LOCUS       NM_175763               4407 bp    mRNA    linear   ROD 02-APR-2024
DEFINITION  Rattus norvegicus immunoglobulin superfamily, member 1 (Igsf1),
            mRNA.
ACCESSION   NM_175763
VERSION     NM_175763.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4407)
  AUTHORS   Wang,Y., Brule,E., Silander,T., Bak,B., Joustra,S.D. and
            Bernard,D.J.
  TITLE     The short mRNA isoform of the immunoglobulin superfamily, member 1
            gene encodes an intracellular glycoprotein
  JOURNAL   PLoS One 12 (7), e0180731 (2017)
   PUBMED   28686733
  REMARK    GeneRIF: Contrary to earlier predictions, neither the murine nor
            rat IGSF1-2 is secreted from heterologous or homologous cells. In
            addition, neither protein associates with the plasma membrane.
            Rather, IGSF1-2 appears to be retained in the endoplasmic
            reticulum.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4407)
  AUTHORS   Joustra,S.D., Meijer,O.C., Heinen,C.A., Mol,I.M., Laghmani el,H.,
            Sengers,R.M., Carreno,G., van Trotsenburg,A.S., Biermasz,N.R.,
            Bernard,D.J., Wit,J.M., Oostdijk,W., van Pelt,A.M., Hamer,G. and
            Wagenaar,G.T.
  TITLE     Spatial and temporal expression of immunoglobulin superfamily
            member 1 in the rat
  JOURNAL   J Endocrinol 226 (3), 181-191 (2015)
   PUBMED   26163525
  REMARK    GeneRIF: High levels of Igsf1 in brain, pituitary and fetal liver.
            Also expressed in pancreas, heart, skeletal muscle, adrenal gland
            and testis.
REFERENCE   3  (bases 1 to 4407)
  AUTHORS   Chapman,S.C. and Woodruff,T.K.
  TITLE     Modulation of activin signal transduction by inhibin B and
            inhibin-binding protein (INhBP)
  JOURNAL   Mol Endocrinol 15 (4), 668-679 (2001)
   PUBMED   11266516
REFERENCE   4  (bases 1 to 4407)
  AUTHORS   Bernard,D.J. and Woodruff,T.K.
  TITLE     Inhibin binding protein in rats: alternative transcripts and
            regulation in the pituitary across the estrous cycle
  JOURNAL   Mol Endocrinol 15 (4), 654-667 (2001)
   PUBMED   11266515
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF322216.1.
            
            On Jun 3, 2003 this sequence version replaced NM_175763.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF322216.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5756307,
                                           SAMEA5760383 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..4407
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq36"
     gene            1..4407
                     /gene="Igsf1"
                     /gene_synonym="Inhbp"
                     /note="immunoglobulin superfamily, member 1"
                     /db_xref="GeneID:302822"
                     /db_xref="RGD:631402"
     exon            1..73
                     /gene="Igsf1"
                     /gene_synonym="Inhbp"
                     /inference="alignment:Splign:2.1.0"
     exon            74..211
                     /gene="Igsf1"
                     /gene_synonym="Inhbp"
                     /inference="alignment:Splign:2.1.0"
     CDS             172..4134
                     /gene="Igsf1"
                     /gene_synonym="Inhbp"
                     /note="inhibin-binding protein"
                     /codon_start=1
                     /product="immunoglobulin superfamily member 1 precursor"
                     /protein_id="NP_786939.1"
                     /db_xref="GeneID:302822"
