LOCUS       NM_013122               1316 bp    mRNA    linear   ROD 29-OCT-2024
DEFINITION  Rattus norvegicus insulin-like growth factor binding protein 2
            (Igfbp2), mRNA.
ACCESSION   NM_013122
VERSION     NM_013122.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1316)
  AUTHORS   An,J., Wen,L., Yu,H., Bu,Z. and Feng,J.
  TITLE     Insulin-Like Growth Factor Binding Protein 2 Drives
            Neurodegeneration in Parkinson's Disease: Insights From In Vivo and
            In Vitro Studies
  JOURNAL   CNS Neurosci Ther 30 (10), e70076 (2024)
   PUBMED   39412224
  REMARK    GeneRIF: Insulin-Like Growth Factor Binding Protein 2 Drives
            Neurodegeneration in Parkinson's Disease: Insights From In Vivo and
            In Vitro Studies.
REFERENCE   2  (bases 1 to 1316)
  AUTHORS   Kutasy,B., Friedmacher,F., Duess,J.W. and Puri,P.
  TITLE     Prenatal administration of retinoic acid increases the
            trophoblastic insulin-like growth factor 2 protein expression in
            the nitrofen model of congenital diaphragmatic hernia
  JOURNAL   Pediatr Surg Int 30 (2), 137-142 (2014)
   PUBMED   24352370
  REMARK    GeneRIF: Insulin-like growth factor 2 (IGF2) is an important
            regulator of fetal growth.
REFERENCE   3  (bases 1 to 1316)
  AUTHORS   Cha,D.M., Woo,S.J., Kim,H.J., Lee,C. and Park,K.H.
  TITLE     Comparative analysis of aqueous humor cytokine levels between
            patients with exudative age-related macular degeneration and normal
            controls
  JOURNAL   Invest Ophthalmol Vis Sci 54 (10), 7038-7044 (2013)
   PUBMED   24106111
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1316)
  AUTHORS   Abonnenc,M., Nabeebaccus,A.A., Mayr,U., Barallobre-Barreiro,J.,
            Dong,X., Cuello,F., Sur,S., Drozdov,I., Langley,S.R., Lu,R.,
            Stathopoulou,K., Didangelos,A., Yin,X., Zimmermann,W.H., Shah,A.M.,
            Zampetaki,A. and Mayr,M.
  TITLE     Extracellular matrix secretion by cardiac fibroblasts: role of
            microRNA-29b and microRNA-30c
  JOURNAL   Circ Res 113 (10), 1138-1147 (2013)
   PUBMED   24006456
REFERENCE   5  (bases 1 to 1316)
  AUTHORS   Zhou,J., Li,W., Kamei,H. and Duan,C.
  TITLE     Duplication of the IGFBP-2 gene in teleost fish: protein structure
            and functionality conservation and gene expression divergence
  JOURNAL   PLoS One 3 (12), e3926 (2008)
   PUBMED   19081843
REFERENCE   6  (bases 1 to 1316)
  AUTHORS   Shimasaki,S., Shimonaka,M., Zhang,H.P. and Ling,N.
  TITLE     Identification of five different insulin-like growth factor binding
            proteins (IGFBPs) from adult rat serum and molecular cloning of a
            novel IGFBP-5 in rat and human
  JOURNAL   J Biol Chem 266 (16), 10646-10653 (1991)
   PUBMED   1709938
REFERENCE   7  (bases 1 to 1316)
  AUTHORS   Shimonaka,M., Schroeder,R., Shimasaki,S. and Ling,N.
  TITLE     Identification of a novel binding protein for insulin-like growth
            factors in adult rat serum
  JOURNAL   Biochem Biophys Res Commun 165 (1), 189-195 (1989)
   PUBMED   2480123
REFERENCE   8  (bases 1 to 1316)
  AUTHORS   Margot,J.B., Binkert,C., Mary,J.L., Landwehr,J., Heinrich,G. and
            Schwander,J.
  TITLE     A low molecular weight insulin-like growth factor binding protein
            from rat: cDNA cloning and tissue distribution of its messenger RNA
  JOURNAL   Mol Endocrinol 3 (7), 1053-1060 (1989)
   PUBMED   2477691
REFERENCE   9  (bases 1 to 1316)
  AUTHORS   Brown,A.L., Chiariotti,L., Orlowski,C.C., Mehlman,T., Burgess,W.H.,
            Ackerman,E.J., Bruni,C.B. and Rechler,M.M.
  TITLE     Nucleotide sequence and expression of a cDNA clone encoding a fetal
            rat binding protein for insulin-like growth factors
  JOURNAL   J Biol Chem 264 (9), 5148-5154 (1989)
   PUBMED   2538475
REFERENCE   10 (bases 1 to 1316)
  AUTHORS   Mottola,C., MacDonald,R.G., Brackett,J.L., Mole,J.E., Anderson,J.K.
            and Czech,M.P.
  TITLE     Purification and amino-terminal sequence of an insulin-like growth
            factor-binding protein secreted by rat liver BRL-3A cells
  JOURNAL   J Biol Chem 261 (24), 11180-11188 (1986)
   PUBMED   2426267
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC092570.1.
