LOCUS       NP_001102324             717 aa            linear   ROD 26-FEB-2024
DEFINITION  inhibitor of nuclear factor kappa-B kinase subunit epsilon [Rattus
            norvegicus].
ACCESSION   NP_001102324 XP_001058036 XP_344140
VERSION     NP_001102324.1
DBSOURCE    REFSEQ: accession NM_001108854.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 717)
  AUTHORS   Chen G, Xu Y, Fan R, Liu Y, Yao Y, Jiang H, Wu Q, Li L, Chen W and
            Chen X.
  TITLE     IKKepsilon protects against starvation-induced NLRP3 inflammasome
            and pyroptosis in H9c2 cells by alleviating mitochondrial injury
  JOURNAL   Biochem Biophys Res Commun 589, 267-274 (2022)
   PUBMED   34933200
  REMARK    GeneRIF: IKKepsilon protects against starvation-induced NLRP3
            inflammasome and pyroptosis in H9c2 cells by alleviating
            mitochondrial injury.
REFERENCE   2  (residues 1 to 717)
  AUTHORS   Yuan Y, Wang J, Chen Q, Wu Q, Deng W, Zhou H and Shen D.
  TITLE     Long non-coding RNA cytoskeleton regulator RNA (CYTOR) modulates
            pathological cardiac hypertrophy through miR-155-mediated IKKi
            signaling
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1865 (6), 1421-1427 (2019)
   PUBMED   30794866
  REMARK    GeneRIF: Long non-coding RNA CYTOR modulates pathological cardiac
            hypertrophy through miR-155-mediated IKBKE signaling.
REFERENCE   3  (residues 1 to 717)
  AUTHORS   Ren Y, Zhao Y, Lin D, Xu X, Zhu Q, Yao J, Shu HB and Zhong B.
  TITLE     The Type I Interferon-IRF7 Axis Mediates Transcriptional Expression
            of Usp25 Gene
  JOURNAL   J Biol Chem 291 (25), 13206-13215 (2016)
   PUBMED   27129230
REFERENCE   4  (residues 1 to 717)
  AUTHORS   Rajsbaum R, Versteeg GA, Schmid S, Maestre AM, Belicha-Villanueva
            A, Martinez-Romero C, Patel JR, Morrison J, Pisanelli G, Miorin L,
            Laurent-Rolle M, Moulton HM, Stein DA, Fernandez-Sesma A, tenOever
            BR and Garcia-Sastre A.
  TITLE     Unanchored K48-linked polyubiquitin synthesized by the E3-ubiquitin
            ligase TRIM6 stimulates the interferon-IKKepsilon kinase-mediated
            antiviral response
  JOURNAL   Immunity 40 (6), 880-895 (2014)
   PUBMED   24882218
REFERENCE   5  (residues 1 to 717)
  AUTHORS   Chen Q, Liu Q, Liu D, Wang D, Chen H, Xiao S and Fang L.
  TITLE     Molecular cloning, functional characterization and antiviral
            activity of porcine DDX3X
  JOURNAL   Biochem Biophys Res Commun 443 (4), 1169-1175 (2014)
   PUBMED   24380861
REFERENCE   6  (residues 1 to 717)
  AUTHORS   Renner F, Moreno R and Schmitz ML.
  TITLE     SUMOylation-dependent localization of IKKepsilon in PML nuclear
            bodies is essential for protection against DNA-damage-triggered
            cell death
  JOURNAL   Mol Cell 37 (4), 503-515 (2010)
   PUBMED   20188669
REFERENCE   7  (residues 1 to 717)
  AUTHORS   Hiscott J, Lacoste J and Lin R.
  TITLE     Recruitment of an interferon molecular signaling complex to the
            mitochondrial membrane: disruption by hepatitis C virus NS3-4A
            protease
  JOURNAL   Biochem Pharmacol 72 (11), 1477-1484 (2006)
   PUBMED   16876765
REFERENCE   8  (residues 1 to 717)
  AUTHORS   Matsuda A, Suzuki Y, Honda G, Muramatsu S, Matsuzaki O, Nagano Y,
            Doi T, Shimotohno K, Harada T, Nishida E, Hayashi H and Sugano S.
  TITLE     Large-scale identification and characterization of human genes that
            activate NF-kappaB and MAPK signaling pathways
  JOURNAL   Oncogene 22 (21), 3307-3318 (2003)
   PUBMED   12761501
REFERENCE   9  (residues 1 to 717)
  AUTHORS   Peters RT, Liao SM and Maniatis T.
