LOCUS       NM_001190163            3507 bp    mRNA    linear   ROD 07-FEB-2025
DEFINITION  Rattus norvegicus insulin-like growth factor 2 (Igf2), transcript
            variant 3, mRNA.
ACCESSION   NM_001190163
VERSION     NM_001190163.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3507)
  AUTHORS   Pandey,K., Bessieres,B., Sheng,S.L., Taranda,J., Osten,P.,
            Sandovici,I., Constancia,M. and Alberini,C.M.
  TITLE     Neuronal activity drives IGF2 expression from pericytes to form
            long-term memory
  JOURNAL   Neuron 111 (23), 3819-3836 (2023)
   PUBMED   37788670
  REMARK    GeneRIF: Neuronal activity drives IGF2 expression from pericytes to
            form long-term memory.
REFERENCE   2  (bases 1 to 3507)
  AUTHORS   Zolov,S.N., Imai,H., Losiewicz,M.K., Singh,R.S.J., Fort,P.E. and
            Gardner,T.W.
  TITLE     Insulin-like growth factor-2 regulates basal retinal insulin
            receptor activity
  JOURNAL   J Biol Chem 296, 100712 (2021)
   PUBMED   33915127
  REMARK    GeneRIF: Insulin-like growth factor-2 regulates basal retinal
            insulin receptor activity.
REFERENCE   3  (bases 1 to 3507)
  AUTHORS   Mogulkoc,R., Dasdelen,D., Baltaci,S.B., Baltaci,A.K. and
            Sivrikaya,A.
  TITLE     The effect of thyroid dysfunction and treatment on adropin,
            asprosin and preptin levels in rats
  JOURNAL   Horm Mol Biol Clin Investig 42 (1), 37-42 (2020)
   PUBMED   33781005
  REMARK    GeneRIF: The effect of thyroid dysfunction and treatment on
            adropin, asprosin and preptin levels in rats.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3507)
  AUTHORS   Arous,C., Mizgier,M.L., Rickenbach,K., Pinget,M., Bouzakri,K. and
            Wehrle-Haller,B.
  TITLE     Integrin and autocrine IGF2 pathways control fasting insulin
            secretion in beta-cells
  JOURNAL   J Biol Chem 295 (49), 16510-16528 (2020)
   PUBMED   32934005
  REMARK    GeneRIF: Integrin and autocrine IGF2 pathways control fasting
            insulin secretion in beta-cells.
REFERENCE   5  (bases 1 to 3507)
  AUTHORS   Wang,C., Li,X., Dang,H., Liu,P., Zhang,B.O. and Xu,F.
  TITLE     Insulin-like growth factor 2 regulates the proliferation and
            differentiation of rat adipose-derived stromal cells via IGF-1R and
            IR
  JOURNAL   Cytotherapy 21 (6), 619-630 (2019)
   PUBMED   30956007
  REMARK    GeneRIF: IGF2 expression in inguinal adipose tissues from rats of
            different ages.
REFERENCE   6  (bases 1 to 3507)
  AUTHORS   Price,W.A., Rong,L., Stiles,A.D. and D'Ercole,A.J.
  TITLE     Changes in IGF-I and -II, IGF binding protein, and IGF receptor
            transcript abundance after uterine artery ligation
  JOURNAL   Pediatr Res 32 (3), 291-295 (1992)
   PUBMED   1408464
REFERENCE   7  (bases 1 to 3507)
  AUTHORS   Ikejiri,K., Ueno,T., Matsuguchi,T., Takahashi,K., Endo,H. and
            Yamamoto,M.
  TITLE     The primary structure of the rat insulin-like growth factor II gene
            region
  JOURNAL   Biochim Biophys Acta 1049 (3), 350-353 (1990)
   PUBMED   2383591
REFERENCE   8  (bases 1 to 3507)
  AUTHORS   Matsuguchi,T., Takahashi,K., Ikejiri,K., Ueno,T., Endo,H. and
            Yamamoto,M.
  TITLE     Functional analysis of multiple promoters of the rat insulin-like
            factor II gene
  JOURNAL   Biochim Biophys Acta 1048 (2-3), 165-170 (1990)
   PUBMED   2322575
REFERENCE   9  (bases 1 to 3507)
  AUTHORS   Ueno,T., Takahashi,K., Matsuguchi,T., Ikejiri,K., Endo,H. and
            Yamamoto,M.
  TITLE     Multiple polyadenylation sites in a large 3'-most exon of the rat
            insulin-like growth factor II gene
  JOURNAL   Biochim Biophys Acta 1009 (1), 27-34 (1989)
   PUBMED   2477062
REFERENCE   10 (bases 1 to 3507)
  AUTHORS   Soares,M.B., Turken,A., Ishii,D., Mills,L., Episkopou,V.,
            Cotter,S., Zeitlin,S. and Efstratiadis,A.
