LOCUS       NM_012756               8803 bp    mRNA    linear   ROD 29-MAR-2024
DEFINITION  Rattus norvegicus insulin-like growth factor 2 receptor (Igf2r),
            mRNA.
ACCESSION   NM_012756
VERSION     NM_012756.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 8803)
  AUTHORS   Lu,S.Y., Tsai,B.C., Van Thao,D., Lai,C.H., Chen,M.Y., Kuo,W.W.,
            Kuo,C.H., Lin,K.H., Hsieh,D.J. and Huang,C.Y.
  TITLE     Cardiac-specific overexpression of insulin-like growth factor II
            receptor-alpha interferes with the regulation of calcium
            homeostasis in the heart under hyperglycemic conditions
  JOURNAL   Mol Biol Rep 50 (5), 4329-4338 (2023)
   PUBMED   36928640
  REMARK    GeneRIF: Cardiac-specific overexpression of insulin-like growth
            factor II receptor-alpha interferes with the regulation of calcium
            homeostasis in the heart under hyperglycemic conditions.
REFERENCE   2  (bases 1 to 8803)
  AUTHORS   Lai,C.H., Van Thao,D., Tsai,B.C., Hsieh,D.J., Chen,M.Y., Kuo,W.W.,
            Kuo,C.H., Lu,S.Y., Liao,S.C., Lin,K.H. and Huang,C.Y.
  TITLE     Insulin-like growth factor II receptor alpha overexpression in
            heart aggravates hyperglycemia-induced cardiac inflammation and
            myocardial necrosis
  JOURNAL   Environ Toxicol 38 (3), 676-684 (2023)
   PUBMED   36462176
  REMARK    GeneRIF: Insulin-like growth factor II receptor alpha
            overexpression in heart aggravates hyperglycemia-induced cardiac
            inflammation and myocardial necrosis.
REFERENCE   3  (bases 1 to 8803)
  AUTHORS   Pandey,S., Kuo,C.H., Chen,W.S., Yeh,Y.L., Kuo,W.W., Chen,R.J.,
            Day,C.H., Pai,P.Y., Ho,T.J. and Huang,C.Y.
  TITLE     Perturbed ER homeostasis by IGF-IIRalpha promotes cardiac damage
            under stresses
  JOURNAL   Mol Cell Biochem 477 (1), 143-152 (2022)
   PUBMED   34586566
  REMARK    GeneRIF: Perturbed ER homeostasis by IGF-IIRalpha promotes cardiac
            damage under stresses.
REFERENCE   4  (bases 1 to 8803)
  AUTHORS   Concina,G., Renna,A., Milano,L., Manassero,E., Stabile,F. and
            Sacchetti,B.
  TITLE     Expression of IGF-2 Receptor in the Auditory Cortex Improves the
            Precision of Recent Fear Memories and Maintains Detailed Remote
            Fear Memories Over Time
  JOURNAL   Cereb Cortex 31 (12), 5381-5395 (2021)
   PUBMED   34145441
  REMARK    GeneRIF: Expression of IGF-2 Receptor in the Auditory Cortex
            Improves the Precision of Recent Fear Memories and Maintains
            Detailed Remote Fear Memories Over Time.
REFERENCE   5  (bases 1 to 8803)
  AUTHORS   Chen,C.H., Lin,J.W., Huang,C.Y., Yeh,Y.L., Shen,C.Y.,
            Badrealam,K.F., Ho,T.J., Padma,V.V., Kuo,W.W. and Huang,C.Y.
  TITLE     The combined inhibition of the CaMKIIdelta and calcineurin
            signaling cascade attenuates IGF-IIR-induced cardiac hypertrophy
  JOURNAL   J Cell Physiol 235 (4), 3539-3547 (2020)
   PUBMED   31584202
  REMARK    GeneRIF: The combined inhibition of the CaMKIIdelta and calcineurin
            signaling cascade attenuates IGF-IIR-induced cardiac hypertrophy.
REFERENCE   6  (bases 1 to 8803)
  AUTHORS   Price,W.A., Rong,L., Stiles,A.D. and D'Ercole,A.J.
  TITLE     Changes in IGF-I and -II, IGF binding protein, and IGF receptor
            transcript abundance after uterine artery ligation
  JOURNAL   Pediatr Res 32 (3), 291-295 (1992)
   PUBMED   1408464
REFERENCE   7  (bases 1 to 8803)
  AUTHORS   Thesleff,I.
  TITLE     Craniofacial developmental biology--an expanding field of dental
            research
  JOURNAL   Proc Finn Dent Soc 88 (3-4), 163-168 (1992)
   PUBMED   1298967
  REMARK    Review article
REFERENCE   8  (bases 1 to 8803)
  AUTHORS   Corvera,S., Folander,K., Clairmont,K.B. and Czech,M.P.
