LOCUS       NM_001013911            2905 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Rattus norvegicus intraflagellar transport 80 (Ift80), mRNA.
ACCESSION   NM_001013911 XM_215577
VERSION     NM_001013911.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2905)
  AUTHORS   Yuan,X., Cao,J., He,X., Serra,R., Qu,J., Cao,X. and Yang,S.
  TITLE     Ciliary IFT80 balances canonical versus non-canonical hedgehog
            signalling for osteoblast differentiation
  JOURNAL   Nat Commun 7, 11024 (2016)
   PUBMED   26996322
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2905)
  AUTHORS   Yuan,X. and Yang,S.
  TITLE     Deletion of IFT80 Impairs Epiphyseal and Articular Cartilage
            Formation Due to Disruption of Chondrocyte Differentiation
  JOURNAL   PLoS One 10 (6), e0130618 (2015)
   PUBMED   26098911
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2905)
  AUTHORS   Liew,G.M., Ye,F., Nager,A.R., Murphy,J.P., Lee,J.S., Aguiar,M.,
            Breslow,D.K., Gygi,S.P. and Nachury,M.V.
  TITLE     The intraflagellar transport protein IFT27 promotes BBSome exit
            from cilia through the GTPase ARL6/BBS3
  JOURNAL   Dev Cell 31 (3), 265-278 (2014)
   PUBMED   25443296
REFERENCE   4  (bases 1 to 2905)
  AUTHORS   Fu,W., Asp,P., Canter,B. and Dynlacht,B.D.
  TITLE     Primary cilia control hedgehog signaling during muscle
            differentiation and are deregulated in rhabdomyosarcoma
  JOURNAL   Proc Natl Acad Sci U S A 111 (25), 9151-9156 (2014)
   PUBMED   24927541
REFERENCE   5  (bases 1 to 2905)
  AUTHORS   Ishikawa,H., Ide,T., Yagi,T., Jiang,X., Hirono,M., Sasaki,H.,
            Yanagisawa,H., Wemmer,K.A., Stainier,D.Y., Qin,H., Kamiya,R. and
            Marshall,W.F.
  TITLE     TTC26/DYF13 is an intraflagellar transport protein required for
            transport of motility-related proteins into flagella
  JOURNAL   Elife 3, e01566 (2014)
   PUBMED   24596149
  REMARK    Erratum:[Elife. 2014 Apr 01;3:e02897. doi: 10.7554/eLife.02897..
            PMID: 24692455]
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2905)
  AUTHORS   Wang,C., Yuan,X. and Yang,S.
  TITLE     IFT80 is essential for chondrocyte differentiation by regulating
            Hedgehog and Wnt signaling pathways
  JOURNAL   Exp Cell Res 319 (5), 623-632 (2013)
   PUBMED   23333501
REFERENCE   7  (bases 1 to 2905)
  AUTHORS   Yang,S. and Wang,C.
  TITLE     The intraflagellar transport protein IFT80 is required for cilia
            formation and osteogenesis
  JOURNAL   Bone 51 (3), 407-417 (2012)
   PUBMED   22771375
REFERENCE   8  (bases 1 to 2905)
  AUTHORS   Ezratty,E.J., Stokes,N., Chai,S., Shah,A.S., Williams,S.E. and
            Fuchs,E.
  TITLE     A role for the primary cilium in Notch signaling and epidermal
            differentiation during skin development
  JOURNAL   Cell 145 (7), 1129-1141 (2011)
   PUBMED   21703454
REFERENCE   9  (bases 1 to 2905)
  AUTHORS   Rix,S., Calmont,A., Scambler,P.J. and Beales,P.L.
  TITLE     An Ift80 mouse model of short rib polydactyly syndromes shows
            defects in hedgehog signalling without loss or malformation of
            cilia
  JOURNAL   Hum Mol Genet 20 (7), 1306-1314 (2011)
   PUBMED   21227999
REFERENCE   10 (bases 1 to 2905)
  AUTHORS   Follit,J.A., Xu,F., Keady,B.T. and Pazour,G.J.
