LOCUS       NM_013144               1502 bp    mRNA    linear   ROD 17-JUN-2024
DEFINITION  Rattus norvegicus insulin-like growth factor binding protein 1
            (Igfbp1), mRNA.
ACCESSION   NM_013144 XM_001053362
VERSION     NM_013144.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1502)
  AUTHORS   Yuan,Z., Wang,W., Song,S., Ling,Y., Xu,J. and Tao,Z.
  TITLE     IGFBP1 stabilizes Umod expression through m6A modification to
            inhibit the occurrence and development of cystitis by blocking
            NF-kappaB and ERK signaling pathways
  JOURNAL   Int Immunopharmacol 134, 111997 (2024)
   PUBMED   38759370
  REMARK    GeneRIF: IGFBP1 stabilizes Umod expression through m6A modification
            to inhibit the occurrence and development of cystitis by blocking
            NF-kappaB and ERK signaling pathways.
REFERENCE   2  (bases 1 to 1502)
  AUTHORS   Hou,J., Yan,J. and Kang,Q.Q.
  TITLE     [Study on intermittent hypoxia in children sleep apnea hypopnea
            syndrome model and insulin-like growth factor-1 and insulin-like
            growth factor binding protein-3 levels in serum]
  JOURNAL   Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 47 (3), 218-222
            (2012)
   PUBMED   22805023
  REMARK    GeneRIF: In simulated sleep apnea hypopnea syndrome, intermittent
            hypoxia in young rats does not cause physical growth retardation,
            but serum IGF-1 and IGFBP-3 levels decreased with the increase of
            hypoxia and decline of oxygen saturation.
REFERENCE   3  (bases 1 to 1502)
  AUTHORS   Brandt,K., Lundell,K. and Brismar,K.
  TITLE     Neutrophil-derived azurocidin cleaves insulin-like growth
            factor-binding protein-1, -2 and -4
  JOURNAL   Growth Horm IGF Res 21 (3), 167-173 (2011)
   PUBMED   21550830
REFERENCE   4  (bases 1 to 1502)
  AUTHORS   Chesik,D., De Keyser,J., Bron,R. and Fuhler,G.M.
  TITLE     Insulin-like growth factor binding protein-1 activates
            integrin-mediated intracellular signaling and migration in
            oligodendrocytes
  JOURNAL   J Neurochem 113 (5), 1319-1330 (2010)
   PUBMED   20345750
  REMARK    GeneRIF: up-regulation of IGFBP-1 in oligodendrocytes in multiple
            sclerosis may serve two functions: (i) regulate IGF-1 actions, (ii)
            exert IGF-independent effects through its RGD sequence
REFERENCE   5  (bases 1 to 1502)
  AUTHORS   Rutkute,K. and Nikolova-Karakashian,M.N.
  TITLE     Regulation of insulin-like growth factor binding protein-1
            expression during aging
  JOURNAL   Biochem Biophys Res Commun 361 (2), 263-269 (2007)
   PUBMED   17645865
  REMARK    GeneRIF: Age-related oxidative stress underlies the upregulated JNK
            activation and IGFBP-1 expression.
REFERENCE   6  (bases 1 to 1502)
  AUTHORS   Donahue,L.R., Watson,G. and Beamer,W.G.
  TITLE     Regulation of metabolic water and protein compartments by
            insulin-like growth factor-I and testosterone in growth
            hormone-deficient lit/lit mice
  JOURNAL   J Endocrinol 139 (3), 431-439 (1993)
   PUBMED   7510770
REFERENCE   7  (bases 1 to 1502)
  AUTHORS   Ooi,G.T., Tseng,L.Y., Tran,M.Q. and Rechler,M.M.
  TITLE     Insulin rapidly decreases insulin-like growth factor-binding
            protein-1 gene transcription in streptozotocin-diabetic rats
  JOURNAL   Mol Endocrinol 6 (12), 2219-2228 (1992)
   PUBMED   1283442
REFERENCE   8  (bases 1 to 1502)
  AUTHORS   Mohn,K.L., Melby,A.E., Tewari,D.S., Laz,T.M. and Taub,R.
  TITLE     The gene encoding rat insulinlike growth factor-binding protein 1
            is rapidly and highly induced in regenerating liver
  JOURNAL   Mol Cell Biol 11 (3), 1393-1401 (1991)
   PUBMED   1705004
REFERENCE   9  (bases 1 to 1502)
  AUTHORS   Unterman,T.G., Oehler,D.T., Gotway,M.B. and Morris,P.W.
  TITLE     Production of the rat type 1 insulin-like growth factor-binding
            protein by well differentiated H4EIIC3 hepatoma cells:
            identification, purification, and N-terminal amino acid analysis
  JOURNAL   Endocrinology 127 (2), 789-797 (1990)
   PUBMED   2164920
  REMARK    Erratum:[Endocrinology 1990 Oct;127(4):1977]
REFERENCE   10 (bases 1 to 1502)
  AUTHORS   Murphy,L.J., Seneviratne,C., Ballejo,G., Croze,F. and Kennedy,T.G.
  TITLE     Identification and characterization of a rat decidual insulin-like
            growth factor-binding protein complementary DNA
  JOURNAL   Mol Endocrinol 4 (2), 329-336 (1990)
   PUBMED   1691820
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000014.1.
