LOCUS       NM_053329               2175 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus insulin-like growth factor binding protein, acid
            labile subunit (Igfals), mRNA.
ACCESSION   NM_053329
VERSION     NM_053329.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2175)
  AUTHORS   Hess,O., Khayat,M., Hwa,V., Heath,K.E., Teitler,A., Hritan,Y.,
            Allon-Shalev,S. and Tenenbaum-Rakover,Y.
  TITLE     A novel mutation in IGFALS, c.380T>C (p.L127P), associated with
            short stature, delayed puberty, osteopenia and hyperinsulinaemia in
            two siblings: insights into the roles of insulin growth factor-1
            (IGF1)
  JOURNAL   Clin Endocrinol (Oxf) 79 (6), 838-844 (2013)
   PUBMED   23488611
REFERENCE   2  (bases 1 to 2175)
  AUTHORS   Volkl,T.M., Rauh,M., Schofl,C. and Dorr,H.G.
  TITLE     IGF-I-IGFBP-3-acid-labile subunit (ALS) complex in children and
            adolescents with classical congenital adrenal hyperplasia due to
            21-hydroxylase deficiency (CAH)
  JOURNAL   Growth Horm IGF Res 21 (4), 191-198 (2011)
   PUBMED   21636299
REFERENCE   3  (bases 1 to 2175)
  AUTHORS   Miller,B.S., Khosravi,M.J., Patterson,M.C. and Conover,C.A.
  TITLE     IGF system in children with congenital disorders of glycosylation
  JOURNAL   Clin Endocrinol (Oxf) 70 (6), 892-897 (2009)
   PUBMED   19207313
REFERENCE   4  (bases 1 to 2175)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   5  (bases 1 to 2175)
  AUTHORS   Limal,J.M., Parfait,B., Cabrol,S., Bonnet,D., Leheup,B.,
            Lyonnet,S., Vidaud,M. and Le Bouc,Y.
  TITLE     Noonan syndrome: relationships between genotype, growth, and growth
            factors
  JOURNAL   J Clin Endocrinol Metab 91 (1), 300-306 (2006)
   PUBMED   16263833
REFERENCE   6  (bases 1 to 2175)
  AUTHORS   Delhanty,P.J. and Baxter,R.C.
  TITLE     Cloning and characterization of the rat gene for the acid-labile
            subunit of the insulin-like growth factor binding protein complex
  JOURNAL   J Mol Endocrinol 19 (3), 267-277 (1997)
   PUBMED   9460648
REFERENCE   7  (bases 1 to 2175)
  AUTHORS   Hashimoto,R., Ono,M., Fujiwara,H., Higashihashi,N., Yoshida,M.,
            Enjoh-Kimura,T. and Sakano,K.
  TITLE     Binding sites and binding properties of binary and ternary
            complexes of insulin-like growth factor-II (IGF-II), IGF-binding
            protein-3, and acid-labile subunit
  JOURNAL   J Biol Chem 272 (44), 27936-27942 (1997)
   PUBMED   9346943
REFERENCE   8  (bases 1 to 2175)
  AUTHORS   Dai,J., Scott,C.D. and Baxter,R.C.
  TITLE     Regulation of the acid-labile subunit of the insulin-like growth
            factor complex in cultured rat hepatocytes
  JOURNAL   Endocrinology 135 (3), 1066-1072 (1994)
   PUBMED   8070348
REFERENCE   9  (bases 1 to 2175)
  AUTHORS   Baxter,R.C. and Dai,J.
  TITLE     Purification and characterization of the acid-labile subunit of rat
            serum insulin-like growth factor binding protein complex
  JOURNAL   Endocrinology 134 (2), 848-852 (1994)
   PUBMED   7507839
REFERENCE   10 (bases 1 to 2175)
  AUTHORS   Dai,J. and Baxter,R.C.
  TITLE     Molecular cloning of the acid-labile subunit of the rat
            insulin-like growth factor binding protein complex
  JOURNAL   Biochem Biophys Res Commun 188 (1), 304-309 (1992)
   PUBMED   1384485
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Nov 24, 2020 this sequence version replaced NM_053329.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643286.29737.1,
                                           SRR26643287.23803.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760400, SAMEA5760476
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-117               JAXUCZ010000010.1  14403850-14403966
            118-2175            JAXUCZ010000010.1  14405083-14407140
FEATURES             Location/Qualifiers
     source          1..2175
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q12"
     gene            1..2175
                     /gene="Igfals"
                     /gene_synonym="Als"
                     /note="insulin-like growth factor binding protein, acid
                     labile subunit"
                     /db_xref="GeneID:79438"
                     /db_xref="RGD:68429"
     exon            1..117
                     /gene="Igfals"
                     /gene_synonym="Als"
                     /inference="alignment:Splign:2.1.0"