  TITLE     Rat insulin-like growth factor II gene. A single gene with two
            promoters expressing a multitranscript family
  JOURNAL   J Mol Biol 192 (4), 737-752 (1986)
   PUBMED   2438416
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            X14833.1 and JAXUCZ010000001.1.
            
            Transcript Variant: This variant (3) uses an alternate exon at its
            5' terminus and uses a downstream in-frame start codon, compared to
            variant 1. This results in a protein (isoform 2) with a shorter
            N-terminus, compared to isoform 1. Variants 2 and 3 encode the same
            protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X14833.1, SRR26643296.3360.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-46                X14833.1           302-347
            47-2488             JAXUCZ010000001.1  207243873-207246314 c
            2489-3506           X14833.1           348-1365
            3507-5948           JAXUCZ010000001.1  207243873-207246314 c
FEATURES             Location/Qualifiers
     source          1..3507
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q41"
     gene            1..3507
                     /gene="Igf2"
                     /gene_synonym="IGFII; RNIGF2"
                     /note="insulin-like growth factor 2"
                     /db_xref="GeneID:24483"
                     /db_xref="RGD:2870"
     exon            1..70
                     /gene="Igf2"
                     /gene_synonym="IGFII; RNIGF2"
                     /inference="alignment:Splign:2.1.0"
     exon            71..233
                     /gene="Igf2"
                     /gene_synonym="IGFII; RNIGF2"
                     /inference="alignment:Splign:2.1.0"
     CDS             77..619
                     /gene="Igf2"
                     /gene_synonym="IGFII; RNIGF2"
                     /note="isoform 2 preproprotein is encoded by transcript
                     variant 3; MSA; IGF-II; multiplication-stimulating
                     activity; multiplication-stimulating polypeptide;
                     Insulin-like growth factor II (somatomedin A);
                     insulin-like growth factor II (IGF-II)"
                     /codon_start=1
                     /product="insulin-like growth factor 2 isoform 2
                     preproprotein"
                     /protein_id="NP_001177092.1"
                     /db_xref="GeneID:24483"
                     /db_xref="RGD:2870"
                     /translation="MGIPVGKSMLVLLISLAFALCCIAAYRPSETLCGGELVDTLQFV
                     CSDRGFYFSRPSSRANRRSRGIVEECCFRSCDLALLETYCATPAKSERDVSTSQAVLP
                     DDFPRYPVGKFFKFDTWRQSAGRLRRGLPALLRARRGRMLAKELEAFREAKRHRPLIV
                     LPPKDPAHGGASSEMSSNHQ"
     exon            234..382
                     /gene="Igf2"
                     /gene_synonym="IGFII; RNIGF2"
                     /inference="alignment:Splign:2.1.0"
     exon            383..3507
                     /gene="Igf2"
                     /gene_synonym="IGFII; RNIGF2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tcccacttct gcagctctcc cgcccttctc cgatcctcct gcgccagcgg acccgacctt
       61 cggccttgcg gtaccaatgg ggatcccagt ggggaagtcg atgttggtgc ttctcatctc
      121 tttggccttc gccttgtgct gcatcgctgc ttaccgcccc agcgagactc tgtgcggagg
      181 ggagcttgtt gacacgcttc agtttgtctg ttcggaccgc ggcttctact tcagcaggcc
      241 ttcaagccgt gccaaccgtc gcagccgtgg catcgtggaa gagtgctgct tccgcagctg
      301 cgacttggcc ctcctggaga catactgtgc cacccccgcc aagtccgaga gggacgtgtc
      361 tacctctcag gccgtacttc cggacgactt ccccagatac cccgtgggca agttcttcaa
      421 attcgacacc tggagacagt ccgcgggacg cctgcgcaga ggcctgcctg ccctcctgcg
      481 tgcccgccgg ggtcgcatgc ttgccaaaga gctcgaagcg ttcagagagg ccaagcgcca
