LOCUS       NM_001082479            1827 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Rattus norvegicus insulin-like growth factor 1 (Igf1), transcript
            variant 4, mRNA.
ACCESSION   NM_001082479
VERSION     NM_001082479.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1827)
  AUTHORS   Xiong,J., Wang,Y., Wang,H., Luo,J., Chen,T., Sun,J., Xi,Q. and
            Zhang,Y.
  TITLE     GHRH-stimulated pituitary small extracellular vesicles inhibit
            hepatocyte proliferation and IGF-1 expression by its cargo
            miR-375-3p
  JOURNAL   J Nanobiotechnology 22 (1), 649 (2024)
   PUBMED   39438882
  REMARK    GeneRIF: GHRH-stimulated pituitary small extracellular vesicles
            inhibit hepatocyte proliferation and IGF-1 expression by its cargo
            miR-375-3p.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1827)
  AUTHORS   Maleki,A.H., Azar,J.T., Razi,M. and Tofighi,A.
  TITLE     The Effect of Different Exercise Modalities on Sertoli-germ Cells
            Metabolic Interactions in High-fat Diet-induced Obesity Rat Models:
            Implication on Glucose and Lactate Transport, Igf1, and
            Igf1R-dependent Pathways
  JOURNAL   Reprod Sci 31 (8), 2246-2260 (2024)
   PUBMED   38632221
  REMARK    GeneRIF: The Effect of Different Exercise Modalities on
            Sertoli-germ Cells Metabolic Interactions in High-fat Diet-induced
            Obesity Rat Models: Implication on Glucose and Lactate Transport,
            Igf1, and Igf1R-dependent Pathways.
REFERENCE   3  (bases 1 to 1827)
  AUTHORS   Banjac,K., Obradovic,M., Zafirovic,S., Essack,M., Gluvic,Z.,
            Sunderic,M., Nedic,O. and Isenovic,E.R.
  TITLE     The involvement of Akt, mTOR, and S6K in the in vivo effect of
            IGF-1 on the regulation of rat cardiac Na+/K+-ATPase
  JOURNAL   Mol Biol Rep 51 (1), 517 (2024)
   PUBMED   38622478
  REMARK    GeneRIF: The involvement of Akt, mTOR, and S6K in the in vivo
            effect of IGF-1 on the regulation of rat cardiac Na[+]/K[+]-ATPase.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1827)
  AUTHORS   Barik,P., Kuo,W.W., Kuo,C.H., Hsieh,D.J., Day,C.H., Daddam,J.,
            Chen,M.Y., Padma,V.V., Shibu,M.A. and Huang,C.Y.
  TITLE     Rewiring of IGF1 secretion and enhanced IGF1R signaling induced by
            co-chaperone carboxyl-terminus of Hsp70 interacting protein in
            adipose-derived stem cells provide augmented cardioprotection in
            aging-hypertensive rats
  JOURNAL   Aging (Albany NY) 15 (23), 14019-14038 (2023)
   PUBMED   38085649
  REMARK    GeneRIF: Rewiring of IGF1 secretion and enhanced IGF1R signaling
            induced by co-chaperone carboxyl-terminus of Hsp70 interacting
            protein in adipose-derived stem cells provide augmented
            cardioprotection in aging-hypertensive rats.
REFERENCE   5  (bases 1 to 1827)
  AUTHORS   Zhao,H., Wang,L., Yan,Y., Zhao,Q.H., He,J., Jiang,R., Luo,C.J.,
            Qiu,H.L., Miao,Y.Q., Gong,S.G., Yuan,P. and Wu,W.H.
  TITLE     Identification of the shared gene signatures between pulmonary
            fibrosis and pulmonary hypertension using bioinformatics analysis
  JOURNAL   Front Immunol 14, 1197752 (2023)
   PUBMED   37731513
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1827)
  AUTHORS   Nanto-Salonen,K. and Rosenfeld,R.G.
  TITLE     Insulin-like growth factor binding protein expression in the
            hypothyroid rat is age dependent
  JOURNAL   Endocrinology 131 (3), 1489-1496 (1992)
   PUBMED   1380443
REFERENCE   7  (bases 1 to 1827)
  AUTHORS   Hall,L.J., Kajimoto,Y., Bichell,D., Kim,S.W., James,P.L.,
            Counts,D., Nixon,L.J., Tobin,G. and Rotwein,P.
  TITLE     Functional analysis of the rat insulin-like growth factor I gene
            and identification of an IGF-I gene promoter
  JOURNAL   DNA Cell Biol 11 (4), 301-313 (1992)
   PUBMED   1605853
REFERENCE   8  (bases 1 to 1827)
  AUTHORS   Bouillon,R.
  TITLE     Diabetic bone disease. Low turnover osteoporosis related to
            decreased IGF-I production
  JOURNAL   Verh K Acad Geneeskd Belg 54 (4), 365-91 (1992)
   PUBMED   1466160
REFERENCE   9  (bases 1 to 1827)
  AUTHORS   Nanto-Salonen,K., Glasscock,G.F. and Rosenfeld,R.G.
  TITLE     The effects of thyroid hormone on insulin-like growth factor (IGF)
            and IGF-binding protein (IGFBP) expression in the neonatal rat:
            prolonged high expression of IGFBP-2 in methimazole-induced
            congenital hypothyroidism
  JOURNAL   Endocrinology 129 (5), 2563-2570 (1991)
   PUBMED   1718729
REFERENCE   10 (bases 1 to 1827)
  AUTHORS   Kato,H., Okoshi,A., Miura,Y. and Noguchi,T.
