LOCUS       NM_001309521            4002 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus intraflagellar transport 122 (Ift122), transcript
            variant 1, mRNA.
ACCESSION   NM_001309521 XM_001054604 XM_001057925
VERSION     NM_001309521.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4002)
  AUTHORS   Takahara,M., Kunii,M., Nakamura,K., Harada,A., Hirano,T., Katoh,Y.
            and Nakayama,K.
  TITLE     C11ORF74 interacts with the IFT-A complex and participates in
            ciliary BBSome localization
  JOURNAL   J Biochem 165 (3), 257-267 (2019)
   PUBMED   30476139
REFERENCE   2  (bases 1 to 4002)
  AUTHORS   Takahara,M., Katoh,Y., Nakamura,K., Hirano,T., Sugawa,M.,
            Tsurumi,Y. and Nakayama,K.
  TITLE     Ciliopathy-associated mutations of IFT122 impair ciliary protein
            trafficking but not ciliogenesis
  JOURNAL   Hum Mol Genet 27 (3), 516-528 (2018)
   PUBMED   29220510
REFERENCE   3  (bases 1 to 4002)
  AUTHORS   Burnett,J.B., Lupu,F.I. and Eggenschwiler,J.T.
  TITLE     Proper ciliary assembly is critical for restricting Hedgehog
            signaling during early eye development in mice
  JOURNAL   Dev Biol 430 (1), 32-40 (2017)
   PUBMED   28778798
REFERENCE   4  (bases 1 to 4002)
  AUTHORS   Hirano,T., Katoh,Y. and Nakayama,K.
  TITLE     Intraflagellar transport-A complex mediates ciliary entry and
            retrograde trafficking of ciliary G protein-coupled receptors
  JOURNAL   Mol Biol Cell 28 (3), 429-439 (2017)
   PUBMED   27932497
REFERENCE   5  (bases 1 to 4002)
  AUTHORS   Liem,K.F. Jr., Ashe,A., He,M., Satir,P., Moran,J., Beier,D.,
            Wicking,C. and Anderson,K.V.
  TITLE     The IFT-A complex regulates Shh signaling through cilia structure
            and membrane protein trafficking
  JOURNAL   J Cell Biol 197 (6), 789-800 (2012)
   PUBMED   22689656
REFERENCE   6  (bases 1 to 4002)
  AUTHORS   Mukhopadhyay,S., Wen,X., Chih,B., Nelson,C.D., Lane,W.S.,
            Scales,S.J. and Jackson,P.K.
  TITLE     TULP3 bridges the IFT-A complex and membrane phosphoinositides to
            promote trafficking of G protein-coupled receptors into primary
            cilia
  JOURNAL   Genes Dev 24 (19), 2180-2193 (2010)
   PUBMED   20889716
REFERENCE   7  (bases 1 to 4002)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   8  (bases 1 to 4002)
  AUTHORS   Jiang,S.T., Chiou,Y.Y., Wang,E., Chien,Y.L., Ho,H.H., Tsai,F.J.,
            Lin,C.Y., Tsai,S.P. and Li,H.
  TITLE     Essential role of nephrocystin in photoreceptor intraflagellar
            transport in mouse
  JOURNAL   Hum Mol Genet 18 (9), 1566-1577 (2009)
   PUBMED   19208653
REFERENCE   9  (bases 1 to 4002)
  AUTHORS   Cortellino,S., Wang,C., Wang,B., Bassi,M.R., Caretti,E.,
            Champeval,D., Calmont,A., Jarnik,M., Burch,J., Zaret,K.S., Larue,L.
            and Bellacosa,A.
  TITLE     Defective ciliogenesis, embryonic lethality and severe impairment
            of the Sonic Hedgehog pathway caused by inactivation of the mouse
            complex A intraflagellar transport gene Ift122/Wdr10, partially
            overlapping with the DNA repair gene Med1/Mbd4
  JOURNAL   Dev Biol 325 (1), 225-237 (2009)
   PUBMED   19000668
REFERENCE   10 (bases 1 to 4002)
  AUTHORS   Garcia-Garcia,M.J., Eggenschwiler,J.T., Caspary,T., Alcorn,H.L.,
            Wyler,M.R., Huangfu,D., Rakeman,A.S., Lee,J.D., Feinberg,E.H.,
            Timmer,J.R. and Anderson,K.V.
