LOCUS       NM_001004274            2194 bp    mRNA    linear   ROD 24-OCT-2024
DEFINITION  Rattus norvegicus insulin-like growth factor binding protein 4
            (Igfbp4), mRNA.
ACCESSION   NM_001004274 XM_340897
VERSION     NM_001004274.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2194)
  AUTHORS   Dya,G.A., Lebedeva,O.S., Gushchevarov,D.A., Volovikov,E.A.,
            Belikova,L.D., Kopylova,I.V., Postnikov,A.B., Artemieva,M.M.,
            Medvedeva,N.A., Lagarkova,M.A., Katrukha,A.G. and Serebryanaya,D.V.
  TITLE     Specific cleavage of IGFBP-4 by papp-a in nervous tissue
  JOURNAL   Biochem Biophys Res Commun 733, 150655 (2024)
   PUBMED   39244846
  REMARK    GeneRIF: Specific cleavage of IGFBP-4 by papp-a in nervous tissue.
REFERENCE   2  (bases 1 to 2194)
  AUTHORS   Wang,H., Yu,R., Wang,M., Wang,S., Ouyang,X., Yan,Z., Chen,S.,
            Wang,W., Wu,F. and Fan,C.
  TITLE     Insulin-like growth factor binding protein 4 loaded electrospun
            membrane ameliorating tendon injury by promoting retention of IGF-1
  JOURNAL   J Control Release 356, 162-174 (2023)
   PUBMED   36868516
  REMARK    GeneRIF: Insulin-like growth factor binding protein 4 loaded
            electrospun membrane ameliorating tendon injury by promoting
            retention of IGF-1.
REFERENCE   3  (bases 1 to 2194)
  AUTHORS   Serebryanaya,D.V., Adasheva,D.A., Konev,A.A., Artemieva,M.M.,
            Katrukha,I.A., Postnikov,A.B., Medvedeva,N.A. and Katrukha,A.G.
  TITLE     IGFBP-4 Proteolysis by PAPP-A in a Primary Culture of Rat Neonatal
            Cardiomyocytes under Normal and Hypertrophic Conditions
  JOURNAL   Biochemistry (Mosc) 86 (11), 1395-1406 (2021)
   PUBMED   34906040
  REMARK    GeneRIF: IGFBP-4 Proteolysis by PAPP-A in a Primary Culture of Rat
            Neonatal Cardiomyocytes under Normal and Hypertrophic Conditions.
REFERENCE   4  (bases 1 to 2194)
  AUTHORS   Wu,J., Wang,C., Miao,X., Wu,Y., Yuan,J., Ding,M., Li,J. and Shi,Z.
  TITLE     Age-Related Insulin-Like Growth Factor Binding Protein-4
            Overexpression Inhibits Osteogenic Differentiation of Rat
            Mesenchymal Stem Cells
  JOURNAL   Cell Physiol Biochem 42 (2), 640-650 (2017)
   PUBMED   28595186
  REMARK    GeneRIF: IGFBP4 overexpression impaired BMP2-induced osteogenic
            differentiation potential of young MSCs, whereas IGFBP4 knockdown
            restored the osteogenic potency of aged MSCs. Moreover, IGFBP4
            knockdown stimulated the activation of Erk and Smad by increasing
            phosphorylation.
REFERENCE   5  (bases 1 to 2194)
  AUTHORS   Jiang,X., Zhao,J., Ju,L., Liu,Y., Wang,B., Zou,X. and Xu,C.
  TITLE     Temporal expression patterns of insulin-like growth factor binding
            protein-4 in the embryonic and postnatal rat brain
  JOURNAL   BMC Neurosci 14, 132 (2013)
   PUBMED   24175938
  REMARK    GeneRIF: The temporal expression pattern of IGFBP-4 in the
            embryonic brain suggests an important role of IGFBP-4 in regulating
            differentiation of neural stem cells
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2194)
  AUTHORS   Fernandez-Celemin,L. and Thissen,J.P.
