LOCUS       NM_001107266            3068 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus intraflagellar transport 88 (Ift88), mRNA.
ACCESSION   NM_001107266 XM_001061160 XM_224165
VERSION     NM_001107266.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3068)
  AUTHORS   Wang,Z., Sa,G., Zheng,L., Wei,Z., Zhang,Z., Hu,Y. and Yang,X.
  TITLE     Intraflagellar transport protein 88 interacts with polycystin 2 to
            regulate mechanosensitive hedgehog signaling in mandibular condylar
            chondrocytes
  JOURNAL   Arch Oral Biol 143, 105548 (2022)
   PUBMED   36155344
  REMARK    GeneRIF: Intraflagellar transport protein 88 interacts with
            polycystin 2 to regulate mechanosensitive hedgehog signaling in
            mandibular condylar chondrocytes.
REFERENCE   2  (bases 1 to 3068)
  AUTHORS   Li,S., Wei,Z., Li,G., Zhang,Q., Niu,S., Xu,D., Mao,N., Chen,S.,
            Gao,X., Cai,W., Zhu,Y., Zhang,G., Li,D., Yi,X., Yang,F. and Xu,H.
  TITLE     Silica Perturbs Primary Cilia and Causes Myofibroblast
            Differentiation during Silicosis by Reduction of the
            KIF3A-Repressor GLI3 Complex
  JOURNAL   Theranostics 10 (4), 1719-1732 (2020)
   PUBMED   32042332
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3068)
  AUTHORS   Hilgendorf,K.I., Johnson,C.T., Mezger,A., Rice,S.L., Norris,A.M.,
            Demeter,J., Greenleaf,W.J., Reiter,J.F., Kopinke,D. and
            Jackson,P.K.
  TITLE     Omega-3 Fatty Acids Activate Ciliary FFAR4 to Control Adipogenesis
  JOURNAL   Cell 179 (6), 1289-1305 (2019)
   PUBMED   31761534
REFERENCE   4  (bases 1 to 3068)
  AUTHORS   Mahuzier,A., Shihavuddin,A., Fournier,C., Lansade,P., Faucourt,M.,
            Menezes,N., Meunier,A., Garfa-Traore,M., Carlier,M.F.,
            Voituriez,R., Genovesio,A., Spassky,N. and Delgehyr,N.
  TITLE     Ependymal cilia beating induces an actin network to protect
            centrioles against shear stress
  JOURNAL   Nat Commun 9 (1), 2279 (2018)
   PUBMED   29891944
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3068)
  AUTHORS   Wang,C., Li,J., Takemaru,K.I., Jiang,X., Xu,G. and Wang,B.
  TITLE     Centrosomal protein Dzip1l binds Cby, promotes ciliary bud
            formation, and acts redundantly with Bromi to regulate ciliogenesis
            in the mouse
  JOURNAL   Development 145 (6) (2018)
   PUBMED   29487109
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3068)
  AUTHORS   Sommardahl,C., Cottrell,M., Wilkinson,J.E., Woychik,R.P. and
            Johnson,D.K.
  TITLE     Phenotypic variations of orpk mutation and chromosomal localization
            of modifiers influencing kidney phenotype
  JOURNAL   Physiol Genomics 7 (2), 127-134 (2001)
   PUBMED   11773599
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 3068)
  AUTHORS   Taulman,P.D., Haycraft,C.J., Balkovetz,D.F. and Yoder,B.K.
  TITLE     Polaris, a protein involved in left-right axis patterning,
            localizes to basal bodies and cilia
  JOURNAL   Mol Biol Cell 12 (3), 589-599 (2001)
   PUBMED   11251073
REFERENCE   8  (bases 1 to 3068)
  AUTHORS   Pazour,G.J., Dickert,B.L., Vucica,Y., Seeley,E.S., Rosenbaum,J.L.,
            Witman,G.B. and Cole,D.G.
  TITLE     Chlamydomonas IFT88 and its mouse homologue, polycystic kidney
            disease gene tg737, are required for assembly of cilia and flagella
  JOURNAL   J Cell Biol 151 (3), 709-718 (2000)
   PUBMED   11062270
REFERENCE   9  (bases 1 to 3068)
  AUTHORS   Murcia,N.S., Richards,W.G., Yoder,B.K., Mucenski,M.L., Dunlap,J.R.
            and Woychik,R.P.