  TITLE     A highly phosphorylated subpopulation of insulin-like growth factor
            II/mannose 6-phosphate receptors is concentrated in a
            clathrin-enriched plasma membrane fraction
  JOURNAL   Proc Natl Acad Sci U S A 85 (20), 7567-7571 (1988)
   PUBMED   2971973
REFERENCE   9  (bases 1 to 8803)
  AUTHORS   Lee,S.J. and Nathans,D.
  TITLE     Proliferin secreted by cultured cells binds to mannose 6-phosphate
            receptors
  JOURNAL   J Biol Chem 263 (7), 3521-3527 (1988)
   PUBMED   2963825
REFERENCE   10 (bases 1 to 8803)
  AUTHORS   MacDonald,R.G., Pfeffer,S.R., Coussens,L., Tepper,M.A.,
            Brocklebank,C.M., Mole,J.E., Anderson,J.K., Chen,E., Czech,M.P. and
            Ullrich,A.
  TITLE     A single receptor binds both insulin-like growth factor II and
            mannose-6-phosphate
  JOURNAL   Science 239 (4844), 1134-1137 (1988)
   PUBMED   2964083
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Sep 1, 2015 this sequence version replaced NM_012756.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U59809.1, SRR26643295.644.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-229               JAXUCZ010000001.1  50526878-50527106
            230-369             JAXUCZ010000001.1  50548718-50548857
            370-488             JAXUCZ010000001.1  50557692-50557810
            489-587             JAXUCZ010000001.1  50558833-50558931
            588-720             JAXUCZ010000001.1  50562057-50562189
            721-850             JAXUCZ010000001.1  50564228-50564357
            851-956             JAXUCZ010000001.1  50566733-50566838
            957-1122            JAXUCZ010000001.1  50571165-50571330
            1123-1285           JAXUCZ010000001.1  50571468-50571630
            1286-1389           JAXUCZ010000001.1  50572438-50572541
            1390-1554           JAXUCZ010000001.1  50575711-50575875
            1555-1695           JAXUCZ010000001.1  50578128-50578268
            1696-1839           JAXUCZ010000001.1  50579273-50579416
            1840-1977           JAXUCZ010000001.1  50580699-50580836
            1978-2125           JAXUCZ010000001.1  50581398-50581545
            2126-2300           JAXUCZ010000001.1  50582082-50582256
            2301-2416           JAXUCZ010000001.1  50582631-50582746
            2417-2585           JAXUCZ010000001.1  50583102-50583270
            2586-2765           JAXUCZ010000001.1  50583990-50584169
            2766-2867           JAXUCZ010000001.1  50586023-50586124
            2868-2969           JAXUCZ010000001.1  50587404-50587505
            2970-3165           JAXUCZ010000001.1  50588529-50588724
            3166-3330           JAXUCZ010000001.1  50592117-50592281
            3331-3474           JAXUCZ010000001.1  50592886-50593029
            3475-3650           JAXUCZ010000001.1  50593118-50593293
            3651-3738           JAXUCZ010000001.1  50593542-50593629
            3739-3954           JAXUCZ010000001.1  50594393-50594608
            3955-4085           JAXUCZ010000001.1  50596187-50596317
            4086-4183           JAXUCZ010000001.1  50596488-50596585
            4184-4320           JAXUCZ010000001.1  50597082-50597218
            4321-4511           JAXUCZ010000001.1  50597997-50598187
            4512-4638           JAXUCZ010000001.1  50599337-50599463
            4639-4758           JAXUCZ010000001.1  50599982-50600101
            4759-5015           JAXUCZ010000001.1  50600270-50600526
            5016-5234           JAXUCZ010000001.1  50600931-50601149
            5235-5384           JAXUCZ010000001.1  50602975-50603124
            5385-5546           JAXUCZ010000001.1  50603794-50603955
            5547-5754           JAXUCZ010000001.1  50605002-50605209
            5755-5901           JAXUCZ010000001.1  50605495-50605641
            5902-6136           JAXUCZ010000001.1  50606312-50606546
            6137-6273           JAXUCZ010000001.1  50607132-50607268
