LOCUS       NM_001108854            3235 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus inhibitor of nuclear factor kappa B kinase
            subunit epsilon (Ikbke), mRNA.
ACCESSION   NM_001108854 XM_001058036 XM_344139
VERSION     NM_001108854.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3235)
  AUTHORS   Chen G, Xu Y, Fan R, Liu Y, Yao Y, Jiang H, Wu Q, Li L, Chen W and
            Chen X.
  TITLE     IKKepsilon protects against starvation-induced NLRP3 inflammasome
            and pyroptosis in H9c2 cells by alleviating mitochondrial injury
  JOURNAL   Biochem Biophys Res Commun 589, 267-274 (2022)
   PUBMED   34933200
  REMARK    GeneRIF: IKKepsilon protects against starvation-induced NLRP3
            inflammasome and pyroptosis in H9c2 cells by alleviating
            mitochondrial injury.
REFERENCE   2  (bases 1 to 3235)
  AUTHORS   Yuan Y, Wang J, Chen Q, Wu Q, Deng W, Zhou H and Shen D.
  TITLE     Long non-coding RNA cytoskeleton regulator RNA (CYTOR) modulates
            pathological cardiac hypertrophy through miR-155-mediated IKKi
            signaling
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1865 (6), 1421-1427 (2019)
   PUBMED   30794866
  REMARK    GeneRIF: Long non-coding RNA CYTOR modulates pathological cardiac
            hypertrophy through miR-155-mediated IKBKE signaling.
REFERENCE   3  (bases 1 to 3235)
  AUTHORS   Ren Y, Zhao Y, Lin D, Xu X, Zhu Q, Yao J, Shu HB and Zhong B.
  TITLE     The Type I Interferon-IRF7 Axis Mediates Transcriptional Expression
            of Usp25 Gene
  JOURNAL   J Biol Chem 291 (25), 13206-13215 (2016)
   PUBMED   27129230
REFERENCE   4  (bases 1 to 3235)
  AUTHORS   Rajsbaum R, Versteeg GA, Schmid S, Maestre AM, Belicha-Villanueva
            A, Martinez-Romero C, Patel JR, Morrison J, Pisanelli G, Miorin L,
            Laurent-Rolle M, Moulton HM, Stein DA, Fernandez-Sesma A, tenOever
            BR and Garcia-Sastre A.
  TITLE     Unanchored K48-linked polyubiquitin synthesized by the E3-ubiquitin
            ligase TRIM6 stimulates the interferon-IKKepsilon kinase-mediated
            antiviral response
  JOURNAL   Immunity 40 (6), 880-895 (2014)
   PUBMED   24882218
REFERENCE   5  (bases 1 to 3235)
  AUTHORS   Chen Q, Liu Q, Liu D, Wang D, Chen H, Xiao S and Fang L.
  TITLE     Molecular cloning, functional characterization and antiviral
            activity of porcine DDX3X
  JOURNAL   Biochem Biophys Res Commun 443 (4), 1169-1175 (2014)
   PUBMED   24380861
REFERENCE   6  (bases 1 to 3235)
  AUTHORS   Renner F, Moreno R and Schmitz ML.
  TITLE     SUMOylation-dependent localization of IKKepsilon in PML nuclear
            bodies is essential for protection against DNA-damage-triggered
            cell death
  JOURNAL   Mol Cell 37 (4), 503-515 (2010)
   PUBMED   20188669
REFERENCE   7  (bases 1 to 3235)
  AUTHORS   Hiscott J, Lacoste J and Lin R.
  TITLE     Recruitment of an interferon molecular signaling complex to the
            mitochondrial membrane: disruption by hepatitis C virus NS3-4A
            protease
  JOURNAL   Biochem Pharmacol 72 (11), 1477-1484 (2006)
   PUBMED   16876765
REFERENCE   8  (bases 1 to 3235)
  AUTHORS   Matsuda A, Suzuki Y, Honda G, Muramatsu S, Matsuzaki O, Nagano Y,
            Doi T, Shimotohno K, Harada T, Nishida E, Hayashi H and Sugano S.
