LOCUS       NM_001414181           12368 bp    mRNA    linear   ROD 11-SEP-2024
DEFINITION  Rattus norvegicus insulin-like growth factor 1 receptor (Igf1r),
            transcript variant 1, mRNA.
ACCESSION   NM_001414181 XM_006229324
VERSION     NM_001414181.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 12368)
  AUTHORS   Maleki,A.H., Azar,J.T., Razi,M. and Tofighi,A.
  TITLE     The Effect of Different Exercise Modalities on Sertoli-germ Cells
            Metabolic Interactions in High-fat Diet-induced Obesity Rat Models:
            Implication on Glucose and Lactate Transport, Igf1, and
            Igf1R-dependent Pathways
  JOURNAL   Reprod Sci 31 (8), 2246-2260 (2024)
   PUBMED   38632221
  REMARK    GeneRIF: The Effect of Different Exercise Modalities on
            Sertoli-germ Cells Metabolic Interactions in High-fat Diet-induced
            Obesity Rat Models: Implication on Glucose and Lactate Transport,
            Igf1, and Igf1R-dependent Pathways.
REFERENCE   2  (bases 1 to 12368)
  AUTHORS   Zhang,P., Li,H., Zhang,A., Wang,X., Song,Q., Li,Z., Wang,W., Xu,J.,
            Hou,Y. and Zhang,Y.
  TITLE     Mechanism of myocardial fibrosis regulation by IGF-1R in atrial
            fibrillation through the PI3K/Akt/FoxO3a pathway
  JOURNAL   Biochem Cell Biol 101 (5), 432-442 (2023)
   PUBMED   37018819
  REMARK    GeneRIF: Mechanism of myocardial fibrosis regulation by IGF-1R in
            atrial fibrillation through the PI3K/Akt/FoxO3a pathway.
REFERENCE   3  (bases 1 to 12368)
  AUTHORS   Zhu,Y., Chen,S., Liu,W., Xu,F., Lu,J., Hayashi,T., Mizuno,K.,
            Hattori,S., Fujisaki,H. and Ikejima,T.
  TITLE     IGF-1R/YAP signaling pathway is involved in collagen V-induced
            insulin biosynthesis and secretion in rat islet INS-1 cells
  JOURNAL   Connect Tissue Res 63 (5), 498-513 (2022)
   PUBMED   35129018
  REMARK    GeneRIF: IGF-1R/YAP signaling pathway is involved in collagen
            V-induced insulin biosynthesis and secretion in rat islet INS-1
            cells.
REFERENCE   4  (bases 1 to 12368)
  AUTHORS   Liu,J., Lin,M., Qiao,F. and Zhang,C.
  TITLE     Exosomes Derived from lncRNA TCTN2-Modified Mesenchymal Stem Cells
            Improve Spinal Cord Injury by miR-329-3p/IGF1R Axis
  JOURNAL   J Mol Neurosci 72 (3), 482-495 (2022)
   PUBMED   34623606
  REMARK    GeneRIF: Exosomes Derived from lncRNA TCTN2-Modified Mesenchymal
            Stem Cells Improve Spinal Cord Injury by miR-329-3p/IGF1R Axis.
REFERENCE   5  (bases 1 to 12368)
  AUTHORS   Liu,X.M., Zhang,Z., Zhong,J., Li,N., Wang,T., Wang,L. and Zhang,Q.
  TITLE     Long non-coding RNA MALAT1 modulates myocardial
            ischemia-reperfusion injury through the PI3K/Akt/eNOS pathway by
            sponging miRNA-133a-3p to target IGF1R expression
  JOURNAL   Eur J Pharmacol 916, 174719 (2022)
   PUBMED   34968461
  REMARK    GeneRIF: Long non-coding RNA MALAT1 modulates myocardial
            ischemia-reperfusion injury through the PI3K/Akt/eNOS pathway by
            sponging miRNA-133a-3p to target IGF1R expression.
REFERENCE   6  (bases 1 to 12368)
  AUTHORS   Antich,M., Fabian,E., Sarquella,J. and Bassas,L.
  TITLE     Effect of testicular damage induced by cryptorchidism on
            insulin-like growth factor I receptors in rat Sertoli cells
  JOURNAL   J Reprod Fertil 104 (2), 267-275 (1995)
   PUBMED   7473418
REFERENCE   7  (bases 1 to 12368)
  AUTHORS   Kurachi,H., Jobo,K., Ohta,M., Kawasaki,T. and Itoh,N.
  TITLE     A new member of the insulin receptor family, insulin
            receptor-related receptor, is expressed preferentially in the
            kidney
  JOURNAL   Biochem Biophys Res Commun 187 (2), 934-939 (1992)
   PUBMED   1530648
REFERENCE   8  (bases 1 to 12368)
  AUTHORS   Tollefsen,S.E., Stoszek,R.M. and Thompson,K.
