LOCUS       NM_053355               3525 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus inhibitor of nuclear factor kappa B kinase
            subunit beta (Ikbkb), mRNA.
ACCESSION   NM_053355
VERSION     NM_053355.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3525)
  AUTHORS   Yang,J., Li,H., Zhang,C. and Zhou,Y.
  TITLE     Indoxyl sulfate reduces Ito,f by activating ROS/MAPK and NF-kappaB
            signaling pathways
  JOURNAL   JCI Insight 7 (3), e145475 (2022)
   PUBMED   35132967
  REMARK    GeneRIF: Indoxyl sulfate reduces Ito,f by activating ROS/MAPK and
            NF-kappaB signaling pathways.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3525)
  AUTHORS   Lee,S., Shin,H.J., Noh,C., Kim,S.I., Ko,Y.K., Lee,S.Y., Lim,C.,
            Hong,B., Yang,S.Y., Kim,D.W., Lee,W.H. and Kim,Y.H.
  TITLE     IKBKB siRNA-Encapsulated Poly (Lactic-co-Glycolic Acid)
            Nanoparticles Diminish Neuropathic Pain by Inhibiting Microglial
            Activation
  JOURNAL   Int J Mol Sci 22 (11), 5657 (2021)
   PUBMED   34073390
  REMARK    GeneRIF: IKBKB siRNA-Encapsulated Poly (Lactic-co-Glycolic Acid)
            Nanoparticles Diminish Neuropathic Pain by Inhibiting Microglial
            Activation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3525)
  AUTHORS   Li,M., Guo,Q., Cai,H., Wang,H., Ma,Z. and Zhang,X.
  TITLE     miR-218 regulates diabetic nephropathy via targeting IKK-beta and
            modulating NK-kappaB-mediated inflammation
  JOURNAL   J Cell Physiol 235 (4), 3362-3371 (2020)
   PUBMED   31549412
  REMARK    GeneRIF: miR-218 regulates diabetic nephropathy via targeting
            IKK-beta and modulating NK-kappaB-mediated inflammation.
REFERENCE   4  (bases 1 to 3525)
  AUTHORS   Wei,S.F., Sun,J.J., Zhou,N., Li,X.L., Lin,Y., Zhang,Y.D.,
            Zhang,Y.R. and Wu,L.Y.
  TITLE     Protective effect of RNA interference targeting Ikkbeta on hepatic
            fibrosis in rats
  JOURNAL   J Cell Biochem 120 (11), 18894-18900 (2019)
   PUBMED   31297885
  REMARK    GeneRIF: Protective effect of RNA interference targeting Ikkbeta on
            hepatic fibrosis in rats.
REFERENCE   5  (bases 1 to 3525)
  AUTHORS   Dondelinger,Y., Delanghe,T., Priem,D., Wynosky-Dolfi,M.A.,
            Sorobetea,D., Rojas-Rivera,D., Giansanti,P., Roelandt,R.,
            Gropengiesser,J., Ruckdeschel,K., Savvides,S.N., Heck,A.J.R.,
            Vandenabeele,P., Brodsky,I.E. and Bertrand,M.J.M.
  TITLE     Serine 25 phosphorylation inhibits RIPK1 kinase-dependent cell
            death in models of infection and inflammation
  JOURNAL   Nat Commun 10 (1), 1729 (2019)
   PUBMED   30988283
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3525)
  AUTHORS   Kupfer,R. and Scheinman,R.I.
  TITLE     Measurement of IKK activity in primary rat T cells: rapid
            activation and inactivation
  JOURNAL   J Immunol Methods 266 (1-2), 155-164 (2002)
   PUBMED   12133632
REFERENCE   7  (bases 1 to 3525)
  AUTHORS   Pasparakis,M., Courtois,G., Hafner,M., Schmidt-Supprian,M.,
            Nenci,A., Toksoy,A., Krampert,M., Goebeler,M., Gillitzer,R.,
            Israel,A., Krieg,T., Rajewsky,K. and Haase,I.