  TITLE     Analysis of mouse embryonic patterning and morphogenesis by forward
            genetics
  JOURNAL   Proc Natl Acad Sci U S A 102 (17), 5913-5919 (2005)
   PUBMED   15755804
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On or before Jun 9, 2015 this sequence version replaced
            XM_001057925.4, XM_001054604.4.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments and orthologous data.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643293.24708.1,
                                           SRR26643289.13864.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-125               JAXUCZ010000004.1  150577642-150577766
            126-192             JAXUCZ010000004.1  150587427-150587493
            193-277             JAXUCZ010000004.1  150589089-150589173
            278-356             JAXUCZ010000004.1  150596228-150596306
            357-433             JAXUCZ010000004.1  150598483-150598559
            434-500             JAXUCZ010000004.1  150601836-150601902
            501-647             JAXUCZ010000004.1  150602642-150602788
            648-723             JAXUCZ010000004.1  150605813-150605888
            724-915             JAXUCZ010000004.1  150609122-150609313
            916-1054            JAXUCZ010000004.1  150609463-150609601
            1055-1257           JAXUCZ010000004.1  150610922-150611124
            1258-1395           JAXUCZ010000004.1  150612421-150612558
            1396-1560           JAXUCZ010000004.1  150614075-150614239
            1561-1758           JAXUCZ010000004.1  150616364-150616561
            1759-1899           JAXUCZ010000004.1  150621969-150622109
            1900-1953           JAXUCZ010000004.1  150625369-150625422
            1954-2115           JAXUCZ010000004.1  150628357-150628518
            2116-2282           JAXUCZ010000004.1  150632734-150632900
            2283-2454           JAXUCZ010000004.1  150634893-150635064
            2455-2557           JAXUCZ010000004.1  150636362-150636464
            2558-2698           JAXUCZ010000004.1  150638387-150638527
            2699-2793           JAXUCZ010000004.1  150639641-150639735
            2794-2894           JAXUCZ010000004.1  150642623-150642723
            2895-3060           JAXUCZ010000004.1  150644502-150644667
            3061-3172           JAXUCZ010000004.1  150645108-150645219
            3173-3298           JAXUCZ010000004.1  150645616-150645741
            3299-3378           JAXUCZ010000004.1  150646711-150646790
            3379-3543           JAXUCZ010000004.1  150647093-150647257
            3544-4002           JAXUCZ010000004.1  150647594-150648052
FEATURES             Location/Qualifiers
     source          1..4002
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q42"
     gene            1..4002
                     /gene="Ift122"
                     /gene_synonym="Wdr10"
                     /note="intraflagellar transport 122"
                     /db_xref="GeneID:312651"
                     /db_xref="RGD:1311302"
     exon            1..125
                     /gene="Ift122"
                     /gene_synonym="Wdr10"
                     /inference="alignment:Splign:2.1.0"
     CDS             85..3633
                     /gene="Ift122"
                     /gene_synonym="Wdr10"
                     /note="isoform 1 is encoded by transcript variant 1;
                     intraflagellar transport protein 122 homolog; WD repeat
                     domain 10; intraflagellar transport 122 homolog"
                     /codon_start=1
                     /product="intraflagellar transport protein 122 homolog
                     isoform 1"
                     /protein_id="NP_001296450.1"
                     /db_xref="GeneID:312651"
                     /db_xref="RGD:1311302"