  TITLE     Interaction of the alpha beta dimers of the insulin-like growth
            factor I receptor is required for receptor autophosphorylation
  JOURNAL   Biochemistry 30 (1), 48-54 (1991)
   PUBMED   1846292
REFERENCE   9  (bases 1 to 12368)
  AUTHORS   Werner,H., Stannard,B., Bach,M.A., LeRoith,D. and Roberts,C.T. Jr.
  TITLE     Cloning and characterization of the proximal promoter region of the
            rat insulin-like growth factor I (IGF-I) receptor gene
  JOURNAL   Biochem Biophys Res Commun 169 (3), 1021-1027 (1990)
   PUBMED   2163625
REFERENCE   10 (bases 1 to 12368)
  AUTHORS   Werner,H., Woloschak,M., Adamo,M., Shen-Orr,Z., Roberts,C.T. Jr.
            and LeRoith,D.
  TITLE     Developmental regulation of the rat insulin-like growth factor I
            receptor gene
  JOURNAL   Proc Natl Acad Sci U S A 86 (19), 7451-7455 (1989)
   PUBMED   2477843
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Nov 16, 2022 this sequence version replaced XM_006229324.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643297.1993.1,
                                           SRR26643429.2197.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1049              JAXUCZ010000001.1  130959997-130961045
            1050-1595           JAXUCZ010000001.1  131013488-131014033
            1596-1908           JAXUCZ010000001.1  131177485-131177797
            1909-2060           JAXUCZ010000001.1  131182024-131182175
            2061-2205           JAXUCZ010000001.1  131184657-131184801
            2206-2420           JAXUCZ010000001.1  131193981-131194195
            2421-2547           JAXUCZ010000001.1  131196037-131196163
            2548-2786           JAXUCZ010000001.1  131197596-131197834
            2787-2954           JAXUCZ010000001.1  131201772-131201939
            2955-3159           JAXUCZ010000001.1  131202136-131202340
            3160-3443           JAXUCZ010000001.1  131207157-131207440
            3444-3580           JAXUCZ010000001.1  131208989-131209125
            3581-3740           JAXUCZ010000001.1  131209591-131209750
            3741-3843           JAXUCZ010000001.1  131215575-131215677
            3844-3914           JAXUCZ010000001.1  131216230-131216300
            3915-4144           JAXUCZ010000001.1  131221836-131222065
            4145-4255           JAXUCZ010000001.1  131222348-131222458
            4256-4418           JAXUCZ010000001.1  131226836-131226998
            4419-4548           JAXUCZ010000001.1  131230129-131230258
            4549-4683           JAXUCZ010000001.1  131233616-131233750
            4684-12368          JAXUCZ010000001.1  131240980-131248664
FEATURES             Location/Qualifiers
     source          1..12368
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q22"
     gene            1..12368
                     /gene="Igf1r"
                     /gene_synonym="IGF-1 receptor; IGFIRC; Igfr1; JTK13"
                     /note="insulin-like growth factor 1 receptor"
                     /db_xref="GeneID:25718"
                     /db_xref="RGD:2869"
     exon            1..1049
                     /gene="Igf1r"
                     /gene_synonym="IGF-1 receptor; IGFIRC; Igfr1; JTK13"
                     /inference="alignment:Splign:2.1.0"
     CDS             956..5071
                     /gene="Igf1r"
                     /gene_synonym="IGF-1 receptor; IGFIRC; Igfr1; JTK13"
                     /EC_number="2.7.10.1"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; IGF-I receptor; insulin-like growth factor I
                     receptor; type-I IGF receptor"
                     /codon_start=1
