LOCUS       NM_001190162            3519 bp    mRNA    linear   ROD 07-FEB-2025
DEFINITION  Rattus norvegicus insulin-like growth factor 2 (Igf2), transcript
            variant 2, mRNA.
ACCESSION   NM_001190162
VERSION     NM_001190162.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3519)
  AUTHORS   Pandey,K., Bessieres,B., Sheng,S.L., Taranda,J., Osten,P.,
            Sandovici,I., Constancia,M. and Alberini,C.M.
  TITLE     Neuronal activity drives IGF2 expression from pericytes to form
            long-term memory
  JOURNAL   Neuron 111 (23), 3819-3836 (2023)
   PUBMED   37788670
  REMARK    GeneRIF: Neuronal activity drives IGF2 expression from pericytes to
            form long-term memory.
REFERENCE   2  (bases 1 to 3519)
  AUTHORS   Zolov,S.N., Imai,H., Losiewicz,M.K., Singh,R.S.J., Fort,P.E. and
            Gardner,T.W.
  TITLE     Insulin-like growth factor-2 regulates basal retinal insulin
            receptor activity
  JOURNAL   J Biol Chem 296, 100712 (2021)
   PUBMED   33915127
  REMARK    GeneRIF: Insulin-like growth factor-2 regulates basal retinal
            insulin receptor activity.
REFERENCE   3  (bases 1 to 3519)
  AUTHORS   Mogulkoc,R., Dasdelen,D., Baltaci,S.B., Baltaci,A.K. and
            Sivrikaya,A.
  TITLE     The effect of thyroid dysfunction and treatment on adropin,
            asprosin and preptin levels in rats
  JOURNAL   Horm Mol Biol Clin Investig 42 (1), 37-42 (2020)
   PUBMED   33781005
  REMARK    GeneRIF: The effect of thyroid dysfunction and treatment on
            adropin, asprosin and preptin levels in rats.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3519)
  AUTHORS   Arous,C., Mizgier,M.L., Rickenbach,K., Pinget,M., Bouzakri,K. and
            Wehrle-Haller,B.
  TITLE     Integrin and autocrine IGF2 pathways control fasting insulin
            secretion in beta-cells
  JOURNAL   J Biol Chem 295 (49), 16510-16528 (2020)
   PUBMED   32934005
  REMARK    GeneRIF: Integrin and autocrine IGF2 pathways control fasting
            insulin secretion in beta-cells.
REFERENCE   5  (bases 1 to 3519)
  AUTHORS   Wang,C., Li,X., Dang,H., Liu,P., Zhang,B.O. and Xu,F.
  TITLE     Insulin-like growth factor 2 regulates the proliferation and
            differentiation of rat adipose-derived stromal cells via IGF-1R and
            IR
  JOURNAL   Cytotherapy 21 (6), 619-630 (2019)
   PUBMED   30956007
  REMARK    GeneRIF: IGF2 expression in inguinal adipose tissues from rats of
            different ages.
REFERENCE   6  (bases 1 to 3519)
  AUTHORS   Price,W.A., Rong,L., Stiles,A.D. and D'Ercole,A.J.
  TITLE     Changes in IGF-I and -II, IGF binding protein, and IGF receptor
            transcript abundance after uterine artery ligation
  JOURNAL   Pediatr Res 32 (3), 291-295 (1992)
   PUBMED   1408464
REFERENCE   7  (bases 1 to 3519)
  AUTHORS   Ikejiri,K., Ueno,T., Matsuguchi,T., Takahashi,K., Endo,H. and
            Yamamoto,M.
  TITLE     The primary structure of the rat insulin-like growth factor II gene
            region
  JOURNAL   Biochim Biophys Acta 1049 (3), 350-353 (1990)
   PUBMED   2383591
REFERENCE   8  (bases 1 to 3519)
  AUTHORS   Matsuguchi,T., Takahashi,K., Ikejiri,K., Ueno,T., Endo,H. and
            Yamamoto,M.
  TITLE     Functional analysis of multiple promoters of the rat insulin-like
            factor II gene
  JOURNAL   Biochim Biophys Acta 1048 (2-3), 165-170 (1990)
   PUBMED   2322575
REFERENCE   9  (bases 1 to 3519)
  AUTHORS   Ueno,T., Takahashi,K., Matsuguchi,T., Ikejiri,K., Endo,H. and
            Yamamoto,M.
  TITLE     Multiple polyadenylation sites in a large 3'-most exon of the rat
            insulin-like growth factor II gene
  JOURNAL   Biochim Biophys Acta 1009 (1), 27-34 (1989)
   PUBMED   2477062
REFERENCE   10 (bases 1 to 3519)
  AUTHORS   Soares,M.B., Turken,A., Ishii,D., Mills,L., Episkopou,V.,
            Cotter,S., Zeitlin,S. and Efstratiadis,A.