  TITLE     IKKepsilon is part of a novel PMA-inducible IkappaB kinase complex
  JOURNAL   Mol Cell 5 (3), 513-522 (2000)
   PUBMED   10882136
REFERENCE   10 (residues 1 to 717)
  AUTHORS   Shimada T, Kawai T, Takeda K, Matsumoto M, Inoue J, Tatsumi Y,
            Kanamaru A and Akira S.
  TITLE     IKK-i, a novel lipopolysaccharide-inducible kinase that is related
            to IkappaB kinases
  JOURNAL   Int Immunol 11 (8), 1357-1362 (1999)
   PUBMED   10421793
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473958.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XP_344140.3, XP_001058036.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMD00132261, SAMD00132262
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..717
                     /organism="Rattus norvegicus"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q13"
     Protein         1..717
                     /product="inhibitor of nuclear factor kappa-B kinase
                     subunit epsilon"
                     /EC_number="2.7.11.10"
                     /note="inhibitor of kappaB kinase epsilon; inhibitor of
                     kappa light polypeptide gene enhancer in B-cells, kinase
                     epsilon"
                     /calculated_mol_wt=80590
     Region          15..330
                     /region_name="Protein Kinases, catalytic domain"
                     /note="The protein kinase superfamily is mainly composed
                     of the catalytic domains of serine/threonine-specific and
                     tyrosine-specific protein kinases. It also includes RIO
                     kinases, which are atypical serine protein kinases,
                     aminoglycoside phosphotransferases; cl21453"
                     /db_xref="CDD:473864"
     Site            order(15..18,21,23,36,38,68,86..89,135,139..140,142,
                     156..157)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270870"
     Region          308..383
                     /region_name="Ubl_IKKE"
                     /note="ubiquitin-like (Ubl) domain found in inhibitor of
                     nuclear factor kappa-B kinase subunit epsilon (IKK-E);
                     cd17128"
                     /db_xref="CDD:340648"
     Site            order(316,353,382)
                     /site_type="other"
                     /note="putative hydrophobic patch [polypeptide binding]"
                     /db_xref="CDD:340648"
     Region          402..648
                     /region_name="TBK1_CCD1"
                     /note="TANK-binding kinase 1 coiled-coil domain 1;
                     pfam18394"
                     /db_xref="CDD:465742"
     Region          670..715
                     /region_name="TBK1_IKKE-like_C"
                     /note="C-terminal domain of non-canonical Inhibitor of
                     kappa B kinases, IKK-E and TBK1, and similar proteins;
                     cl41735"
                     /db_xref="CDD:425366"
     Site            order(676..677,679..681,683..684,687..688,690..691,
                     694..695,697..698,701..702,704..705,707..709,711..713)
                     /site_type="other"
                     /note="heterotetramer interface [polypeptide binding]"
                     /db_xref="CDD:409261"
     CDS             1..717
                     /gene="Ikbke"
                     /coded_by="NM_001108854.1:376..2529"
                     /db_xref="GeneID:363984"
                     /db_xref="RGD:1308352"
ORIGIN      
        1 mqsttnylwh tddllgqgat anvykarnkk sgevvavkvf nsasyrrppe vqvrefevlr
       61 rldhenivkl faveetggsr qkvlvmeycs sgsllsvled pentfglpee eflvvlrcvv
      121 agmnhlreng ivhrdikpgn imrlvgkegq siyklsdfga arkldddekf vsvygteeyl
      181 hpdmyeravl rkpqqkafgv tvdlwsigvt lyhaatgslp fipfggprrn keimyritte
      241 kpagaisgtq kqengplews yslpitcrls vglqsqlvpi lanileaeqa kcwgfdqffa
      301 etsdilqrtv ihvfslpqav lhhiyihahn tiaifleavy eqtnvapkhq eyffeghpcv
      361 lepslsaqhi ahtaassplt lfsmasdtpk glafrdpald vpkfvpkvdl qadystakgv
      421 lgagyqalwl arvlldgqal mlrglhwvlv vlqntcqqtl eitrtallfl ssslgterls
      481 sgagmldiqe lkeatelrsr lqtfsevlsk cshnvtetqr slsclvgell ksrdqihedn
      541 rsiqkiqccl dkmhfiykqf kksrmrpgls yneeqihkld kvnfshlakr llqvfqeeca
      601 qtyqvslvth gkrmrqvqka qnhlhlighs vatcnsearg aqeslakmfd qllldraskq
      661 gaevspqpma thpgpdpkdl vfhmqelcnd mkllafdlqd nnrlierlhr vpptpev
//