                     /product="insulin-like growth factor 1 receptor isoform 1
                     precursor"
                     /protein_id="NP_001401110.1"
                     /db_xref="GeneID:25718"
                     /db_xref="RGD:2869"
                     /translation="MKSGSGGGSPTSLWGLVFLSAALSLWPTSGEICGPGIDIRNDYQ
                     QLKRLENCTVIEGFLHILLISKAEDYRSYRFPKLTVITEYLLLFRVAGLESLGDLFPN
                     LTVIRGWKLFYNYALVIFEMTNLKDIGLYNLRNITRGAIRIEKNADLCYLSTIDWSLI
                     LDAVSNNYIVGNKPPKECGDLCPGTLEEKPMCEKTTINNEYNYRCWTTNRCQKMCPSV
                     CGKRACTENNECCHPECLGSCHTPDDNTTCVACRHYYYKGVCVPACPPGTYRFEGWRC
                     VDRDFCANIPNAESSDSDGFVIHDGECMQECPSGFIRNSTQSMYCIPCEGPCPKVCGD
                     EEKKTKTIDSVTSAQMLQGCTILKGNLLINIRRGNNIASELENFMGLIEVVTGYVKIR
                     HSHALVSLSFLKNLRLILGEEQLEGNYSFYVLDNQNLQQLWDWNHRNLTVRSGKMYFA
                     FNPKLCVSEIYRMEEVTGTKGRQSKGDINTRNNGERASCESDVLRFTSTTTWKNRIII
                     TWHRYRPPDYRDLISFTVYYKEAPFKNVTEYDGQDACGSNSWNMVDVDLPPNKEGEPG
                     ILLHGLKPWTQYAVYVKAVTLTMVENDHIRGAKSEILYIRTNASVPSIPLDVLSASNS
                     SSQLIVKWNPPTLPNGNLSYYIVRWQRQPQDGYLFRHNYCSKDKIPIRKYADGTIDVE
                     EVTENPKTEVCGGDKGPCCACPKTEAEKQAEKEEAEYRKVFENFLHNSIFVPRPERRR
                     RDVLQVANTTMSSRSRNTTVADTYNITDPEEFETEYPFFESRVDNKERTVISNLRPFT
                     LYRIDIHSCNHEAEKLGCSASNFVFARTMPAEGADDIPGPVTWEPRPENSIFLKWPEP
                     ENPNGLILMYEIKYGSQVEDQRECVSRQEYRKYGGAKLNRLNPGNYTARIQATSLSGN
                     GSWTDPVFFYVPAKTTYENFMHLIIALPVAILLIVGGLVIMLYVFHRKRNNSRLGNGV
                     LYASVNPEYFSAADVYVPDEWEVAREKITMNRELGQGSFGMVYEGVAKGVVKDEPETR
                     VAIKTVNEAASMRERIEFLNEASVMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDL
                     KSYLRSLRPEVEQNNLVLIPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVA
                     EDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTTHSDVWSFGVVL
                     WEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFL
                     EIIGSIKDEMEPSFQEVSFYYSEENKPPEPEELEMELELEPENMESVPLDPSASSASL
                     PLPERHSGHKAENGPGVLVLRASFDERQPYAHMNGGRANERALPLPQSSTC"
     exon            1050..1595
                     /gene="Igf1r"
                     /gene_synonym="IGF-1 receptor; IGFIRC; Igfr1; JTK13"
                     /inference="alignment:Splign:2.1.0"
     exon            1596..1908
                     /gene="Igf1r"
                     /gene_synonym="IGF-1 receptor; IGFIRC; Igfr1; JTK13"
                     /inference="alignment:Splign:2.1.0"
     exon            1909..2060
                     /gene="Igf1r"
                     /gene_synonym="IGF-1 receptor; IGFIRC; Igfr1; JTK13"
                     /inference="alignment:Splign:2.1.0"
     exon            2061..2205
                     /gene="Igf1r"
                     /gene_synonym="IGF-1 receptor; IGFIRC; Igfr1; JTK13"
                     /inference="alignment:Splign:2.1.0"
     exon            2206..2420
                     /gene="Igf1r"
                     /gene_synonym="IGF-1 receptor; IGFIRC; Igfr1; JTK13"
                     /inference="alignment:Splign:2.1.0"
     exon            2421..2547
                     /gene="Igf1r"
                     /gene_synonym="IGF-1 receptor; IGFIRC; Igfr1; JTK13"
                     /inference="alignment:Splign:2.1.0"
     exon            2548..2786
                     /gene="Igf1r"
                     /gene_synonym="IGF-1 receptor; IGFIRC; Igfr1; JTK13"
                     /inference="alignment:Splign:2.1.0"
     exon            2787..2954