                     /db_xref="RGD:631402"
                     /translation="MMLRTFTLLLLCIWLNRGMTSMAAVESQPELWIESNYPQAPWEN
                     ITLWCKSPSRVSSKFLLLKDNTQMTWIHPPYKTFQVSFFIGALTESNTGLYRCCYWNE
                     KGWSKPSKILELEAPGQLPKPIFWIQAETPPFPGCNVNILCHGWLQDLVFMLFKEGYT
                     EPIDYQVPTGTMAIFSIDNLAPENEGIYICRTHIQMLPTLWSEPSNPLKLVVAGLYPK
                     PTLTAHPGPILAPGESLSLRCQGPIYGMTFALMRLEDLKKPYYYKKPIKNEAYFYFQA
                     LKTQDTGHYLCFYYDGSYRGSLLSDILKIWVTDTFPKTWLLVQPSPVIQMGQNVSLRC
                     GGLMDGVGLALHKKGEEKPLQFLDATSNTGNNSFFLKNVTYRDAGIYSCHYYLTWKTS
                     IKMATYNTVELIVVAWPSSVFKVGKTITLQCRVSHPVLEFSLEWEETTTFQKFSVDGD
                     FIITNIEGQGTGTYSCSYRIESHANIWSHRSEPLKLVGPAVTGFLPWNSILNEAIRVS
                     LTVQFLSLLLLVLWLQWKCRRLRLREAWLLGTAQGVAMLVILIALLCCGLCNGALTEE
                     IEIIMPTPKPELWAETNFPQAPWKNVTLWCRSPSGSTKEFVLLKDGTGWIATRPASEQ
                     VRAAFPLGALTQSHTGSYHCHSWEEMAVSEPSEALELVGTDILPKPVISASLPIRGQE
                     LQIRCKGWLEGLGFALYKMGEQEPVQQLGAVGREAFFTIQRMEDKEEGNYSCRTHTEK
                     QPFKWSEPSAPLELVIKELYPKPFFKTWASPVVTPGSRVTFNCSTSREHMSFILYKDG
                     NEIASSDPVWGNPGTSTAHFLIISVGIGDGGNYSCRYYDFSIWSEPSDPVELIVTEFY
                     PKPTLLAQPGPVVLPGKNVTLRCQGIFQGMRFALLQEGAHAPLQFQSASGTSVDFLLH
                     TVGAEDFGNYSCVYYETTMSNRGSYLSTPLMIWVTDTFPRPWLSAEPSSVVTMGQNVT
                     LWCQGPVHGVGYILHKEGEATSMQLWDSTSNEGAFPIINISGASIGRYSCCYHPDWMS
                     PIKIQPSNTLELIVTGLLPKPSLLVQPGPMVVPGENMTFQCQGELPDSTFVLLKEGTQ
                     QPIEQQRPSGYRADFWMPVVRDQDSGVYSCVYYLDSAPLVASNHSNSLEIWVTDKPPK
                     PSLSAWPSTVFKLGKDITLQCRGPLPGVEFVLEHDGEEAPQQFSEDGDFVIGNMEGKG
                     IGNYSCSYRLQAYPDIWSEPSDSLELVGAAGPVAQECTVGNIVRSTLIVVVVVALGIV
                     LAIEWKKWPRLRTRGSETDGRDQTIVLEECNQDGEPGTATNSPSSALQGVSVEQTVPI
                     "
     exon            212..238
                     /gene="Igsf1"
                     /gene_synonym="Inhbp"
                     /inference="alignment:Splign:2.1.0"
     exon            239..523
                     /gene="Igsf1"
                     /gene_synonym="Inhbp"
                     /inference="alignment:Splign:2.1.0"
     exon            524..811
                     /gene="Igsf1"
                     /gene_synonym="Inhbp"
                     /inference="alignment:Splign:2.1.0"
     exon            812..1096
                     /gene="Igsf1"
                     /gene_synonym="Inhbp"
                     /inference="alignment:Splign:2.1.0"
     exon            1097..1390
                     /gene="Igsf1"
                     /gene_synonym="Inhbp"
                     /inference="alignment:Splign:2.1.0"
     exon            1391..1642
                     /gene="Igsf1"
                     /gene_synonym="Inhbp"
                     /inference="alignment:Splign:2.1.0"
     exon            1643..1769
                     /gene="Igsf1"
                     /gene_synonym="Inhbp"
                     /inference="alignment:Splign:2.1.0"
     exon            1770..1840
                     /gene="Igsf1"
                     /gene_synonym="Inhbp"
                     /inference="alignment:Splign:2.1.0"
     exon            1841..1873
                     /gene="Igsf1"
                     /gene_synonym="Inhbp"
                     /inference="alignment:Splign:2.1.0"
     exon            1874..2164
                     /gene="Igsf1"
