ctgtgatgca acatatctgc atggcctgca tatcagcagg cctgagtggc tagcatcttg
     4501 aaccttttat cacatgaaca ttctctgtag gctggtataa aaaggccaga ggattaaatt
     4561 atgtataaaa tatgaaataa agaagtaaga cctgcaa
//