                     /gene="Igf1r"
                     /gene_synonym="IGF-1 receptor; IGFIRC; Igfr1; JTK13"
                     /inference="alignment:Splign:2.1.0"
     exon            2955..3159
                     /gene="Igf1r"
                     /gene_synonym="IGF-1 receptor; IGFIRC; Igfr1; JTK13"
                     /inference="alignment:Splign:2.1.0"
     exon            3160..3443
                     /gene="Igf1r"
                     /gene_synonym="IGF-1 receptor; IGFIRC; Igfr1; JTK13"
                     /inference="alignment:Splign:2.1.0"
     exon            3444..3580
                     /gene="Igf1r"
                     /gene_synonym="IGF-1 receptor; IGFIRC; Igfr1; JTK13"
                     /inference="alignment:Splign:2.1.0"
     exon            3581..3740
                     /gene="Igf1r"
                     /gene_synonym="IGF-1 receptor; IGFIRC; Igfr1; JTK13"
                     /inference="alignment:Splign:2.1.0"
     exon            3741..3843
                     /gene="Igf1r"
                     /gene_synonym="IGF-1 receptor; IGFIRC; Igfr1; JTK13"
                     /inference="alignment:Splign:2.1.0"
     exon            3844..3914
                     /gene="Igf1r"
                     /gene_synonym="IGF-1 receptor; IGFIRC; Igfr1; JTK13"
                     /inference="alignment:Splign:2.1.0"
     exon            3915..4144
                     /gene="Igf1r"
                     /gene_synonym="IGF-1 receptor; IGFIRC; Igfr1; JTK13"
                     /inference="alignment:Splign:2.1.0"
     exon            4145..4255
                     /gene="Igf1r"
                     /gene_synonym="IGF-1 receptor; IGFIRC; Igfr1; JTK13"
                     /inference="alignment:Splign:2.1.0"
     exon            4256..4418
                     /gene="Igf1r"
                     /gene_synonym="IGF-1 receptor; IGFIRC; Igfr1; JTK13"
                     /inference="alignment:Splign:2.1.0"
     exon            4419..4548
                     /gene="Igf1r"
                     /gene_synonym="IGF-1 receptor; IGFIRC; Igfr1; JTK13"
                     /inference="alignment:Splign:2.1.0"
     exon            4549..4683
                     /gene="Igf1r"
                     /gene_synonym="IGF-1 receptor; IGFIRC; Igfr1; JTK13"
                     /inference="alignment:Splign:2.1.0"
     exon            4684..12368
                     /gene="Igf1r"
                     /gene_synonym="IGF-1 receptor; IGFIRC; Igfr1; JTK13"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agagccccca gtgtgtggcg gcggcggcgc ggtgaggctg aggttcttgt ttaccagcat
       61 taactccgct gagcggaaaa aaaggaggag ggggaaccga ggaggagcga gcgcaccggg
      121 cgaactcgag agaggcgagc gacagggaag ccgccagcga gcctatcccg gcgcgcccgg
      181 cgctcgcaga ccctcggccc cgctccttgg accctccacg cctctcccgt gcctgcaaga
      241 gctccacggc acgcggcgtg ctcggctttg accttcagcg agccggagcc cccgcgcacg
      301 gagtcggcgg cgggcggggg ccgacgcggg gcggcgggag cgctgagcgc tgcgcggccg
      361 ccgctttgtg tgtcctggat ttggatttgg gaaggagctc gcggcggcgg cgctgaggga
      421 ggaggcggcg gcgagcggag cccagaggag gaggaggagc cggaggaggg ggaaccgctc
      481 attcatttcc actcagcatt tctgcccctc gccggcctcg cccgcgcccg ggacttcgga
      541 ccagtctcgc caactgcgtc gggctctccc gccgcgtagg ctcgggtggt cgttccctcc
      601 gggaatcggg ggcgtttgtc cccgcctgcg gcgatttggg ctttgctcct ctttctgtac
      661 agttttcctc cctcttctgc atctctgggt ttgcaaatgg aggccgacga caccgacagc
      721 ccgccccggc gcgccccggc ttccctactc cgccgccccg tgggccgctg ctgccggcgc
      781 tgaggggccg ccccgcgcca ccctccctgt ccacgccgct ttccgaggat cttcgctctt
      841 gtttttggac gagagtgagg actgagttga agactttttt cttttttttt tcttttcttt
