LOCUS       NM_175594               2105 bp    mRNA    linear   ROD 07-FEB-2025
DEFINITION  Rattus norvegicus insulin-like growth factor 2 mRNA binding protein
            1 (Igf2bp1), mRNA.
ACCESSION   NM_175594
VERSION     NM_175594.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2105)
  AUTHORS   Su,Y., Tian,W., Cheng,L., Yin,L., He,X. and Wei,X.
  TITLE     Inhibition of IGF2BP1 attenuates the progression of endometriosis
            through PTBP1
  JOURNAL   Folia Histochem Cytobiol 62 (1), 25-36 (2024)
   PUBMED   38563050
  REMARK    GeneRIF: Inhibition of IGF2BP1 attenuates the progression of
            endometriosis through PTBP1.
REFERENCE   2  (bases 1 to 2105)
  AUTHORS   Guo,H., Gilley,R.P., Fisher,A., Lane,R., Landsteiner,V.J.,
            Ragan,K.B., Dovey,C.M., Carette,J.E., Upton,J.W., Mocarski,E.S. and
            Kaiser,W.J.
  TITLE     Species-independent contribution of ZBP1/DAI/DLM-1-triggered
            necroptosis in host defense against HSV1
  JOURNAL   Cell Death Dis 9 (8), 816 (2018)
   PUBMED   30050136
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2105)
  AUTHORS   Hamilton,K.E., Chatterji,P., Lundsmith,E.T., Andres,S.F.,
            Giroux,V., Hicks,P.D., Noubissi,F.K., Spiegelman,V.S. and
            Rustgi,A.K.
  TITLE     Loss of Stromal IMP1 Promotes a Tumorigenic Microenvironment in the
            Colon
  JOURNAL   Mol Cancer Res 13 (11), 1478-1486 (2015)
   PUBMED   26194191
REFERENCE   4  (bases 1 to 2105)
  AUTHORS   Fallini,C., Rouanet,J.P., Donlin-Asp,P.G., Guo,P., Zhang,H.,
            Singer,R.H., Rossoll,W. and Bassell,G.J.
  TITLE     Dynamics of survival of motor neuron (SMN) protein interaction with
            the mRNA-binding protein IMP1 facilitates its trafficking into
            motor neuron axons
  JOURNAL   Dev Neurobiol 74 (3), 319-332 (2014)
   PUBMED   23897586
  REMARK    GeneRIF: Data support a role for SMN in the regulation of mRNA
            localization and axonal transport through its interaction with
            mRNA-binding proteins such as IMP1
REFERENCE   5  (bases 1 to 2105)
  AUTHORS   Nishino,J., Kim,S., Zhu,Y., Zhu,H. and Morrison,S.J.
  TITLE     A network of heterochronic genes including Imp1 regulates temporal
            changes in stem cell properties
  JOURNAL   Elife 2, e00924 (2013)
   PUBMED   24192035
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2105)
  AUTHORS   Yisraeli,J.K.
  TITLE     VICKZ proteins: a multi-talented family of regulatory RNA-binding
            proteins
  JOURNAL   Biol Cell 97 (1), 87-96 (2005)
   PUBMED   15601260
  REMARK    Review article
REFERENCE   7  (bases 1 to 2105)
  AUTHORS   Eom,T., Antar,L.N., Singer,R.H. and Bassell,G.J.
  TITLE     Localization of a beta-actin messenger ribonucleoprotein complex
            with zipcode-binding protein modulates the density of dendritic
            filopodia and filopodial synapses
  JOURNAL   J Neurosci 23 (32), 10433-10444 (2003)
   PUBMED   14614102
  REMARK    GeneRIF: ZBP1 is required for the localization of beta-actin mRNA
            to dendrites of hippocampal neurons
REFERENCE   8  (bases 1 to 2105)
  AUTHORS   Tiruchinapalli,D.M., Oleynikov,Y., Kelic,S., Shenoy,S.M.,
            Hartley,A., Stanton,P.K., Singer,R.H. and Bassell,G.J.
  TITLE     Activity-dependent trafficking and dynamic localization of zipcode
            binding protein 1 and beta-actin mRNA in dendrites and spines of
            hippocampal neurons
  JOURNAL   J Neurosci 23 (8), 3251-3261 (2003)
   PUBMED   12716932
REFERENCE   9  (bases 1 to 2105)
  AUTHORS   Nielsen,J., Christiansen,J., Lykke-Andersen,J., Johnsen,A.H.,
            Wewer,U.M. and Nielsen,F.C.