            6274-6388           JAXUCZ010000001.1  50608188-50608302
            6389-6535           JAXUCZ010000001.1  50609339-50609485
            6536-6723           JAXUCZ010000001.1  50610025-50610212
            6724-6910           JAXUCZ010000001.1  50610492-50610678
            6911-7054           JAXUCZ010000001.1  50611523-50611666
            7055-7124           JAXUCZ010000001.1  50612525-50612594
            7125-8803           JAXUCZ010000001.1  50613587-50615265
FEATURES             Location/Qualifiers
     source          1..8803
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q11"
     gene            1..8803
                     /gene="Igf2r"
                     /gene_synonym="IGF-IIR; Igfr2"
                     /note="insulin-like growth factor 2 receptor"
                     /db_xref="GeneID:25151"
                     /db_xref="RGD:2871"
     exon            1..229
                     /gene="Igf2r"
                     /gene_synonym="IGF-IIR; Igfr2"
                     /inference="alignment:Splign:2.1.0"
     CDS             96..7541
                     /gene="Igf2r"
                     /gene_synonym="IGF-IIR; Igfr2"
                     /note="cation-independent mannose-6-phosphate receptor"
                     /codon_start=1
                     /product="cation-independent mannose-6-phosphate receptor
                     precursor"
                     /protein_id="NP_036888.2"
                     /db_xref="GeneID:25151"
                     /db_xref="RGD:2871"
                     /translation="MRAVLPGPVPSGPRVALLLPLLLLLLVAAAGSAQAQAVDLDALC
                     SYTWEAVDSKNNAVYKINPCGHVDNPRCGPTSAVCMCDLKSENCRSVGDSLLRSSAKS
                     LLEFNTTTGCQPSEHRIQTSITFLCGKTLGTPEFVTATDCVHYFEWRTTAACKKDIFK
                     ADKEVPCYVFDDKLQKHDLNPLIKLNGGYLVDDSDADASLFINVCRDIDSLRDPSTQL
                     RVCPAGTAACLLKGNQAFDVGRPKEGLKLLSKDRLVLTYVKEEGEKPDFCNGHSPAVT
                     VTFVCPSERREGTIPKLTAKSNCRYEVEWITEYACHRDYLESETCSLSSEQHDIAIDL
                     SPLAQHEEGSPYVADGGEYRFFMNVCGDTKVSLCNKEAAVCQEKKVDSTQVKIAGRHQ
                     NQTLRYSDGDLTLIYSGGDECSSGFQRMSVINFECNKTAGQDGRGEPVFTGEVDCTYF
                     FTWDTKYACVKEKEDLLCGAIDGKKRYDLSVLARHSESEQNWEAVDGSQAESEKRNFF
                     INVCHRVLQAGKAKNCPEGAAVCAVDKSGSKNLGKFVSSPTKEKGHIQLSYSDGDDCG
                     NDKKITTNITFVCKPGDLESAPVLRAAGPDGCSYEFEWHTAAACVLSQTEGENCTVLD
                     AQAGFSFDLSLLTKKNGAYKVETDKYDFYINVCGPVSVNLCQSNSGACQVAKSGKSWN
                     LGLSNTKLTYYDGMIQLSYRNGTLYNNEKHTPRSTLITFLCDRDAGVGFPEYQEEDNS
                     TYNFRWYTSYACPEEPLECMVTDPSMMEQYDLSSLVKFEGGRGGNWYAMENSREHFTR
                     RKYYLNVCRPLNPVPGCDRYASACQMKYENNEGSLAETVAISNLGVAKTGPVVEESGS
                     LLLEYVNGSACTTSDGRLTTYSTRIHLVCGRGTMNSHPIFTFNWECVVSFLWNTEAAC
                     PIQTITDSDQACSIRDPNSGFVFNLSPLNYSQGHMVLGIGKTFVFNICGTMPACGTVA
                     GKPALGCEAETKIKDIKDLKPERPVGMEKSLQLSAEGFLTLTYKGSSPSDRGTAFIIR
                     FICNGDIYPGTPKFLHQDIDSARGIRNTFFEFETALACIPSVVDCQVTDPAGNEYDLS
                     ALSMVRKPWTAVDTSVHGKKRRFYLSVCTPLPYIPGCDGIAMGSCMVSEDKSQNLGVV
                     QISPQATGNGSLSILYVNGDRCGNQRYSTRIVFECAQTSGSPMFQLLNNCEYVFVWRT
                     VEACPVVREEGDNCQVKDPRHGNLYDLKPLALNDTIISAGEYTYYFRVCGKLSLDVCS
                     AHDGSKAVSSCQEKKGPQGFQKVAGLLNQKLTFENGLLKMNYSGGDTCHKVYQRSTTI
                     YFYCDRTTQKPVFLKETLDCSYLFEWRTQYACPPFNVTECSIQDEAGNSIDLSSLSRY
                     SDNWEAVTRTGATEHYLINVCKSLSPQAGTDPCPPEAAVCLLDGSKPVNLGRVRDGPQ
                     WTAGVTVLKYVDGDLCPDKIRKRSTIIRFTCSDSQVNSRPLFISAVQDCEYTFSWPTP
                     AACPVKSNIHDDCQVTNPSTGHLFDLSSLSGKAGITASYSEKGMVFMSICEENVNCSP
                     GVGACFGQTRISVGQASKRLSYKDQVLQLVYENGSPCPSKSGLRYKSVISFVCRPEAG
                     PTNRPMLISLDKQSCTLFFSWHTPLACEQATECTVRNGSSIIDLSPLIHRTGGYEAYD
                     ESEDDTSDTTPDFYINICQPLNPMHGVPCPAGASVCKVPVDGPPIDIGRVTGPPIFNP
