LOCUS       NM_031586               3167 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus immunoglobulin mu DNA binding protein 2
            (Ighmbp2), mRNA.
ACCESSION   NM_031586
VERSION     NM_031586.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3167)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   2  (bases 1 to 3167)
  AUTHORS   de Planell-Saguer,M., Schroeder,D.G., Rodicio,M.C., Cox,G.A. and
            Mourelatos,Z.
  TITLE     Biochemical and genetic evidence for a role of IGHMBP2 in the
            translational machinery
  JOURNAL   Hum Mol Genet 18 (12), 2115-2126 (2009)
   PUBMED   19299493
REFERENCE   3  (bases 1 to 3167)
  AUTHORS   Guenther,U.P., Handoko,L., Laggerbauer,B., Jablonka,S., Chari,A.,
            Alzheimer,M., Ohmer,J., Plottner,O., Gehring,N., Sickmann,A., von
            Au,K., Schuelke,M. and Fischer,U.
  TITLE     IGHMBP2 is a ribosome-associated helicase inactive in the
            neuromuscular disorder distal SMA type 1 (DSMA1)
  JOURNAL   Hum Mol Genet 18 (7), 1288-1300 (2009)
   PUBMED   19158098
REFERENCE   4  (bases 1 to 3167)
  AUTHORS   Ruiz,R., Lin,J., Forgie,A., Foletti,D., Shelton,D., Rosenthal,A.
            and Tabares,L.
  TITLE     Treatment with trkC agonist antibodies delays disease progression
            in neuromuscular degeneration (nmd) mice
  JOURNAL   Hum Mol Genet 14 (13), 1825-1837 (2005)
   PUBMED   15888478
REFERENCE   5  (bases 1 to 3167)
  AUTHORS   Grohmann,K., Rossoll,W., Kobsar,I., Holtmann,B., Jablonka,S.,
            Wessig,C., Stoltenburg-Didinger,G., Fischer,U., Hubner,C.,
            Martini,R. and Sendtner,M.
  TITLE     Characterization of Ighmbp2 in motor neurons and implications for
            the pathomechanism in a mouse model of human spinal muscular
            atrophy with respiratory distress type 1 (SMARD1)
  JOURNAL   Hum Mol Genet 13 (18), 2031-2042 (2004)
   PUBMED   15269181
REFERENCE   6  (bases 1 to 3167)
  AUTHORS   Uchiumi,F., Komuro,M., Mizuta,R. and Tanuma,S.
  TITLE     Characterization of Smubp-2 as a mouse mammary tumor virus
            promoter-binding protein
  JOURNAL   Biochem Biophys Res Commun 321 (2), 355-363 (2004)
   PUBMED   15358184
  REMARK    GeneRIF: results suggest that the negative transcriptional effect
            of Smubp-2 arises from its binding to the 50-bp element located in
            the MMTV promoter region
REFERENCE   7  (bases 1 to 3167)
  AUTHORS   Grohmann,K., Schuelke,M., Diers,A., Hoffmann,K., Lucke,B.,
            Adams,C., Bertini,E., Leonhardt-Horti,H., Muntoni,F., Ouvrier,R.,
            Pfeufer,A., Rossi,R., Van Maldergem,L., Wilmshurst,J.M.,
            Wienker,T.F., Sendtner,M., Rudnik-Schoneborn,S., Zerres,K. and
            Hubner,C.
  TITLE     Mutations in the gene encoding immunoglobulin mu-binding protein 2
            cause spinal muscular atrophy with respiratory distress type 1
  JOURNAL   Nat Genet 29 (1), 75-77 (2001)
   PUBMED   11528396
REFERENCE   8  (bases 1 to 3167)
  AUTHORS   Miao,M., Chan,S.L., Fletcher,G.L. and Hew,C.L.
  TITLE     The rat ortholog of the presumptive flounder antifreeze
            enhancer-binding protein is a helicase domain-containing protein
  JOURNAL   Eur J Biochem 267 (24), 7237-7246 (2000)
   PUBMED   11106437
REFERENCE   9  (bases 1 to 3167)
  AUTHORS   Mizuta,T.R., Fukita,Y., Miyoshi,T., Shimizu,A. and Honjo,T.
