LOCUS       NM_013104                869 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Rattus norvegicus insulin-like growth factor binding protein 6
            (Igfbp6), mRNA.
ACCESSION   NM_013104
VERSION     NM_013104.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 869)
  AUTHORS   Dai,Q., Jiang,P., Gu,Y., Zhu,L., Dai,H., Yao,Z., Liu,H., Ma,X.,
            Duan,C. and Qu,L.
  TITLE     Insulin-like Growth Factor Binding Protein6 Associated with
            Neuronal Apoptosis Following Intracerebral Hemorrhage in Rats
  JOURNAL   Cell Mol Neurobiol 37 (7), 1207-1216 (2017)
   PUBMED   28044240
  REMARK    GeneRIF: IGFBP-6 was significantly up-regulated adjacent to the
            hematoma following intracerebral hemorrhage.
REFERENCE   2  (bases 1 to 869)
  AUTHORS   Wang,S., Liu,Y., Wu,C., Zhao,W., Zhang,J., Bao,G., Xu,G., Sun,Y.,
            Chen,J. and Cui,Z.
  TITLE     The Expression of IGFBP6 after Spinal Cord Injury: Implications for
            Neuronal Apoptosis
  JOURNAL   Neurochem Res 42 (2), 455-467 (2017)
   PUBMED   27888466
  REMARK    GeneRIF: Following spinal cord injury, IGFBP6 was significantly
            up-regulated.
REFERENCE   3  (bases 1 to 869)
  AUTHORS   Yu,J., Peng,R., Chen,H., Cui,C., Ba,J. and Wang,F.
  TITLE     Kininogen 1 and insulin-like growth factor binding protein 6:
            candidate serum biomarkers of proliferative vitreoretinopathy
  JOURNAL   Clin Exp Optom 97 (1), 72-79 (2014)
   PUBMED   23808406
REFERENCE   4  (bases 1 to 869)
  AUTHORS   Abonnenc,M., Nabeebaccus,A.A., Mayr,U., Barallobre-Barreiro,J.,
            Dong,X., Cuello,F., Sur,S., Drozdov,I., Langley,S.R., Lu,R.,
            Stathopoulou,K., Didangelos,A., Yin,X., Zimmermann,W.H., Shah,A.M.,
            Zampetaki,A. and Mayr,M.
  TITLE     Extracellular matrix secretion by cardiac fibroblasts: role of
            microRNA-29b and microRNA-30c
  JOURNAL   Circ Res 113 (10), 1138-1147 (2013)
   PUBMED   24006456
REFERENCE   5  (bases 1 to 869)
  AUTHORS   Koh,A., Niikura,T., Lee,S.Y., Oe,K., Koga,T., Dogaki,Y. and
            Kurosaka,M.
  TITLE     Differential gene expression and immunolocalization of insulin-like
            growth factors and insulin-like growth factor binding proteins
            between experimental nonunions and standard healing fractures
  JOURNAL   J Orthop Res 29 (12), 1820-1826 (2011)
   PUBMED   21598309
  REMARK    GeneRIF: IGFs/IGFBPs may have important roles not only in fracture
            healing but also in nonunion formation.
REFERENCE   6  (bases 1 to 869)
  AUTHORS   Kaulsay,K.K., Ng,E.H., Ji,C.Y., Ho,G.H., Aw,T.C. and Lee,K.O.
  TITLE     Serum IGF-binding protein-6 and prostate specific antigen in breast
            cancer
  JOURNAL   Eur J Endocrinol 140 (2), 164-168 (1999)
   PUBMED   10069662
REFERENCE   7  (bases 1 to 869)
  AUTHORS   Bach,L.A., Tseng,L.Y., Swartz,J.E. and Rechler,M.M.
  TITLE     Rat PC12 pheochromocytoma cells synthesize insulin-like growth
            factor-binding protein-6
  JOURNAL   Endocrinology 133 (3), 990-995 (1993)
   PUBMED   7689963
REFERENCE   8  (bases 1 to 869)
  AUTHORS   Zhu,X., Ling,N. and Shimasaki,S.
  TITLE     Structural characterization of the rat insulin-like growth factor
            binding protein-6 gene
  JOURNAL   Biochem Biophys Res Commun 191 (3), 1237-1243 (1993)
   PUBMED   7682065
REFERENCE   9  (bases 1 to 869)
  AUTHORS   Shimasaki,S., Gao,L., Shimonaka,M. and Ling,N.