                     VANEVYLNFESSTPCLADKYMNYTSLIAFHCRRGISMGTPKLIRNNDCDFVFEWETPI
                     VCPDEVKTQGCAVTDEQLLYSFNLTSLSTSTFKVTRDAHTYSIGVCTTAADLDQEGCK
                     DGGVCLLSGSKGASFGRLASMQLDYRHQDEAVILSYVNGDPCPPETEDGEPCVFPFIY
                     KGETYDECVLEGRAKLWCSKTANYDRDHEWGFCRPSNSHRMSAIIFTCDENEDIGRPE
                     VFSEDRGCEVTFEWKTKVVCPPKKMECKFVQKHKTYDLRLLSSLTGSWDFVHEGNSYF
                     INLCQRVYKGPLDCSERASICKKSATGQVQVLGLVHTQKLEVIDETVLVTYSKGHSCG
                     GNKTASSVIELTCAKTVGRPAFKRFDIDSCTYYFYWYSRAACAVRPQEVNMVNGTLTN
                     PVTGKSFSLGEIYFKLFSASGDMRSNGDNYLYEIQLSSISSSSNPACSGANICQVKPN
                     DQHFSRKVGTSDMTKYYVQDGDLDVVFTSSSTCGKDKTKSVSSTIFFHCDPLLKDGVP
                     EFSHETADCQYLFSWYTSAVCPLGVDFDDENAVPEYKGLSERSQAVGAVLSLLLVALT
                     GCLLALLLHKKERRETVINKLTNCCRRSSGVSYKYSKVSKEEETDENETEWLMEEIQV
                     PAARLGKDGQENGHITTKTVKAEALTSLHGDDQDSEDEVLTIPEVKVHTGRGAEVESS
                     QPLRNPQRKVLKEREGERMGLVRGEKARRGKFRPGQRKPTTPAKLVSFHDDSDEDLLH
                     I"
     exon            230..369
                     /gene="Igf2r"
                     /gene_synonym="IGF-IIR; Igfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            370..488
                     /gene="Igf2r"
                     /gene_synonym="IGF-IIR; Igfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            489..587
                     /gene="Igf2r"
                     /gene_synonym="IGF-IIR; Igfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            588..720
                     /gene="Igf2r"
                     /gene_synonym="IGF-IIR; Igfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            721..850
                     /gene="Igf2r"
                     /gene_synonym="IGF-IIR; Igfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            851..956
                     /gene="Igf2r"
                     /gene_synonym="IGF-IIR; Igfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            957..1122
                     /gene="Igf2r"
                     /gene_synonym="IGF-IIR; Igfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1123..1285
                     /gene="Igf2r"
                     /gene_synonym="IGF-IIR; Igfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1286..1389
                     /gene="Igf2r"
                     /gene_synonym="IGF-IIR; Igfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1390..1554
                     /gene="Igf2r"
                     /gene_synonym="IGF-IIR; Igfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1555..1695
                     /gene="Igf2r"
                     /gene_synonym="IGF-IIR; Igfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1696..1839
                     /gene="Igf2r"
                     /gene_synonym="IGF-IIR; Igfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1840..1977
                     /gene="Igf2r"
                     /gene_synonym="IGF-IIR; Igfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1978..2125
                     /gene="Igf2r"
                     /gene_synonym="IGF-IIR; Igfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            2126..2300
                     /gene="Igf2r"
                     /gene_synonym="IGF-IIR; Igfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            2301..2416
                     /gene="Igf2r"
                     /gene_synonym="IGF-IIR; Igfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            2417..2585
                     /gene="Igf2r"
                     /gene_synonym="IGF-IIR; Igfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            2586..2765
                     /gene="Igf2r"
                     /gene_synonym="IGF-IIR; Igfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            2766..2867
                     /gene="Igf2r"