                     /translation="MRAVLTWRDKAEQCIYDLAFKPDGTQLILAAGNRLLVYDTSDGT
                     LLQPLKGHKDTVYCVAYAKDGKRFASGSADKSIIIWTSKLEGILKYTHNDSIQCVSYN
                     PVTHQLASCSSSDFGLWSPEQKSVSKHKSNSKITCCSWTNDGQYLALGMSNGIISIRN
                     KNGEEKVKIERPGGSLSPIWSICWNPSREEHNDILAVADWGQKLSFYQLSGKQIGKDR
                     PLNFDPCCISYFTKGEYILVGGSDKQVSLFTKDGVRLGTVGEQNSWVWTCRVKPDSNY
                     VVVGCQDGTISFYQLIFSTVHGLYKDRYAYRDSMTDVIVQHLITEQKVRIKCRELVKK
                     IAIYKNRLAIQLPEKILIYELYSDDSADMHYRVKEKIVKKFECNLLVVCADHIILCQE
                     KRLQCLSFSGVREREWQMESLIRYIKVIGGPAGREGLLVGLKNGQILKIFVDNLFAIV
                     LLKQATAVRCLDMSASRNKLAVVDENDTCLVYDIHTKELLFQEPNANSVAWNTQCEDM
                     LCFSGGGYLNIKASTFPVHQQKLQGFVVGYNGSKIFCLHVFSMSAVEVPQSAPMYQYL
                     DRKMFKEAYQIACLGVTDTDWRELAMEALEGLEFETAKKAFTRVQDLRYLELISTIEE
                     RKKRGESNNDLFLADVFSYQGKFHEAAKLYKRSGHENLALNMYTDLCMFEYAKDFLGS
                     GDPKETKMLITKQADWARNINEPKAAVEMYISAGEHAKAIEISGSHGWVDMLIDIARK
                     LDKAEREPLLMCARYFKKLDSPGYAAETYLKIGDLKSLVQLYVDTKRWDEAFALGEKH
                     PEFKDDIYVPYAQWLAENDRFEEAQKAFHKAGRQGEAVRVLEQLTHNAVVESRFNDAA
                     YYYWMLSMQCLDMAQDPAQKDVMLDKFHHFQHLAELYHGYQTIHRYTEEPFSFDLPET
                     LFNISKFLLHSLTKATPLGISKVNTLFTLAKQSKALGAYKLARHAYDKLRGLQIPARI
                     QKSIELGTLTIRSKPFHDSEELVPLCYRCSTNNPLLNNLGNVCINCRQPFIFSASSYE
                     VLHLVEFYLEEGITDEEAVALIDLEAPRHKREGKWQETSSNNSQTLRLDETMDSIGED
                     DPFTAKLSFEQGGSEFVPVVVSRSVLRSMSRRDVLIKRWPPPLQWQYFRSLLPDASIT
                     MCPSCFQMFHSEDYELLVLQHACCPYCRRRIDDTGP"
     exon            126..192
                     /gene="Ift122"
                     /gene_synonym="Wdr10"
                     /inference="alignment:Splign:2.1.0"
     exon            193..277
                     /gene="Ift122"
                     /gene_synonym="Wdr10"
                     /inference="alignment:Splign:2.1.0"
     exon            278..356
                     /gene="Ift122"
                     /gene_synonym="Wdr10"
                     /inference="alignment:Splign:2.1.0"
     exon            357..433
                     /gene="Ift122"
                     /gene_synonym="Wdr10"
                     /inference="alignment:Splign:2.1.0"
     exon            434..500
                     /gene="Ift122"
                     /gene_synonym="Wdr10"
                     /inference="alignment:Splign:2.1.0"
     exon            501..647
                     /gene="Ift122"
                     /gene_synonym="Wdr10"
                     /inference="alignment:Splign:2.1.0"
     exon            648..723
                     /gene="Ift122"
                     /gene_synonym="Wdr10"
                     /inference="alignment:Splign:2.1.0"
     exon            724..915
                     /gene="Ift122"
                     /gene_synonym="Wdr10"
                     /inference="alignment:Splign:2.1.0"
     exon            916..1054
                     /gene="Ift122"
                     /gene_synonym="Wdr10"
                     /inference="alignment:Splign:2.1.0"
     exon            1055..1257
                     /gene="Ift122"
                     /gene_synonym="Wdr10"
                     /inference="alignment:Splign:2.1.0"
     exon            1258..1395
                     /gene="Ift122"
                     /gene_synonym="Wdr10"
                     /inference="alignment:Splign:2.1.0"
     exon            1396..1560
                     /gene="Ift122"
                     /gene_synonym="Wdr10"
                     /inference="alignment:Splign:2.1.0"
     exon            1561..1758
                     /gene="Ift122"
                     /gene_synonym="Wdr10"
                     /inference="alignment:Splign:2.1.0"