  TITLE     TNF-mediated inflammatory skin disease in mice with
            epidermis-specific deletion of IKK2
  JOURNAL   Nature 417 (6891), 861-866 (2002)
   PUBMED   12075355
REFERENCE   8  (bases 1 to 3525)
  AUTHORS   Chang,N.S.
  TITLE     The non-ankyrin C terminus of Ikappa Balpha physically interacts
            with p53 in vivo and dissociates in response to apoptotic stress,
            hypoxia, DNA damage, and transforming growth factor-beta 1-mediated
            growth suppression
  JOURNAL   J Biol Chem 277 (12), 10323-10331 (2002)
   PUBMED   11799106
REFERENCE   9  (bases 1 to 3525)
  AUTHORS   Zhang,Y., Sun,S., Chen,W.C., Kaluzhny,Y., Chinnappan,D., Yu,G. and
            Ravid,K.
  TITLE     Repression of AIM-1 kinase mRNA as part of a program of genes
            regulated by Mpl ligand
  JOURNAL   Biochem Biophys Res Commun 282 (3), 844-849 (2001)
   PUBMED   11401541
REFERENCE   10 (bases 1 to 3525)
  AUTHORS   Nemoto,S., DiDonato,J.A. and Lin,A.
  TITLE     Coordinate regulation of IkappaB kinases by mitogen-activated
            protein kinase kinase kinase 1 and NF-kappaB-inducing kinase
  JOURNAL   Mol Cell Biol 18 (12), 7336-7343 (1998)
   PUBMED   9819420
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Nov 27, 2020 this sequence version replaced NM_053355.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.432458.1,
                                           SRR26360190.2174589.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-83                JAXUCZ010000016.1  76022031-76022113
            84-210              JAXUCZ010000016.1  76022385-76022511
            211-305             JAXUCZ010000016.1  76033692-76033786
            306-423             JAXUCZ010000016.1  76035155-76035272
            424-493             JAXUCZ010000016.1  76037894-76037963
            494-582             JAXUCZ010000016.1  76048571-76048659
            583-672             JAXUCZ010000016.1  76049647-76049736
            673-797             JAXUCZ010000016.1  76053182-76053306
            798-905             JAXUCZ010000016.1  76056865-76056972
            906-1035            JAXUCZ010000016.1  76059948-76060077
            1036-1230           JAXUCZ010000016.1  76060942-76061136
            1231-1345           JAXUCZ010000016.1  76061743-76061857
            1346-1469           JAXUCZ010000016.1  76064007-76064130
            1470-1621           JAXUCZ010000016.1  76064699-76064850
            1622-1683           JAXUCZ010000016.1  76064979-76065040
            1684-1793           JAXUCZ010000016.1  76066322-76066431
            1794-1843           JAXUCZ010000016.1  76067628-76067677
            1844-1943           JAXUCZ010000016.1  76067775-76067874
            1944-2091           JAXUCZ010000016.1  76068051-76068198
            2092-2219           JAXUCZ010000016.1  76070652-76070779
            2220-2310           JAXUCZ010000016.1  76073644-76073734
            2311-3525           JAXUCZ010000016.1  76074503-76075717
FEATURES             Location/Qualifiers
     source          1..3525
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16q12.5"
     gene            1..3525
                     /gene="Ikbkb"
                     /gene_synonym="AIM-1; IKK2"
                     /note="inhibitor of nuclear factor kappa B kinase subunit
                     beta"
                     /db_xref="GeneID:84351"
                     /db_xref="RGD:621375"