                     /gene_synonym="IGF-IIR; Igfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            2868..2969
                     /gene="Igf2r"
                     /gene_synonym="IGF-IIR; Igfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            2970..3165
                     /gene="Igf2r"
                     /gene_synonym="IGF-IIR; Igfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            3166..3330
                     /gene="Igf2r"
                     /gene_synonym="IGF-IIR; Igfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            3331..3474
                     /gene="Igf2r"
                     /gene_synonym="IGF-IIR; Igfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            3475..3650
                     /gene="Igf2r"
                     /gene_synonym="IGF-IIR; Igfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            3651..3738
                     /gene="Igf2r"
                     /gene_synonym="IGF-IIR; Igfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            3739..3954
                     /gene="Igf2r"
                     /gene_synonym="IGF-IIR; Igfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            3955..4085
                     /gene="Igf2r"
                     /gene_synonym="IGF-IIR; Igfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            4086..4183
                     /gene="Igf2r"
                     /gene_synonym="IGF-IIR; Igfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            4184..4320
                     /gene="Igf2r"
                     /gene_synonym="IGF-IIR; Igfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            4321..4511
                     /gene="Igf2r"
                     /gene_synonym="IGF-IIR; Igfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            4512..4638
                     /gene="Igf2r"
                     /gene_synonym="IGF-IIR; Igfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            4639..4758
                     /gene="Igf2r"
                     /gene_synonym="IGF-IIR; Igfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            4759..5015
                     /gene="Igf2r"
                     /gene_synonym="IGF-IIR; Igfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            5016..5234
                     /gene="Igf2r"
                     /gene_synonym="IGF-IIR; Igfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            5235..5384
                     /gene="Igf2r"
                     /gene_synonym="IGF-IIR; Igfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            5385..5546
                     /gene="Igf2r"
                     /gene_synonym="IGF-IIR; Igfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            5547..5754
                     /gene="Igf2r"
                     /gene_synonym="IGF-IIR; Igfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            5755..5901
                     /gene="Igf2r"
                     /gene_synonym="IGF-IIR; Igfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            5902..6136
                     /gene="Igf2r"
                     /gene_synonym="IGF-IIR; Igfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            6137..6273
                     /gene="Igf2r"
                     /gene_synonym="IGF-IIR; Igfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            6274..6388
                     /gene="Igf2r"
                     /gene_synonym="IGF-IIR; Igfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            6389..6535
                     /gene="Igf2r"
                     /gene_synonym="IGF-IIR; Igfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            6536..6723
                     /gene="Igf2r"
                     /gene_synonym="IGF-IIR; Igfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            6724..6910