  TITLE     Rat insulin-like growth factor II gene. A single gene with two
            promoters expressing a multitranscript family
  JOURNAL   J Mol Biol 192 (4), 737-752 (1986)
   PUBMED   2438416
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            X13101.1 and JAXUCZ010000001.1.
            
            Transcript Variant: This variant (2) uses an alternate exon at its
            5' terminus and uses a downstream in-frame start codon, compared to
            variant 1. This results in a protein (isoform 2) with a shorter
            N-terminus, compared to isoform 1. Variants 2 and 3 encode the same
            protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X13101.1, SRR26643429.4191.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840127 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1077              X13101.1           13-1089
            1078-3519           JAXUCZ010000001.1  207243873-207246314 c
FEATURES             Location/Qualifiers
     source          1..3519
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q41"
     gene            1..3519
                     /gene="Igf2"
                     /gene_synonym="IGFII; RNIGF2"
                     /note="insulin-like growth factor 2"
                     /db_xref="GeneID:24483"
                     /db_xref="RGD:2870"
     exon            1..82
                     /gene="Igf2"
                     /gene_synonym="IGFII; RNIGF2"
                     /inference="alignment:Splign:2.1.0"
     exon            83..245
                     /gene="Igf2"
                     /gene_synonym="IGFII; RNIGF2"
                     /inference="alignment:Splign:2.1.0"
     CDS             89..631
                     /gene="Igf2"
                     /gene_synonym="IGFII; RNIGF2"
                     /note="isoform 2 preproprotein is encoded by transcript
                     variant 2; MSA; IGF-II; multiplication-stimulating
                     activity; multiplication-stimulating polypeptide;
                     Insulin-like growth factor II (somatomedin A);
                     insulin-like growth factor II (IGF-II)"
                     /codon_start=1
                     /product="insulin-like growth factor 2 isoform 2
                     preproprotein"
                     /protein_id="NP_001177091.1"
                     /db_xref="GeneID:24483"
                     /db_xref="RGD:2870"
                     /translation="MGIPVGKSMLVLLISLAFALCCIAAYRPSETLCGGELVDTLQFV
                     CSDRGFYFSRPSSRANRRSRGIVEECCFRSCDLALLETYCATPAKSERDVSTSQAVLP
                     DDFPRYPVGKFFKFDTWRQSAGRLRRGLPALLRARRGRMLAKELEAFREAKRHRPLIV
                     LPPKDPAHGGASSEMSSNHQ"
     exon            246..394
                     /gene="Igf2"
                     /gene_synonym="IGFII; RNIGF2"
                     /inference="alignment:Splign:2.1.0"
     exon            395..3519
                     /gene="Igf2"
                     /gene_synonym="IGFII; RNIGF2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tttgcttctc ctgtgagaac cttccagcct tttcctgtct tcatcctctt ccagccccag
       61 cggcctcctt atccaacttc aggtaccaat ggggatccca gtggggaagt cgatgttggt
      121 gcttctcatc tctttggcct tcgccttgtg ctgcatcgct gcttaccgcc ccagcgagac
      181 tctgtgcgga ggggagcttg ttgacacgct tcagtttgtc tgttcggacc gcggcttcta
      241 cttcagcagg ccttcaagcc gtgccaaccg tcgcagccgt ggcatcgtgg aagagtgctg
      301 cttccgcagc tgcgacttgg ccctcctgga gacatactgt gccacccccg ccaagtccga
      361 gagggacgtg tctacctctc aggccgtact tccggacgac ttccccagat accccgtggg
      421 caagttcttc aaattcgaca cctggagaca gtccgcggga cgcctgcgca gaggcctgcc
      481 tgccctcctg cgtgcccgcc ggggtcgcat gcttgccaaa gagctcgaag cgttcagaga