  TITLE     Interleukin-6 stimulates hepatic insulin-like growth factor binding
            protein-4 messenger ribonucleic acid and protein
  JOURNAL   Endocrinology 142 (1), 241-248 (2001)
   PUBMED   11145587
REFERENCE   7  (bases 1 to 2194)
  AUTHORS   Landau,D., Chin,E., Bondy,C., Domene,H., Roberts,C.T. Jr.,
            Gronbaek,H., Flyvbjerg,A. and LeRoith,D.
  TITLE     Expression of insulin-like growth factor binding proteins in the
            rat kidney: effects of long-term diabetes
  JOURNAL   Endocrinology 136 (5), 1835-1842 (1995)
   PUBMED   7536658
REFERENCE   8  (bases 1 to 2194)
  AUTHORS   Donahue,L.R., Watson,G. and Beamer,W.G.
  TITLE     Regulation of metabolic water and protein compartments by
            insulin-like growth factor-I and testosterone in growth
            hormone-deficient lit/lit mice
  JOURNAL   J Endocrinol 139 (3), 431-439 (1993)
   PUBMED   7510770
REFERENCE   9  (bases 1 to 2194)
  AUTHORS   Gao,L., Ling,N. and Shimasaki,S.
  TITLE     Structure of the rat insulin-like growth factor binding protein-4
            gene
  JOURNAL   Biochem Biophys Res Commun 190 (3), 1053-1059 (1993)
   PUBMED   7679899
REFERENCE   10 (bases 1 to 2194)
  AUTHORS   Donahue,L.R. and Beamer,W.G.
  TITLE     Growth hormone deficiency in 'little' mice results in aberrant body
            composition, reduced insulin-like growth factor-I and insulin-like
            growth factor-binding protein-3 (IGFBP-3), but does not affect
            IGFBP-2, -1 or -4
  JOURNAL   J Endocrinol 136 (1), 91-104 (1993)
   PUBMED   7679139
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC098750.1.
            
            On Jul 13, 2005 this sequence version replaced NM_001004274.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC098750.1, EX490420.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132303, SAMD00132304
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2194
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q31"
     gene            1..2194
                     /gene="Igfbp4"
                     /gene_synonym="IBP4; IGF-BP4"
                     /note="insulin-like growth factor binding protein 4"
                     /db_xref="GeneID:360622"
                     /db_xref="RGD:2875"
     exon            1..590
                     /gene="Igfbp4"
                     /gene_synonym="IBP4; IGF-BP4"
                     /inference="alignment:Splign:2.1.0"
     CDS             242..1006
                     /gene="Igfbp4"
                     /gene_synonym="IBP4; IGF-BP4"
                     /note="IGF-binding protein 4; IBP-4; IGFBP-4"
                     /codon_start=1
                     /product="insulin-like growth factor-binding protein 4
                     precursor"
                     /protein_id="NP_001004274.1"
                     /db_xref="GeneID:360622"
                     /db_xref="RGD:2875"
                     /translation="MLPFGLVAALLLAAGPRPSLGDEAIHCPPCSEEKLARCRPPVGC
                     EELVREPGCGCCATCALGLGMPCGVYTPRCGSGMRCYPPRGVEKPLRTLMHGQGVCTE
                     LSEIEAIQESLQTSDKDESEHPNNSFNPCSAHDHRCLQKHMAKVRDRSKMKVVGTPRE
                     EPRPVPQGSCQSELHRALERLAASQSRTHEDLFIIPIPNCDRNGNFHPKQCHPALDGQ
                     RGKCWCVDRKTGVKLPGGLEPKGELDCHQLADSLQE"
     exon            591..736