                     /gene="Igf2r"
                     /gene_synonym="IGF-IIR; Igfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            6911..7054
                     /gene="Igf2r"
                     /gene_synonym="IGF-IIR; Igfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            7055..7124
                     /gene="Igf2r"
                     /gene_synonym="IGF-IIR; Igfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            7125..8803
                     /gene="Igf2r"
                     /gene_synonym="IGF-IIR; Igfr2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctcccgttg cagcttcgac tccgctgttg cggcgcgatc gtgtcccagg cgcggctcgg
       61 aacggccagc cgccgtgagc cccacgccac acgcgatgcg ggccgttctg ccgggacccg
      121 tgccctccgg gccgcgcgtc gcgctcctgc tgccgctcct gctgctgctg ctcgtggcgg
      181 ccgcgggctc cgcgcaggcc caggccgtgg acttggacgc cttgtgcagt tacacatggg
      241 aagctgttga ttccaaaaat aatgcagttt ataaaatcaa cccctgtgga catgtggata
      301 atcccaggtg tgggccgaca agtgctgtct gtatgtgtga cctaaagtca gaaaactgcc
      361 ggtcagtggg tgactcactt ttgagaagtt cagccaaatc actcctggaa tttaacacca
      421 ctacgggctg ccagccttca gagcacagaa tccagactag cattacattt ctgtgtggga
      481 agaccctggg aactcctgaa tttgtaactg ccacagactg tgtgcattac ttcgaatgga
      541 ggactactgc agcctgcaag aaagacatat ttaaagctga taaggaggtg ccatgctatg
      601 tatttgatga caagttacag aagcatgatt tgaacccact gatcaagctg aatggcggct
      661 acctggtgga tgactctgac gctgacgcat ctctgttcat caatgtgtgt agagacatag
      721 actcccttcg ggaccccagc acacagctga gagtctgccc tgctggcact gctgcctgtc
      781 tgctgaaggg gaaccaggca tttgatgttg gccggcccaa ggaggggctg aagctattga
      841 gcaaggacag gctcgttctg acttatgtta aggaagaagg agaaaagcca gacttctgta
      901 atggtcacag ccctgcagtg acagtaacat ttgtgtgccc atctgagcgg agagagggca
      961 ccattcctaa actcactgcc aagtccaact gtcgctatga agttgagtgg atcactgagt
     1021 atgcctgcca cagagattac ttggagagtg aaacctgctc cctcagcagt gagcagcatg
     1081 atattgctat tgaccttagt cccttggccc agcatgaaga agggtccccc tatgtagctg
     1141 atggaggaga atataggttt tttatgaatg tctgtgggga cacaaaggtc tcactctgta
     1201 acaaagaggc tgctgtttgt caagagaaaa aggtggattc cactcaagtc aaaatagcag
     1261 gaagacacca gaaccagaca ctccggtact cagatggaga tctcacccta atctattctg
     1321 gaggtgatga gtgtagttcc ggcttccagc ggatgagtgt cataaacttt gagtgcaaca
     1381 aaaccgcagg tcaagatggg agaggagagc ctgtgttcac aggtgaggtg gactgcacat
     1441 acttcttcac gtgggacact aaatatgcct gtgtaaaaga gaaggaagat ctcctctgcg
     1501 gggccatcga cggcaagaaa cgttacgacc tgtctgtgct ggctcgtcac tcagaatcag
     1561 aacagaattg ggaagcagtg gatggcagcc aggctgagtc agaaaagagg aatttcttca
     1621 tcaatgtctg tcaccgggtg ctgcaggcgg gaaaggccaa gaactgtcct gaaggtgctg
     1681 ccgtgtgtgc tgtggataag agtggaagta aaaatctagg aaaatttgtc tcttctccta
     1741 caaaagagaa aggacacatt cagctctctt actctgatgg cgatgactgt ggtaatgata
     1801 agaaaataac aactaacatc acatttgtgt gcaaaccagg tgatctggaa agtgctccag
     1861 tgctgagagc tgcagggccc gatggctgct cctatgagtt tgagtggcac acagctgctg
     1921 cctgtgtcct gtcgcagacg gagggagaaa actgcactgt ccttgatgct caggcagggt
     1981 tttcttttga tttgtcactc ctcacaaaga agaatggtgc atataaagtt gagacagaca
     2041 agtatgactt ctacataaat gtttgtggcc ctgtatccgt gaacctgtgt cagtcaaact
     2101 caggagcctg ccaggtagca aaaagtggta agtcttggaa cttggggctg agtaatacta
     2161 agcttacgta ctatgatggg atgatccagc tgagctacag gaatggcacg ctgtataaca
     2221 atgaaaagca cacaccgaga tccacactga ttaccttcct ctgtgaccgt gatgctggag
     2281 tgggcttccc agaatatcag gaagaggaca actctaccta caacttccgg tggtacacca
     2341 gttatgcttg cccggaagag cccctggagt gcatggtgac agacccctcc atgatggagc
     2401 aatatgacct ctccagtcta gtgaagtttg aaggtggccg tggaggaaac tggtatgcca
     2461 tggaaaactc ccgagaacat ttcacacgga ggaaatacta cctcaacgtg tgccggcctc
     2521 tgaatcctgt gccaggctgt gatcgatatg catctgcttg ccagatgaaa tacgaaaaca