  TITLE     Isolation and molecular cloning of insulin-like growth
            factor-binding protein-6
  JOURNAL   Mol Endocrinol 5 (7), 938-948 (1991)
   PUBMED   1719383
REFERENCE   10 (bases 1 to 869)
  AUTHORS   Shimasaki,S., Shimonaka,M., Zhang,H.P. and Ling,N.
  TITLE     Identification of five different insulin-like growth factor binding
            proteins (IGFBPs) from adult rat serum and molecular cloning of a
            novel IGFBP-5 in rat and human
  JOURNAL   J Biol Chem 266 (16), 10646-10653 (1991)
   PUBMED   1709938
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from M69055.1.
            
            On Aug 31, 2012 this sequence version replaced NM_013104.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC099742.1, FQ220221.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-869               M69055.1           4-872
FEATURES             Location/Qualifiers
     source          1..869
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q36"
     gene            1..869
                     /gene="Igfbp6"
                     /gene_synonym="IGF-BP6; RBP6A; RBP6G"
                     /note="insulin-like growth factor binding protein 6"
                     /db_xref="GeneID:25641"
                     /db_xref="RGD:2877"
     exon            1..312
                     /gene="Igfbp6"
                     /gene_synonym="IGF-BP6; RBP6A; RBP6G"
                     /inference="alignment:Splign:2.1.0"
     CDS             3..683
                     /gene="Igfbp6"
                     /gene_synonym="IGF-BP6; RBP6A; RBP6G"
                     /note="IBP-6; IGFBP-6; IGF-binding protein 6"
                     /codon_start=1
                     /product="insulin-like growth factor-binding protein 6
                     precursor"
                     /protein_id="NP_037236.1"
                     /db_xref="GeneID:25641"
                     /db_xref="RGD:2877"
                     /translation="MTWDGLPTQPLLMLLMLLFAAGSESALAGCPGCGPGVQEEDAGS
                     PADGCAETGGCFRREGQPCGVYIPKCAPGLQCQPRENEETPLRALLIGQGRCQRARGP
                     SEETTKESKPHGGASRPRDRDRQKNPRTSAAPIRPSPVQDGEMGPCRRHLDSVLQQLQ
                     TEVFRGGANGLYVPNCDLRGFYRKQQCRSSQGNRRGPCWCVDPMGQPLPVSPDGQGSS
                     QCSARSSG"
     exon            313..437
                     /gene="Igfbp6"
                     /gene_synonym="IGF-BP6; RBP6A; RBP6G"
                     /inference="alignment:Splign:2.1.0"
     exon            438..560
                     /gene="Igfbp6"
                     /gene_synonym="IGF-BP6; RBP6A; RBP6G"
                     /inference="alignment:Splign:2.1.0"
     exon            561..869
                     /gene="Igfbp6"
                     /gene_synonym="IGF-BP6; RBP6A; RBP6G"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccatgacctg ggacggactg cccacacagc cgctgttgat gctgttaatg ctgttgttcg
       61 ctgcgggctc cgagtccgcc ttagcggggt gcccgggctg cgggccgggg gtgcaggagg
      121 aagacgcggg gtcgcctgca gacggctgtg cagagaccgg aggctgtttc aggagagagg
      181 ggcaaccgtg cggggtctac atccctaagt gcgccccagg actgcagtgc caaccccgag
      241 agaacgaaga gacacctttg cgggcgctgc tgatcggcca gggccgctgt caacgcgcca
      301 gagggccgtc ggaagagact accaaggaga gcaaacccca tggaggcgcc tcccgcccac
      361 gtgacagaga ccggcaaaag aatccacgga cctcggctgc ccctataagg cccagtcctg
      421 ttcaagatgg tgaaatgggc ccctgccgca gacacttgga ttcagtactg cagcagctcc
      481 agactgaggt cttcagaggc ggagcaaatg ggctctatgt gccaaactgt gacctcagag
      541 gtttctaccg caagcagcag tgtcgttcct cgcaggggaa tcgccgtggt ccctgctggt
      601 gtgtggatcc gatgggccag cctttgccag tgtctccaga tggccaggga agctctcagt
      661 gctctgccag gagcagcggg tgaaacctgg tgggagcctc caggaccctg gcaggagcat
      721 ggggctgtca tttgagctct atgtgaagtg atgataactc tgtgccccga gatgagaccc
      781 accttcaagc cctaccccat tgtccctgtc acccctgggc ctttacacag caagttagaa
      841 agattgttgt tggcttgtgt actaataaa
//