  TITLE     Large-scale identification and characterization of human genes that
            activate NF-kappaB and MAPK signaling pathways
  JOURNAL   Oncogene 22 (21), 3307-3318 (2003)
   PUBMED   12761501
REFERENCE   9  (bases 1 to 3235)
  AUTHORS   Peters RT, Liao SM and Maniatis T.
  TITLE     IKKepsilon is part of a novel PMA-inducible IkappaB kinase complex
  JOURNAL   Mol Cell 5 (3), 513-522 (2000)
   PUBMED   10882136
REFERENCE   10 (bases 1 to 3235)
  AUTHORS   Shimada T, Kawai T, Takeda K, Matsumoto M, Inoue J, Tatsumi Y,
            Kanamaru A and Akira S.
  TITLE     IKK-i, a novel lipopolysaccharide-inducible kinase that is related
            to IkappaB kinases
  JOURNAL   Int Immunol 11 (8), 1357-1362 (1999)
   PUBMED   10421793
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473958.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_344139.3, XM_001058036.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMD00132261, SAMD00132262
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3235
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q13"
     gene            1..3235
                     /gene="Ikbke"
                     /note="inhibitor of nuclear factor kappa B kinase subunit
                     epsilon"
                     /db_xref="GeneID:363984"
                     /db_xref="RGD:1308352"
     exon            1..278
                     /gene="Ikbke"
                     /inference="alignment:Splign:2.1.0"
     exon            279..367
                     /gene="Ikbke"
                     /inference="alignment:Splign:2.1.0"
     exon            368..462
                     /gene="Ikbke"
                     /inference="alignment:Splign:2.1.0"
     CDS             376..2529
                     /gene="Ikbke"
                     /EC_number="2.7.11.10"
                     /note="inhibitor of kappaB kinase epsilon; inhibitor of
                     kappa light polypeptide gene enhancer in B-cells, kinase
                     epsilon"
                     /codon_start=1
                     /product="inhibitor of nuclear factor kappa-B kinase
                     subunit epsilon"
                     /protein_id="NP_001102324.1"
                     /db_xref="GeneID:363984"
                     /db_xref="RGD:1308352"
                     /translation="MQSTTNYLWHTDDLLGQGATANVYKARNKKSGEVVAVKVFNSAS
                     YRRPPEVQVREFEVLRRLDHENIVKLFAVEETGGSRQKVLVMEYCSSGSLLSVLEDPE
                     NTFGLPEEEFLVVLRCVVAGMNHLRENGIVHRDIKPGNIMRLVGKEGQSIYKLSDFGA
                     ARKLDDDEKFVSVYGTEEYLHPDMYERAVLRKPQQKAFGVTVDLWSIGVTLYHAATGS
                     LPFIPFGGPRRNKEIMYRITTEKPAGAISGTQKQENGPLEWSYSLPITCRLSVGLQSQ
                     LVPILANILEAEQAKCWGFDQFFAETSDILQRTVIHVFSLPQAVLHHIYIHAHNTIAI
                     FLEAVYEQTNVAPKHQEYFFEGHPCVLEPSLSAQHIAHTAASSPLTLFSMASDTPKGL
                     AFRDPALDVPKFVPKVDLQADYSTAKGVLGAGYQALWLARVLLDGQALMLRGLHWVLV
                     VLQNTCQQTLEITRTALLFLSSSLGTERLSSGAGMLDIQELKEATELRSRLQTFSEVL
                     SKCSHNVTETQRSLSCLVGELLKSRDQIHEDNRSIQKIQCCLDKMHFIYKQFKKSRMR
                     PGLSYNEEQIHKLDKVNFSHLAKRLLQVFQEECAQTYQVSLVTHGKRMRQVQKAQNHL
                     HLIGHSVATCNSEARGAQESLAKMFDQLLLDRASKQGAEVSPQPMATHPGPDPKDLVF