     2581 atgagggctc cttggcagag actgtggcca tcagtaactt gggagttgca aagacaggcc
     2641 ctgtggtgga ggagagcggc agcctcctct tagagtatgt gaacggctct gcgtgcacca
     2701 ccagtgatgg ccggctaacc acctacagca ccaggatcca tcttgtgtgt ggtcgaggaa
     2761 ctatgaattc ccatcccata ttcactttca actgggaatg tgtggtcagt ttcttgtgga
     2821 acacggaggc tgcctgcccc atccagacga tcacagattc agaccaggct tgctctataa
     2881 gggaccccaa cagcggattt gtgtttaatc tgagcccact taactattct caaggacaca
     2941 tggtcttagg cattgggaag acttttgtgt tcaatatctg tggtacaatg cctgcctgtg
     3001 gaacggttgc agggaagcca gcccttggct gtgaggcaga aactaagatc aaagacatta
     3061 aggatctgaa gccagaaagg ccagtcggga tggagaagag cctccagttg tctgccgagg
     3121 ggttcctcac tctgacctac aaaggctctt ctccttctga cagaggcaca gccttcatca
     3181 tccgtttcat ttgcaatggt gacatttacc cagggacccc caagttcctg catcaggaca
     3241 ttgactctgc acgagggatc cggaacacct tctttgagtt tgaaactgca ttggcttgta
     3301 ttccttctgt agtggattgt caagtgactg acccagctgg gaacgagtac gacctgagtg
     3361 ccctgagcat ggtcaggaag ccgtggactg ctgtggacac gtctgtgcat gggaagaaga
     3421 ggcgcttcta tctgagcgtg tgcaccccac tgccttacat tcctggctgc gatggcattg
     3481 caatggggtc ctgcatggtg tcagaagaca aaagtcagaa cttgggtgtg gtgcagatca
     3541 gtcctcaagc tactggaaac ggatctctca gcatcctgta tgtgaatggg gataggtgtg
     3601 gaaaccagcg ctactccacc aggatagtgt tcgaatgtgc ccagacgtcg ggctcaccta
     3661 tgttccagct cctgaacaac tgtgagtatg tgtttgtgtg gcgaacagtg gaggcctgcc
     3721 ctgtggtcag agaggaagga gacaactgcc aggtgaaaga ccccagacac ggcaatttgt
     3781 atgacctgaa gcccctggcc ctcaatgaca ccatcatcag tgctggcgag tacacctact
     3841 acttccgggt ctgtggaaag ctgtccttag atgtgtgctc tgcccatgat gggtccaagg
     3901 cagtctcatc atgccaggaa aagaaaggac cacaaggatt ccagaaagtg gcagggctcc
     3961 ttaatcagaa gctgactttc gaaaatggac tgttgaaaat gaactacagt gggggggaca
     4021 cctgccataa ggtgtatcag cgctccacaa ccatctattt ctactgtgac cggacgactc
     4081 agaagccagt gtttctgaag gaaactttgg actgctccta tttgtttgag tggcgaacac
     4141 agtatgcctg cccacctttc aatgtgacag agtgctctat ccaggatgag gctggcaact
     4201 ccattgacct ctcctcactg tcaagataca gtgacaactg ggaggctgtg accaggacag
     4261 gggccactga gcattacctc atcaacgtat gcaagtctct gtctccacag gctggcacag
     4321 atccatgccc tccagaggca gctgtttgtc tgctggatgg ctccaagcct gtgaacctcg
     4381 gcagggtgag ggatggtcct cagtggacag ctggtgtgac tgtcctgaag tatgtggatg
     4441 gtgacttgtg ccccgacaaa attcggaaaa ggtcaaccat tattcgcttc acctgcagtg
     4501 acagccaagt gaactccagg cctctgttca tcagtgctgt acaggactgt gagtacacat
     4561 tttcctggcc cacacctgct gcctgtcctg tgaagagcaa catacacgat gactgccaag
     4621 tcaccaaccc cagcacaggc cacctgtttg acctgagctc cctaagtggc aaagctggca
     4681 tcacagcctc ctacagcgag aaggggatgg tcttcatgag catctgtgag gagaatgtga
     4741 actgtagccc tggagtaggg gcctgctttg gacagaccag gatcagtgtg ggccaggcca
     4801 gcaagaggct gagctacaag gatcaggtct tgcagctggt gtatgagaat gggtccccat
     4861 gcccctccaa gtcaggcctg aggtacaaga gtgtcatcag cttcgtgtgc cggccggagg
     4921 ctggacccac caacaggccc atgctcatct ccttggacaa gcagtcgtgt acactcttct
     4981 tctcctggca cacgcccctg gcctgtgagc aggcgacgga atgcaccgtg cggaatggaa
     5041 gctcgattat tgacctgtca cctctcatcc accgcactgg tggttatgaa gcatacgatg
     5101 agagtgagga cgacacctct gataccaccc ctgacttcta catcaacatc tgtcagccac
     5161 tgaatcccat gcatggagtg ccctgccctg caggcgcctc agtatgcaaa gtccccgtgg
     5221 acgggccccc tatagatatt gggagagtca caggccctcc aatattcaat cccgtggcca
     5281 atgaggtcta cctgaacttt gagagcagca ctccttgctt agcggacaaa tatatgaact
     5341 acacctcact aattgcgttt cactgcagga gagggatcag catgggaact cctaagctga
     5401 taaggaacaa tgactgtgac tttgtgtttg agtgggagac tccgattgtc tgtcctgacg
     5461 aagtgaagac acagggctgt gctgtaacag atgagcagct gctctatagc ttcaacctga
     5521 cgagcctttc cacaagcact ttcaaagtca ctcgggacgc tcacacatac agtatagggg
     5581 tgtgcacaac ggcagctgac ttagaccagg aaggctgcaa ggacggcggg gtctgtctgc
     5641 tctctgggag caaaggagct tcttttgggc gcctagcgtc gatgcagctg gattacaggc
