LOCUS       NM_001013048            1125 bp    mRNA    linear   ROD 26-NOV-2024
DEFINITION  Rattus norvegicus insulin-like growth factor binding protein 7
            (Igfbp7), mRNA.
ACCESSION   NM_001013048 XM_214014
VERSION     NM_001013048.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1125)
  AUTHORS   Gao,R., Wang,J., He,X., Wang,T., Zhou,L., Ren,Z., Yang,J.,
            Xiang,X., Wen,S., Yu,Z., Ai,H., Wang,Y., Liang,H., Li,S., Lu,Y.,
            Zhu,Y., Shi,G. and Chen,Y.
  TITLE     Comprehensive analysis of endoplasmic reticulum-related and
            secretome gene expression profiles in the progression of
            non-alcoholic fatty liver disease
  JOURNAL   Front Endocrinol (Lausanne) 13, 967016 (2022)
   PUBMED   36034446
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1125)
  AUTHORS   Yao,K., Tarabra,E., Sia,D., Morotti,R., Fawaz,R., Valentino,P.,
            Santoro,N., Caprio,S., Liu,S. and Yimlamai,D.
  TITLE     Transcriptomic profiling of a multiethnic pediatric NAFLD cohort
            reveals genes and pathways associated with disease
  JOURNAL   Hepatol Commun 6 (7), 1598-1610 (2022)
   PUBMED   35312185
REFERENCE   3  (bases 1 to 1125)
  AUTHORS   Godina,C., Khazaei,S., Tryggvadottir,H., Visse,E., Nodin,B.,
            Jirstrom,K., Borgquist,S., Bosch,A., Isaksson,K. and Jernstrom,H.
  TITLE     Prognostic impact of tumor-specific insulin-like growth factor
            binding protein 7 (IGFBP7) levels in breast cancer: a prospective
            cohort study
  JOURNAL   Carcinogenesis 42 (11), 1314-1325 (2021)
   PUBMED   34606580
REFERENCE   4  (bases 1 to 1125)
  AUTHORS   Li,T., Yan,H., Geng,Y., Shi,H., Li,H., Wang,S., Wang,Y., Xu,J.,
            Zhao,G. and Lu,X.
  TITLE     Target genes associated with lipid and glucose metabolism in
            non-alcoholic fatty liver disease
  JOURNAL   Lipids Health Dis 18 (1), 211 (2019)
   PUBMED   31805951
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1125)
  AUTHORS   Yan,H., Li,T., Wang,Y., Li,H., Xu,J. and Lu,X.
  TITLE     Insulin-like growth factor binding protein 7 accelerates hepatic
            steatosis and insulin resistance in non-alcoholic fatty liver
            disease
  JOURNAL   Clin Exp Pharmacol Physiol 46 (12), 1101-1110 (2019)
   PUBMED   31397492
REFERENCE   6  (bases 1 to 1125)
  AUTHORS   Lang,C.H., Nystrom,G.J. and Frost,R.A.
  TITLE     Burn-induced changes in IGF-I and IGF-binding proteins are
            partially glucocorticoid dependent
  JOURNAL   Am J Physiol Regul Integr Comp Physiol 282 (1), R207-R215 (2002)
   PUBMED   11742840
REFERENCE   7  (bases 1 to 1125)
  AUTHORS   Tanaka,T., Kondo,S., Iwasa,Y., Hiai,H. and Toyokuni,S.
  TITLE     Expression of stress-response and cell proliferation genes in renal
            cell carcinoma induced by oxidative stress
  JOURNAL   Am J Pathol 156 (6), 2149-2157 (2000)
   PUBMED   10854235
REFERENCE   8  (bases 1 to 1125)
  AUTHORS   Pereira,R.C. and Canalis,E.
  TITLE     Parathyroid hormone increases mac25/insulin-like growth
            factor-binding protein-related protein-1 expression in cultured
            osteoblasts
  JOURNAL   Endocrinology 140 (5), 1998-2003 (1999)
   PUBMED   10218947
REFERENCE   9  (bases 1 to 1125)
  AUTHORS   Pereira,R.C., Blanquaert,F. and Canalis,E.
  TITLE     Cortisol enhances the expression of mac25/insulin-like growth
            factor-binding protein-related protein-1 in cultured osteoblasts
  JOURNAL   Endocrinology 140 (1), 228-232 (1999)
   PUBMED   9886829
REFERENCE   10 (bases 1 to 1125)
  AUTHORS   Akaogi,K., Okabe,Y., Funahashi,K., Yoshitake,Y., Nishikawa,K.,
            Yasumitsu,H., Umeda,M. and Miyazaki,K.
  TITLE     Cell adhesion activity of a 30-kDa major secreted protein from
            human bladder carcinoma cells
  JOURNAL   Biochem Biophys Res Commun 198 (3), 1046-1053 (1994)
   PUBMED   8117260
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC086582.1.