                     HMQELCNDMKLLAFDLQDNNRLIERLHRVPPTPEV"
     exon            463..603
                     /gene="Ikbke"
                     /inference="alignment:Splign:2.1.0"
     exon            604..733
                     /gene="Ikbke"
                     /inference="alignment:Splign:2.1.0"
     exon            734..915
                     /gene="Ikbke"
                     /inference="alignment:Splign:2.1.0"
     exon            916..1076
                     /gene="Ikbke"
                     /inference="alignment:Splign:2.1.0"
     exon            1077..1187
                     /gene="Ikbke"
                     /inference="alignment:Splign:2.1.0"
     exon            1188..1367
                     /gene="Ikbke"
                     /inference="alignment:Splign:2.1.0"
     exon            1368..1564
                     /gene="Ikbke"
                     /inference="alignment:Splign:2.1.0"
     exon            1565..1629
                     /gene="Ikbke"
                     /inference="alignment:Splign:2.1.0"
     exon            1630..1721
                     /gene="Ikbke"
                     /inference="alignment:Splign:2.1.0"
     exon            1722..1808
                     /gene="Ikbke"
                     /inference="alignment:Splign:2.1.0"
     exon            1809..1884
                     /gene="Ikbke"
                     /inference="alignment:Splign:2.1.0"
     exon            1885..2000
                     /gene="Ikbke"
                     /inference="alignment:Splign:2.1.0"
     exon            2001..2077
                     /gene="Ikbke"
                     /inference="alignment:Splign:2.1.0"
     exon            2078..2117
                     /gene="Ikbke"
                     /inference="alignment:Splign:2.1.0"
     exon            2118..2219
                     /gene="Ikbke"
                     /inference="alignment:Splign:2.1.0"
     exon            2220..2316
                     /gene="Ikbke"
                     /inference="alignment:Splign:2.1.0"
     exon            2317..2423
                     /gene="Ikbke"
                     /inference="alignment:Splign:2.1.0"
     exon            2424..2495
                     /gene="Ikbke"
                     /inference="alignment:Splign:2.1.0"
     exon            2496..3235
                     /gene="Ikbke"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggaggggaga aagagagaaa gagagagagc gagagagaga agtgaatcag gaagtatgac
       61 agacctaaga gcctggggct gtgtatccca ctgctattag agaggcaggc gagaaacctt
      121 caggctcaag accatactct gccttagtgg atcccggggg cccatcgcta ccaggatctt
      181 ctaggcactg ctcaggattg acttcaaggc ctgaacccct gagggtgcca cccagtccca
      241 caagtccgca ttcccctgca gctgagatgg gagatgggct tggctcctgg acttgcccca
      301 gacagaaagc atagcacaga cctgccaggg agagtctttg cctgattcta ggccccttgg
      361 agtgcaggag gaaggatgca gagtaccact aactacctgt ggcatactga tgacctgcta
      421 gggcaggggg ccactgccaa tgtgtacaag gcccggaata agaaatccgg ggaggtggtt
      481 gctgtaaagg tcttcaactc agccagctac cggcggcccc ctgaggtaca agtgagggag
      541 ttcgaggtct tgcggaggct ggatcatgag aacatcgtga agctattcgc agtggaggaa
      601 acgggaggca gccggcagaa ggtgctagtg atggagtact gctccagtgg gagcctgctg