     exon            1759..1899
                     /gene="Ift122"
                     /gene_synonym="Wdr10"
                     /inference="alignment:Splign:2.1.0"
     exon            1900..1953
                     /gene="Ift122"
                     /gene_synonym="Wdr10"
                     /inference="alignment:Splign:2.1.0"
     exon            1954..2115
                     /gene="Ift122"
                     /gene_synonym="Wdr10"
                     /inference="alignment:Splign:2.1.0"
     exon            2116..2282
                     /gene="Ift122"
                     /gene_synonym="Wdr10"
                     /inference="alignment:Splign:2.1.0"
     exon            2283..2454
                     /gene="Ift122"
                     /gene_synonym="Wdr10"
                     /inference="alignment:Splign:2.1.0"
     exon            2455..2557
                     /gene="Ift122"
                     /gene_synonym="Wdr10"
                     /inference="alignment:Splign:2.1.0"
     exon            2558..2698
                     /gene="Ift122"
                     /gene_synonym="Wdr10"
                     /inference="alignment:Splign:2.1.0"
     exon            2699..2793
                     /gene="Ift122"
                     /gene_synonym="Wdr10"
                     /inference="alignment:Splign:2.1.0"
     exon            2794..2894
                     /gene="Ift122"
                     /gene_synonym="Wdr10"
                     /inference="alignment:Splign:2.1.0"
     exon            2895..3060
                     /gene="Ift122"
                     /gene_synonym="Wdr10"
                     /inference="alignment:Splign:2.1.0"
     exon            3061..3172
                     /gene="Ift122"
                     /gene_synonym="Wdr10"
                     /inference="alignment:Splign:2.1.0"
     exon            3173..3298
                     /gene="Ift122"
                     /gene_synonym="Wdr10"
                     /inference="alignment:Splign:2.1.0"
     exon            3299..3378
                     /gene="Ift122"
                     /gene_synonym="Wdr10"
                     /inference="alignment:Splign:2.1.0"
     exon            3379..3543
                     /gene="Ift122"
                     /gene_synonym="Wdr10"
                     /inference="alignment:Splign:2.1.0"
     exon            3544..4002
                     /gene="Ift122"
                     /gene_synonym="Wdr10"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 caaaggtagc cgaagtggtt tgtggagaga agcctgttgc tgccgaggct gggaggaggg
       61 gcccgaggcg tgtgggaaac ggcgatgagg gccgtgttga cgtggagaga caaagcggag
      121 cagtgtatct acgaccttgc atttaaacct gatggaactc aactgattct ggctgcagga
      181 aacagattgc tggtttatga cacctctgat ggcaccttac ttcagcccct gaagggacac
      241 aaagacactg tgtactgtgt ggcgtatgca aaggatggca agcgctttgc ttctggatct
      301 gctgacaaga gcatcattat ctggacctca aaactggaag gcattctgaa gtacacgcac
      361 aatgactcta tacagtgtgt ctcctacaat cctgttaccc accagctggc atcttgttcc
      421 tccagtgact ttgggctgtg gtctcctgag cagaagtctg tctccaagca caaatccaac
      481 agcaagatca cctgctgcag ctggacaaat gatggtcagt acctggctct ggggatgtcc
      541 aatggtatca tcagcatccg gaacaaaaat ggcgaagaga aagtgaagat cgagcgccct
      601 gggggctccc tctccccaat atggtccatc tgctggaacc cttcaagaga ggaacataat
      661 gacatcctgg ctgtagctga ctggggacag aaactttcct tctaccagct gagtgggaaa
      721 cagatcggga aggatcggcc actgaacttt gacccctgtt gcatcagcta cttcactaaa
      781 ggagagtaca ttttggtagg gggttcagac aagcaggtat ctcttttcac caaggatgga
      841 gtgcggctgg ggaccgttgg ggagcagaac tcctgggtgt ggacctgtag agtgaaacct
      901 gactccaatt acgtggtggt aggctgccag gatggcacca tttccttcta ccagcttatc
      961 tttagcacag ttcacggact ttacaaggat cggtatgcct acagggacag catgacagat