     exon            1..83
                     /gene="Ikbkb"
                     /gene_synonym="AIM-1; IKK2"
                     /inference="alignment:Splign:2.1.0"
     exon            84..210
                     /gene="Ikbkb"
                     /gene_synonym="AIM-1; IKK2"
                     /inference="alignment:Splign:2.1.0"
     CDS             106..2379
                     /gene="Ikbkb"
                     /gene_synonym="AIM-1; IKK2"
                     /EC_number="2.7.11.1"
                     /EC_number="2.7.11.10"
                     /note="IKK-B; NFKBIKB; IKK-beta; I-kappa-B kinase 2;
                     I-kappa-B-kinase beta; nuclear factor NF-kappa-B inhibitor
                     kinase beta; inhibitor of nuclear factor kappa B kinase
                     beta subunit; inhibitor of kappaB kinase beta; inhibitor
                     of kappa light polypeptide gene enhancer in B-cells,
                     kinase beta; serine/threonine protein kinase IKBKB"
                     /codon_start=1
                     /product="inhibitor of nuclear factor kappa-B kinase
                     subunit beta"
                     /protein_id="NP_445807.2"
                     /db_xref="GeneID:84351"
                     /db_xref="RGD:621375"
                     /translation="MSWSPSLPTQTCGAWEMKERLGTGGFGNVIRWHNQVTGEQIAIK
                     QCRQELSPKNRDRWCLEIQIMRRLNHPNVVAARDVPEGMQNLAPNDLPLLAMEYCQGG
                     DLRRYLNQFENCCGLREGAILTLLSDIASALRYLHENRIIHRDLKPENIVLQQGEKRL
                     IHKIIDLGYAKELDQGSLCTSFVGTLQYLAPELLEQQKYTVTVDYWSFGTLAFECITG
                     FRPFLPNWQPVQWHSKVRQKSEVDIVVSEDLNGTVKFSSSLPFPNNLNSVLAERLEKW
                     LQLMLTWQPRQRGVDPQYGPNGCFRALDDILNLKLVHILNMVTGTIHTYPVMEDESLQ
                     SLKTRIREDTGILETDQELLQEAGLVLLPDKPATQCISDSKTNEGLTLDMDLVFLFDN
                     SKMSYETQITPRPQPESVSCVLQEPKRNLSFFQMRKVWGQVWHSIQTLKEDCNRLQQG
                     QRAAMMNLLRNNSCLSKMKNAMASTAQQLKAKLDFFKTSIQIDLEKYREQTEFGITSD
                     KLLLAWREMEQAVEQCGRENDVKVLVERMMALQTDIVDLQRSPMGRKQGGTLDDLEEQ
                     ARELYRRLREKPRDQRTEGDSQDMVRLLLQAIQSFEKKVRVIYSQLSKTVVCKQKALE
                     LLPKVEEVVRLMNEDEKTVVRLQEKRQKELWNLLKIACSKVRGPVSGSPDSMNVSRLS
                     HPGHLMSQPSSACDSLPDSDKKSEELVAEAHALCSRLESALQDTVKQQDRSFTTLDWS
                     WLQMEDEERCGLEQACD"
     exon            211..305
                     /gene="Ikbkb"
                     /gene_synonym="AIM-1; IKK2"
                     /inference="alignment:Splign:2.1.0"
     exon            306..423
                     /gene="Ikbkb"
                     /gene_synonym="AIM-1; IKK2"
                     /inference="alignment:Splign:2.1.0"
     exon            424..493
                     /gene="Ikbkb"
                     /gene_synonym="AIM-1; IKK2"
                     /inference="alignment:Splign:2.1.0"
     exon            494..582
                     /gene="Ikbkb"
                     /gene_synonym="AIM-1; IKK2"
                     /inference="alignment:Splign:2.1.0"
     exon            583..672
                     /gene="Ikbkb"
                     /gene_synonym="AIM-1; IKK2"
                     /inference="alignment:Splign:2.1.0"
     exon            673..797
                     /gene="Ikbkb"
                     /gene_synonym="AIM-1; IKK2"
                     /inference="alignment:Splign:2.1.0"
     exon            798..905
