LOCUS       NM_001007001            2133 bp    mRNA    linear   ROD 23-MAR-2023
DEFINITION  Rattus norvegicus intraflagellar transport 74 (Ift74), mRNA.
ACCESSION   NM_001007001 XM_233229
VERSION     NM_001007001.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2133)
  AUTHORS   Li Y, Klena NT, Gabriel GC, Liu X, Kim AJ, Lemke K, Chen Y,
            Chatterjee B, Devine W, Damerla RR, Chang C, Yagi H, San Agustin
            JT, Thahir M, Anderton S, Lawhead C, Vescovi A, Pratt H, Morgan J,
            Haynes L, Smith CL, Eppig JT, Reinholdt L, Francis R, Leatherbury
            L, Ganapathiraju MK, Tobita K, Pazour GJ and Lo CW.
  TITLE     Global genetic analysis in mice unveils central role for cilia in
            congenital heart disease
  JOURNAL   Nature 521 (7553), 520-524 (2015)
   PUBMED   25807483
REFERENCE   2  (bases 1 to 2133)
  AUTHORS   Liew GM, Ye F, Nager AR, Murphy JP, Lee JS, Aguiar M, Breslow DK,
            Gygi SP and Nachury MV.
  TITLE     The intraflagellar transport protein IFT27 promotes BBSome exit
            from cilia through the GTPase ARL6/BBS3
  JOURNAL   Dev Cell 31 (3), 265-278 (2014)
   PUBMED   25443296
REFERENCE   3  (bases 1 to 2133)
  AUTHORS   Ishikawa H, Ide T, Yagi T, Jiang X, Hirono M, Sasaki H, Yanagisawa
            H, Wemmer KA, Stainier DY, Qin H, Kamiya R and Marshall WF.
  TITLE     TTC26/DYF13 is an intraflagellar transport protein required for
            transport of motility-related proteins into flagella
  JOURNAL   Elife 3, e01566 (2014)
   PUBMED   24596149
  REMARK    Erratum:[Elife. 2014 Apr 01;3:e02897. PMID: 24692455]
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2133)
  AUTHORS   Bhogaraju S, Cajanek L, Fort C, Blisnick T, Weber K, Taschner M,
            Mizuno N, Lamla S, Bastin P, Nigg EA and Lorentzen E.
  TITLE     Molecular basis of tubulin transport within the cilium by IFT74 and
            IFT81
  JOURNAL   Science 341 (6149), 1009-1012 (2013)
   PUBMED   23990561
REFERENCE   5  (bases 1 to 2133)
  AUTHORS   Howard PW, Jue SF and Maurer RA.
  TITLE     Interaction of mouse TTC30/DYF-1 with multiple intraflagellar
            transport complex B proteins and KIF17
  JOURNAL   Exp Cell Res 319 (14), 2275-2281 (2013)
   PUBMED   23810713
REFERENCE   6  (bases 1 to 2133)
  AUTHORS   Ezratty EJ, Stokes N, Chai S, Shah AS, Williams SE and Fuchs E.
  TITLE     A role for the primary cilium in Notch signaling and epidermal
            differentiation during skin development
  JOURNAL   Cell 145 (7), 1129-1141 (2011)
   PUBMED   21703454
REFERENCE   7  (bases 1 to 2133)
  AUTHORS   Ichiro Ohbayashi K, Tanaka K, Kitajima K, Tamura K and Hara T.
  TITLE     Novel role for the intraflagellar transport protein CMG-1 in
            regulating the transcription of cyclin-D2, E-cadherin and
            integrin-alpha family genes in mouse spermatocyte-derived cells
  JOURNAL   Genes Cells 15 (7), 699-710 (2010)
   PUBMED   20545763
REFERENCE   8  (bases 1 to 2133)
  AUTHORS   Follit JA, Xu F, Keady BT and Pazour GJ.
  TITLE     Characterization of mouse IFT complex B
  JOURNAL   Cell Motil Cytoskeleton 66 (8), 457-468 (2009)
   PUBMED   19253336
REFERENCE   9  (bases 1 to 2133)
  AUTHORS   Fujino RS, Ishikawa Y, Tanaka K, Kanatsu-Shinohara M, Tamura K,
            Kogo H, Shinohara T and Hara T.
  TITLE     Capillary morphogenesis gene (CMG)-1 is among the genes
            differentially expressed in mouse male germ line stem cells and
            embryonic stem cells
  JOURNAL   Mol Reprod Dev 73 (8), 955-966 (2006)
   PUBMED   16705683
REFERENCE   10 (bases 1 to 2133)
  AUTHORS   Bell SE, Mavila A, Salazar R, Bayless KJ, Kanagala S, Maxwell SA
            and Davis GE.