      661 agcgtgctgg aagaccctga gaacacattc ggccttcctg aggaggagtt cctggtggta
      721 ctgcgctgtg tggtggctgg catgaaccac ctgcgggaga atggcattgt ccaccgtgac
      781 atcaagcccg ggaatatcat gcgcctggta ggcaaggagg ggcagagcat ctacaagctg
      841 tctgacttcg gggctgcccg gaagctggac gacgatgaga agtttgtttc tgtctatggt
      901 acagaggagt acctgcaccc tgacatgtat gagcgggcag tgcttcgcaa accccagcaa
      961 aaggcgttcg gggtgacagt ggatctctgg agtattgggg tgaccttgta ccacgcagcc
     1021 accggtagtc tgcccttcat cccctttggt gggccccggc gcaacaagga gatcatgtat
     1081 aggatcacca cagagaagcc agctggggcc atttccggga ctcagaagca ggaaaatggt
     1141 cccctggaat ggagctacag cctccccatc acctgtagac tgtctgtggg gctgcagagt
     1201 cagctagtgc ccatcctggc caacatcctg gaggccgaac aggctaaatg ctggggcttc
     1261 gatcagttct ttgcagagac cagtgacatc ctgcagcgaa ctgtcatcca tgtcttctcc
     1321 ctgccccagg cggttttgca tcacatctac atccatgccc acaacacgat tgccatcttt
     1381 ttggaggctg tatatgaaca gaccaacgtg gcccccaaac accaagaata cttcttcgag
     1441 ggtcaccctt gtgtcctcga gccaagcctc tcagcccagc acatcgccca cacagctgcc
     1501 agcagccctc taactctgtt cagcatggcc agcgacacac ccaaggggct ggccttcagg
     1561 gaccctgctc tggatgtccc aaagttcgtc cctaaggttg acctacaggc cgattacagc
     1621 accgctaagg gcgtgctggg cgctggttac caggccttgt ggctggcgcg ggtcctgctg
     1681 gatggacagg cgttgatgct tcgagggtta cactgggtcc tggtggtgct tcagaacacg
     1741 tgccaacaga cactggagat cacacggaca gccctcctct tcctcagtag cagcctgggc
     1801 actgaaaggc tcagcagtgg agctgggatg cttgacatcc aggaactaaa ggaagccacg
     1861 gagctgaggt ccaggctgca gactttctca gaggtcctgt ctaagtgttc ccacaatgtc
     1921 acagaaaccc aaaggagcct gagttgtctg gttggagagc ttttgaagag ccgggatcag
     1981 attcatgagg ataacagaag tatccagaag attcagtgtt gtttggacaa gatgcacttc
     2041 atctacaaac agttcaagaa gtctaggatg aggccaggcc tcagctacaa tgaggagcag
     2101 atccacaagc tggataaggt aaattttagt cacctagcca agaggctgct gcaggtgttc
     2161 caggaggagt gtgcacagac gtatcaggtg tcactggtca cacatggcaa gcggatgagg
     2221 caggtgcaga aggcccagaa ccacctgcac ctcattggcc actccgtggc tacctgtaac
     2281 tcagaagccc ggggagccca ggagagcctg gccaagatgt ttgatcagct cctcctggac
     2341 agagcttcca aacagggagc tgaggtctca ccacaaccta tggcaactca tcccggcccc
     2401 gatccgaagg acctggtctt ccacatgcag gaactttgta atgatatgaa gctattggcc
     2461 tttgatctcc aggacaacaa cagactcatc gaacggctac atagagttcc accaacacca
     2521 gaagtctgag ccccctgggg gtgcacaagg cactcggaag caatagagtc attcataccg
     2581 tacccctgca ctgcaagacc aaattcaggg caagttctgg tcccatctca ctagcctacc
     2641 tccctcttgg ccattggcca acaaattagc attactttga ctgcctgtcc tcttgggaag
     2701 cagccagcac agggactcct ggccattcag ggcagtaccc gcaagagaga ccatgtggct
     2761 acctaccact gcctcattga gacaccaaga ctgtttttcc tcacccaggc caggaggtct
     2821 gaactcaggc gggtctcggg gagaaaagcc tcagtcctct cacactctgc acttcccagg
     2881 accagcaggc ctctcctgtg gcttctccag gaggttggat aagtgggctt attcttcacc
     2941 gttttccatg ctgtttcctg agtcccatcc ttggccgcag gcgacccaca aatggcccct
     3001 ctgtgtttgg tctggatgca cctgcatttg agaaagtggg aagttgaggc caacggctgg
     3061 tgctttaggg atcctttgcc ttttctccct gaggaaccct tgattctgag aaacagctgg
     3121 ttggtatcaa gcatagccat gccaactgga cagatgttag aacccagagt cctaaggaga
     3181 gagaaggcct gtacctccct tcagacatgg aataaatgta ccgccttttc tgttt
//