     CDS             102..1913
                     /gene="Igfals"
                     /gene_synonym="Als"
                     /note="insulin-like growth factor-binding protein complex
                     acid labile chain; insulin-like growth factor-binding
                     protein complex acid labile subunit"
                     /codon_start=1
                     /product="insulin-like growth factor-binding protein
                     complex acid labile subunit precursor"
                     /protein_id="NP_445781.3"
                     /db_xref="GeneID:79438"
                     /db_xref="RGD:68429"
                     /translation="MALRTGGPALVVLLAFWVALGPCHLQGTDPGASADAEGPQCPVA
                     CTCSHDDYTDELSVFCSSKNLTHLPDDIPVSTRALWLDGNNLSSIPSAAFQNLSSLDF
                     LNLQGSWLRSLEPQALLGLQNLYHLHLERNRLRNLAVGLFTHTPSLASLSLSSNLLGR
                     LEEGLFQGLSHLWDLNLGWNSLVVLPDTVFQGLGNLHELVLAGNKLTYLQPALFCGLG
                     ELRELDLSRNALRSVKANVFVHLPRLQKLYLDRNLITAVAPRAFLGMKALRWLDLSHN
                     RVAGLMEDTFPGLLGLHVLRLAHNAIASLRPRTFKDLHFLEELQLGHNRIRQLGERTF
                     EGLGQLEVLTLNDNQITEVRVGAFSGLFNVAVMNLSGNCLRSLPERVFQGLDKLHSLH
                     LEHSCLGHVRLHTFAGLSGLRRLFLRDNSISSIEEQSLAGLSELLELDLTTNRLTHLP
                     RQLFQGLGHLEYLLLSYNQLTTLSAEVLGPLQRAFWLDISHNHLETLAEGLFSSLGRL
                     RYLSLRNNSLQTFSPQPGLERLWLDANPWDCSCPLKALRDFALQNPGVVPRFVQTVCE
                     GDDCQPVYTYNNITCAGPANVSGLDLRDVSETHFVHC"
     exon            118..2175
                     /gene="Igfals"
                     /gene_synonym="Als"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctgccagct acaggcagtg gggaaatcca cagggcagca gcctgtattg tagacggccc
       61 ttgctcactg cctgcctgca gccagctctg tacaaggaac aatggccctg aggacaggag
      121 gcccagccct ggtggtgctt ctggctttct gggtggcact gggcccctgt cacctgcagg
      181 ggacagatcc cggagcgtcg gcagatgccg agggccccca gtgccccgtc gcctgtacct
      241 gcagccatga tgactacaca gatgagctca gcgtcttttg cagttcaaag aacctcacac
      301 atctgcctga tgacatccca gtcagcacca gagccctgtg gcttgatggc aacaacctct
      361 cttctatccc ctcagcggcc ttccagaacc tgtccagcct ggactttctc aacctgcagg
      421 gcagctggct gaggagcctg gagccacagg cactgctggg gctgcagaac ctctaccatc
      481 tgcacctgga acggaaccgg ctccggaacc tcgccgtggg cttgttcaca cacacaccga
      541 gtctggcttc actcagcctg agcagcaacc tcttgggccg gctggaggaa gggctgttcc
      601 agggcctcag tcacctttgg gacctcaacc tgggttggaa cagtctagtg gtcctgcctg
      661 acacagtgtt ccagggactg ggcaacctcc acgagctggt gctggctggc aacaaactga
      721 cttacctgca gcctgcgctc ttctgtggct tgggcgagct gcgggagctg gatctgagca
      781 ggaacgcact ccgaagcgtc aaagctaacg tctttgtaca tttgcccagg ctgcagaagc
      841 tgtacctgga ccggaacctc attacagccg tggcccctcg tgcctttctg ggcatgaagg
      901 ccctgcgttg gctggacctg tcgcacaacc gcgtggctgg cctcatggag gacaccttcc
      961 caggcctgct gggcctgcac gtcctgcgcc tggcacacaa tgcgatcgct agcttgcggc
     1021 cgcgcacttt caaagacctg cacttcctgg aggaactgca gctgggccac aatcgaatca
     1081 ggcagctcgg ggagaggaca ttcgagggcc tggggcagct ggaggtgctg acgctcaatg
     1141 acaaccagat cactgaggtc agggtgggcg ccttctctgg ccttttcaat gtggcggtta
     1201 tgaatctctc cggcaactgt ctgaggagcc tcccggagcg ggtgtttcag ggtctggaca
     1261 aactgcacag cctgcaccta gagcacagct gcctgggtca cgtccgcctg cacacttttg
     1321 ctggcctctc agggctgcgc aggctcttcc tcagggacaa cagcatctcc agcatcgaag
     1381 aacagagcct ggcagggctt tcggagctcc tggaactgga tcttactacc aaccgcctca
     1441 cacatctgcc ccgccagctc ttccagggcc tcggccacct ggagtacctg cttctctcct
     1501 acaaccaact gacgacttta tccgcggagg tcctgggccc tctgcagcgg gccttctggt
     1561 tggatatctc acacaaccac ctggagacgc tggccgaagg ccttttctca tctctggggc
     1621 ggcttcgcta cctcagcctc aggaataact ccttgcagac cttttcgcca cagcccggcc
     1681 tggagcgcct gtggcttgat gccaacccct gggactgcag ctgtcccctc aaggcgcttc
     1741 gagactttgc cctgcagaac cctggtgttg tcccccgctt tgttcagact gtctgtgagg
     1801 gggacgactg ccagccggtg tacacctaca acaatatcac ttgcgctggc cccgccaacg
     1861 tctcgggcct cgacctaaga gacgttagtg aaacacattt tgtgcactgc tgacactggc
     1921 tacttactgg cccggtctgg ccgaacactg cctcatggcc aggacggggt ctcattgtta
     1981 acagaataag ctggctctca aattcctacc catctctagg ggacaggtcc tggctgctca
     2041 cttcctggaa gcaggctgta ctggaagcta tgtggcctag aaagggtggg ctcaggccaa
     2101 gtgtccaagg gcccaaagga gggaggtgct cagaggctct ccctgctgcc aacaattaaa
     2161 gcaaatacta agata
//