  TITLE     The Oak Ridge Polycystic Kidney (orpk) disease gene is required for
            left-right axis determination
  JOURNAL   Development 127 (11), 2347-2355 (2000)
   PUBMED   10804177
REFERENCE   10 (bases 1 to 3068)
  AUTHORS   Yoder,B.K., Richards,W.G., Sommardahl,C., Sweeney,W.E.,
            Michaud,E.J., Wilkinson,J.E., Avner,E.D. and Woychik,R.P.
  TITLE     Differential rescue of the renal and hepatic disease in an
            autosomal recessive polycystic kidney disease mouse mutant. A new
            model to study the liver lesion
  JOURNAL   Am J Pathol 150 (6), 2231-2241 (1997)
   PUBMED   9176412
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474049.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001061160.1, XM_224165.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: partial sample support SAMD00132291, SAMD00132292
                              [ECO:0000350]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..3068
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15p12"
     gene            1..3068
                     /gene="Ift88"
                     /gene_synonym="Ttc10"
                     /note="intraflagellar transport 88"
                     /db_xref="GeneID:305918"
                     /db_xref="RGD:1309717"
     exon            1..63
                     /gene="Ift88"
                     /gene_synonym="Ttc10"
                     /inference="alignment:Splign:2.1.0"
     exon            64..159
                     /gene="Ift88"
                     /gene_synonym="Ttc10"
                     /inference="alignment:Splign:2.1.0"
     CDS             70..2517
                     /gene="Ift88"
                     /gene_synonym="Ttc10"
                     /note="tetratricopeptide repeat domain 10; intraflagellar
                     transport 88 homolog"
                     /codon_start=1
                     /product="intraflagellar transport protein 88 homolog"
                     /protein_id="NP_001100736.1"
                     /db_xref="GeneID:305918"
                     /db_xref="RGD:1309717"
                     /translation="MMENVHLAPETDEDDLYSGFNDYNPAYDTEELENDTGFQQAVRT
                     SHGRRPPVTAKIPSTAVSRPIATGYGSKTSLTSSMGRPMTGTIQDGVARPMTAVRAAG
                     FSKAALRGSAFDPLGQSRGPAPPLEAKNEDSPEEKIRQLEKKVNELVEESCIANSCGD
                     LKLALEKAKDAGRKERVLVRQREQVTSPENINLDLTYSVLFNLASQYSANEMYAEALN
                     TYQVIVKNKMFSNAGRLKVNMGNIYLKQRNYSKAIKFYRMALDQIPSVHKEMRIKIMQ
                     NIGITFIKTGQYSDAINSFEHIMSMAPSLKAGFNLILSCFAIGDREKMKKAFQKLIAV
                     PLEIDEDDKYISPSDDPHTNLLIEAIKNDHLRQMERERKAMAEKYIMTAAKLIAPVIE
                     ASFAVGYNWCVEVVKASQYVELANDLEINKAITYLRQKDFNQAVDTLKMFEKKDSRVK
                     SAAATNLSFLYYLENEFAQASSYADLAVSSDRYNPSALTNKGNTVFANGDYEKAAEFY
                     KEALRNDSSCTEALYNIGLTYKKLNRLDEALDSFLKLHAILRNSAQVLCQIANVYELM
                     EDPNQAIEWLMQLISVVPTDSQALSKLGELYDSEGDKSQAFQYYYESYRYFPSNIEVI
                     EWLGAYYIDTQFCEKAIQYFERASLIQPTQVKWQLMVASCFRRSGNYQKALDTYKEIH
                     RKFPENVECLRFLVRLCTDIGLKEVQEYATKLKRLEKMKEMREQRIKSGRDSGGGSRS
                     KREGSAGSDSGQNSSASSKSERLSAKLRALPGTDEPYESSGNKEIGKCLLCGSTGPSD
                     RKTKNCSQKENRRGRFC"
     exon            160..222
                     /gene="Ift88"
                     /gene_synonym="Ttc10"
                     /inference="alignment:Splign:2.1.0"
     exon            223..279
                     /gene="Ift88"
                     /gene_synonym="Ttc10"
                     /inference="alignment:Splign:2.1.0"
     exon            280..333
                     /gene="Ift88"
                     /gene_synonym="Ttc10"