            
            On Apr 20, 2005 this sequence version replaced XM_214014.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC086582.1, CF111104.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1125
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14p11"
     gene            1..1125
                     /gene="Igfbp7"
                     /gene_synonym="IGFBP-RP-1; IGFBP-rP1; IGFBPRP1; mac25"
                     /note="insulin-like growth factor binding protein 7"
                     /db_xref="GeneID:289560"
                     /db_xref="RGD:1306201"
     exon            1..491
                     /gene="Igfbp7"
                     /gene_synonym="IGFBP-RP-1; IGFBP-rP1; IGFBPRP1; mac25"
                     /inference="alignment:Splign:2.1.0"
     CDS             20..865
                     /gene="Igfbp7"
                     /gene_synonym="IGFBP-RP-1; IGFBP-rP1; IGFBPRP1; mac25"
                     /codon_start=1
                     /product="insulin-like growth factor-binding protein 7
                     precursor"
                     /protein_id="NP_001013066.1"
                     /db_xref="GeneID:289560"
                     /db_xref="RGD:1306201"
                     /translation="MERSPRALLLGAAGLLLLLLPLSSSSSSDACGPCVPASCPALPP
                     FGCPLGETRDACGCCPVCARGEGEPCGGGAAGGGHCAPGMECVKSRKRRRGKAGAAAG
                     GPATLAVCVCKSRYPVCGSDGVTYPSGCQLRAASLRAESRGEKAITQVSKGTCEQGPS
                     IVTPPKDIWNITGAKVYLSCEVIGIPTPVLIWNKVKRDHSGVQRTELLPGDRENLAIQ
                     TRGGPEKHEVTGWVLVSPLSKEDTGEYECHASNSQGQASASAKITVVDAIHEIPVKKG
                     EGAQL"
     exon            492..601
                     /gene="Igfbp7"
                     /gene_synonym="IGFBP-RP-1; IGFBP-rP1; IGFBPRP1; mac25"
                     /inference="alignment:Splign:2.1.0"
     exon            602..718
                     /gene="Igfbp7"
                     /gene_synonym="IGFBP-RP-1; IGFBP-rP1; IGFBPRP1; mac25"
                     /inference="alignment:Splign:2.1.0"
     exon            719..845
                     /gene="Igfbp7"
                     /gene_synonym="IGFBP-RP-1; IGFBP-rP1; IGFBPRP1; mac25"
                     /inference="alignment:Splign:2.1.0"
     exon            846..1105
                     /gene="Igfbp7"
                     /gene_synonym="IGFBP-RP-1; IGFBP-rP1; IGFBPRP1; mac25"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgcgtctagc caccccatca tggagcggtc accgcgcgcc ctgctgctgg gtgcagccgg
       61 attgctgctc ctgctcctgc ccctctcctc ttcctcctct tccgatgcct gcggcccgtg
      121 cgtgccggcc tcctgccccg cgctgccccc gttcggctgc ccgctgggtg agacccgcga
      181 cgcgtgcggc tgctgcccag tgtgcgctcg cggcgagggt gagccgtgcg ggggcggcgc
      241 ggccggcggg gggcactgcg cgccgggcat ggagtgcgtg aagagccgca agaggcggag
      301 gggtaaagcc ggggcagcag ccggcggtcc cgcgaccctc gccgtgtgcg tgtgcaagag
      361 ccgctacccg gtgtgcggca gcgacggcgt cacctacccc agcggctgcc agctgcgcgc
      421 cgccagcctg cgcgctgaga gccgcggaga gaaggccatc acccaggtca gcaaaggcac
      481 ctgcgagcaa ggtccttcca tagtgacgcc ccccaaggac atctggaaca tcactggcgc
      541 caaggtgtac ttgagctgcg aagtcatcgg aatcccaacc cctgtcctca tctggaacaa
      601 ggtaaaaagg gatcactctg gagttcaaag gacagaactc ttgcctggtg accgggaaaa
      661 cctggccatt cagacccggg gtggtccaga aaagcatgaa gtaactggct gggtgctggt
      721 atctcctcta agtaaggaag acactggaga atacgagtgc cacgcgtcca attcccaagg
      781 acaggcttca gcgtcggcca aaattacagt ggttgatgcc atacacgaaa taccagtgaa
      841 aaaaggtgaa ggtgctcagc tataaacctg cgaatacatt agcctctgta gctgacgcgc
      901 tctcagacag ctgacagctg taaccccact cctgcctgac atattccttt gaacctaaca
      961 cactaacact ttattacagc cagctgattt tacagagaaa tcaaagataa cacataagac
     1021 tatctacaaa agtttattgt ttatttacag aaaaagcatg cagagcttta aacaaaacaa
     1081 ataaaattct tattacaaca ggaaaaaaaa aaaaaaaaaa aaaaa
//