      901 tcttttcttt tctttttttt tttgagaaaa gggaattttg tcccaaataa aaggaatgaa
      961 gtctggctcc ggaggagggt ccccgacctc gctgtggggg ctcgtgtttc tctccgccgc
     1021 gctctcgctc tggccgacga gtggagaaat ttgtgggccc ggcattgaca tccgcaacga
     1081 ctatcagcag ctgaagcgcc tggaaaactg cacggtgatc gagggcttcc tccacatcct
     1141 gctcatctcc aaggccgagg actaccgaag ctaccgcttc cccaagctca cggtcatcac
     1201 cgagtacttg ctgctgtttc gagtggccgg cctcgagagc ctgggagacc tcttcccgaa
     1261 cctcacagtc atccgtggct ggaaactctt ctacaattac gcactggtca tcttcgagat
     1321 gaccaatctc aaggatattg ggctttataa tctgaggaac attactcggg gggccatcag
     1381 gattgagaaa aacgctgacc tctgttacct ctccaccata gactggtctc tcatcttgga
     1441 tgcggtgtcc aataactaca ttgtggggaa caagccccca aaggaatgtg gggacctgtg
     1501 tccagggacc ttggaggaga agcccatgtg tgagaagacc accatcaaca atgagtacaa
     1561 ctaccgctgc tggaccacaa atcgctgcca gaaaatgtgc ccaagtgtgt gtgggaagcg
     1621 agcctgcacc gagaacaatg agtgctgcca cccggagtgc ctaggcagct gccacacacc
     1681 ggacgacaac acaacctgcg tggcctgccg acactactac tacaaaggcg tgtgcgtgcc
     1741 tgcctgcccg cctggcacct acaggttcga gggctggcgc tgtgtggacc gggatttctg
     1801 cgccaacatc cccaacgccg agagcagtga ctcagatggc ttcgtcatcc acgatggcga
     1861 gtgcatgcag gagtgtccat caggcttcat ccgcaacagc acccagagca tgtactgtat
     1921 cccctgtgaa ggcccctgcc ccaaggtctg cggcgatgaa gaaaagaaaa cgaaaaccat
     1981 cgattctgtg acgtctgccc agatgctcca agggtgcacc attttgaagg gcaatctgct
     2041 tattaacatc cggcgaggca ataacattgc ctcggaattg gagaacttca tggggctcat
     2101 cgaggtggtg actggctacg tgaagatccg ccattcccat gccttggtct ccttgtcctt
     2161 cctgaagaac cttcgtctca tcttaggaga ggagcagcta gaagggaact actccttcta
     2221 tgtcctggac aaccagaact tgcagcagct gtgggactgg aaccaccgga acctgaccgt
     2281 caggtcaggg aaaatgtact tcgctttcaa tcccaagctg tgtgtctctg aaatttaccg
     2341 gatggaggag gtgacaggaa caaagggacg gcagagcaaa ggagacataa acaccaggaa
     2401 caacggagag cgagcttcct gtgaaagtga tgttctccgt ttcacctcca ccaccacctg
     2461 gaagaaccgc atcatcataa cgtggcaccg gtaccggccg ccggactacc gggatctcat
     2521 cagtttcaca gtctactaca aggaggcacc ctttaaaaac gtcacggaat acgacgggca
     2581 ggatgcctgt ggctccaaca gctggaacat ggtggacgtg gacctgcctc cgaacaagga
     2641 gggggagcct ggcattttgc tgcatgggct gaagccctgg acccagtatg cagtctatgt
     2701 caaggctgtg accctcacca tggtggaaaa cgaccacatc cgtggggcca aaagtgaaat
     2761 cttgtacatt cgcaccaacg cttcagttcc ttccattcct ctagatgtcc tctcggcatc
     2821 aaactcctcc tctcagctga tcgtgaagtg gaacccccca actctgccca atggtaactt
     2881 gagttactac attgtgaggt ggcagcggca gccgcaggat ggctatctgt tccggcacaa
     2941 ctactgctcc aaagacaaaa tacccatcag aaagtacgcc gatggtacca tcgatgtgga
     3001 ggaggtgaca gaaaatccca agacagaagt gtgcggtggt gataaagggc cgtgctgtgc
     3061 ctgtcctaaa accgaagctg agaagcaggc tgagaaggag gaggctgagt accgtaaagt
     3121 ctttgagaat ttccttcaca actccatctt tgtgcccaga cctgagagga ggcggagaga
     3181 tgtcctgcag gtggctaaca ccaccatgtc cagccgaagc aggaacacca cggtagctga
     3241 cacctacaat atcacagacc cggaagagtt cgagacagaa taccctttct ttgagagcag
     3301 agtggataac aaggagagga ctgtcatttc caacctccgg cctttcactc tgtaccgtat
     3361 cgatatccac agctgcaacc acgaggctga gaagctgggc tgcagcgcct ccaactttgt
     3421 ctttgcaaga accatgccag cagaaggagc agatgacatt cctggcccag tgacctggga
     3481 gccaagacct gaaaactcca tctttttaaa gtggccagaa cccgagaacc ccaacggatt
     3541 gattctaatg tatgaaataa aatacggatc gcaagtcgag gatcagcggg aatgtgtgtc
     3601 cagacaggag tacaggaagt atggaggggc caaacttaac cgtctaaacc cagggaacta
     3661 tacggcccgg attcaggcta cctccctctc tgggaatggg tcgtggacag atcctgtgtt
     3721 cttctatgtc ccagccaaaa caacgtatga gaatttcatg catctgatca ttgctctgcc