                     /inference="alignment:Splign:2.1.0"
     exon            334..397
                     /gene="Ift88"
                     /gene_synonym="Ttc10"
                     /inference="alignment:Splign:2.1.0"
     exon            398..467
                     /gene="Ift88"
                     /gene_synonym="Ttc10"
                     /inference="alignment:Splign:2.1.0"
     exon            468..558
                     /gene="Ift88"
                     /gene_synonym="Ttc10"
                     /inference="alignment:Splign:2.1.0"
     exon            559..663
                     /gene="Ift88"
                     /gene_synonym="Ttc10"
                     /inference="alignment:Splign:2.1.0"
     exon            664..766
                     /gene="Ift88"
                     /gene_synonym="Ttc10"
                     /inference="alignment:Splign:2.1.0"
     exon            767..881
                     /gene="Ift88"
                     /gene_synonym="Ttc10"
                     /inference="alignment:Splign:2.1.0"
     exon            882..1113
                     /gene="Ift88"
                     /gene_synonym="Ttc10"
                     /inference="alignment:Splign:2.1.0"
     exon            1114..1184
                     /gene="Ift88"
                     /gene_synonym="Ttc10"
                     /inference="alignment:Splign:2.1.0"
     exon            1185..1271
                     /gene="Ift88"
                     /gene_synonym="Ttc10"
                     /inference="alignment:Splign:2.1.0"
     exon            1272..1371
                     /gene="Ift88"
                     /gene_synonym="Ttc10"
                     /inference="alignment:Splign:2.1.0"
     exon            1372..1458
                     /gene="Ift88"
                     /gene_synonym="Ttc10"
                     /inference="alignment:Splign:2.1.0"
     exon            1459..1645
                     /gene="Ift88"
                     /gene_synonym="Ttc10"
                     /inference="alignment:Splign:2.1.0"
     exon            1646..1754
                     /gene="Ift88"
                     /gene_synonym="Ttc10"
                     /inference="alignment:Splign:2.1.0"
     exon            1755..1905
                     /gene="Ift88"
                     /gene_synonym="Ttc10"
                     /inference="alignment:Splign:2.1.0"
     exon            1906..2021
                     /gene="Ift88"
                     /gene_synonym="Ttc10"
                     /inference="alignment:Splign:2.1.0"
     exon            2022..2074
                     /gene="Ift88"
                     /gene_synonym="Ttc10"
                     /inference="alignment:Splign:2.1.0"
     exon            2075..2140
                     /gene="Ift88"
                     /gene_synonym="Ttc10"
                     /inference="alignment:Splign:2.1.0"
     exon            2141..2247
                     /gene="Ift88"
                     /gene_synonym="Ttc10"
                     /inference="alignment:Splign:2.1.0"
     exon            2248..2314
                     /gene="Ift88"
                     /gene_synonym="Ttc10"
                     /inference="alignment:Splign:2.1.0"
     exon            2315..2429
                     /gene="Ift88"
                     /gene_synonym="Ttc10"
                     /inference="alignment:Splign:2.1.0"
     exon            2430..3068
                     /gene="Ift88"
                     /gene_synonym="Ttc10"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcctcaggcg tcgcgtcttc cctcaggccc actcgtggtc aggccgctcc ccctcggcgc
       61 gaggtacaca tgatggaaaa tgttcatctg gcaccagaaa cagatgagga tgatctttac
      121 tctggtttca atgactacaa tccagcctac gatactgagg agttggagaa tgacacgggt