  TITLE     Isolation of cDNA encoding a binding protein specific to
            5'-phosphorylated single-stranded DNA with G-rich sequences
  JOURNAL   Nucleic Acids Res 21 (8), 1761-1766 (1993)
   PUBMED   8493094
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Nov 26, 2020 this sequence version replaced NM_031586.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF199411.1, SRR26643290.4560.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-86                JAXUCZ010000001.1  209958485-209958570 c
            87-256              JAXUCZ010000001.1  209957276-209957445 c
            257-446             JAXUCZ010000001.1  209955376-209955565 c
            447-544             JAXUCZ010000001.1  209955115-209955212 c
            545-708             JAXUCZ010000001.1  209952257-209952420 c
            709-909             JAXUCZ010000001.1  209949462-209949662 c
            910-1057            JAXUCZ010000001.1  209948028-209948175 c
            1058-1232           JAXUCZ010000001.1  209945936-209946110 c
            1233-1415           JAXUCZ010000001.1  209942772-209942954 c
            1416-1534           JAXUCZ010000001.1  209942407-209942525 c
            1535-1629           JAXUCZ010000001.1  209941745-209941839 c
            1630-1753           JAXUCZ010000001.1  209940822-209940945 c
            1754-2593           JAXUCZ010000001.1  209939288-209940127 c
            2594-2763           JAXUCZ010000001.1  209936667-209936836 c
            2764-3167           JAXUCZ010000001.1  209935922-209936325 c
FEATURES             Location/Qualifiers
     source          1..3167
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q42"
     gene            1..3167
                     /gene="Ighmbp2"
                     /gene_synonym="AEP"
                     /note="immunoglobulin mu DNA binding protein 2"
                     /db_xref="GeneID:29532"
                     /db_xref="RGD:68325"
     CDS             1..2967
                     /gene="Ighmbp2"
                     /gene_synonym="AEP"
                     /EC_number="3.6.4.13"
                     /EC_number="3.6.4.12"
                     /note="ATP-dependent helicase IGHMBP2; antifreeze
                     enhancer-binding protein ortholog; immunoglobulin S mu
                     binding protein 2; immunoglobulin mu binding protein 2"
                     /codon_start=1
                     /product="DNA-binding protein SMUBP-2"
                     /protein_id="NP_113774.2"
                     /db_xref="GeneID:29532"
                     /db_xref="RGD:68325"
                     /translation="MDSSTVESFVAQQLQLLELERDAEVEERRSWQEHSSLKELQSRG
                     VCLLKLQVSGQRTGLYGQRLVTFEPRKFGPAVVLPSNSFTSGDIVGLYDTNESSQLAT
                     GVLTRITQKSVIVAFDESHDFQLNLDRENTYRLLKLANDVTYKRLKKALLTLKKYHSG
                     PASSLIDVLLGGSTPSPATEIPPLTFYNTTLDPSQKEAVSFALAQKEVAIIHGPPGTG
                     KTTTVVEIILQAVKQGLKVLCCAPSNIAVDNLVERLALCKKQILRLGHPARLLESVQQ
                     HSLDAVLARSDNAQIVADIRRDIDQVFGKNKKTQDKREKSNFRNEIKLLRKELKEREE
                     AAIVQSLSAADVVLATNTGASTDGPLKLLPEDYFDVVVVDECAQALEASCWIPLLKAP
                     KCILAGDHKQLPPTTVSHKAALAGLSRSLMERLAEKHGAAVVRMLAVQYRMHQAITRW
                     ASEAMYHGQLTAHPSVAGHLLKDLPGVADTEETSVPLLLIDTAGCGLLELEEEDSQSK
                     GNPGEVRLVTLHIQALVDAGVQAGDIAVIAPYNLQVDLLRQSLSNKHPELEIKSVDGF
                     QGREKEAVILTFVRSNRKGEVGFLAEDRRINVAVTRARRHVAVICDSHTVNNHAFLKT