  TITLE     A family of insulin-like growth factor II mRNA-binding proteins
            represses translation in late development
  JOURNAL   Mol Cell Biol 19 (2), 1262-1270 (1999)
   PUBMED   9891060
REFERENCE   10 (bases 1 to 2105)
  AUTHORS   Leeds,P., Kren,B.T., Boylan,J.M., Betz,N.A., Steer,C.J.,
            Gruppuso,P.A. and Ross,J.
  TITLE     Developmental regulation of CRD-BP, an RNA-binding protein that
            stabilizes c-myc mRNA in vitro
  JOURNAL   Oncogene 14 (11), 1279-1286 (1997)
   PUBMED   9178888
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF541940.1.
            
            On Jun 3, 2003 this sequence version replaced NM_175594.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF541940.1, BC161831.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2105
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q26"
     gene            1..2105
                     /gene="Igf2bp1"
                     /gene_synonym="Imp1; ZBP1"
                     /note="insulin-like growth factor 2 mRNA binding protein
                     1"
                     /db_xref="GeneID:303477"
                     /db_xref="RGD:708580"
     exon            1..397
                     /gene="Igf2bp1"
                     /gene_synonym="Imp1; ZBP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             223..1956
                     /gene="Igf2bp1"
                     /gene_synonym="Imp1; ZBP1"
                     /note="IGF-II mRNA-binding protein 1; zipcode-binding
                     protein-1; IMP-1; rZBP-1; VICKZ family member 1; IGF2
                     mRNA-binding protein 1; B-actin zipcode-binding protein 1;
                     insulin-like growth factor 2, binding protein 1"
                     /codon_start=1
                     /product="insulin-like growth factor 2 mRNA-binding
                     protein 1"
                     /protein_id="NP_783184.1"
                     /db_xref="GeneID:303477"
                     /db_xref="RGD:708580"
                     /translation="MNKLYIGNLNESVTPADLEKVFAEHKISYSGQFLVKSGYAFVDC
                     PDEHWAMKAIETFSGKVELQGKRLEIEHSVPKKQRSRKIQIRNIPPQLRWEVLDSLLA
                     QYGTVENCEQVNTESETAVVNVTYSNREQTRQAIMKLNGHQLENHALKVSYIPDEQIA
                     QGPENGRRGGFGSRGQPRQGSPVAAGAPAKQQQVDIPLRLLVPTQYVGAIIGKEGATI
                     RNITKQTQSKIDVHRKENAGAAEKAISVHSTPEGCSSACKMILEIMHKEAKDTKTADE
                     VPLKILAHNNFVGRLIGKEGRNLKKVEQDTETKITISSLQDLTLYNPERTITVKGAIE
                     NCCRAEQEIMKKVREAYENDVAAMSLQSHLIPGLNLAAVGLFPASSSAVPPPPSSVTG
                     AAPYGSFMQAPEQEMVQVFIPAQAVGAIIGKKGQHIKQLSRFASASIKIAPPETPDSK
                     VRMVVITGPPEAQFKAQGRIYGKLKEENFFGPKEEVKLETHIRVPASAAGRVIGKGGK
                     TVNELQNLTAAEVVVPRDQTPDENDQVIVKIIGHFYASQMAQRKIRDILAQVKQQHQK
                     GQSNQAQARRK"
     exon            398..458
                     /gene="Igf2bp1"
                     /gene_synonym="Imp1; ZBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            459..507
                     /gene="Igf2bp1"
                     /gene_synonym="Imp1; ZBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            508..559
                     /gene="Igf2bp1"
                     /gene_synonym="Imp1; ZBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            560..623
                     /gene="Igf2bp1"
                     /gene_synonym="Imp1; ZBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            624..905
                     /gene="Igf2bp1"
                     /gene_synonym="Imp1; ZBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            906..1040
                     /gene="Igf2bp1"
                     /gene_synonym="Imp1; ZBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1041..1163