  TITLE     Differential gene expression during capillary morphogenesis in 3D
            collagen matrices: regulated expression of genes involved in
            basement membrane matrix assembly, cell cycle progression, cellular
            differentiation and G-protein signaling
  JOURNAL   J Cell Sci 114 (Pt 15), 2755-2773 (2001)
   PUBMED   11683410
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC083611.1.
            
            On Nov 22, 2004 this sequence version replaced XM_233229.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC083611.1, SRR8487231.85942.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132293, SAMD00132301
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2133
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q33"
     gene            1..2133
                     /gene="Ift74"
                     /gene_synonym="Ccdc2"
                     /note="intraflagellar transport 74"
                     /db_xref="GeneID:313365"
                     /db_xref="RGD:1359704"
     exon            1..124
                     /gene="Ift74"
                     /gene_synonym="Ccdc2"
                     /inference="alignment:Splign:2.1.0"
     exon            125..259
                     /gene="Ift74"
                     /gene_synonym="Ccdc2"
                     /inference="alignment:Splign:2.1.0"
     CDS             140..1942
                     /gene="Ift74"
                     /gene_synonym="Ccdc2"
                     /note="coiled-coil domain containing 2; intraflagellar
                     transport 74 homolog"
                     /codon_start=1
                     /product="intraflagellar transport protein 74 homolog"
                     /protein_id="NP_001007002.1"
                     /db_xref="GeneID:313365"
                     /db_xref="RGD:1359704"
                     /translation="MASNHKSAAPRPISRGGIGLTGRPPSGIRPPSGTVRVATAMPPA
                     TARPGSRGGPLGTGGVLSSQIKVADRPVTQQGLSGMKTGMKGPQRQILDKSYYLGLLR
                     SKISELTTEINKLQKEIEMYNQENSVYLSYEKRAETLAVEIKDFQGQLADYNMLVDKL
                     NTNTEMEEVMNDYNMLKAQNDRETQSMDVIFTERQAKEKQIRSVEEEVEQEKQAADGI
                     IKNMSPEKQVKYIEMKTTNEKLLQELDTLQQQLDSLNIKKESLETEIAHSQVKQEAVL
                     LYEKLYELESHRDQMIAEDKSMGSPMEERERLLKQVKEDNQEIASMERQLTDIKEKIN
                     QFSEEIRQLDMDLEEHQGEMNQKYKELKKREENMDAFIETFEETKNQELERKAQIETS
                     IITLLEHCSRNINRMKQISSITNQELKMMQDDLSFKSTEMQKSQTTARNLTSDSQRLQ
                     LDLQKMELLESKMTEEQQSLKNKIKQMTADLETYSDLAALKSSAEEKKKKLHQERTVL
                     STHRNAFKKIMEKLTTDYEALKTQLQDNETHAQLTNLERKWQHLEQNNFVMKEFIATK
                     SQESDYQPVIKNVMKQIAEYNKTIMDALHSASRS"
     exon            260..395
                     /gene="Ift74"
                     /gene_synonym="Ccdc2"
                     /inference="alignment:Splign:2.1.0"
     exon            396..444
                     /gene="Ift74"
                     /gene_synonym="Ccdc2"
                     /inference="alignment:Splign:2.1.0"
     exon            445..543
                     /gene="Ift74"
                     /gene_synonym="Ccdc2"
                     /inference="alignment:Splign:2.1.0"
     exon            544..604
                     /gene="Ift74"
                     /gene_synonym="Ccdc2"
                     /inference="alignment:Splign:2.1.0"
     exon            605..664
                     /gene="Ift74"
                     /gene_synonym="Ccdc2"
                     /inference="alignment:Splign:2.1.0"
     exon            665..726
                     /gene="Ift74"
                     /gene_synonym="Ccdc2"
                     /inference="alignment:Splign:2.1.0"
     exon            727..865
                     /gene="Ift74"
                     /gene_synonym="Ccdc2"
                     /inference="alignment:Splign:2.1.0"
     exon            866..928
                     /gene="Ift74"
                     /gene_synonym="Ccdc2"
                     /inference="alignment:Splign:2.1.0"
     exon            929..1072
                     /gene="Ift74"