                     LVDYFTEHGEVRTAFEYLDDIVPENYTHEGSRSHSCAPKPKCPTTSVRKPASAQESRQ
                     EARAATGHSRRKPSEKPLGSQVQPQHSSKANGSDRTGGTDRTEHFRAMIEEFVASKEA
                     QLEFPTSLSSHDRLRVHQLAEEFGLKHDSTGEGKARHITVSRRSPAGSGSATPQPPSP
                     PSPAQAEPEPQVEQPVGQPHGSTQLDLKALHLERLQRQQGCQAQSQLGGGSRPQKAPQ
                     KKKKKEPKGPAMALPSEEDFDALVSAVVKADNTCSFTKCSASTTTLGQFCMHCSRRYC
                     LSHHLPEIHGCGEKARAHARQRISREGVLYAGSGTKDRALDPAKRAQLQRKLDKKLGE
                     LSSQRTSKKKEKERGT"
     exon            1..86
                     /gene="Ighmbp2"
                     /gene_synonym="AEP"
                     /inference="alignment:Splign:2.1.0"
     exon            87..256
                     /gene="Ighmbp2"
                     /gene_synonym="AEP"
                     /inference="alignment:Splign:2.1.0"
     exon            257..446
                     /gene="Ighmbp2"
                     /gene_synonym="AEP"
                     /inference="alignment:Splign:2.1.0"
     exon            447..544
                     /gene="Ighmbp2"
                     /gene_synonym="AEP"
                     /inference="alignment:Splign:2.1.0"
     exon            545..708
                     /gene="Ighmbp2"
                     /gene_synonym="AEP"
                     /inference="alignment:Splign:2.1.0"
     exon            709..909
                     /gene="Ighmbp2"
                     /gene_synonym="AEP"
                     /inference="alignment:Splign:2.1.0"
     exon            910..1057
                     /gene="Ighmbp2"
                     /gene_synonym="AEP"
                     /inference="alignment:Splign:2.1.0"
     exon            1058..1232
                     /gene="Ighmbp2"
                     /gene_synonym="AEP"
                     /inference="alignment:Splign:2.1.0"
     exon            1233..1415
                     /gene="Ighmbp2"
                     /gene_synonym="AEP"
                     /inference="alignment:Splign:2.1.0"
     exon            1416..1534
                     /gene="Ighmbp2"
                     /gene_synonym="AEP"
                     /inference="alignment:Splign:2.1.0"
     exon            1535..1629
                     /gene="Ighmbp2"
                     /gene_synonym="AEP"
                     /inference="alignment:Splign:2.1.0"
     exon            1630..1753
                     /gene="Ighmbp2"
                     /gene_synonym="AEP"
                     /inference="alignment:Splign:2.1.0"
     exon            1754..2593
                     /gene="Ighmbp2"
                     /gene_synonym="AEP"
                     /inference="alignment:Splign:2.1.0"
     exon            2594..2763
                     /gene="Ighmbp2"
                     /gene_synonym="AEP"
                     /inference="alignment:Splign:2.1.0"
     exon            2764..3167
                     /gene="Ighmbp2"
                     /gene_synonym="AEP"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggactcgt ccaccgtgga gagttttgtg gcccagcagc tacagctgtt ggagctagag
       61 cgggacgccg aggtggagga gcgcaggtcc tggcaggaac acagttctct gaaagagctt
      121 cagagccgag gggtgtgttt gctgaagctt caggtatcgg gccagcgcac tgggttgtat
      181 ggacagcggc tggtcacctt tgagcccagg aagtttgggc ctgcagtggt gcttcccagc
      241 aacagcttca cctctggtga tatcgtgggt ctgtatgata ctaatgaaag cagccaactg
      301 gccactgggg tcctgacccg catcacccaa aaatcggtca tagtggcctt tgatgagtcc
      361 catgatttcc agttgaacct ggaccgagaa aatacctaca gactgctgaa gcttgccaat