      181 tttcagcaag cagtgagaac cagtcatggc agaagacctc cagtaactgc aaagatacca
      241 agcacagctg tcagcagacc catagctact ggatatgggt ccaagacatc cctgacatca
      301 tcaatgggaa ggccgatgac agggactatt caggatggag ttgctcgacc gatgacggcg
      361 gtgagagcag ctggcttttc caaggcagct ttgcgaggct ctgcatttga cccccttggt
      421 cagtctaggg gccctgctcc tcctttggaa gccaaaaatg aagacagtcc agaagaaaag
      481 attagacagt tagagaagaa agtaaatgag ttggtggaag aaagctgtat tgccaacagt
      541 tgtggagact taaaactggc cttagagaag gcaaaagatg caggaagaaa agagagagtc
      601 ctggtgagac aacgagagca agtcacaagt ccagaaaata tcaacttgga cctaacctac
      661 tccgttcttt tcaacttggc aagtcagtat tctgctaatg aaatgtatgc agaagcacta
      721 aacacatacc aagttatagt gaaaaataag atgtttagca atgcaggaag actgaaagtg
      781 aatatgggaa atatttattt aaagcagagg aattattcca aagctattaa attctaccga
      841 atggccttag atcagatccc aagtgtccat aaagaaatga ggattaaaat aatgcagaac
      901 atcgggatca cgtttataaa gaccggtcag tactcagacg ccatcaactc attcgagcac
      961 atcatgagca tggccccaag cctgaaggca ggcttcaacc tcattctcag ctgcttcgcc
     1021 attggagatc gagagaaaat gaagaaggca ttccaaaagt taattgctgt tccgttggaa
     1081 attgacgaag acgataaata tatctccccc agtgatgatc cccatactaa cttattgatt
     1141 gaagctataa aaaatgacca tcttaggcaa atggaacgtg aaaggaaagc catggcagaa
     1201 aaatacatca tgacagctgc aaaactcatt gctcctgtga tcgaagcctc ctttgctgtg
     1261 ggttataact ggtgtgtgga agtagtgaag gcctctcagt acgtggagct ggccaacgac
     1321 ctggagatta acaaagcaat cacctacttg agacagaagg acttcaacca ggctgtagac
     1381 acattgaaaa tgtttgagaa gaaggacagt agagtgaaga gtgcagctgc gaccaacctc
     1441 tcattcctgt attatctgga gaacgaattt gcccaagcca gcagctatgc agatttagct
     1501 gtgagctcag acagatacaa cccatcagct ctcactaaca aggggaacac agtgtttgca
     1561 aatggtgact acgagaaggc agctgagttc tataaagagg ccctaagaaa cgattcttct
     1621 tgtactgaag cactttataa cattggcctc acctacaaga agctcaaccg cctggacgaa
     1681 gcgttggact ccttcctgaa actgcatgca atccttcgga acagcgctca agttctgtgc
     1741 cagatagcaa atgtatacga gttaatggaa gatcccaatc aggctattga gtggctgatg
     1801 cagttgatca gcgtggttcc aactgattcc caagcgctgt ctaaactggg agagttgtac
     1861 gatagtgagg gagacaagtc ccaggcgttc caatattact atgagtcata taggtatttc
     1921 ccttctaaca ttgaagtcat cgaatggctt ggagcttatt acattgatac ccagttctgc
     1981 gagaaagcca ttcagtactt tgaaagagct tcccttatac aacccacaca agtgaaatgg
     2041 cagctgatgg tagctagctg ttttagaaga agtggtaact accaaaaggc attagatact
     2101 tacaaagaga ttcacaggaa atttccagag aatgttgaat gtttgcgttt cttggttcgt
     2161 ctctgcacag atattggatt aaaagaagtt caagaatatg ccacaaaact caagaggttg
     2221 gaaaaaatga aagaaatgcg ggaacagcgc ataaaatcag gcagagacag cggcgggggc
     2281 tctcgcagca aacgagaggg gagcgctggc agtgatagtg gccagaacag tagtgccagt
     2341 agtaaaagtg aacgactgag tgccaagctc agagctttgc ctgggacaga cgaaccttat
     2401 gaaagtagcg ggaacaaaga aataggcaaa tgcctcctat gtggatccac tgggccctca
     2461 gatagaaaga ccaaaaactg cagccagaaa gagaatcgac gaggacgatt ttgctgatga
     2521 agagttagga gatgacttgc tcccagaata atataaactc ttgtgtgtgt gtgtgtgtgt
     2581 gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtat ttatggaagc cagaagccag
     2641 cctcaggtgt ttctcaggca ccatctatca tctttttaaa cttgtgacaa ggttcctctg
     2701 gcccggaact tgccatataa gcaagactgg ctggctagca accccacgga tccgcccgtc
     2761 tctgcttcct tgctgggaga ttcataagca catggtacta aatccagctt tcttcaaacg
     2821 gactctcggg cttgagctca ggccctccag cttgcaaggc aagcaatttc caattgtgtt
     2881 ctctctggcc aaagaagtca tttaccaaag ggaagaaatt gccttataag gtaatgctca
     2941 tggtaaacct gggaccaatt gtccaaactt taattctgta cactgttgaa actttaaatg
     3001 agtgtatttt gttcttgagg atggatttgt gctgtcagtt ttaagatgga ataaacctgt
     3061 gaaacaac
//