      541 ggccaagcgc caccgtcccc tgatcgtgtt accacccaaa gaccccgccc acgggggagc
      601 ctcttcggag atgtccagca accatcagtg aaccaaatta tgtggtaatt ctgcaatgta
      661 gtaccatcag tctgtgacct cctcttgagc agggacagct ccatcatgtc ccacactaag
      721 gtctctctgc tccacttccc ttcccaggtt tctccccacc cacccccatg ccccgcctcc
      781 ccacatcagg ctgctcccct tgccccacac catcgggcaa ggggatccca gcaactcttc
      841 aaaaccaaat ttgattggct ctaaacaacc caattggcac cctccaaatt atatatgaac
      901 attaaaaaaa aactttaaag catatagtcc ctttacaaca aattggctta agaaactcca
      961 taactgataa tctaaaaatt aaataaccaa agaaattaat tggctaaaaa catactaaaa
     1021 attaattggc ttaaaaacaa ttggcaaaaa tcaaataatt tggcccgccc cccccccttc
     1081 atcttctttc catttagatc tttagtcaaa ttggctcaga cttggatctc agaacccaag
     1141 aagaaaggaa ggggacccaa aattttgcag gtagcatgtc attgcttcag tgctctctcc
     1201 ttgtcactag tcacttttag cataatctgg ctgtgaacaa caatagccgc ccaaactctt
     1261 tcttcactgg tcattccatc acaaatgtca cccatgtcac caaggggctg ggtaaaggaa
     1321 cccaaggaga ggaacagaac atgaaaactg aaaatagaac ctaattggca caagccccca
     1381 gtcccaaaaa tctcactttt catacctact ctaaaaagca catgattata cccacacgta
     1441 catgcacaca cacatgcaca caggcatgca tacacacaca cacacacaca cacacactat
     1501 tagatgagaa cattgaaatg gctgagcaac ttcgattgga accacattgc ccaatccaag
     1561 gcccatctta aattccctga gcagtttgca tggtttgagc tcctctctga atccatctag
     1621 tttctgctgc cagtgtagag tcagtttggc cagataagga gatggcactg ccaagtgata
     1681 catgctaccc gagtagcctg acccctaggt gtgctcctgg gaggaaagat ctgggggaca
     1741 acccctaccc caagcacacc tatgggccat ctctgtcaat ctcctgggga gcccccactt
     1801 tttaggggct ccccaggaga ctcacactga tgtggggagt gtgggaagtc tggcggttgg
     1861 aggggtgggt ggggggcagt gggggctggg tggggggaaa ctatgggtag gaagtggtcc
     1921 cagagaggtc ttaggtggaa cagtcaggag gaggcacagg tcaacttgca gaattactga
     1981 agaatcagga ccccaaattt tatgtcaatt gatctattcc cctcttttta tgtctggggc
     2041 aggttttttc cttttttttt tttaatccct ccttagcttt taatgcgctc ataatcccat
     2101 tccctatgta acgggggcag cgatcaagta atgaatgcat caagccatca ataccagcga
     2161 gagccagtaa caccggctag agccatcaac accggcttcc accatgtcct gctcccaacc
     2221 atttatcaac cttttttttt tttatctgtc tctatcgctt ggcctgagtt gggagtggag
     2281 tctctgtggg gtgctggcca cgcacccgca gagaaataaa aggaattgag aaggccgcta
     2341 cctggcctga cttctgggga cagtggctgg tccccagaag ttctgaggag tggagggggc
     2401 gtggggcagt gtcccctcag gtgttaggaa ggtgctcgga ggccacaaag atggggaccc
     2461 cagctggccc tgccagttgg gggggaaggg gatgtagatg taagactaga gaggttccat
     2521 caggcgggag caagtggctg ccttctgagc acttggggga ggtcctcccc gtgcccctca
     2581 gtgtcatctt gcccactcct cagcacccca tcttaccctc aggaggtctg gagctctaca
     2641 gacctcctgg gggcaaggtg gggtgaggcc tggagctggg gaagcgagga ggctttaaag
     2701 ccttcagagc caggagaact gtgtacatgg ggttgtctgg gccctggggc ccgagggtct
     2761 ggtgagccgt agcagccact ccacggtgcc taggactgcg gcggggaaca gggcggctgg
     2821 aggtttacct cacccccact tctgcttcca gtgcagtccc cctgcccaac agtcctacta
     2881 gtaatctaga ggcctgaggc ttctgggccc aggtgacagg actggcacca ccctgggggc
     2941 ggtgtgtgtc agccagccat ggcacagagg gttctcagca agtgcctaaa gaatgggcca
     3001 tttggaacat tggacagaaa ctcaaagagt aaattgttat aattggagaa tatgaattgg
     3061 cctggtaccc aaaatatctc gaggcaccct aaattacctg cccatttgac tggacatcca
     3121 cccagtgtta atatgcctcg tgggatgggt gttttcaggg gcatttgctg accatcctct
     3181 gtgtccccag atttgcagtt ctccccatca taggtcaccc tgatgcaggc acctccctgg
     3241 cctcccatgc ctagtgtggc cctccatctt gttttgtctc ttccctactg tcttcggtgg
     3301 gatcccctct tgggtccccc aatttgtcat cctgtgaaga cttcccacgc gtcgaatgcc
     3361 atatgtcacc tgtgccactg cccatgtcat ccagcagtgg ccccgggtat ttgccccaac
     3421 tcagtccttt taacatgcat tttctggcaa aatccaaagc ttgggttttg tttttaacct
     3481 gttaacgctt gcaaacctaa taaagcattc aaaatacta
//