                     /gene_synonym="Inhbp"
                     /inference="alignment:Splign:2.1.0"
     exon            2165..2443
                     /gene="Igsf1"
                     /gene_synonym="Inhbp"
                     /inference="alignment:Splign:2.1.0"
     exon            2444..2731
                     /gene="Igsf1"
                     /gene_synonym="Inhbp"
                     /inference="alignment:Splign:2.1.0"
     exon            2732..3019
                     /gene="Igsf1"
                     /gene_synonym="Inhbp"
                     /inference="alignment:Splign:2.1.0"
     exon            3020..3307
                     /gene="Igsf1"
                     /gene_synonym="Inhbp"
                     /inference="alignment:Splign:2.1.0"
     exon            3308..3595
                     /gene="Igsf1"
                     /gene_synonym="Inhbp"
                     /inference="alignment:Splign:2.1.0"
     exon            3596..3874
                     /gene="Igsf1"
                     /gene_synonym="Inhbp"
                     /inference="alignment:Splign:2.1.0"
     exon            3875..3998
                     /gene="Igsf1"
                     /gene_synonym="Inhbp"
                     /inference="alignment:Splign:2.1.0"
     exon            3999..4407
                     /gene="Igsf1"
                     /gene_synonym="Inhbp"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgccgggca gtttgctgca tctggaggag ctctctggag aatctccaac ctcagagcgg
       61 gccttcttct accattctac taccttttaa gaagaagcaa agccttcaag acttgaaata
      121 cacatcctgc accagagggc ccataggccg ggacaggcta gagtgacagc catgatgctt
      181 cggaccttca ctcttttgct cctttgcatt tggctcaatc ggggtatgac ttcaatggca
      241 gcagtggagt ctcaaccaga gctatggata gagtccaact acccccaggc cccttgggag
      301 aacatcacac tttggtgcaa aagcccctct cgggtatcca gcaagttcct gctgctgaag
      361 gataacacac agatgacctg gattcatcct ccttacaaga ccttccaagt ttcattcttc
      421 ataggtgccc ttactgagtc caatacaggt ctttatcgat gctgctactg gaatgagaaa
      481 ggctggtcga agcccagtaa aattctagag ctagaagcac caggccaact ccctaaacct
      541 atcttctgga tccaggcaga gaccccccct tttcctggat gcaatgttaa tattctctgc
      601 catggatggc ttcaggattt ggtatttatg ctgtttaaag agggatacac agagcccata
      661 gattaccaag tcccaactgg gacaatggcc atcttctcca ttgacaactt ggcacctgag
      721 aatgaaggca tttacatctg ccgcacccat atccagatgc tccccactct gtggtcagag
      781 cccagcaacc ccctaaagtt ggtggtagca ggtctctacc ccaaaccaac tctgacagcc
      841 catcctgggc ccatcctggc accaggagaa agcctgagtc tcaggtgcca agggccaata
      901 tatggaatga cgtttgcttt aatgaggttg gaagacttga agaaaccata ttactacaag
      961 aagccaataa aaaatgaggc atatttctac ttccaggctc tgaagacaca ggatacaggg
     1021 cactacctct gtttttacta tgatgggtca tacaggggct cactgcttag tgatatcctg
     1081 aaaatctggg tgactgacac ttttcccaag acctggctac ttgttcagcc cagccctgtg
     1141 attcaaatgg gtcaaaacgt gagcctgaga tgtggaggac tgatggatgg agtgggtctt
     1201 gcactccata agaagggaga agaaaagccc cttcagtttc tggatgccac cagcaacact
     1261 ggcaacaatt cattcttcct aaagaatgtg acctacaggg atgctggcat ctatagctgc
     1321 cactattatc ttacctggaa gacttccatt aagatggcga catacaacac tgtggagctg
     1381 attgttgtag cttggcccag ttccgtgttc aaagtaggaa agaccatcac ccttcagtgc
     1441 cgagtatctc atccagttct tgaattttct ttggaatggg aagaaacaac aacattccaa
     1501 aaattctcag tagacggaga cttcatcatc actaacattg aagggcaagg cacgggtacc
     1561 tacagttgca gctatcgtat tgagtcacac gctaacatct ggtcacatcg cagtgagcct
     1621 ctcaagttgg tggggccagc agtcacaggc ttcctcccct ggaattccat tctgaatgaa