                     /gene="Igfbp4"
                     /gene_synonym="IBP4; IGF-BP4"
                     /inference="alignment:Splign:2.1.0"
     exon            737..871
                     /gene="Igfbp4"
                     /gene_synonym="IBP4; IGF-BP4"
                     /inference="alignment:Splign:2.1.0"
     exon            872..2164
                     /gene="Igfbp4"
                     /gene_synonym="IBP4; IGF-BP4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccctgccccc gccgcctgct gggccggccg aggatgcagc gcagcgcctc ggtgtccagg
       61 ctcgctctgc tccagcgtgc ttgctaactt cccttggctc cgtcccagcc tgccggggcc
      121 gcaccgtgtc ctctcgctct ccgggtctgg ttctctaagc tctctgggag ctgcctccgg
      181 gttccttgca gcccgctcgc gagcccgcgc tccccttctg cgccccaccc tcgttctcac
      241 catgctgccc ttcggcctcg tggccgccct gctgctggcc gcagggcctc ggccgagcct
      301 gggcgacgaa gccatccact gccctccttg ctccgaggag aagctggcgc gctgccgccc
      361 ccccgtgggt tgtgaggagc tggtgcggga gcctggctgc ggttgttgtg ccacttgcgc
      421 cctgggcttg gggatgcctt gcggggtgta caccccacgc tgtggctcag gcatgcgctg
      481 ctacccgccc cggggggtgg agaagcccct gcgcacattg atgcacgggc aaggtgtatg
      541 cacggagctg tcggaaatcg aagccatcca ggaaagcctg cagacctctg acaaggatga
      601 gagtgagcat cccaacaaca gcttcaaccc ctgcagcgcc cacgatcaca ggtgcctgca
      661 gaagcatatg gccaaagtga gagatcggag caagatgaag gttgtgggga cacctcggga
      721 ggaaccccgt cctgtgcccc agggttcttg ccagagcgag ctgcaccggg ccctggaacg
      781 actggccgcc tcgcagagcc gtacccacga agacctcttc atcatcccca tccccaactg
      841 tgaccgcaac ggcaacttcc accccaaaca gtgtcatcct gctctggatg gacagcgtgg
      901 caaatgctgg tgtgtggatc ggaagacagg ggtgaagctt ccagggggct tggaacccaa
      961 gggggagctg gactgccacc aactggctga cagcctccaa gagtgagacc tgccagcagg
     1021 tggggggact cagtgccccc tactaggtcc ctatgctctg gggactgtag agttgacctg
     1081 gcatggagtc ttggcctgag tcctggctct ctgcctctgg ccctgcccaa agtttccctt
     1141 ggtgtgtgtg tgtctgtctc tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg
     1201 tgtgtgtgtt tatgggatgt gccccacggg gtaaacctga gccttggcgt gcccacagtg
     1261 ggcttagata gcccaagagg tctgagtgta gcaacaggaa accccggtga gttttcaagt
     1321 cattcttgaa ttcattcatt cattcattca ttcagccatc tgaaaacatc tattgaccac
     1381 atactacaag ccagctttag ttttcggccc caggaagcct catcctgact tcctcttgat
     1441 tgtgggatgc gaggtgttcc cagctagagg cctgtgggag aaaagaaacc tcattcttgg
     1501 agtcggagag aaagttgtga acattgaaca ccctccctct caatgtggcc agagtgtggg
     1561 aaggagtggg gtagaggctt gtagctcatg agacccacct ccgctctgtg ctctgtaggt
     1621 cattcctcag gtcctccagg gcacaagctt gagggacagg gcccagcttt gggtctgggg
     1681 attcagtcat ctgacattgc ctggcaggtg gatctccact gtgggagggg aatggggtga
     1741 ggaaggcctg agggacaggg cgcagagagg tgagctcatg gatgtgagca aacaggagag
     1801 aagaaagaat gtgagattgg attgcgtgtg tatgaaggag aggaagactc gtgctggggg
     1861 attagctgtg ggggtcctgt tccactccct gtttgtggtg actggtcatg aagtaagtca
     1921 ccaggatgac cctgtctttc caattgccca ccacctgtgg ctctttttcc cccccctgcc
     1981 cccccatatt tcccttccct gacacctcct gtcccaacct ctctaacccc cctgggcatt
     2041 ttctggcttg cctggatagt tttagagacc tgcttgttgg ctataatgtc ttttcattca
     2101 ttcattcttc tttttctttt tttaaaaaaa caaaatgaaa caacaaaacc aaaaagtatc
     2161 cagaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaa
//