     5701 accaggatga agcagtcatc ctgagttatg tgaacggtga tccttgccct ccagaaacgg
     5761 aagatggcga gccctgtgtc ttccccttca tttacaaagg ggagacctat gacgaatgtg
     5821 tattagaggg acgagcgaaa ctgtggtgta gcaaaactgc gaattacgat cgtgaccacg
     5881 agtggggctt ctgcagaccg agcaacagtc accggatgtc tgcgatcata tttacttgtg
     5941 atgagaacga agatattggg aggccagaag tgttcagtga agatcgtggg tgtgaggtga
     6001 catttgagtg gaaaacaaaa gttgtctgcc ctccgaagaa gatggagtgc aagtttgttc
     6061 agaagcataa aacctatgac ttgcgattgc tctcatccct cacggggtcc tgggattttg
     6121 tgcatgaagg aaactcgtac tttatcaatc tgtgccaaag agtatataaa ggtcccctgg
     6181 actgctctga gagagccagc atttgcaaga agagtgccac tggtcaagtc caggttttgg
     6241 ggcttgttca tactcaaaaa ctggaagtca tagatgaaac agtccttgtc acttactcaa
     6301 aaggccattc ttgtggtggg aataagactg catcctcagt gatcgagttg acctgtgcaa
     6361 agactgtggg caggcctgca ttcaagaggt ttgatattga cagctgcacc tactactttt
     6421 actggtactc acgggctgcc tgtgctgtga gacctcagga ggtgaacatg gtgaatggaa
     6481 ctcttaccaa ccctgtgact ggcaagagct tcagcctcgg ggaaatttat tttaagctgt
     6541 tcagcgcctc tggggacatg agaagcaatg gggacaacta tctgtatgag atccagctct
     6601 cctctatctc cagctcttct aaccctgcgt gctccggtgc caacatctgc caggtgaagc
     6661 ccaatgacca gcacttcagc aggaaagtgg gcacctctga catgaccaag tactacgtcc
     6721 aagacggtga tctggatgtg gtgtttacct cttcctccac gtgtggcaaa gataagacca
     6781 agtctgtgtc ttccaccatc ttcttccact gtgaccctct gctgaaggac ggggtccccg
     6841 agttcagcca cgagactgct gactgccagt accttttctc ctggtacact tcagctgtgt
     6901 gtcctctggg tgtggacttt gatgatgaga atgctgtgcc agagtataaa gggctctcag
     6961 agcggagtca ggccgttggg gcagtcctca gtctcctcct ggtggcactg actggctgtc
     7021 tgctggcctt gctgcttcat aagaaggaga gaagggaaac tgtgataaac aagctgacca
     7081 attgctgcag aaggagctcg ggggtgtcct ataagtactc aaaggtcagc aaggaggagg
     7141 agacagatga gaatgagaca gaatggctga tggaagagat ccaggtgcca gccgccagac
     7201 taggcaagga cgggcaggag aacggccaca ttaccaccaa gacggtgaaa gcagaagctc
     7261 tcacttccct gcatggggat gaccaagaca gtgaggatga ggtcctgacc atcccagagg
     7321 tgaaagttca cacaggcaga ggagccgagg tggaaagctc acagcccctg agaaatcccc
     7381 agcgcaaggt cctgaaggaa agggaggggg agaggatggg gctggtccgc ggtgagaagg
     7441 ccagaagagg gaagttcaga cccggacagc gcaagccaac aacccctgcc aagctggtgt
     7501 ccttccatga tgacagtgac gaggacctcc tacacatctg actccgtggt gcctacagga
     7561 gaaggtggca ccatggacag ccaagcatct ccaaccaaat aagacttcag ctcgatgatg
     7621 cgtctgtcat tttgccttta acaaaactgc ttcaaaggga agtttctgta atgggggaga
     7681 ggatggggga ggtgggcacc actcttccat gatcgtttac agtcagtgga acaaggtgtt
     7741 gcttgaatcg gccaaagggc gctacttggt gcccagggtt ttgccccaag tcctcactta
     7801 cgatcatagc tgctgtgtgc ttccaacagg tgcccaggcc acatgcatct cacaacagag
     7861 ggctgtgttt gaaaaaaacc cttgctgctt tagaccctat agggtgacca tttatatttt
     7921 tagcattgta attctctccc cctatttatt gactttgaca attactactc aggtttgcga
     7981 aaaaggaaaa aaaaaaaaaa ccagtttctt ctgccagcaa gggcataagg tgaagctggc
     8041 attatgctgg agccttgtac gtggctcctg agctggtcct tgatgcacac tttagtgagc
     8101 tgcagtattc tattcttcgc tttgcgtttt gtaagggcac acatacatgc acaggtcccc
     8161 gagtgcctcg gtttgggaag gcccgcctgc tccgtgccct acctcgtctc tatagctgca
     8221 gctctttgca cgaatccttc tgggtgtcgc ttttgcccgc tggtgagcgc cagcagctca
     8281 cccagaggtg ggtgtttgtg catgcgatgg agtagaggct cttggagagg agccgcactt
     8341 caggtttggg ctgtaggtct catctcttca ggttctcaat gccaccttta ctgtgctttt
     8401 tgcttttatt ttaaggggga aatgtttatc acccattcaa cctataagaa gccttaattt
     8461 gcacagggtg acttacagac accgtgaaat acggtgggcc agtgttgtgt gtgggcttgt
     8521 gcagggcagt gtcccgggat ggaaggccag gcccggtcca ctggctgtgg actcctttcc
     8581 tgatgtgttc aatgacttct cacattatag agttgtatat aggtggtatt tacataccca
     8641 gaagcaaagt accccgcaga atttcttggt ttatgcctga ttttgctagc ttatttgatt
     8701 tcacattgag tgtattttta aaaattgatt tttttcttca ttttttaatc aactttactg
     8761 taatatgaag tattcaattt caataaaaat aaattattaa cta
//