                     /gene="Ikbkb"
                     /gene_synonym="AIM-1; IKK2"
                     /inference="alignment:Splign:2.1.0"
     exon            906..1035
                     /gene="Ikbkb"
                     /gene_synonym="AIM-1; IKK2"
                     /inference="alignment:Splign:2.1.0"
     exon            1036..1230
                     /gene="Ikbkb"
                     /gene_synonym="AIM-1; IKK2"
                     /inference="alignment:Splign:2.1.0"
     exon            1231..1345
                     /gene="Ikbkb"
                     /gene_synonym="AIM-1; IKK2"
                     /inference="alignment:Splign:2.1.0"
     exon            1346..1469
                     /gene="Ikbkb"
                     /gene_synonym="AIM-1; IKK2"
                     /inference="alignment:Splign:2.1.0"
     exon            1470..1621
                     /gene="Ikbkb"
                     /gene_synonym="AIM-1; IKK2"
                     /inference="alignment:Splign:2.1.0"
     exon            1622..1683
                     /gene="Ikbkb"
                     /gene_synonym="AIM-1; IKK2"
                     /inference="alignment:Splign:2.1.0"
     exon            1684..1793
                     /gene="Ikbkb"
                     /gene_synonym="AIM-1; IKK2"
                     /inference="alignment:Splign:2.1.0"
     exon            1794..1843
                     /gene="Ikbkb"
                     /gene_synonym="AIM-1; IKK2"
                     /inference="alignment:Splign:2.1.0"
     exon            1844..1943
                     /gene="Ikbkb"
                     /gene_synonym="AIM-1; IKK2"
                     /inference="alignment:Splign:2.1.0"
     exon            1944..2091
                     /gene="Ikbkb"
                     /gene_synonym="AIM-1; IKK2"
                     /inference="alignment:Splign:2.1.0"
     exon            2092..2219
                     /gene="Ikbkb"
                     /gene_synonym="AIM-1; IKK2"
                     /inference="alignment:Splign:2.1.0"
     exon            2220..2310
                     /gene="Ikbkb"
                     /gene_synonym="AIM-1; IKK2"
                     /inference="alignment:Splign:2.1.0"
     exon            2311..3525
                     /gene="Ikbkb"
                     /gene_synonym="AIM-1; IKK2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tggcgctgag ctggctgcgt ggggaccccg agttttcatg tcctcagcgg gtgtcgctag
       61 cggccccgcg gcccccgggg cagagttagc agggagggca tcgatatgag ctggtcacct
      121 tctctcccaa cccagacatg tggggcctgg gaaatgaaag aacgcctcgg aactggggga
      181 tttggaaacg tcatccggtg gcacaatcag gtgacaggtg aacaaattgc catcaagcaa
      241 tgccgacagg agctcagccc caagaaccgc gatcgctggt gcctagagat ccagatcatg
      301 agaaggctga accatcccaa cgtggtggcc gcccgggatg tcccagaggg gatgcagaac
      361 ttggcaccca atgatttgcc tctgctggcc atggagtact gccaaggagg agacctccgg
      421 agatacttga accagttcga aaactgctgt ggcctccggg aaggagccat cctcaccctg
      481 ctgagtgaca tagcatcggc tcttagatac cttcatgaaa acagaatcat ccaccgggac
      541 ctgaagccag agaacattgt cctacagcaa ggagagaaaa gattaataca caaaattatt
      601 gatctaggat atgccaagga gctggatcag ggcagtctgt gcacgtcatt tgtggggacc
      661 ctgcaatacc tggccccaga gcttctggag cagcagaagt acaccgtgac tgttgactac
      721 tggagcttcg gcaccctggc ctttgaatgc atcaccggct tccggccctt tctccctaac
      781 tggcagcctg tgcagtggca ctctaaagtc cggcagaaga gcgaagtgga cattgttgtt
