LOCUS       NM_012817               1627 bp    mRNA    linear   ROD 27-MAR-2024
DEFINITION  Rattus norvegicus insulin-like growth factor binding protein 5
            (Igfbp5), mRNA.
ACCESSION   NM_012817
VERSION     NM_012817.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1627)
  AUTHORS   Yao,Z., Lin,M., Lin,T., Gong,X., Qin,P., Li,H., Kang,T., Ye,J.,
            Zhu,Y., Hong,Q., Liu,Y., Li,Y., Wang,J. and Fang,F.
  TITLE     The expression of IGFBP-5 in the reproductive axis and effect on
            the onset of puberty in female rats
  JOURNAL   Reprod Biol Endocrinol 20 (1), 100 (2022)
   PUBMED   35821045
  REMARK    GeneRIF: The expression of IGFBP-5 in the reproductive axis and
            effect on the onset of puberty in female rats.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1627)
  AUTHORS   Lai,G., Wang,L., Li,Z. and Zhao,Y.
  TITLE     Homocysteine downregulates cardiac homeobox transcription factor
            NKX2.5 via IGFBP5
  JOURNAL   Am J Physiol Heart Circ Physiol 319 (6), H1380-H1386 (2020)
   PUBMED   33035436
  REMARK    GeneRIF: Homocysteine downregulates cardiac homeobox transcription
            factor NKX2.5 via IGFBP5.
REFERENCE   3  (bases 1 to 1627)
  AUTHORS   Chen,Z., Liu,M., Zhang,W., Deng,M., Zhou,Y. and Li,Y.
  TITLE     miR-24-3p induces human intervertebral disc degeneration by
            targeting insulin-like growth factor binding protein 5 and the ERK
            signaling pathway
  JOURNAL   Life Sci 243, 117288 (2020)
   PUBMED   31926246
  REMARK    GeneRIF: IGFBP5 was determined as a target of miR-24-3p, and IGFBP5
            knockdown induced effects on NP cells similar to those induced by
            miR-24-3p
REFERENCE   4  (bases 1 to 1627)
  AUTHORS   Wang,T., Wang,C.J., Tian,S. and Song,H.B.
  TITLE     Overexpressed IGFBP5 promotes cell proliferation and inhibits
            apoptosis of nucleus pulposus derived from rats with disc
            degeneration through inactivating the ERK/MAPK axis
  JOURNAL   J Cell Biochem 120 (11), 18782-18792 (2019)
   PUBMED   31310371
  REMARK    GeneRIF: Overexpressed IGFBP5 promotes cell proliferation and
            inhibits apoptosis of nucleus pulposus derived from rats with disc
            degeneration through inactivating the ERK/MAPK axis.
REFERENCE   5  (bases 1 to 1627)
  AUTHORS   Pan,J., Li,K., Huang,W. and Zhang,X.
  TITLE     MiR-137 inhibited cell proliferation and migration of vascular
            smooth muscle cells via targeting IGFBP-5 and modulating the
            mTOR/STAT3 signaling
  JOURNAL   PLoS One 12 (10), e0186245 (2017)
   PUBMED   29016699
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1627)
  AUTHORS   Twigg,S.M. and Baxter,R.C.
  TITLE     Insulin-like growth factor (IGF)-binding protein 5 forms an
            alternative ternary complex with IGFs and the acid-labile subunit
  JOURNAL   J Biol Chem 273 (11), 6074-6079 (1998)
   PUBMED   9497324
REFERENCE   7  (bases 1 to 1627)
  AUTHORS   Duan,C. and Clemmons,D.R.
  TITLE     Transcription factor AP-2 regulates human insulin-like growth
            factor binding protein-5 gene expression
  JOURNAL   J Biol Chem 270 (42), 24844-24851 (1995)
   PUBMED   7559606
REFERENCE   8  (bases 1 to 1627)
  AUTHORS   Landau,D., Chin,E., Bondy,C., Domene,H., Roberts,C.T. Jr.,
            Gronbaek,H., Flyvbjerg,A. and LeRoith,D.
  TITLE     Expression of insulin-like growth factor binding proteins in the
            rat kidney: effects of long-term diabetes
  JOURNAL   Endocrinology 136 (5), 1835-1842 (1995)
   PUBMED   7536658
REFERENCE   9  (bases 1 to 1627)
  AUTHORS   Zhu,X., Ling,N. and Shimasaki,S.
  TITLE     Cloning of the rat insulin- like growth factor binding protein-5
            gene and DNA sequence analysis of its promoter region
  JOURNAL   Biochem Biophys Res Commun 190 (3), 1045-1052 (1993)
   PUBMED   7679898
REFERENCE   10 (bases 1 to 1627)
  AUTHORS   Shimasaki,S., Shimonaka,M., Zhang,H.P. and Ling,N.
  TITLE     Identification of five different insulin-like growth factor binding
            proteins (IGFBPs) from adult rat serum and molecular cloning of a
            novel IGFBP-5 in rat and human
  JOURNAL   J Biol Chem 266 (16), 10646-10653 (1991)
   PUBMED   1709938
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000009.1.
