LOCUS       XM_039086922            4454 bp    mRNA    linear   ROD 11-JUN-2023
DEFINITION  PREDICTED: Rattus norvegicus insulin-like growth factor binding
            protein, acid labile subunit (Igfals), transcript variant X1, mRNA.
ACCESSION   XM_039086922
VERSION     XM_039086922.1
DBLINK      BioProject: PRJNA677964
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_051345.1) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            [WARNING] On Feb 22, 2024 this sequence was replaced by
            XM_039086922.2.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_015227675.2-RS_2023_06
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.1
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 06/06/2023
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..4454
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN/NHsdMcwi"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /sex="male"
                     /tissue_type="kidney"
                     /geo_loc_name="USA: Wisconsin, Milwaukee, Medical College
                     of Wisconsin"
                     /collection_date="2019-03-08"
                     /collected_by="Rebecca Schilling"
     gene            1..4454
                     /gene="Igfals"
                     /gene_synonym="Als"
                     /note="insulin-like growth factor binding protein, acid
                     labile subunit; Derived by automated computational
                     analysis using gene prediction method: Gnomon. Supporting
                     evidence includes similarity to: 17 ESTs, 2 long SRA
                     reads, 3 Proteins, and 100% coverage of the annotated
                     genomic feature by RNAseq alignments, including 16 samples
                     with support for all annotated introns"
                     /db_xref="GeneID:79438"
                     /db_xref="RGD:68429"
     CDS             1082..2893
                     /gene="Igfals"
                     /gene_synonym="Als"
                     /codon_start=1
                     /product="insulin-like growth factor-binding protein
                     complex acid labile subunit isoform X1"
                     /protein_id="XP_038942850.1"
                     /db_xref="GeneID:79438"
                     /db_xref="RGD:68429"
                     /translation="MWLRQGGPALVVLLAFWVALGPCHLQGTDPGASADAEGPQCPVA
                     CTCSHDDYTDELSVFCSSKNLTHLPDDIPVSTRALWLDGNNLSSIPSAAFQNLSSLDF
                     LNLQGSWLRSLEPQALLGLQNLYHLHLERNRLRNLAVGLFTHTPSLASLSLSSNLLGR
                     LEEGLFQGLSHLWDLNLGWNSLVVLPDTVFQGLGNLHELVLAGNKLTYLQPALFCGLG
                     ELRELDLSRNALRSVKANVFVHLPRLQKLYLDRNLITAVAPRAFLGMKALRWLDLSHN
                     RVAGLMEDTFPGLLGLHVLRLAHNAIASLRPRTFKDLHFLEELQLGHNRIRQLGERTF
                     EGLGQLEVLTLNDNQITEVRVGAFSGLFNVAVMNLSGNCLRSLPERVFQGLDKLHSLH
                     LEHSCLGHVRLHTFAGLSGLRRLFLRDNSISSIEEQSLAGLSELLELDLTTNRLTHLP
