LOCUS       NP_783184                577 aa            linear   ROD 07-FEB-2025
DEFINITION  insulin-like growth factor 2 mRNA-binding protein 1 [Rattus
            norvegicus].
ACCESSION   NP_783184
VERSION     NP_783184.1
DBSOURCE    REFSEQ: accession NM_175594.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 577)
  AUTHORS   Su,Y., Tian,W., Cheng,L., Yin,L., He,X. and Wei,X.
  TITLE     Inhibition of IGF2BP1 attenuates the progression of endometriosis
            through PTBP1
  JOURNAL   Folia Histochem Cytobiol 62 (1), 25-36 (2024)
   PUBMED   38563050
  REMARK    GeneRIF: Inhibition of IGF2BP1 attenuates the progression of
            endometriosis through PTBP1.
REFERENCE   2  (residues 1 to 577)
  AUTHORS   Guo,H., Gilley,R.P., Fisher,A., Lane,R., Landsteiner,V.J.,
            Ragan,K.B., Dovey,C.M., Carette,J.E., Upton,J.W., Mocarski,E.S. and
            Kaiser,W.J.
  TITLE     Species-independent contribution of ZBP1/DAI/DLM-1-triggered
            necroptosis in host defense against HSV1
  JOURNAL   Cell Death Dis 9 (8), 816 (2018)
   PUBMED   30050136
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 577)
  AUTHORS   Hamilton,K.E., Chatterji,P., Lundsmith,E.T., Andres,S.F.,
            Giroux,V., Hicks,P.D., Noubissi,F.K., Spiegelman,V.S. and
            Rustgi,A.K.
  TITLE     Loss of Stromal IMP1 Promotes a Tumorigenic Microenvironment in the
            Colon
  JOURNAL   Mol Cancer Res 13 (11), 1478-1486 (2015)
   PUBMED   26194191
REFERENCE   4  (residues 1 to 577)
  AUTHORS   Fallini,C., Rouanet,J.P., Donlin-Asp,P.G., Guo,P., Zhang,H.,
            Singer,R.H., Rossoll,W. and Bassell,G.J.
  TITLE     Dynamics of survival of motor neuron (SMN) protein interaction with
            the mRNA-binding protein IMP1 facilitates its trafficking into
            motor neuron axons
  JOURNAL   Dev Neurobiol 74 (3), 319-332 (2014)
   PUBMED   23897586
  REMARK    GeneRIF: Data support a role for SMN in the regulation of mRNA
            localization and axonal transport through its interaction with
            mRNA-binding proteins such as IMP1
REFERENCE   5  (residues 1 to 577)
  AUTHORS   Nishino,J., Kim,S., Zhu,Y., Zhu,H. and Morrison,S.J.
  TITLE     A network of heterochronic genes including Imp1 regulates temporal
            changes in stem cell properties
  JOURNAL   Elife 2, e00924 (2013)
   PUBMED   24192035
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 577)
  AUTHORS   Yisraeli,J.K.
  TITLE     VICKZ proteins: a multi-talented family of regulatory RNA-binding
            proteins
  JOURNAL   Biol Cell 97 (1), 87-96 (2005)
   PUBMED   15601260
  REMARK    Review article
REFERENCE   7  (residues 1 to 577)
  AUTHORS   Eom,T., Antar,L.N., Singer,R.H. and Bassell,G.J.
  TITLE     Localization of a beta-actin messenger ribonucleoprotein complex
            with zipcode-binding protein modulates the density of dendritic
            filopodia and filopodial synapses
  JOURNAL   J Neurosci 23 (32), 10433-10444 (2003)
   PUBMED   14614102
  REMARK    GeneRIF: ZBP1 is required for the localization of beta-actin mRNA
            to dendrites of hippocampal neurons
REFERENCE   8  (residues 1 to 577)
  AUTHORS   Tiruchinapalli,D.M., Oleynikov,Y., Kelic,S., Shenoy,S.M.,
            Hartley,A., Stanton,P.K., Singer,R.H. and Bassell,G.J.
  TITLE     Activity-dependent trafficking and dynamic localization of zipcode
            binding protein 1 and beta-actin mRNA in dendrites and spines of
            hippocampal neurons
  JOURNAL   J Neurosci 23 (8), 3251-3261 (2003)
   PUBMED   12716932
REFERENCE   9  (residues 1 to 577)
  AUTHORS   Nielsen,J., Christiansen,J., Lykke-Andersen,J., Johnsen,A.H.,
            Wewer,U.M. and Nielsen,F.C.
  TITLE     A family of insulin-like growth factor II mRNA-binding proteins
            represses translation in late development
  JOURNAL   Mol Cell Biol 19 (2), 1262-1270 (1999)
   PUBMED   9891060
REFERENCE   10 (residues 1 to 577)
  AUTHORS   Leeds,P., Kren,B.T., Boylan,J.M., Betz,N.A., Steer,C.J.,
            Gruppuso,P.A. and Ross,J.