  TITLE     A new cDNA clone relating to larger molecular species of rat
            insulin-like growth factor-I mRNA
  JOURNAL   Agric Biol Chem 54 (6), 1599-1601 (1990)
   PUBMED   1368571
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB751206.1, BC086374.1 and CB761687.1.
            
            Transcript Variant: This variant (4) lacks an alternate
            frame-shifting exon in the 3' coding region, compared to variant 3,
            resulting in a protein (isoform d) with a novel C-terminus,
            compared to isoform c. This isoform is also known as IA.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M17335.1, CF108511.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-343               CB751206.1         48-390
            344-948             BC086374.1         47-651
            949-1688            BC086374.1         653-1392
            1689-1827           CB761687.1         291-429
FEATURES             Location/Qualifiers
     source          1..1827
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q13"
     gene            1..1827
                     /gene="Igf1"
                     /gene_synonym="IGF"
                     /note="insulin-like growth factor 1"
                     /db_xref="GeneID:24482"
                     /db_xref="RGD:2868"
     exon            1..343
                     /gene="Igf1"
                     /gene_synonym="IGF"
                     /inference="alignment:Splign:2.1.0"
     CDS             281..742
                     /gene="Igf1"
                     /gene_synonym="IGF"
                     /note="isoform d preproprotein is encoded by transcript
                     variant 4; somatomedin; IGF-I; Insulin-like growth factor
                     I"
                     /codon_start=1
                     /product="insulin-like growth factor 1 isoform d
                     preproprotein"
                     /protein_id="NP_001075948.1"
                     /db_xref="GeneID:24482"
                     /db_xref="RGD:2868"
                     /translation="MGKISSLPTQLFKICLCDFLKIKIHIMSSSHLFYLALCLLTFTS
                     SATAGPETLCGAELVDALQFVCGPRGFYFNKPTGYGSSIRRAPQTGIVDECCFRSCDL
                     RRLEMYCAPLKPTKSARSIRAQRHTDMPKTQKEVHLKNTSRGSAGNKTYRM"
     exon            344..500
                     /gene="Igf1"
                     /gene_synonym="IGF"
                     /inference="alignment:Splign:2.1.0"
     exon            501..682
                     /gene="Igf1"
                     /gene_synonym="IGF"
                     /inference="alignment:Splign:2.1.0"
     exon            683..1827
                     /gene="Igf1"
                     /gene_synonym="IGF"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aagagggaga gagagagaag gcgaatgttc ccccagctgt ttcctgtcta cagtgtctgt
       61 gttttgtaga taaatgtgag gattttctct aaatccctct tctgcttgct aaatctcact
      121 gtcgctgcta aattcagagc agatagagcc tgcgcaatcg aaataaagtc ctcaaaattg
      181 aaatgtgact ttgctctaac atctcccatc tctctggatt tctttttgcc tcattattcc
      241 tgcccaccaa ttcatttcca gactttgtac ttcagaagcg atggggaaaa tcagcagtct
      301 tccaactcaa ttatttaaga tctgcctctg tgacttcttg aagataaaga tacacatcat
      361 gtcgtcttca catctcttct acctggcact ctgcttgctc acctttacca gctcggccac
      421 agccggacca gagacccttt gcggggctga gctggtggac gctcttcagt tcgtgtgtgg
      481 accaaggggc ttttacttca acaagcccac aggctatggc tccagcattc ggagggcacc
      541 acagacgggc attgtggatg agtgttgctt ccggagctgt gatctgagga ggctggagat
      601 gtactgtgct ccgctgaagc ctacaaagtc agctcgttcc atccgggccc agcgccacac
      661 tgacatgccc aagactcaga aggaagtaca cttgaagaac acaagtagag gaagtgcagg
      721 aaacaagacc tacagaatgt aggaggagcc tcccgaggaa cagaaaatgc cacgtcaccg
      781 caagatcctt tgctgcttga gcaacctgca aaacatcgga acacctgcca aatatcaata
      841 atgagttcaa taccatttca gagatgggca tttccctcaa tgaaatacac aagtaaacat
      901 tccgacattg tctttaggag tgtttgttaa aaaaaaaaaa aaaaaaaaca aaaacaaaaa
      961 caaaaaaaaa aagctttgca ccttgcaaaa gtggtcctgg cgtgggtaga ttgctgttaa
     1021 tcctttatca ataacgttct atagagaata tataaatata tatataatta tatctcctag
     1081 tccctgcctc ttaagagccg aaaatgcatg ggtgttgtag acattcggtt gcactaaatt
     1141 cctctctgaa ttttggctgc tgaagccgtt catttagcaa ctgtttatag gtggttgatg
     1201 aatggttcct tatctccatt tcttcctatg tagcttaagc cgcttccttc acagaatcta
     1261 ataatctcgt ctaggccatt agccctgccc tttcttaaca ttcttgtatt tgttgaattt
     1321 ggcctcctcg aaagcaatag caactgggtg gcccacccaa gttttaacgc ccctgattcc
     1381 atctatggca tttgtaccaa atataagttg gatgcattta ttttagacac aaagctttat
     1441 tttttcgaca tcgtgtttca agaaaaaaaa caaatagaat aacaataact atgactttga
     1501 ggccaatcat ttttaggtgt gtgtttgaag catagaacgt ctcttaaact ctcaatggtt
     1561 ccttcaaatg atgagttagt atgtaacgta aatagcagtt tctctctctc tctctctctt
     1621 tttatttttt ccatatagag cactatgtaa atttagcata tcaataatac aggaactatc
     1681 aaacagtatg taaactccgt tgttgttgtt tttagtacaa tggtgctatt ttgtagtttg
     1741 ttctatgaaa gaatctagtc aacacagaga aaggagaaag caaagcaaaa acaatgaaag
     1801 cctggagccc aaaaggacaa aattagg
//