     3781 ggttgccatc ctgctgattg tggggggcct ggtaatcatg ctgtatgtct tccatagaaa
     3841 gaggaataac agcagattgg gcaacggggt gctgtacgcc tctgtgaacc ccgagtattt
     3901 cagcgcagct gatgtgtacg tgcctgatga atgggaggta gctcgggaga agatcaccat
     3961 gaaccgggag ctcggacaag ggtccttcgg gatggtctat gaaggagtgg ccaagggcgt
     4021 ggtcaaggac gagcctgaaa ccagagtggc catcaagaca gtgaatgagg ctgcaagtat
     4081 gcgtgagaga attgagtttc tcaacgaggc ctcagtgatg aaggagttca actgtcacca
     4141 tgtggtccgg ttgctgggtg tagtatccca aggccagccc accctggtca tcatggaact
     4201 aatgacacgt ggcgatctca aaagttatct ccggtctcta aggccagagg tggagcagaa
     4261 taatctagtc ctgattcctc cgagcttaag caagatgatc cagatggctg gagagattgc
     4321 agatggcatg gcctacctca atgccaacaa gttcgtccac agagacctgg ctgctcggaa
     4381 ctgcatggta gctgaagatt tcacagtcaa aattggagat tttggtatga cacgagacat
     4441 ctacgagacg gactactacc ggaaaggcgg gaagggcttg ctgcctgtgc gctggatgtc
     4501 tcccgagtcc ctcaaggatg gcgtcttcac cactcattcc gatgtctggt cctttggggt
     4561 cgtcctctgg gagatcgcca ctctggctga gcagccgtac cagggcctgt ccaacgagca
     4621 agttcttcgt ttcgtcatgg agggcggcct tctggacaag ccggataact gccccgatat
     4681 gctgtttgaa cttatgcgca tgtgctggca gtacaacccc aagatgcggc cctccttcct
     4741 ggagatcatc ggaagcatca aggatgagat ggagcccagt ttccaggagg tctccttcta
     4801 ctacagcgag gagaacaagc ctccagagcc ggaggagctg gagatggagc tggagctgga
     4861 gcccgagaac atggagagcg tcccgctgga cccttcggcc tcctcagcct ccctgcctct
     4921 gcctgaaaga cactcaggac acaaggctga gaacggccct ggcgtgctgg ttctccgtgc
     4981 cagttttgat gagagacagc cttacgctca catgaatggg ggacgcgcca acgagagggc
     5041 cttgcctctg ccccagtcct caacctgctg atcctcggac cccgaagcac gtgcaaacag
     5101 taacgtgtgt gtgtgtgtgc gtgcgtgcgt gtgtgctcac tcggtgggcg gaggggggag
     5161 caggttgtaa caatctattc acaagcctcc tgtatctcag tggatcttca gaactgccct
     5221 tgctgcccac gggagtcggc ttctctgcag taaacacact tgggaccttc cttttttcaa
     5281 tatgcaagca gcttttttta tttccctacc caaaccctta actgacatgg gcctctgcaa
     5341 accttaatga cagctcttaa tagcaacagg acactcgaga attgagtctc ctcattctct
     5401 gccttttctc tcttctgcct tccctctctc tcctctccct tcccacttcc aggctctcct
     5461 ctcttttctc cgcttcccag tggaaagccc agcggggaag cctttattta ttttttttta
     5521 aatcaaattg acttaatggc tgccctgggg ctcctcatca cacctgcctg acaccatagg
     5581 tctttacaaa aaagaaagga aaaaaaaaaa aaaggaaaaa aaaaatcaca cactgagatg
     5641 gaattttttt aactgtacct ttaacctttt ttagggtcat ccaaaaattt aaaagggcca
     5701 ttgttcatct gtggttatca ttttcacgct gccatttttg ccaaaatcct gtcttcggtt
     5761 tggtttctct ctcacatgcg tgttctccct gcgctgattt ccttttgtcc agaggcatgg
     5821 gaagaaacgt ggagtctggt tgataatacc acttgcgaga cacgccgtca tcgaggcctc
     5881 cactgtgccc ggtgtgctct cctagcccac gtcccctggg tctgtttagg agaactggac
     5941 aagatggaat ccgccctcct tgaagaaggg gaaagtggaa ctggttctcg acccctaccc
     6001 cacccacagc cccccaagat ttctggagga aatggccatg ggcaaggctg aaggtcaggt
     6061 tgtgggtcaa ggtggtcctc ataccagcct cgtccccctt cccagcctcc ctcctggcat
     6121 ccccgaaggc cacaagatgt aaaagggttg cagggactcg gcccaggtac tggtccagat
     6181 gtgtgaggaa gggactcaga cacacagcag tatggagcag cccaggcagt ggctcccagc
     6241 agtctacgct ttgacatggt ctgttactag gacttcttca tgggtctctc agttctatgt
     6301 tagaccctga aacatttgca tacgcatcgt ctttaatgtc agttttataa cttttttaca
     6361 gttcagatat acatctatac gtctgtacag gaaaaaaaaa gctgctattt ttttttttgt
     6421 tgttgttgtt ctttatcttt gtggatttaa tctatgaaac tttcaggtct acccttcttc
     6481 ctttccaagc tcactccaag aaactcccta tgcttactag agtgtggttt ttcttcctct
     6541 tctcccgcaa ctgatgcttc taggacataa tttgccatga actgtttgat gcctttttat
     6601 aaatatatct cccttcccct gctccctgaa gccccgttca ttatcctcta acccataggc