                     /gene_synonym="Ccdc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1073..1113
                     /gene="Ift74"
                     /gene_synonym="Ccdc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1114..1193
                     /gene="Ift74"
                     /gene_synonym="Ccdc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1194..1247
                     /gene="Ift74"
                     /gene_synonym="Ccdc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1248..1345
                     /gene="Ift74"
                     /gene_synonym="Ccdc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1346..1472
                     /gene="Ift74"
                     /gene_synonym="Ccdc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1473..1636
                     /gene="Ift74"
                     /gene_synonym="Ccdc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1637..1762
                     /gene="Ift74"
                     /gene_synonym="Ccdc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1763..1823
                     /gene="Ift74"
                     /gene_synonym="Ccdc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1824..2109
                     /gene="Ift74"
                     /gene_synonym="Ccdc2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctgaggcctg gcgccctggc tgtgctctgg tgtgtggtga gaccggaact gactctcggt
       61 taggctcctc agaaagaagt tcctgtcgta gagtcctagt ggcgtcccat tcgcaccaag
      121 caagtggttg aagtgaacaa tggccagtaa tcacaaatct gcagcacctc gccctatttc
      181 tcggggtgga ataggactaa caggaaggcc tccttctgga ataagacccc catctgggac
      241 tgttcgagtg gccactgcaa tgccaccagc aacagcaaga ccaggttccc gtggtggtcc
      301 cctagggact ggcggagttt tgtcatctca aatcaaagtt gctgatcgtc ctgtaaccca
      361 gcaaggtttg agtggaatga agactggcat gaaaggtccc cagaggcaaa ttttagacaa
      421 atcttactat cttggacttc ttaggagcaa aataagtgaa cttacaactg aaattaataa
      481 acttcagaaa gagatagaaa tgtacaacca agaaaattca gtatatttgt catatgaaaa
      541 gagggcagag acattagctg tggaaattaa agactttcaa ggacaactag cagactacaa
      601 tatgttggta gataaactta ataccaatac cgaaatggaa gaagtaatga atgattacaa
      661 catgcttaaa gctcaaaatg atcgagaaac acaaagtatg gatgtcatat ttaccgaaag
      721 acaagcgaaa gaaaaacaaa tcagaagtgt agaagaagaa gttgaacaag aaaagcaggc
      781 agcagatggc attatcaaaa atatgtctcc tgaaaaacaa gtcaagtaca tagaaatgaa
      841 aaccacgaat gagaaactat tgcaggaatt agatacactt cagcaacaac tagattcact
      901 gaacattaaa aaggagagcc tagaaactga aatagcacac tcccaggtaa aacaagaggc
      961 tgtattgcta tatgaaaaac tttatgagtt agagtcccat cgagatcaaa tgattgcaga
     1021 agacaaaagc atgggatcgc caatggagga aagggagaga ttgcttaagc aggttaaaga
     1081 agataatcag gaaatagcca gcatggagag acagttaaca gatataaagg aaaaaataaa
     1141 tcagtttagt gaagagatta gacaacttga catggattta gaggaacacc aaggtgaaat
     1201 gaatcaaaaa tacaaggagc ttaaaaaaag ggaagaaaat atggatgctt ttatagagac
     1261 ttttgaggaa acgaagaatc aggaactaga gcggaaggca cagatagaaa ccagcatcat
     1321 cacactctta gagcattgca gtcggaatat aaatcgtatg aaacagatat cctccatcac
     1381 caaccaagag ctaaagatga tgcaggatga cctcagtttt aaatcaactg aaatgcagaa
     1441 gtcacagaca acagctagga atttgacctc agacagtcag cgtctacagc tggatctcca
     1501 gaaaatggaa cttttggaaa gtaagatgac agaagagcaa cagtctctga aaaacaaaat
     1561 caagcaaatg actgctgacc tggagacata cagtgacctg gcagctttaa aatcatcagc
     1621 tgaagagaag aagaagaaat tacatcaaga aagaacagta ttgtcaaccc acagaaatgc
     1681 ctttaagaaa ataatggaga agctgactac agattatgag gcactgaaaa cacaacttca
     1741 agacaatgag acacatgctc agcttacaaa cttggagagg aagtggcagc atctggagca
     1801 aaataatttt gtaatgaaag agttcatagc aaccaagagt caggagagtg attaccagcc
     1861 agtgattaaa aatgtgatga agcagattgc agagtacaat aaaaccatca tggatgctct
     1921 ccatagtgcc agcagaagct gaaacgaagt ccactgaatc tacaagaatc cacaagcatg
     1981 ctaaaagtaa attagcttcc tcttgaagag ttagacccca ggtttttaaa tgccatggtt
     2041 ttgtgatctc cttgacggag agatatcttg catagttaaa taattcaata aatgtttgca
     2101 tataactcaa aaaaaaaaaa aaaaaaaaaa aaa
//