  TITLE     Characterization of mouse IFT complex B
  JOURNAL   Cell Motil Cytoskeleton 66 (8), 457-468 (2009)
   PUBMED   19253336
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC081937.1.
            
            On Apr 20, 2005 this sequence version replaced XM_215577.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC081937.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..2905
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q32"
     gene            1..2905
                     /gene="Ift80"
                     /gene_synonym="RGD1312006; Wdr56"
                     /note="intraflagellar transport 80"
                     /db_xref="GeneID:295106"
                     /db_xref="RGD:1312006"
     exon            1..89
                     /gene="Ift80"
                     /gene_synonym="RGD1312006; Wdr56"
                     /inference="alignment:Splign:2.1.0"
     exon            90..171
                     /gene="Ift80"
                     /gene_synonym="RGD1312006; Wdr56"
                     /inference="alignment:Splign:2.1.0"
     CDS             135..2468
                     /gene="Ift80"
                     /gene_synonym="RGD1312006; Wdr56"
                     /note="WD repeat domain 56; WD repeat-containing protein
                     56; intraflagellar transport 80 homolog"
                     /codon_start=1
                     /product="intraflagellar transport protein 80 homolog"
                     /protein_id="NP_001013933.1"
                     /db_xref="GeneID:295106"
                     /db_xref="RGD:1312006"
                     /translation="MRLKISLLKEPKHQELVSCVGWTTAEELYSCSDDHQIVKWNLLT
                     SETSLIVKLPDDIYPIDLHWFPKSLGIKKQTQAESFVLTSSDGKFHLISKLGRVEKSV
                     EAHCGAVLAGRWNYEGTALVTVGEDGQVKIWSKTGMLRSTLAQQGIPVYSVAWGPDSE
                     KVLYTAGKQLIIKPLQPNAKVLQWKAHDGIILKVDWNSVNDLILSAGEDCKYKVWDSY
                     GRVLYGSQPHEHPITSVAWAPDGELFAVGSFHTLRLCDKTGWSYALEKPNTGSIFNIA
                     WSIDGTQIAGACGNGHVVFAHVVEQRWEWKNFQVTLTKRRTMQVRNVLNDAVDLLEFR
                     DRVIKASLNHAHLVVSTSLQCYVFSTKNWNTPLIFDLKEGTVSLILQAERHFLLVDGG
                     GIYLHSYEGRFISSPKFPGMRTDILNAQTVSLSNDTIAIKDKADEKIIFLFEASTGKP
                     LGDGKLLSHKNEISEVALDQKGLTNDRKIAFIDKNRDLYITSVKRFGKEEQIIKLGTM
                     VHTLAWCDTCNILCGLQDTRFTVWYYPNAVYVDRDILPKTLYERDASEYSKNPHIVSF
                     VGNQVTVRRADGSLVHISISPYPAILHEYVSSSKWEDAVRLCRFVKEQSLWACLAAMA
                     VANRDMVTAEIAYAAVGEIDKVRYINAMKDLPSRESKMAHILMFSGNIQEAETILLQA
                     GLVYQAIQININLYNWERALELAVKYKTHVDTVLAYRQKFLETFGKQETNKRYLQYAE
                     GLQIDWEKIKAKIEMEITKERDRSSSGQSSKNTGLKP"
     exon            172..393
                     /gene="Ift80"
                     /gene_synonym="RGD1312006; Wdr56"
                     /inference="alignment:Splign:2.1.0"
     exon            394..504
                     /gene="Ift80"
                     /gene_synonym="RGD1312006; Wdr56"
                     /inference="alignment:Splign:2.1.0"
     exon            505..573
                     /gene="Ift80"
                     /gene_synonym="RGD1312006; Wdr56"
                     /inference="alignment:Splign:2.1.0"