     6661 tctgtgagca cagtcgctgt taagggagtg gggaggatgg gaggccagag cccacgtact
     6721 cctgggccct gctctctctt ttctgcacct cccggcacac agcgttggag tctgttacag
     6781 tacatggcat gccacaaact caggtcagaa acaacatggt taaaaaatct cacacatcct
     6841 ggtttagtgt ttccagtccc cactgttgaa agtcacactt tgctttctct ctttgctttg
     6901 attgacacac acacacacat acaacacaca cacacacata caacacacac acacacatac
     6961 aacacacaca cacacacaca tcaattttgg gatacaatag cagttttaac tgcagacggt
     7021 agtcattgga ttatttttgt tttaaaatga atatttgatc ttctacaaaa aaacaaaaca
     7081 gaaaacagct gctgagtccc cagggcacag cagagctggc ccagtggccc atcggccacc
     7141 ttgccatctc cttcactaga ctgacccacc tgtctttaga accaacatgt ctgaaggggt
     7201 ggcctccaca tgaagtgggt gtaaggcacc aacaccccat ggccaggaac agcaacttca
     7261 acttctgtgg gttctaaagc ccactcctgg gtcagaaggc ccaagtgaca ggaggagcag
     7321 agatgaccct gcggtggccc tagggccctt tgctgttcct ccttaaccag aatcccagct
     7381 ctctgggcct gtgggtcctg ctctgtttag tttttagcac ttcttaccag agtagtgaca
     7441 gcatgagaga cacttctggg tgggaatatt taaatcagga gtaaaagaaa cgttggaaga
     7501 tgatgattgc agttgtgact ggagattaga cacagaaaag aaagcgtgga gctccgggct
     7561 tgtctgcatt ttcaggctca cggctctccc tagcgtctgc cccacggtgt ttccccgtaa
     7621 cagaaataga gaaaaggagg agggggaaaa gcttatgaag aaggtatttc atgtaggagt
     7681 tgtaatttat tttgtgatgc ctgttttaat cactgtagag aagcccccca ttatgaattt
     7741 aaatgctaag gaaaaggtgt atgtatctct gtgtatgtgt gtattagatg ggacagtttt
     7801 tgttttgggg ggtgttttgt ttttcaaaca tttatctacc tcactcttgt ttttcgtgtg
     7861 tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg taaaatacat
     7921 ctcacacttc tcagtacctg acagtaggcc aatgacactg gtaacctcat ccactctata
     7981 ggccacatac ccaggggaag cagaggggct aggctggatt ctggggtcaa agcaacacta
     8041 actcaaatca gcctcttccc gatctatccc caaaagccca cctttcctag ggcaactttg
     8101 gtctttcacc tcacctgatt ccctactttg aacccagcaa ccaccatgag cacagagcat
     8161 gccagtggag ggggtcacct gcccatctca gctggctgac tttggaacag aactttatac
     8221 agattgaatg actgacagat tctatcccta agagagcagg tactcccagg ttttgagggc
     8281 aggaggcacc cacacatagg ttgtctgaga gtcccaatgt gtgcacatgt aagggtgccc
     8341 tgttggcccc tcagctgctc ctctgagacc tgcacccgcg gcaggggcat gccaccattg
     8401 ctctctttgc atcagttcct cttagaggta caacagtcag ggagctctcc tctcaccctc
     8461 tgcttctgac agaaggccag tataataaag ggggcaagac aaagcctgcg ccccctgcag
     8521 gctgctgtcc ttccctcctc ctcccccctc accccgcccc cccagggcta aacaaggact
     8581 gaccaaatct tgaggctgga aggccagtgg ttggcaccta gccttccctg tgctctgcct
     8641 ctgtccaccc catccatctg ctgctcacgg gtggacagtg cactcctcaa ctccagcagc
     8701 tgctctcaca ggccctgggg actttagctg agaaacatgg tggctgatct tttccccaca
     8761 gtgtggagaa ctgcctaaca gttcagttaa gctcaggggc ctttgcctcc tgccagaatg
     8821 ctgccttctc tgggttccaa gatgctcaca gggtcactgg gagaaactgt ttgatcaggg
     8881 ttttcttcta cactgtgggt gacttctctg gtatagtggc ctctcctctc ttgcacatac
     8941 ctgccggttt tccacaactg gatttctaca gctcactcaa ttgattttta aggatttttc
     9001 tttttcttat ttttaaaact gtccgagttg ttggtgtcct tttgttttgc gtgggtgttt
     9061 tgtttttttt tttttcttta agtagagaga cggcactaac ggtgtagtgt ccatcatagc
     9121 aaatgctcca aaaatacttc agtaaaagaa aaagtcagct tgtgtgaggg tgcagtcatc
     9181 ctgctggatc gacccaccct gaccgttgca aggcatcata tccacagttc tagcctgatc
     9241 tcacgctggt gttccccgcc tcttcctgat ttttctcctt atgtgcttca agtaatcttt
     9301 ccaagctgag ttgtggcctt tttcacgcac ccccctcctc tgataggagc tcacactgct
     9361 tgaagtaaca cgaaccactg aggcacagca tgcaggcgac gcaagtgttc aggtgttccc
     9421 cacacacaca caacccttcc tgaatcgcgg agtcgaacct gagctgtgcg aggcccacgc