  TITLE     Developmental regulation of CRD-BP, an RNA-binding protein that
            stabilizes c-myc mRNA in vitro
  JOURNAL   Oncogene 14 (11), 1279-1286 (1997)
   PUBMED   9178888
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF541940.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF541940.1, BC161831.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..577
                     /organism="Rattus norvegicus"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q26"
     Protein         1..577
                     /product="insulin-like growth factor 2 mRNA-binding
                     protein 1"
                     /note="IGF-II mRNA-binding protein 1; zipcode-binding
                     protein-1; IMP-1; rZBP-1; VICKZ family member 1; IGF2
                     mRNA-binding protein 1; B-actin zipcode-binding protein 1;
                     insulin-like growth factor 2, binding protein 1"
                     /calculated_mol_wt=63306
     Region          1..77
                     /region_name="RRM1_IGF2BP1"
                     /note="RNA recognition motif 1 (RRM1) found in vertebrate
                     insulin-like growth factor 2 mRNA-binding protein 1
                     (IGF2BP1); cd12625"
                     /db_xref="CDD:241069"
     Site            12
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9NZI8; propagated from
                     UniProtKB/Swiss-Prot (Q8CGX0.1)"
     Site            73
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9NZI8; propagated from
                     UniProtKB/Swiss-Prot (Q8CGX0.1)"
     Region          81..156
                     /region_name="RRM2_IGF2BP1"
                     /note="RNA recognition motif 2 (RRM2) found in vertebrate
                     insulin-like growth factor 2 mRNA-binding protein 1
                     (IGF2BP1); cd12628"
                     /db_xref="CDD:410037"
     Region          160..190
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8CGX0.1)"
     Site            181
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9NZI8; propagated from
                     UniProtKB/Swiss-Prot (Q8CGX0.1)"
     Region          197..272
                     /region_name="KH-I_IGF2BP1_rpt1"
                     /note="first type I K homology (KH) RNA-binding domain
                     found in insulin-like growth factor 2 mRNA-binding protein
                     1 (IGF2BP1) and similar proteins; cd22490"
                     /db_xref="CDD:411918"
     Site            order(205,207..209,211..215,218..219,222..223,228..231)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:411918"
     Region          273..369
                     /region_name="KH-I_IGF2BP1_rpt2"
                     /note="second type I K homology (KH) RNA-binding domain
                     found in insulin-like growth factor 2 mRNA-binding protein
                     1 (IGF2BP1) and similar proteins; cd22493"
                     /db_xref="CDD:411921"
     Site            order(286,288..290,292..296,299..300,303..304,309..312)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:411921"
     Region          312..323
                     /region_name="Sufficient for nuclear export.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8CGX0.1)"
     Region          404..479
                     /region_name="KH-I_IGF2BP1_rpt3"
                     /note="third type I K homology (KH) RNA-binding domain
                     found in insulin-like growth factor 2 mRNA-binding protein
                     1 (IGF2BP1) and similar proteins; cd22496"
                     /db_xref="CDD:411924"
     Site            order(417..419,421..425,428..429,439..443,452)
                     /site_type="other"
                     /note="RNA binding site [nucleotide binding]"
                     /db_xref="CDD:411924"
     Region          485..495
                     /region_name="Sufficient for nuclear export.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8CGX0.1)"
     Region          487..562
                     /region_name="KH-I_IGF2BP1_rpt4"
                     /note="fourth type I K homology (KH) RNA-binding domain
                     found in insulin-like growth factor 2 mRNA-binding protein
                     1 (IGF2BP1) and similar proteins; cd22499"
                     /db_xref="CDD:411927"
     Site            order(500..501,503..507,510,521..527)
                     /site_type="other"
                     /note="RNA binding site [nucleotide binding]"
                     /db_xref="CDD:411927"
     Site            528
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q9NZI8; propagated from
                     UniProtKB/Swiss-Prot (Q8CGX0.1)"
     CDS             1..577
                     /gene="Igf2bp1"
                     /gene_synonym="Imp1; ZBP1"
                     /coded_by="NM_175594.2:223..1956"
                     /db_xref="GeneID:303477"
                     /db_xref="RGD:708580"
ORIGIN      
        1 mnklyignln esvtpadlek vfaehkisys gqflvksgya fvdcpdehwa mkaietfsgk
       61 velqgkrlei ehsvpkkqrs rkiqirnipp qlrwevldsl laqygtvenc eqvnteseta
      121 vvnvtysnre qtrqaimkln ghqlenhalk vsyipdeqia qgpengrrgg fgsrgqprqg
      181 spvaagapak qqqvdiplrl lvptqyvgai igkegatirn itkqtqskid vhrkenagaa
      241 ekaisvhstp egcssackmi leimhkeakd tktadevplk ilahnnfvgr ligkegrnlk
      301 kveqdtetki tisslqdltl ynpertitvk gaienccrae qeimkkvrea yendvaamsl
      361 qshlipglnl aavglfpass savppppssv tgaapygsfm qapeqemvqv fipaqavgai
      421 igkkgqhikq lsrfasasik iappetpdsk vrmvvitgpp eaqfkaqgri ygklkeenff
      481 gpkeevklet hirvpasaag rvigkggktv nelqnltaae vvvprdqtpd endqvivkii
      541 ghfyasqmaq rkirdilaqv kqqhqkgqsn qaqarrk
//