     exon            574..683
                     /gene="Ift80"
                     /gene_synonym="RGD1312006; Wdr56"
                     /inference="alignment:Splign:2.1.0"
     exon            684..773
                     /gene="Ift80"
                     /gene_synonym="RGD1312006; Wdr56"
                     /inference="alignment:Splign:2.1.0"
     exon            774..911
                     /gene="Ift80"
                     /gene_synonym="RGD1312006; Wdr56"
                     /inference="alignment:Splign:2.1.0"
     exon            912..1091
                     /gene="Ift80"
                     /gene_synonym="RGD1312006; Wdr56"
                     /inference="alignment:Splign:2.1.0"
     exon            1092..1210
                     /gene="Ift80"
                     /gene_synonym="RGD1312006; Wdr56"
                     /inference="alignment:Splign:2.1.0"
     exon            1211..1285
                     /gene="Ift80"
                     /gene_synonym="RGD1312006; Wdr56"
                     /inference="alignment:Splign:2.1.0"
     exon            1286..1449
                     /gene="Ift80"
                     /gene_synonym="RGD1312006; Wdr56"
                     /inference="alignment:Splign:2.1.0"
     exon            1450..1514
                     /gene="Ift80"
                     /gene_synonym="RGD1312006; Wdr56"
                     /inference="alignment:Splign:2.1.0"
     exon            1515..1650
                     /gene="Ift80"
                     /gene_synonym="RGD1312006; Wdr56"
                     /inference="alignment:Splign:2.1.0"
     exon            1651..1798
                     /gene="Ift80"
                     /gene_synonym="RGD1312006; Wdr56"
                     /inference="alignment:Splign:2.1.0"
     exon            1799..1970
                     /gene="Ift80"
                     /gene_synonym="RGD1312006; Wdr56"
                     /inference="alignment:Splign:2.1.0"
     exon            1971..2060
                     /gene="Ift80"
                     /gene_synonym="RGD1312006; Wdr56"
                     /inference="alignment:Splign:2.1.0"
     exon            2061..2233
                     /gene="Ift80"
                     /gene_synonym="RGD1312006; Wdr56"
                     /inference="alignment:Splign:2.1.0"
     exon            2234..2357
                     /gene="Ift80"
                     /gene_synonym="RGD1312006; Wdr56"
                     /inference="alignment:Splign:2.1.0"
     exon            2358..2880
                     /gene="Ift80"
                     /gene_synonym="RGD1312006; Wdr56"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aatcactatg gtgacggaaa ggtcgggagg ctacttggta actggtctga gctctgagag
       61 caattgccac cgctttcctg gaacttgagt gaatacaatc aagtggtatt tagcatttct
      121 ctggaactgg agacatgaga ctgaagatat ctctcttaaa agaaccaaag catcaagaat
      181 tagtgagctg cgtgggttgg actactgccg aggagctgta ctcatgcagt gacgatcacc
      241 agatagtgaa gtggaacctg ttaaccagtg aaaccagcct aatcgtcaag ctgcctgatg
      301 acatctaccc gatagacctt cactggtttc cgaagagttt aggcataaag aagcagactc
      361 aggcagaaag tttcgtcctc acaagctctg atggtaagtt tcatctgatt tccaagttag
