LOCUS       NM_001005537            2032 bp    mRNA    linear   ROD 31-MAY-2024
DEFINITION  Rattus norvegicus IK cytokine (Ik), mRNA.
ACCESSION   NM_001005537 XM_214579
VERSION     NM_001005537.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2032)
  AUTHORS   Bertram,K., Agafonov,D.E., Dybkov,O., Haselbach,D., Leelaram,M.N.,
            Will,C.L., Urlaub,H., Kastner,B., Luhrmann,R. and Stark,H.
  TITLE     Cryo-EM Structure of a Pre-catalytic Human Spliceosome Primed for
            Activation
  JOURNAL   Cell 170 (4), 701-713 (2017)
   PUBMED   28781166
REFERENCE   2  (bases 1 to 2032)
  AUTHORS   Hu,L., Yang,F., Liu,X., Xu,D. and Dai,W.
  TITLE     Nuclear protein IK undergoes dynamic subcellular translocation and
            forms unique nuclear bodies during the cell cycle
  JOURNAL   Biomark Res 1 (1), 11 (2013)
   PUBMED   24252166
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2032)
  AUTHORS   Yeh,P.C., Yeh,C.C., Chen,Y.C. and Juang,Y.L.
  TITLE     RED, a spindle pole-associated protein, is required for kinetochore
            localization of MAD1, mitotic progression, and activation of the
            spindle assembly checkpoint
  JOURNAL   J Biol Chem 287 (15), 11704-11716 (2012)
   PUBMED   22351768
REFERENCE   4  (bases 1 to 2032)
  AUTHORS   Hegele,A., Kamburov,A., Grossmann,A., Sourlis,C., Wowro,S.,
            Weimann,M., Will,C.L., Pena,V., Luhrmann,R. and Stelzl,U.
  TITLE     Dynamic protein-protein interaction wiring of the human spliceosome
  JOURNAL   Mol Cell 45 (4), 567-580 (2012)
   PUBMED   22365833
REFERENCE   5  (bases 1 to 2032)
  AUTHORS   Krief,P., Augery-Bourget,Y., Plaisance,S., Merck,M.F., Assier,E.,
            Tanchou,V., Billard,M., Boucheix,C., Jasmin,C. and Azzarone,B.
  TITLE     A new cytokine (IK) down-regulating HLA class II: monoclonal
            antibodies, cloning and chromosome localization
  JOURNAL   Oncogene 9 (12), 3449-3456 (1994)
   PUBMED   7970704
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC081870.1.
            
            On Oct 8, 2004 this sequence version replaced XM_214579.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC081870.1, FQ212525.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2032
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18p11"
     gene            1..2032
                     /gene="Ik"
                     /gene_synonym="CSA2; RED"
                     /note="IK cytokine"
                     /db_xref="GeneID:291659"
                     /db_xref="RGD:1359352"
     exon            1..138
                     /gene="Ik"
                     /gene_synonym="CSA2; RED"
                     /inference="alignment:Splign:2.1.0"
     CDS             123..1796
                     /gene="Ik"
                     /gene_synonym="CSA2; RED"
                     /note="Ik factor; chondrosarcoma-associated protein 2;
                     cytokine IK; IK cytokine, down-regulator of HLA II"
                     /codon_start=1
                     /product="protein Red"
                     /protein_id="NP_001005537.1"
                     /db_xref="GeneID:291659"
                     /db_xref="RGD:1359352"
                     /translation="MPERDSEPFSNPLAPDGHDVDDPHSFHQSKLTNEDFRKLLMTPR
                     AAPTSAPPSKSRHHEMPREYNEDEDPAARRRKKKSYYAKLRQQEIERERELAEKYRDR
                     AKERRDGVNKDYEETELISTTANYRAVGPTAEADKSAAEKRRQLIQESKFLGGDMEHT
                     HLVKGLDFALLQKVRAEIASKEKEEEELMEKPQKETKKDEDPENKIEFKTRLGRNVYR
                     MLFKSKSYERNELFLPGRMAYVVDLDDEYADTDIPTTLIRSKADCPTMEAQTTLTTND
                     IVISKLTQILSYLRQGTRNKKLKKKDKGKLEEKKPPEADMNIFEDIGDYVPSTTKTPR
                     DKERERYRERERDRERDRDRERDRERDRERERERDREREREEEKKRHSYFEKPKVDDE
                     PMDVDKGPGSAKELIKSINEKFAGSAGWEGTESLKKPEDKKQLGDFFGMSNSYAECYP
                     ATMDDMAVDSDEEVDYSKMDQGNKKGPLGRWDFDTQEEYSEYMNNKEALPKAAFQYGI
                     KMSEGRKTRRFKETNDKAELDRQWKKISAIIEKRKKMEADGVEVKRPKY"
     exon            139..205
                     /gene="Ik"
                     /gene_synonym="CSA2; RED"
                     /inference="alignment:Splign:2.1.0"
     exon            206..298
                     /gene="Ik"
                     /gene_synonym="CSA2; RED"
                     /inference="alignment:Splign:2.1.0"
     exon            299..358
                     /gene="Ik"
                     /gene_synonym="CSA2; RED"
                     /inference="alignment:Splign:2.1.0"
     exon            359..526
                     /gene="Ik"
                     /gene_synonym="CSA2; RED"
                     /inference="alignment:Splign:2.1.0"
     exon            527..641
                     /gene="Ik"
                     /gene_synonym="CSA2; RED"
                     /inference="alignment:Splign:2.1.0"
     exon            642..712
                     /gene="Ik"