      841 agcgaggact tgaacggaac agtgaagttc tcaagttcct tacccttccc caataatctc
      901 aacagtgtcc tggctgagcg tctggagaag tggcttcagc tgatgctcac gtggcaacct
      961 cggcaaaggg gcgtggaccc ccagtacggt cccaatggct gtttcagggc cctcgatgac
     1021 atcttgaact taaagctggt tcatatcttg aacatggtca caggcaccat tcacacatac
     1081 cctgtgatgg aggatgaaag tctgcagagc ttaaaaacca gaatccggga agacacaggg
     1141 atcctggaga cagaccagga actgctgcag gaggcagggc tggtgctgct ccctgacaag
     1201 cctgctactc agtgcatctc agacagcaag acaaatgagg gcctcacact ggacatggat
     1261 ctcgtctttc tctttgacaa cagtaaaatg tcctatgaga ctcagatcac cccccgaccc
     1321 caacctgaga gcgtcagctg tgtccttcag gagcccaagc ggaacctctc cttcttccag
     1381 atgaggaaag tgtggggcca agtctggcac agcatccaaa cgctgaagga agactgtaac
     1441 cggctgcagc agggacagcg agctgccatg atgaacctcc ttcggaataa cagctgcctc
     1501 tccaagatga agaatgccat ggcctccacg gcgcagcagc tcaaggccaa gttggacttc
     1561 ttcaaaacca gcatccagat tgacctggag aagtacaggg agcagacgga gtttggcatc
     1621 acatcggaca aactgctgct ggcctggcgg gaaatggagc aggccgtgga gcagtgtggg
     1681 cgggagaatg acgtgaaggt cctggtagaa cggatgatgg cactgcagac cgacattgtg
     1741 gacctacaga ggagcccgat gggtcggaag caggggggca ccttggatga cctagaggaa
     1801 caagcaagag aactctacag aagactcagg gagaagccaa gagaccaaag gacagaaggt
     1861 gacagccagg atatggtacg gctgctgctg caagccatcc agagcttcga gaagaaagtg
     1921 cgggtgattt actctcagct cagtaagacc gtggtttgta agcagaaggc cctggagctg
     1981 ctgcccaaag tagaagaggt ggtgaggctc atgaacgagg atgagaagac tgtggtccgg
     2041 ctccaggaga agcggcagaa ggagctctgg aacctcctga agatcgcctg tagcaaagtc
     2101 cgaggtccgg tgagtggaag cccagatagc atgaatgtgt ctcgacttag tcaccctggt
     2161 catctaatgt cccagccttc cagtgcctgt gacagcttac ctgattcaga caagaaaagt
     2221 gaagaactgg tggccgaagc acacgccctc tgctcccggc tggaaagcgc gctgcaggac
     2281 acggtgaagc agcaggaccg aagcttcacg accctagact ggagctggtt acagatggag
     2341 gatgaagaaa ggtgtggcct ggagcaggcc tgtgactgag gtgcccgtga actggcccgc
     2401 ggctcggcat gtgaggatgc tctggtacct ccagggggac atcccgctct cctggcagct
     2461 gcgatccttg cccacagcag cctgtgctgg cccagtctac acactggacg tcctccacca
     2521 cagaagcaca acaatgtcag ttacaagccc gtgcggcaac aagactgcag tgctgctaca
     2581 caaagagctt acgacagacg tctaccttga gtgtttccag acagcagcca gcctgtcccc
     2641 tttggactgc tgcgggggag ggagccctgc cctcctcgcc tttcagctgg ggtgtcatct
     2701 ggatccagct tccttagaca tttaatcaga agcctgatga ttctacgtct ttcttcctct
     2761 tcacttcccc ctggtaaatg tttctacctt ctgtgccggt cgttgtggca aacggccttt
     2821 gactaagttg taatgacggt gataccaagc tccctgatgt cccggctcct ttaagccaca
     2881 gagcgactta cacagccagg cagaacagaa atgcagctac acatcctgag tcccaaagat
     2941 tacctggagt caactgtcat ggagagaaat ggaagatgaa ggtcctacac cagcccctcc
     3001 cctgctgagc actgtgtgac tctgccacct gtcaggtgtg tgaggacgtt gctgcctctc
     3061 acataagcta gcagcgttat taaactggtt cgttttataa atagtttcta ttttttgtaa
     3121 cattactcag atatgtatcc taggctcaag ggtgtatttc cacagtaata ctaccactag
     3181 tacttctgag ctcagagggc aacatcatgg gaaatttcgt aagattgaac agcgtatcta
     3241 gatcatgtca tttttacatc acacaaaact tgtgtgtttg cgtgcatatg tgtgtatgaa
     3301 agcgaagcag gctcagattg tcataaacag gtttatttga ttagagaata aagttggaac
     3361 agagaaatgt cagagcggcc accgcagaca cagtatgaag cgtcactggt cacgtgagct
     3421 cagcggtgct gcatgctttc tttcccagag attgatgctg tgcactggga acctgtttga
     3481 aaactccgac aataaagatg ctggcttaag ctcagcgtaa attca
//