      421 gaagagtgga aaaaagtgta gaagctcatt gtggggctgt gctcgccgga agatggaatt
      481 acgaagggac tgcattagtt acagttggag aagatggaca agtaaaaatc tggtcaaaga
      541 cggggatgct tagatcaact ttagctcagc aaggaatacc agtgtattca gtagcctggg
      601 gccctgattc agaaaaggtt ctttatacag caggcaaaca gctcatcatt aagcctcttc
      661 aaccaaatgc taaagtttta cagtggaaag cccatgatgg aatcatttta aaagtcgact
      721 ggaactcagt taatgatctt attttatccg ctggtgaaga ctgtaagtat aaggtttggg
      781 atagttatgg ccgtgtgctg tacggttccc agcctcatga gcaccctatc acctcagtgg
      841 cctgggctcc agatggggag ttatttgccg tcggatcatt tcatacttta cgcttgtgtg
      901 ataaaactgg gtggtcatat gctttagaga aacccaacac tggcagcata tttaatatcg
      961 cctggtctat tgatggcact cagattgctg gagcctgtgg aaatggccat gttgtctttg
     1021 cacatgtggt ggagcagcgc tgggagtgga aaaattttca agtaacgcta acgaagagaa
     1081 gaaccatgca ggttcgcaat gttctcaatg atgccgtgga tttgctggag ttccgggaca
     1141 gagtcattaa ggcgtccctg aaccacgcac acttggttgt ttctacgtct ctccagtgct
     1201 acgtgttctc tacgaagaac tggaatacac cacttatatt tgatctcaaa gaaggaactg
     1261 ttagtttaat tctgcaggca gaaagacatt ttcttctggt ggatggcggt ggtatctacc
     1321 ttcactctta tgaaggccgc ttcatttctt ctccaaagtt tcccggcatg agaacagaca
     1381 tcctgaacgc tcagactgtg tctctgagca acgacacgat agcaataaaa gacaaagccg
     1441 atgagaagat aatcttcctc tttgaggctt caactggaaa acccttaggg gatgggaaac
     1501 ttctttctca taagaatgaa atctcagaag ttgctctgga tcaaaaagga cttaccaatg
     1561 acagaaaaat tgctttcatt gataaaaaca gagatctcta tatcacctca gtgaaacgat
     1621 ttgggaaaga agaacagatt attaaacttg gaaccatggt acatactttg gcatggtgtg
     1681 atacatgcaa tatcctctgt ggacttcaag atacgcgatt cacagtatgg tattacccta
     1741 atgctgttta tgtggacaga gacattctgc ctaaaacatt gtatgaaaga gatgcaagtg
     1801 aatatagtaa aaacccacat atagtgagtt ttgttggaaa tcaggtaact gtaagaagag
     1861 ctgatggctc cctggtacac atcagcattt caccgtaccc tgctattctc catgaatatg
     1921 tgagcagctc aaaatgggaa gacgccgtaa ggctctgccg ctttgttaag gagcaaagcc
     1981 tgtgggcttg cctagcggct atggcagttg ctaatcgaga tatggttact gcagaaatag
     2041 cctatgcggc agttggggaa atcgataaag ttcggtacat caatgctatg aaagatcttc
     2101 catctagaga gtcaaaaatg gcccacatac taatgtttag tgggaacatc caggaggctg
     2161 aaacaatact tctccaggct ggcctcgttt atcaagcaat acagatcaac attaatctct
     2221 ataactggga aagggcactg gaattggctg taaagtacaa aacccatgtt gatacagttc
     2281 ttgcttatcg tcaaaagttt ttggagacat ttggtaaaca ggaaacgaat aaacgatatt
     2341 tgcaatacgc agaaggcctc caaatagact gggagaaaat caaagcgaaa atcgagatgg
     2401 aaattacgaa agaacgagac cggtcatcca gcggccagtc cagcaagaat acgggcttaa
     2461 agccctaagt gccatgccaa cctctaccta gtgcggaata accaaagatg tgcatgtttt
     2521 gtttgcttaa aaaaaaaggc ataattttaa ggctagtggt gtctcttgat ggtagagcac
     2581 ttgcctagca tgcatgaggc cctgggtttg atccccagcc ctgtcaaaag aataagtgta
     2641 tgcactttct gtgtatttaa tacttaaggt acattcagga agattaagca caaaataact
     2701 tacacaattc catcatttat atttttctag tctaataatt aagaaaatat ttctatatgc
     2761 ttatctatgc cctaggagtg tggattacat tccagttttt ttttcatttc tttatttctg
     2821 gttcttcagt atgaatagct attaattctt ataataaagc cttgagttat ttacagtgta
     2881 aaaaaaaaaa aaaaaaaaaa aaaaa
//