                     /gene_synonym="CSA2; RED"
                     /inference="alignment:Splign:2.1.0"
     exon            713..759
                     /gene="Ik"
                     /gene_synonym="CSA2; RED"
                     /inference="alignment:Splign:2.1.0"
     exon            760..923
                     /gene="Ik"
                     /gene_synonym="CSA2; RED"
                     /inference="alignment:Splign:2.1.0"
     exon            924..1032
                     /gene="Ik"
                     /gene_synonym="CSA2; RED"
                     /inference="alignment:Splign:2.1.0"
     exon            1033..1072
                     /gene="Ik"
                     /gene_synonym="CSA2; RED"
                     /inference="alignment:Splign:2.1.0"
     exon            1073..1298
                     /gene="Ik"
                     /gene_synonym="CSA2; RED"
                     /inference="alignment:Splign:2.1.0"
     exon            1299..1317
                     /gene="Ik"
                     /gene_synonym="CSA2; RED"
                     /inference="alignment:Splign:2.1.0"
     exon            1318..1396
                     /gene="Ik"
                     /gene_synonym="CSA2; RED"
                     /inference="alignment:Splign:2.1.0"
     exon            1397..1477
                     /gene="Ik"
                     /gene_synonym="CSA2; RED"
                     /inference="alignment:Splign:2.1.0"
     exon            1478..1535
                     /gene="Ik"
                     /gene_synonym="CSA2; RED"
                     /inference="alignment:Splign:2.1.0"
     exon            1536..1624
                     /gene="Ik"
                     /gene_synonym="CSA2; RED"
                     /inference="alignment:Splign:2.1.0"
     exon            1625..1733
                     /gene="Ik"
                     /gene_synonym="CSA2; RED"
                     /inference="alignment:Splign:2.1.0"
     exon            1734..1768
                     /gene="Ik"
                     /gene_synonym="CSA2; RED"
                     /inference="alignment:Splign:2.1.0"
     exon            1769..1995
                     /gene="Ik"
                     /gene_synonym="CSA2; RED"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggaaggcac ggaaggcaaa gccctgtcgc aggctttcgt ggtgcattgt ggataaaagt
       61 ttgtcgccgc tgttttgttg aggatatttc gcgattgctg gcgctgagag accgcggccg
      121 aaatgccgga gcgagatagt gagcccttct ctaacccttt ggccccagat ggccacgatg
      181 tggatgatcc tcattctttc caccaatcaa aacttaccaa tgaagacttc aggaaacttc
      241 ttatgacccc aagagctgca cctacttctg caccaccttc taagtcacgt caccatgaga
      301 tgccaagaga gtacaatgag gatgaagacc cagctgcacg gaggaggaag aagaaaagtt
      361 attatgccaa gcttcgccag caagaaattg agagagagag agaactcgca gagaaatacc
      421 gggaccgtgc caaggaacgg agagatggtg tgaacaaaga ttatgaggaa actgagctga
      481 ttagtacaac agccaactac agggccgtgg gccccactgc tgaggcggac aaatcagcag
      541 cagagaagag aagacaattg attcaggagt ctaaattctt gggtggtgat atggaacaca
      601 cccatttggt gaaaggtttg gattttgcat tgcttcaaaa ggtgcgagct gagattgcca
      661 gcaaagagaa ggaggaagag gaactcatgg aaaagcccca aaaggaaacc aagaaagatg
      721 aggatcctga gaacaaaatt gaattcaaaa ctcggcttgg tcgaaatgtg tatcggatgc
      781 ttttcaagag taaatcttat gagcgaaatg agctgttctt accaggccgg atggcctacg
      841 tggtggacct ggatgatgag tatgcagata cggatatccc tactactctt atccgcagca
      901 aagctgattg ccccaccatg gaggcccaga ctacactgac tacaaatgac attgttatta
      961 gcaagctcac ccagattttg tcatatctga ggcaggggac ccgaaacaag aagctcaaga
     1021 agaaagataa aggaaaactg gaagaaaaga aacctcctga ggctgacatg aacatttttg
     1081 aagacatcgg ggattatgtt ccttccacaa ccaagacacc tcgggacaag gagcgtgaga
     1141 gataccggga acgtgaacgt gatcgggaaa gggacagaga cagggagaga gatcgggagc
     1201 gagaccgtga gagggagaga gagcgagacc gggaacgtga acgagaggag gaaaagaaaa
     1261 ggcacagcta ctttgagaag ccaaaagtgg atgatgagcc catggatgtt gacaaaggac
     1321 ctggatctgc aaaagaattg atcaagtcca taaatgaaaa atttgctggg tctgccggtt
     1381 gggaaggcac tgaatcgctg aagaagccag aagataagaa gcagctgggt gatttctttg
     1441 gcatgtccaa cagttacgca gaatgctatc cagccacgat ggatgacatg gctgtagata
     1501 gtgatgaaga agtagattat agcaaaatgg atcagggtaa caagaagggc cccttaggcc
     1561 gctgggattt tgatactcag gaggagtaca gcgagtatat gaacaacaag gaggctttgc
     1621 ccaaggctgc attccagtat ggcatcaaga tgtctgaagg acggaaaacc aggcgcttca
     1681 aagaaaccaa tgataaggca gagcttgatc gacagtggaa gaaaataagt gcgatcatcg
     1741 agaagaggaa gaagatggaa gctgacgggg ttgaagtgaa aagaccaaag tactaatctc
     1801 aagttccagc tgaccacatg gctgttatta gttgcttgtt tctacaattc ctcaaaaagt
     1861 tgcaaactgt ttttgtttgt gaatgtttat aaatgtttat tgtataactc tttaagatct
     1921 gtgtcccaaa tgctaagatt aatggcaatg caacaccatg tgtccaacat gttcaattaa
     1981 aatcagttaa acctgaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aa
//