            
            On Jun 10, 2007 this sequence version replaced NM_013122.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC092570.1, FQ212531.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1316
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q33"
     gene            1..1316
                     /gene="Igfbp2"
                     /gene_synonym="BRL-BP; IBP-2; IGFBP-2; ILGFBPA"
                     /note="insulin-like growth factor binding protein 2"
                     /db_xref="GeneID:25662"
                     /db_xref="RGD:2873"
     exon            1..456
                     /gene="Igfbp2"
                     /gene_synonym="BRL-BP; IBP-2; IGFBP-2; ILGFBPA"
                     /inference="alignment:Splign:2.1.0"
     CDS             72..986
                     /gene="Igfbp2"
                     /gene_synonym="BRL-BP; IBP-2; IGFBP-2; ILGFBPA"
                     /note="IGF-binding protein 2"
                     /codon_start=1
                     /product="insulin-like growth factor-binding protein 2
                     precursor"
                     /protein_id="NP_037254.2"
                     /db_xref="GeneID:25662"
                     /db_xref="RGD:2873"
                     /translation="MLPRLGGPALPLLLPSLLLLLLLGAGGCGPGVRAEVLFRCPPCT
                     PERLAACGPPPDAPCAELVREPGCGCCSVCARQEGEACGVYIPRCAQTLRCYPNPGSE
                     LPLKALVTGAGTCEKRRVGATPQQVADSEDDHSEGGLVENHVDGTMNMLGGSSAGRKP
                     PKSGMKELAVFREKVNEQHRQMGKGAKHLSLEEPKKLRPPPARTPCQQELDQVLERIS
                     TMRLPDDRGPLEHLYSLHIPNCDKHGLYNLKQCKMSLNGQRGECWCVNPNTGKPIQGA
                     PTIRGDPECHLFYNEQQENDGAHAQRVQ"
     exon            457..680
                     /gene="Igfbp2"
                     /gene_synonym="BRL-BP; IBP-2; IGFBP-2; ILGFBPA"
                     /inference="alignment:Splign:2.1.0"
     exon            681..821
                     /gene="Igfbp2"
                     /gene_synonym="BRL-BP; IBP-2; IGFBP-2; ILGFBPA"
                     /inference="alignment:Splign:2.1.0"
     exon            822..1295
                     /gene="Igfbp2"
                     /gene_synonym="BRL-BP; IBP-2; IGFBP-2; ILGFBPA"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtctcccgcg ctcgccaggg ccgtgccacc tgcccgctag ctcgccgcgc tacggtttcc
       61 cactagccaa catgctgccg agattgggcg gccccgcgct gccgctgctc ctgccgtcgc
      121 tgctcttgct gctgctgttg ggcgcgggcg gttgcggtcc tggggtgcgc gccgaggtgc
      181 tgttccgctg cccaccctgc acgcccgagc gtctggccgc ctgcggaccc ccacccgacg
      241 cgccctgcgc cgagctggtg cgagagcccg gctgcggttg ctgctccgtg tgcgcacgac
      301 aggagggcga agcttgcggc gtctacatcc cgcgctgcgc ccagacgtta cgctgttacc
      361 ccaacccggg ctccgagctg cccctgaagg cactggtcac cggcgcgggt acctgtgaaa
      421 agagacgcgt gggcgccacc ccacagcaag ttgcagacag tgaggatgac cactcggagg
      481 gaggcctggt ggagaaccat gtggacggaa ccatgaacat gttgggaggc agcagtgctg
      541 gccggaagcc ccctaagtca ggcatgaagg aactggctgt gttccgggag aaggtcaacg
      601 agcagcaccg gcagatgggc aaaggtgcca aacacctcag cctggaggag cccaagaagc
      661 tgcgcccacc tcctgccagg accccttgcc agcaggagct ggaccaggtc ctggagcgca
      721 tctccaccat gcgccttccg gatgatcggg gtcctctgga acatctctac tccctgcata
      781 tccccaactg tgacaagcat ggcctgtaca acctcaaaca gtgcaagatg tctctgaatg
      841 gacagcgtgg ggagtgctgg tgtgtgaacc ccaatactgg gaagccaatc cagggagctc
      901 ccaccatccg gggagacccc gagtgccatc tcttctacaa cgagcagcag gagaatgatg
      961 gggctcacgc ccaaagggtg cagtaaacca cagccagtcg gtgcctggct tccccacccc
     1021 aaacaccagc agaaatggag ggtgtcaggg tgatgggtgt ggaggatttc ccagttttga
     1081 cacatgtatt tatatttgga aagagaccaa cactgagctc agaagccccc ctgcgccccc
     1141 cagtggcagt taacctgtac ctccgttcct gcttctaata gagagggtgg tggcactggg
     1201 gatactgggt acaggcttgg gaatggggaa agaaattttt atttttgaac ccctgtgtct
     1261 cttttactta agattaaagg aaggaaaaat aaaaaaaaaa aaaaaaaaaa aaaaaa
//