      541 ccgtcccctg atcgtgttac cacccaaaga ccccgcccac gggggagcct cttcggagat
      601 gtccagcaac catcagtgaa ccaaattatg tggtaattct gcaatgtagt accatcagtc
      661 tgtgacctcc tcttgagcag ggacagctcc atcatgtccc acactaaggt ctctctgctc
      721 cacttccctt cccaggtttc tccccaccca cccccatgcc ccgcctcccc acatcaggct
      781 gctccccttg ccccacacca tcgggcaagg ggatcccagc aactcttcaa aaccaaattt
      841 gattggctct aaacaaccca attggcaccc tccaaattat atatgaacat taaaaaaaaa
      901 ctttaaagca tatagtccct ttacaacaaa ttggcttaag aaactccata actgataatc
      961 taaaaattaa ataaccaaag aaattaattg gctaaaaaca tactaaaaat taattggctt
     1021 aaaaacaatt ggcaaaaatc aaataatttg gcccgccccc cccccttcat cttctttcca
     1081 tttagatctt tagtcaaatt ggctcagact tggatctcag aacccaagaa gaaaggaagg
     1141 ggacccaaaa ttttgcaggt agcatgtcat tgcttcagtg ctctctcctt gtcactagtc
     1201 acttttagca taatctggct gtgaacaaca atagccgccc aaactctttc ttcactggtc
     1261 attccatcac aaatgtcacc catgtcacca aggggctggg taaaggaacc caaggagagg
     1321 aacagaacat gaaaactgaa aatagaacct aattggcaca agcccccagt cccaaaaatc
     1381 tcacttttca tacctactct aaaaagcaca tgattatacc cacacgtaca tgcacacaca
     1441 catgcacaca ggcatgcata cacacacaca cacacacaca cacactatta gatgagaaca
     1501 ttgaaatggc tgagcaactt cgattggaac cacattgccc aatccaaggc ccatcttaaa
     1561 ttccctgagc agtttgcatg gtttgagctc ctctctgaat ccatctagtt tctgctgcca
     1621 gtgtagagtc agtttggcca gataaggaga tggcactgcc aagtgataca tgctacccga
     1681 gtagcctgac ccctaggtgt gctcctggga ggaaagatct gggggacaac ccctacccca
     1741 agcacaccta tgggccatct ctgtcaatct cctggggagc ccccactttt taggggctcc
     1801 ccaggagact cacactgatg tggggagtgt gggaagtctg gcggttggag gggtgggtgg
     1861 ggggcagtgg gggctgggtg gggggaaact atgggtagga agtggtccca gagaggtctt
     1921 aggtggaaca gtcaggagga ggcacaggtc aacttgcaga attactgaag aatcaggacc
     1981 ccaaatttta tgtcaattga tctattcccc tctttttatg tctggggcag gttttttcct
     2041 tttttttttt taatccctcc ttagctttta atgcgctcat aatcccattc cctatgtaac
     2101 gggggcagcg atcaagtaat gaatgcatca agccatcaat accagcgaga gccagtaaca
     2161 ccggctagag ccatcaacac cggcttccac catgtcctgc tcccaaccat ttatcaacct
     2221 tttttttttt tatctgtctc tatcgcttgg cctgagttgg gagtggagtc tctgtggggt
     2281 gctggccacg cacccgcaga gaaataaaag gaattgagaa ggccgctacc tggcctgact
     2341 tctggggaca gtggctggtc cccagaagtt ctgaggagtg gagggggcgt ggggcagtgt
     2401 cccctcaggt gttaggaagg tgctcggagg ccacaaagat ggggacccca gctggccctg
     2461 ccagttgggg gggaagggga tgtagatgta agactagaga ggttccatca ggcgggagca
     2521 agtggctgcc ttctgagcac ttgggggagg tcctccccgt gcccctcagt gtcatcttgc
     2581 ccactcctca gcaccccatc ttaccctcag gaggtctgga gctctacaga cctcctgggg
     2641 gcaaggtggg gtgaggcctg gagctgggga agcgaggagg ctttaaagcc ttcagagcca
     2701 ggagaactgt gtacatgggg ttgtctgggc cctggggccc gagggtctgg tgagccgtag
     2761 cagccactcc acggtgccta ggactgcggc ggggaacagg gcggctggag gtttacctca
     2821 cccccacttc tgcttccagt gcagtccccc tgcccaacag tcctactagt aatctagagg
     2881 cctgaggctt ctgggcccag gtgacaggac tggcaccacc ctgggggcgg tgtgtgtcag
     2941 ccagccatgg cacagagggt tctcagcaag tgcctaaaga atgggccatt tggaacattg
     3001 gacagaaact caaagagtaa attgttataa ttggagaata tgaattggcc tggtacccaa
     3061 aatatctcga ggcaccctaa attacctgcc catttgactg gacatccacc cagtgttaat
     3121 atgcctcgtg ggatgggtgt tttcaggggc atttgctgac catcctctgt gtccccagat
     3181 ttgcagttct ccccatcata ggtcaccctg atgcaggcac ctccctggcc tcccatgcct
     3241 agtgtggccc tccatcttgt tttgtctctt ccctactgtc ttcggtggga tcccctcttg
     3301 ggtcccccaa tttgtcatcc tgtgaagact tcccacgcgt cgaatgccat atgtcacctg
     3361 tgccactgcc catgtcatcc agcagtggcc ccgggtattt gccccaactc agtcctttta
     3421 acatgcattt tctggcaaaa tccaaagctt gggttttgtt tttaacctgt taacgcttgc
     3481 aaacctaata aagcattcaa aatacta
//