            
            On Nov 26, 2020 this sequence version replaced NM_012817.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M62781.1, BC087030.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840111, SAMN12840115
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-882               JAXUCZ010000009.1  81913306-81914187   c
            883-1112            JAXUCZ010000009.1  81903295-81903524   c
            1113-1232           JAXUCZ010000009.1  81902656-81902775   c
            1233-1627           JAXUCZ010000009.1  81901605-81901999   c
FEATURES             Location/Qualifiers
     source          1..1627
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q33"
     gene            1..1627
                     /gene="Igfbp5"
                     /gene_synonym="IGF-BP5"
                     /note="insulin-like growth factor binding protein 5"
                     /db_xref="GeneID:25285"
                     /db_xref="RGD:2876"
     exon            1..882
                     /gene="Igfbp5"
                     /gene_synonym="IGF-BP5"
                     /inference="alignment:Splign:2.1.0"
     CDS             549..1364
                     /gene="Igfbp5"
                     /gene_synonym="IGF-BP5"
                     /note="IBP-5; IGFBP-5; IGF-binding protein 5"
                     /codon_start=1
                     /product="insulin-like growth factor-binding protein 5
                     precursor"
                     /protein_id="NP_036949.1"
                     /db_xref="GeneID:25285"
                     /db_xref="RGD:2876"
                     /translation="MVISVVLLLLAACAVPAQGLGSFVHCEPCDEKALSMCPPSPLGC
                     ELVKEPGCGCCMTCALAEGQSCGVYTERCAQGLRCLPRQDEEKPLHALLHGRGVCLNE
                     KSYGEQTKIERDSREHEEPTTSEMAEETYSPKVFRPKHTRISELKAEAVKKDRRKKLT
                     QSKFVGGAENTAHPRVIPAPEMRQESDQGPCRRHMEASLQEFKASPRMVPRAVYLPNC
                     DRKGFYKRKQCKPSRGRKRGICWCVDKYGMKLPGMEYVDGDFQCHAFDSSNVE"
     exon            883..1112
                     /gene="Igfbp5"
                     /gene_synonym="IGF-BP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1113..1232
                     /gene="Igfbp5"
                     /gene_synonym="IGF-BP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1233..1627
                     /gene="Igfbp5"
                     /gene_synonym="IGF-BP5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ttttttcctc tcccttgatt tcaacatttt cccgatcttc ttggcgccgc cgacgcctct
       61 tacctgttct gcgcagcggc gcagctggca gctgagagaa gtgggggtgc gttttaggtt
      121 ttaagcaaag gcaaaaaaaa aaaaaattaa gccaaatcca ttttttttcc ttcacctctc
      181 cccgtttcaa ggcctccaag atcattattt ctgtagcttt ggggtgagcg attctgtgtt
      241 tctcttcatc acccctccaa ttctgccccg atcccgcctg ggtctccact cactgcgtgc
      301 acctggcgcg cctctttttt tttcaccccc aacctgttgc aagtctttaa tccttgcaat
      361 tgggacttgc gtgcaggcac ctgaatcctc cttgcctcat attttgcaag tgtttggagg
      421 acagcacctg ctttacctgc aagagatatt ttttaaaaaa aaaaaatctc caggctccct
      481 cttggcccct ttctccacac actctcgctc tcctgccccg ccccgaggta aagccagact
      541 cggaaaaaat ggtgatcagc gtggtcctcc tgctgctggc cgcctgtgcc gtgccggctc
      601 aaggcctggg ctctttcgtg cattgtgaac cctgcgacga gaaagctctg tccatgtgtc
      661 cccccagccc tctgggctgt gagctggtca aagagcccgg ctgtggctgc tgcatgactt
      721 gcgccctggc ggagggacag tcgtgtggcg tctacactga gcgctgcgcc cagggtttgc
      781 gctgtctccc ccggcaggat gaggagaagc cgctgcacgc cctgctgcac ggccgcgggg
      841 tttgcctcaa cgaaaagagc tacggcgagc aaaccaagat agagagagac tctcgggagc
      901 atgaggaacc caccacctcc gagatggctg aggagaccta ctccccgaag gtcttccggc
      961 ccaagcacac tcgcatttcc gagctgaagg ccgaggctgt gaagaaggat cgcagaaaga
     1021 agctgaccca gtctaagttt gtggggggcg cggagaacac tgcccacccc cgagtcatcc
     1081 ctgcacctga gatgagacag gaatctgacc aaggcccctg ccgcagacac atggaagctt
     1141 ccctccagga gttcaaagcc agcccacgca tggtgccccg tgccgtgtac ctgcccaact
     1201 gtgaccgcaa aggattctac aagagaaagc agtgcaagcc ttctcgtggc cgcaaacgtg
     1261 gcatctgctg gtgtgtggac aagtatggga tgaagctgcc gggcatggag tacgtcgatg
     1321 gggactttca gtgccacgcc ttcgacagca gtaacgttga gtgacgcgtc ccctcccttc
     1381 ctcccccttt cctacccccc agccccaact ccagccagcg cctccctcca ccccaggacg
     1441 tcactcattt catctcattt aggggaaata tatatacata tatatttgag gaaactgagg
     1501 acctcggaat ctctagcaag ggctaaggag acactcccca tcccgacccc ggaaacgtat
     1561 tcctatttga agcaagttga acggacagag aagggaagaa gagaaggggc aagaaggagc
     1621 gaggaat
//