     9481 ttcccccacc tcctttcagg aatgccctaa cattggattc atagttgggg atgaggcttc
     9541 ctccttgaga tataaaagac tgttcaaggc catcactggt ctctcctgcc tgcctgtttt
     9601 ctttaggact cgggacaatt caatggtggg aaaagcagct tcataaaaca gaagggtgat
     9661 catcgtggga tgagcagatg gcggagtggt acacgggagt gtttctaggg ggcctgacag
     9721 atgagctctg tctgtgtgat gccagttgta agtctgagct cccggagcct ggcccttagg
     9781 agcccaccta tgttggcaat ggccgtacct gaggcaagca agtggtgctg gcaaggtcac
     9841 gctgagctca catgggtgag aagtccggga tgcttaccca aggtcctcag ttgtcgttgt
     9901 tgggtcctct tgagagtggc cacacagtgc taaaggcaac tcccttctta aacattggca
     9961 tcctgcagga gacaggacca ccccatccca gtgcttcagc ccattttagc agtaatgaat
    10021 ttacggtttg gattcttttg ttttgttttt aatgttactt ttatgtctgt ctgatgcctt
    10081 ttcatttcct gggctaagca gttgcattgg gaaacctgga ccagagagat tcactcctta
    10141 agaaccagtg atggtcaaat cttatcactc cactttgaag taggtggagg ttcaaatgag
    10201 aacttcaaga caggatgttt gtttaaaatt gaacccctct tgccagagat gctgaagtta
    10261 cagaccttgg acaggccagg ggtctttgct ttgggtctcc aacttggatg gccagttggc
    10321 aatttagagg gacgaacatt ctgtgatggg atggcagagt gattgagggt gcagtaggaa
    10381 actatggtaa ccggcatcat gacgagacag gaattgctga cagaggggta aagggcctgg
    10441 aagaagcatg gaccacatct ggacctgatg gttcctgaag gtgtcaggac cacacggagg
    10501 ctgtggagtc atctgtgggc ttttggtgtc agataagaaa ctcggcatcc tgctctgggg
    10561 acttctccaa gagctaagcc acatgctgaa gaactcggac gccatcacgc tcatcagatg
    10621 agtggtcagt ctggggcatg acgttaggga tttgatttct cttatttctg tgagagcttc
    10681 ataatcactg atttgtgtgt ccacatttgt gtccgcatct ttccattact cattatcgtg
    10741 tccaataggg cttctaagtc cagtagatta cgggtagtcg ttgacgaaga tctggtttac
    10801 aagaactaat taaatgtttc attgcatttt tgtaagaaca tagaataatt ttataaaatg
    10861 tttgtagttt ataattgccg aaataattta aaaacacctt tttttcctct ccgtgtgcaa
    10921 aaaaatatgt gtttgtggtc tttttttttc cctttgtttt cttttttctt tttcttttct
    10981 ttgttttttt ttttgacact tgtttactag ctagctttac aatatgccaa aaataaaaaa
    11041 taaaaaattt ttaaaaaatt aattaattaa aaaaattctc cccgggaccc aaattgtggt
    11101 tcgccccttt cccatatgct ttctgctcta gtttgtaaaa aataaaaatt tttaaaaaaa
    11161 attaaaacaa aacaaaaaaa aagacaaaag gaatgccagt ggtttaaaaa gtacttctga
    11221 attcttcagt atcttggtct tggaaccctg tgctggggaa tggaattatc tgttacttac
    11281 tgttcccggt ggagtatagc cgcctaaaca gatagaacga accaagaatc tcgctggcca
    11341 tggaagtagt gggtgtgttg ccacccagca agagatggca ctcactggtg acatctggct
    11401 ggtgtggctg attctagtct tgcaacacgg tggagatggg agggtttcag gacacttgag
    11461 aggcttcaca gtggtcacat gattctgttg tgcaggccat gggcacatgt gcctcaggcc
    11521 ctaatgaaag ctgtgcctac ctgtatttaa tgccgaacgc tgaaggtcca tttttttttt
    11581 aaccaataca gaacaaactg gtaacaaaaa ccacagcgtg tgccccctca tccccccccc
    11641 ctgtttttta gaattaaaat ccatgtcctt tggctccctg tgcattattg gccgtgtctc
    11701 tatggttcca caagacaccg ttgttgagaa catctggaac tttctaacac tacaggagaa
    11761 aggtctagga accgtcggtg ggtttggtat ggttttttca gtttcttgtg gatttcaggc
    11821 agtgtgcaga cacagtaccc aggcacgggt gcctgccggt ggcatcccct gtctgcttcc
    11881 taagccagtg aggttgaggt gagaactttg ccagagctta tctacctctg ggattttaaa
    11941 aaataataaa taaataaagt caaatcagaa agcgggacgg aacagatgca tcgtcaataa
    12001 tgcatttctg agttttcttg ttaaattttt tcttaaaaaa gaaaaaaaag tctaaaaaag
    12061 ataaatatgg ccaatttgtt acataaaata actttctgtg tgtaaattat tcctaaaaaa
    12121 aaaaaaaccc tctgtttata tataaaaaaa aatcagtaga tgaaaaaaaa ttcaatgttt
    12181 ttgtatattc tgttgtaaga atttattcct gttgcggcaa catactcggg actctttaca
    12241 ttatgaaaaa aagaaacttt gtctattttg aatggctgaa gctaaggcca cttgagtcta
    12301 ttactctgct tttttctagt agttaaagta ccacatgaat taagttaaat aaaagaattc
    12361 tgtatgca
//