            
            On Nov 26, 2020 this sequence version replaced NM_013144.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M58634.1, BC078889.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760400, SAMEA5760476
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-533               JAXUCZ010000014.1  86261277-86261809
            534-718             JAXUCZ010000014.1  86263111-86263295
            719-847             JAXUCZ010000014.1  86264133-86264261
            848-1502            JAXUCZ010000014.1  86265690-86266344
FEATURES             Location/Qualifiers
     source          1..1502
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14q21"
     gene            1..1502
                     /gene="Igfbp1"
                     /gene_synonym="IBP1; IGF-BP25; IGFBA"
                     /note="insulin-like growth factor binding protein 1"
                     /db_xref="GeneID:25685"
                     /db_xref="RGD:2872"
     exon            1..533
                     /gene="Igfbp1"
                     /gene_synonym="IBP1; IGF-BP25; IGFBA"
                     /inference="alignment:Splign:2.1.0"
     CDS             161..979
                     /gene="Igfbp1"
                     /gene_synonym="IBP1; IGF-BP25; IGFBA"
                     /note="IBP-1; IGFBP-1; IGF-binding protein 1; placental
                     protein 12"
                     /codon_start=1
                     /product="insulin-like growth factor-binding protein 1
                     precursor"
                     /protein_id="NP_037276.1"
                     /db_xref="GeneID:25685"
                     /db_xref="RGD:2872"
                     /translation="MPEFLTVVSWPFLILLSFQVRVVAGAPQPWHCAPCTAERLELCP
                     PVPASCPEISRPAGCGCCPTCALPLGAACGVATARCAQGLSCRALPGEPRPLHALTRG
                     QGACVLEPAAPATSSLSGSQHEEAKAAVASEDELAESPEMTEEQLLDSFHLMAPSRED
                     QPILWNAISTYSSMRAREITDLKKWKEPCQRELYKVLERLAAAQQKAGDEIYKFYLPN
                     CNKNGFYHSKQCETSLDGEAGLCWCVYPWSGKKIPGSLETRGDPNCHQYFNVQN"
     exon            534..718
                     /gene="Igfbp1"
                     /gene_synonym="IBP1; IGF-BP25; IGFBA"
                     /inference="alignment:Splign:2.1.0"
     exon            719..847
                     /gene="Igfbp1"
                     /gene_synonym="IBP1; IGF-BP25; IGFBA"
                     /inference="alignment:Splign:2.1.0"
     exon            848..1502
                     /gene="Igfbp1"
                     /gene_synonym="IBP1; IGF-BP25; IGFBA"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgccgagaca caaacccagc gagcattgaa cactgcacac ggccatctgc ccagagagct
       61 gtgaccacca cttccgctac tatctactca gaaagtcgtg actactgagc cactgctgcc
      121 tgcccagatt ctcatccacc gcctgctgcg tctggttgcg atgccggagt tcctaactgt
      181 tgtttcttgg ccgttcctga tcctcctgtc cttccaggtt cgcgtagtcg ctggagcccc
      241 ccagccatgg cactgtgctc cctgcactgc tgagaggctg gagctctgtc cacccgtgcc
      301 tgcttcgtgc cccgagattt ctcggcctgc gggctgtggc tgctgcccga catgtgcctt
      361 gccactgggt gctgcctgtg gtgtggccac tgcgcgctgc gctcagggac tcagctgccg
      421 tgcgctgcca ggggagcctc gacctctgca tgccctcacc cgtggccagg gagcctgtgt
      481 actagaacct gccgcacccg ccacgagcag cttgtccggt tctcagcatg aagaggcaaa
      541 ggctgctgtg gcctctgagg atgagcttgc cgagagccca gagatgacag aggaacagct
      601 gctggatagc ttccacctca tggccccatc ccgtgaggac cagcccatcc tgtggaatgc
      661 cattagcacc tacagcagca tgcgggcccg ggagatcact gacctcaaga aatggaagga
      721 gccctgccaa cgggaactct ataaagtgtt agagagatta gctgccgctc aacagaaagc
      781 aggagatgag atctacaaat tttatctgcc aaactgcaac aagaatggat tttatcacag
      841 caaacagtgc gagacatctc tggatggaga agctgggctc tgctggtgtg tctacccatg
      901 gagtgggaag aagatccctg gatctctgga gaccagaggg gaccccaact gccaccagta
      961 ttttaatgtg caaaactgaa agttgtttcc tccctccttc ttcacacaaa atatttaagt
     1021 atatagtgta tttatactcc ggagcacacc attttatata tgtgtatatg tatatatcca
     1081 ggaactagtt tttatactcc acatgctgct tgatgtacaa gtgggtttgt atttattcac
     1141 tctaagttta tttttttcta ccctgtcctt gtgctgtatt aatttatata actgaagctt
     1201 ttctcatctc catacatgta aatactacca tctcagctct tccagagttc tgctttgaaa
     1261 gggcagcgcg gtagctgcct agaacgagca caagtcagtc tgaggtaggg gcctttcagt
     1321 gggttcaggg aggaaggtta gccctggctc ggggagactt cctcatcgaa tcccacaagt
     1381 ctgtgtctga tgcctattgg ctgggaaggt tccgatgttg gttgtgtaat caaagctaaa
     1441 cgtggaaagc tgcgtcccat gcactgttaa acacacgtct ggaataaaac attctacctg
     1501 ga
//