      421 gacgtcacct acaaacgcct gaaaaaagct ctgctgacac tgaagaagta ccattctggg
      481 ccagcatcct cgctcattga tgtcctgttg ggtggctcca cccccagtcc tgccactgaa
      541 atacccccgc tcactttcta caacacgacc ctggaccctt cccagaaaga agctgtgtct
      601 tttgcgctgg cgcagaaaga agttgccatc atccatgggc ctcctggcac tgggaaaacc
      661 acaactgtgg tggaaataat ccttcaagct gtgaagcaag gcttaaaggt tctatgctgt
      721 gctccctcca acatcgctgt ggacaacctg gtggagcgtc tggctctgtg caagaagcag
      781 attcttcgcc tgggtcaccc tgcccgcctc ctggagtccg ttcagcagca ctcactggac
      841 gcagtgctag cacgcagtga caatgcccag attgttgctg acatcagaag ggacattgac
      901 caggtctttg gcaagaacaa aaagacccaa gataagagag aaaaaagtaa ttttcgaaat
      961 gaaattaagc tgctaaggaa ggaactgaag gaaagggaag aagcagccat agttcagagc
     1021 ctcagtgcag cagatgtggt tctagccacc aacacaggtg catctactga tggccccctg
     1081 aagctgctgc ctgaggacta ctttgatgtg gtggtggtgg acgagtgcgc ccaggcccta
     1141 gaagccagct gctggattcc cctgctgaag gcccctaagt gcatcctagc tggagaccac
     1201 aaacagctgc cacccaccac tgtctctcac aaggcagcac tggctgggct gtcccgcagc
     1261 ctgatggagc gtctggcaga gaagcatggt gctgctgtgg taaggatgct ggcggtccag
     1321 taccgaatgc accaggccat cacgcgctgg gcctcggaag ccatgtacca cggacagctc
     1381 actgcccatc cctctgtggc aggacacctt ctgaaggacc tcccaggtgt ggctgacaca
     1441 gaggagacga gtgtccctct gctgctcata gacacagctg gctgcgggct gctggagctg
     1501 gaggaggaag acagccagtc caagggaaac cccggtgaag ttcgcctcgt cactttgcac
     1561 atccaggctc tggtggatgc tggggtccag gctggtgaca ttgccgtcat cgcaccctac
     1621 aaccttcagg tggatctgct cagacagagc ctctctaaca agcaccctga gctggagatc
     1681 aagtctgttg acggctttca aggccgagag aaggaggctg tgatcctgac ctttgtcagg
     1741 tccaacagga aaggtgaagt tggttttctg gctgaggaca ggcggatcaa tgttgctgtc
     1801 acccgtgcta ggcggcatgt ggcggtcatc tgtgattccc acactgtcaa caaccacgcc
     1861 tttttgaaga ccttggtgga ttatttcaca gagcatgggg aggtacgcac agcctttgag
     1921 tacctggatg acatcgtccc tgagaactat acccatgagg gctcccggag ccacagttgt
     1981 gcccccaaac ccaagtgccc caccacctca gtcagaaagc ctgccagtgc tcaggagagt
     2041 agacaagagg ccagagcagc cactggacac agccgcagga agccaagtga gaagccccta
     2101 ggctctcaag tccagcccca gcacagctcc aaagcaaatg gctctgaccg aactggaggc
     2161 acagaccgga cagagcactt tagggctatg attgaggagt tcgtggctag caaggaggcc
     2221 cagttggagt ttcccacatc cctgagctcc catgacagac ttcgagtcca ccaattagct
     2281 gaggagttcg ggctgaagca tgacagcacc ggggagggga aggcacggca catcacagtg
     2341 agcaggagga gccctgctgg ttctggcagt gcaaccccac aacctccctc accgcccagc
     2401 cctgcacagg ctgagcctga gcctcaggta gagcagcctg taggacagcc acatggctcc
     2461 acacagctgg atctgaaggc acttcacctg gagaggctgc agcgacagca aggctgccag
     2521 gcccagtctc agctgggcgg gggttcgagg ccacagaagg ctccacagaa gaaaaagaaa
     2581 aaagaaccga aaggcccagc catggctctg ccctctgagg aggacttcga tgccctagtg
     2641 tcagctgtgg tgaaggctga caacacctgt agcttcacca agtgctcggc cagcaccacc
     2701 acgctgggcc agttctgcat gcactgtagc cgccgctatt gcctcagcca ccatctgccc
     2761 gagatccatg gctgtggtga aaaggctcgt gcccatgccc ggcagaggat tagccgggaa
     2821 ggagtactct acgcaggcag tgggaccaag gacagggccc tggacccagc caagagggcc
     2881 cagctgcaga ggaaactgga caagaagctg ggcgagctca gcagccagag gacaagcaag
     2941 aagaaggaga aggagagggg gacgtgaggc cacaccctcg gggagggctg tgtgggcaag
     3001 agtcagcagg tggggacaca gtcctacact ggctatttct ctactcgagc tagtgtgtcc
     3061 ctaactctct catggcaagg agacaagcct agttaccatc agagtaactg ccttgaccgg
     3121 ccaggtctca ttaacgctgt gagtgccttg catggccagc tagccat
//