     1021 gtcattgtgc aacacctgat cacagagcag aaagttcgga ttaaatgcag agagcttgtc
     1081 aagaaaattg ccatctacaa gaatcgatta gctatccagc tgccagagaa gatcctcatc
     1141 tatgagttgt actctgatga ctcggcagac atgcactacc gggtaaagga gaaaattgtc
     1201 aagaagtttg agtgcaacct gctggtggtg tgtgctgacc acatcatcct gtgccaggag
     1261 aaacggctac agtgcctgtc cttcagtgga gtgagggaaa gggaatggca gatggaatct
     1321 ctcattcgct acatcaaggt gattggtggc cccgctggaa gagaaggtct gttggtaggc
     1381 ctgaagaacg gccagattct gaagatcttt gtggacaatc tctttgctat tgtcctgctg
     1441 aagcaggcca cagccgtgcg ctgcttggac atgagtgcct cccggaacaa gctggctgtg
     1501 gtggatgaaa atgacacgtg cctggtgtat gacatccaca caaaggagct gcttttccag
     1561 gaaccaaatg ccaacagtgt ggcctggaac acccagtgtg aggacatgct ttgcttctcc
     1621 ggaggaggtt acctcaacat caaggccagc accttcccag tgcaccagca gaagctgcag
     1681 ggcttcgtcg tcggctacaa tggctccaag atcttctgcc ttcatgtctt ctctatgtct
     1741 gctgtggagg tgccacagtc agctccgatg taccagtacc ttgataggaa aatgttcaaa
     1801 gaagcatacc agatcgcttg cttgggagtg acagacactg attggcgtga acttgccatg
     1861 gaagctctag aaggactaga gtttgagact gcaaagaagg ccttcaccag agtccaagat
     1921 cttcgatacc tagaactgat cagcactatt gaggagagga agaagagggg agagagcaac
     1981 aatgacctgt ttctggcaga cgtgttttca taccagggga agttccatga agccgccaaa
     2041 ctgtacaaga ggagtgggca tgaaaacctc gccctcaaca tgtatactga cctctgcatg
     2101 tttgagtatg ccaaggattt ccttggatct ggagacccta aagaaacaaa gatgctcatc
     2161 accaagcagg ccgactgggc cagaaacatc aatgagccca aagccgcggt ggagatgtac
     2221 atctcggcag gggagcatgc caaggccata gagatcagcg gcagccatgg ctgggttgac
     2281 atgttgatag atattgctcg aaagttggac aaggctgagc gggagcccct gctcatgtgt
     2341 gctcgctact ttaagaagct ggatagtcct ggctacgctg ctgagaccta cctgaagatt
     2401 ggggacctga agtctctggt gcagctgtat gtggacacca agcgctggga tgaggccttt
     2461 gctttaggtg agaagcaccc tgagttcaag gatgacatct acgtgcccta tgcgcagtgg
     2521 ctagcagaga atgaccgctt tgaggaagcc cagaaagcct tccacaaggc cgggaggcag
     2581 ggagaagcag tgcgggtgct ggagcagctc acccacaacg ctgtggtgga gagcagattc
     2641 aacgatgctg cctattatta ctggatgctg tccatgcagt gcctcgacat ggctcaagat
     2701 cccgcccaga aggatgtgat gcttgacaag tttcaccatt tccagcacct ggctgagctg
     2761 taccatggct accaaaccat tcaccgatac acggaggagc cattcagctt tgatctcccc
     2821 gaaaccctct tcaacatctc caagttcttg ctgcacagcc tgaccaaggc cacccccttg
     2881 ggcatctcca aagtgaatac actcttcaca ttggccaagc agagcaaggc tctgggtgct
     2941 tacaagctgg cccggcatgc ctatgacaag ctgcgggggc tgcagatccc tgccaggatc
     3001 cagaagtcca ttgagctggg caccctgacc atccgctcca agcccttcca tgacagtgag
     3061 gagctggttc ccttgtgcta ccgctgttct accaacaacc cactgttgaa caaccttggc
     3121 aatgtctgca tcaactgccg ccagcccttc atcttctccg cctcttccta cgaggtgctg
     3181 cacctggtgg aattctacct ggaagagggc atcactgacg aagaagctgt tgccctcatt
     3241 gatctggagg caccaagaca caagagggag ggcaaatggc aggagacctc aagcaacaat
     3301 tcccagacat tgaggctgga tgagaccatg gactccatag gagaagacga cccatttaca
     3361 gccaagttga gctttgagca aggtggctcc gagtttgtgc ctgtggtggt gagccggtca
     3421 gtcctacgct ccatgagccg aagggatgtt ctcatcaagc gctggccccc accgctgcaa
     3481 tggcagtatt tccgctcact gttgcctgat gcctccatca ccatgtgccc ctcctgcttc
     3541 cagatgttcc attcggagga ctatgagctg ctggtgctcc agcatgcctg ttgcccttac
     3601 tgccgacggc gcatcgacga cactggcccg tgagcagtga tggcctctgg ggcctcctgc
     3661 tcccatggtc tccttgctgt tcccagactg ttggagagaa agaattaaac cctcagaaca
     3721 cgtctcctgc ccagatgaag tttgtatgtt ggggaggggc cttgcctgtg taaccacaga
     3781 gttcctattt atggcatttc attccttgta aatagcatca ggagatgggg aagagaatgc
     3841 acatatattt ttctaagaaa aaaaaatgtg ttacttttag aagggctcat gtgttcatag
     3901 cagcctgctg tagtccatag atccgtcaga ccgttaccgt gcacactttg ccaacagatt
     3961 gcctcaataa cgacaaataa aagggctact cgttttcatc ag
//