                     RQLFQGLGHLEYLLLSYNQLTTLSAEVLGPLQRAFWLDISHNHLETLAEGLFSSLGRL
                     RYLSLRNNSLQTFSPQPGLERLWLDANPWDCSCPLKALRDFALQNPGVVPRFVQTVCE
                     GDDCQPVYTYNNITCAGPANVSGLDLRDVSETHFVHC"
ORIGIN      
        1 agttccagga cagccaggga tgttacacag agaaacccca tctcgaagaa ccaataaata
       61 tccaaaacct ccgtgttcgg tagctggaca gtttcagggg tatcggcctc accagaaacc
      121 agtgaacaat gggcaggcat cttccagtag gcaccttgca gagacagacg tgttagggga
      181 gacatacacc tccctgtggg agctcaactg ctgccctcac agagacaccc acatgccctt
      241 cgggcctcgc aagccaccat tcacaacttc actgtgcgtg gtcctagagg gaggcgccaa
      301 gtgtccagcc aagacagatg taccgtgacg actgcatttc acttggatga tgtctgaaga
      361 aacaggcagt gtgttctgta tctgttggca tattctgggc gacacacagg gcccaggtaa
      421 ggtactagga gatcaaactg gatagaatgg cagggttgtt ggggattaag ggggttcagt
      481 ggctgagcct tctgttcctg cgctgcgtgg ctgcagcact cagaggctga ctcgggtcta
      541 aacaaactct caaaaacctg gcgaggtttt catagcacat aagacagggc ttggagtgga
      601 caggaagagc tcctagtcca gcaggaaccc acaaggactc atgggcactg ctgctggccc
      661 ctgtcctcaa cagaggctgg ccactggccc cggagccctg ctgaggccgc acttttgctg
      721 tgtaaactgc tctgtggctc tgggcggaga ctccctcccc gcagatctat aatttctcag
      781 aaaagaggct gaggaataac ctggaaaatg ccctagacat gggacagcat ggtgggaacc
      841 acagtcccct gaccttccca gacctgccta tttcctctgc ttgcttagag atagcttcca
      901 atgatatccc ccagtccccc taagaaactg tccttcctga aacccagtac tgcctctccc
      961 ggcccctccc gtgtgcattc ccaccatccc agggcaaagg gacagagctc aaggcagggt
     1021 ttgctgagct ttgaagtgtc cagcaggtca cagctctcag gccctggagg aggaagctga
     1081 gatgtggctc cggcagggag gcccagccct ggtggtgctt ctggctttct gggtggcact
     1141 gggcccctgt cacctgcagg ggacagatcc cggagcgtcg gcagatgccg agggccccca
     1201 gtgccccgtc gcctgtacct gcagccatga tgactacaca gatgagctca gcgtcttttg
     1261 cagttcaaag aacctcacac atctgcctga tgacatccca gtcagcacca gagccctgtg
     1321 gcttgatggc aacaacctct cttctatccc ctcagcggcc ttccagaacc tgtccagcct
     1381 ggactttctc aacctgcagg gcagctggct gaggagcctg gagccacagg cactgctggg
     1441 gctgcagaac ctctaccatc tgcacctgga acggaaccgg ctccggaacc tcgccgtggg
     1501 cttgttcaca cacacaccga gtctggcttc actcagcctg agcagcaacc tcttgggccg
     1561 gctggaggaa gggctgttcc agggcctcag tcacctttgg gacctcaacc tgggttggaa
     1621 cagtctagtg gtcctgcctg acacagtgtt ccagggactg ggcaacctcc acgagctggt
     1681 gctggctggc aacaaactga cttacctgca gcctgcgctc ttctgtggct tgggcgagct
     1741 gcgggagctg gatctgagca ggaacgcact ccgaagcgtc aaagctaacg tctttgtaca
     1801 tttgcccagg ctgcagaagc tgtacctgga ccggaacctc attacagccg tggcccctcg
     1861 tgcctttctg ggcatgaagg ccctgcgttg gctggacctg tcgcacaacc gcgtggctgg
     1921 cctcatggag gacaccttcc caggcctgct gggcctgcac gtcctgcgcc tggcacacaa
     1981 tgcgatcgct agcttgcggc cgcgcacttt caaagacctg cacttcctgg aggaactgca
     2041 gctgggccac aatcgaatca ggcagctcgg ggagaggaca ttcgagggcc tggggcagct
     2101 ggaggtgctg acgctcaatg acaaccagat cactgaggtc agggtgggcg ccttctctgg