                     /gene="Igf2bp1"
                     /gene_synonym="Imp1; ZBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1164..1299
                     /gene="Igf2bp1"
                     /gene_synonym="Imp1; ZBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1300..1422
                     /gene="Igf2bp1"
                     /gene_synonym="Imp1; ZBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1423..1542
                     /gene="Igf2bp1"
                     /gene_synonym="Imp1; ZBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1543..1617
                     /gene="Igf2bp1"
                     /gene_synonym="Imp1; ZBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1618..1749
                     /gene="Igf2bp1"
                     /gene_synonym="Imp1; ZBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1750..1863
                     /gene="Igf2bp1"
                     /gene_synonym="Imp1; ZBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1864..2105
                     /gene="Igf2bp1"
                     /gene_synonym="Imp1; ZBP1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcgggcact tctcccgggc taacccgaat tctcccgtga cctccgcgtg ccctcaggcc
       61 acccaccggc ccggatctcc gaccaacttc aggggtgggg tgcgtagaaa gtttgcggct
      121 cccgccgccc atctccacgc ctctcggcct aggaggctct ccgcccgcgc ccgccccgtt
      181 cggccttgcc tgggaccgtg tccttgcccc gccaccgcca ccatgaacaa gctttacatc
      241 ggcaacctca acgagagcgt gacccccgca gacttggaga aagtatttgc ggagcacaag
      301 atctcctaca gcggccagtt cttggtcaaa tccggctacg ccttcgtgga ctgccccgac
      361 gagcactggg cgatgaaggc catcgaaact ttctcgggga aagtagaatt gcaaggaaaa
      421 cgcctagaga ttgaacactc ggtacccaaa aaacaaagga gtcggaaaat acagatccgg
      481 aatattccac ctcagctccg atgggaagtg ctggatagcc ttctggccca gtacggcaca
      541 gtggagaact gtgagcaagt gaacaccgag agtgagacgg cggtggtcaa cgtcacctac
      601 tctaaccggg agcagaccag gcaagccatc atgaagctaa atggccatca actggagaac
      661 catgccctga aggtttccta catacctgat gagcagatag cacaaggtcc tgagaatggg
      721 cgccgtggag gctttgggtc tcgaggccag cccaggcagg ggtcaccggt agcagcaggg
      781 gcgccagcca agcagcagca ggtggacatc cctctccggc tcctggtgcc cacgcagtat
      841 gtaggcgcca tcattggcaa ggagggtgcc accatccgaa acatcacaaa acagactcag
      901 tccaagatag acgtgcacag gaaggagaac gcgggggctg cggagaaggc catcagtgtg
      961 cactcgaccc ctgaaggctg ctcctcggcc tgtaagatga tcttggagat tatgcacaag
     1021 gaggcaaagg acaccaagac ggcagacgaa gttcccctga agatcctggc tcataataac
     1081 ttcgtggggc gactcattgg aaaggaaggg cggaacttga agaaagtgga gcaggataca
     1141 gagactaaga tcaccatctc ctcgctccag gatctcacgc tctataaccc tgaaaggacc
     1201 ataactgtga agggggccat tgagaactgc tgcagggctg agcaggagat catgaagaaa
     1261 gttcgagagg cttacgagaa tgacgtggct gccatgagct tgcagtctca cctcatccct
     1321 ggtctcaacc tggctgctgt cggtctcttc ccagcttctt ctagtgccgt tccgcctcct
     1381 cccagcagcg tcactggggc tgctccctat ggctccttca tgcaggctcc ggagcaggag
     1441 atggtacagg tgttcatccc cgcccaggct gtgggcgcca tcatcggcaa gaagggccag
     1501 cacatcaaac agctctcccg gttcgccagc gcctccatca agattgctcc accagaaaca
     1561 cctgactcca aagttcgaat ggttgtcatc actggacccc cagaggctca gttcaaggct
     1621 cagggaagaa tctatggcaa actaaaagaa gagaatttct ttggtcccaa ggaggaagta
     1681 aagctggaga cccacatccg ggtcccagct tcagcagctg gccgggtcat tggcaaaggt
     1741 ggcaaaacgg tgaatgagct gcagaacttg accgcagccg aggtggtcgt gccgagagac
     1801 cagaccccag acgagaacga ccaagtcatt gttaagatca tcggacattt ctatgccagc
     1861 cagatggccc agcggaagat ccgagacatc ctggctcaag ttaagcagca gcaccagaag
     1921 ggacagagca accaggccca ggcacgaagg aagtgacccc gccctttcct gtcccattgg
     1981 ctccagatca gcaggccgaa cacaggactg gaggacgggt ggagggccgg cgtgctcctc
     2041 ctagcaggcc tgagaatgag tgggaatcag ggcgtttggg tctggctgga gatcaggttt
     2101 gcaca
//