     1681 gctatcaggg tgtccttaac ggtgcagttt ctttccttgc tgttgctagt gctgtggcta
     1741 caatggaagt gtcggagact gagactcaga gaagcctggt tgttgggaac agctcaaggg
     1801 gttgccatgc tcgtcatact catagctctt ctttgctgtg ggctgtgcaa tggggcattg
     1861 acagaggaga ttgaaatcat catgccaacc cctaaacctg aactgtgggc agagacgaac
     1921 ttccctcagg ccccgtggaa gaacgtaacc ctctggtgca gaagcccttc tggctcaact
     1981 aaggagtttg tgctactaaa ggacgggact gggtggattg caactcgccc ggcctcagag
     2041 caggtccggg ctgccttccc ccttggcgcc ctgacccaaa gccacaccgg gagttaccat
     2101 tgccattcat gggaggagat ggctgtgtcg gagcctagtg aagcacttga actagtgggg
     2161 acagacatcc ttcccaaacc tgtcatttcg gcttcccttc caatccgggg ccaggaactg
     2221 cagatccgat gtaaaggatg gctggaaggc ttggggtttg ctctgtataa gatgggagag
     2281 caggaacctg tccagcaact cggtgctgtt gggagagaag ccttctttac aattcaaaga
     2341 atggaggata aagaggaggg caattacagc tgccgcacac atactgaaaa gcagcccttc
     2401 aagtggtctg agcccagtgc tcccctggag cttgtcataa aagaactgta ccccaagcct
     2461 ttcttcaaga catgggctag ccccgtggtc actcctggtt ctagagtgac tttcaattgc
     2521 tccacctccc gggaacacat gagttttatt ctttacaagg atggcaatga aattgcatcc
     2581 agtgacccag tctggggaaa cccaggaacc agcacagcac actttctgat catttcagtg
     2641 ggcattggtg atggaggaaa ctatagctgc cgttattatg acttttccat ctggtctgag
     2701 cccagcgacc ccgtggagct tattgtgaca gaattctacc ccaaacccac tctcctggca
     2761 cagccaggcc ctgtggtgct tcctgggaag aatgtgaccc tgcgctgtca aggaattttc
     2821 cagggcatga ggtttgccct cttacaggag ggtgctcatg ctcccttaca gtttcagagt
     2881 gcctcgggga cctccgttga cttcctcctc cacactgttg gagcagagga ctttgggaac
     2941 tacagctgtg tctactatga gacaaccatg tccaacaggg gctcatatct tagtaccccc
     3001 cttatgatct gggtgactga cacattcccc agaccatggt tgtctgctga gcctagttct
     3061 gtggtcacca tggggcagaa tgttactcta tggtgccaag gaccagtcca tggagttggg
     3121 tacattctgc acaaagaagg agaagccact tcaatgcagc tttgggattc cactagcaat
     3181 gaaggggcat tccctatcat caatatatct ggtgctagca taggacgtta tagctgctgt
     3241 taccaccctg actggatgag ccctatcaag atacagccta gcaacactct ggaactcata
     3301 gtcactggtt tactccctaa gcccagcctg ttagtccagc ctggtcccat ggtagtcccc
     3361 ggagaaaaca tgacttttca atgtcaagga gaactgccag attcgacatt tgtcctgttg
     3421 aaggagggga cacaacagcc catagaacaa cagaggccaa gtgggtacag agctgacttc
     3481 tggatgccag tggtgaggga tcaagattct ggtgtttaca gctgtgttta ttatctggat
     3541 tctgctcccc ttgtggcttc taatcacagc aactctctag agatctgggt gaccgataag
     3601 ccccctaaac cctctctgtc agcgtggccc agcactgtgt tcaaactagg aaaggatatc
     3661 acccttcagt gccgaggacc cctgccagga gttgaattcg tgctagaaca cgatggagaa
     3721 gaggcccccc aacagttctc agaggatgga gattttgtta tcggcaacat ggaagggaaa
     3781 ggcattggaa actacagttg cagctatcgg ctgcaggctt accctgacat ctggtcagag
     3841 cccagcgact ccctggagct ggttggagcc gcagggcctg ttgctcaaga gtgcactgtg
     3901 ggtaacattg tccgaagtac cctgattgtg gtggttgtgg tagccttggg gatagtgcta
     3961 gccatagagt ggaagaagtg gcctcgactt cggactaggg gctctgagac agatgggaga
     4021 gaccagacca tagtccttga agagtgtaac caagatggag aacccggcac tgccaccaat
     4081 tctccttcat ctgctttgca gggtgtctca gtggaacaaa cagtcccaat ataattaccc
     4141 tctcctttac aagagctttc ctcttctgtc ttttacctgc agagacctga gaatcccact
     4201 tgtttaccct ggaattccac agcatttact gcttcttgac ctctaaccac ctgagttggg
     4261 tcaagagggt tctgggagtg acaagttcta ccaggtcaag ctgtttcctt tatctctata
     4321 actcctcacc atactgattt actggtgcat gcgattctgt ttaaaatgtc ttcttctgaa
     4381 taaagagact attcactatt taactgc
//