     2161 ccttttcaat gtggcggtta tgaatctctc cggcaactgt ctgaggagcc tcccggagcg
     2221 ggtgtttcag ggtctggaca aactgcacag cctgcaccta gagcacagct gcctgggtca
     2281 cgtccgcctg cacacttttg ctggcctctc agggctgcgc aggctcttcc tcagggacaa
     2341 cagcatctcc agcatcgaag aacagagcct ggcagggctt tcggagctcc tggaactgga
     2401 tcttactacc aaccgcctca cacatctgcc ccgccagctc ttccagggcc tcggccacct
     2461 ggagtacctg cttctctcct acaaccaact gacgacttta tccgcggagg tcctgggccc
     2521 tctgcagcgg gccttctggt tggatatctc acacaaccac ctggagacgc tggccgaagg
     2581 ccttttctca tctctggggc ggcttcgcta cctcagcctc aggaataact ccttgcagac
     2641 cttttcgcca cagcccggcc tggagcgcct gtggcttgat gccaacccct gggactgcag
     2701 ctgtcccctc aaggcgcttc gagactttgc cctgcagaac cctggtgttg tcccccgctt
     2761 tgttcagact gtctgtgagg gggacgactg ccagccggtg tacacctaca acaatatcac
     2821 ttgcgctggc cccgccaacg tctcgggcct cgacctaaga gacgttagtg aaacacattt
     2881 tgtgcactgc tgacactggc tacttactgg cccggtctgg ccgaacactg cctcatggcc
     2941 aggacggggt ctcattgtta acagaataag ctggctctca aattcctacc catctctagg
     3001 ggacaggtcc tggctgctca cttcctggaa gcaggctgta ctggaagcta tgtggcctag
     3061 aaagggtggg ctcaggccaa gtgtccaagg gcccaaagga gggaggtgct cagaggctct
     3121 ccctgctgcc aacaattaaa gcaaatacta agatagcttg tgacctggag tatgaacttg
     3181 agaaaggtct ctccctgccc catctctcct gtcttcgctc ttgcctgagc agtctgagcc
     3241 ttgctggttt tgagaacatg ggtcccactt cgtttgtacc agatcctacc catttcctct
     3301 tgagcttcct atgactctct tctccaaccc aggaactgca ggcactcacc ccagccccac
     3361 tccaggcatg gcatccctcc cttggggcac cccattgggg ccaagtgggg ttctcacaga
     3421 tgttgtcagc atacaggggt ggagatcacc acacctgccc tctactttta gtgggtgttg
     3481 gtgaagggag caggtggaaa ttgaggactg catctgacca caggaatcac ccccttgcaa
     3541 cattccccag gtccccagtc tcccttgaag acctcagctt tgccccaggg agaaacataa
     3601 caggccctac ttcccttcct gacttttcta ggcaggagga gggagggcct ctgtgtctat
     3661 gctcacactt gaacactcag taatgtgctt gcagaccccc tgggtttctg aaaacacaac
     3721 gtgccaatcc ccatccccca aaacaagaca gacaccctta ccaggccctt cagattttta
     3781 ctaagactgt gcgttccaac catgaaatgt agggagtcaa gagctatctc actgaggaca
     3841 gggtttgttt ggatgctggg ttcctcacaa gatgggtgat atgtttaaca gtggagttct
     3901 gtaaagtcac cagatgtaac tgtaaaccac actgtgtcac aaaaggctca cagcacagca
     3961 tgtgtgggca ctcagggtca gtcggggtga gaaagggcca gctcctgtgt ggtgtggctg
     4021 ttagagcaac ctgttgacct gggggcagaa gtgaccaggg cagaatgaaa gcgtacagac
     4081 tggaggataa ggctagtgct gtcttgaggg accaggaccc aagctctccc tcagctgtag
     4141 actagtttgg tgaagctggt gtcagcgaat gacatggatg taatcgcata gaccagccac
     4201 tgcctgggcc agcaactaca ggtcccaaga cagtcctgag gacctcagct cccgatgctc
     4261 ctgcagccga gaagagagca cacagcccca caaggctgcg aggctgtcag gagcacagag
     4321 caggcatctg gtgcagaact ttatgagcta tggatgtgag tgcggaatat gcggtgcttt
     4381 tgggaaattc ctggatgaag tcacgcccct cctccaagct cctggtaagc tggggatcca
     4441 ggggaacaga acct
//
