LOCUS       NM_019242               1724 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus interferon-related developmental regulator 1
            (Ifrd1), mRNA.
ACCESSION   NM_019242
VERSION     NM_019242.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1724)
  AUTHORS   Li,F.X., Liu,Y., Miao,X.P., Fu,G.Q. and Curry,T.E. Jr.
  TITLE     Expression and regulation of the differentiation regulators ERBB
            Receptor Feedback Inhibitor 1 (ERRFI1) and Interferon-related
            Developmental Regulator 1 (IFRD1) during the periovulatory period
            in the rat ovary
  JOURNAL   Mol Reprod Dev 83 (8), 714-723 (2016)
   PUBMED   27358163
  REMARK    GeneRIF: findings thus suggest that the stimulation of Errfi1 and
            Ifrd1 may be important for theca and granulosa cell differentiation
            and oocyte complexes expansion.
REFERENCE   2  (bases 1 to 1724)
  AUTHORS   Dieplinger,B., Schiefermeier,N., Juchum-Pasquazzo,M., Gstir,R.,
            Huber,L.A., Klimaschewski,L. and Vietor,I.
  TITLE     The transcriptional corepressor TPA-inducible sequence 7 regulates
            adult axon growth through cellular retinoic acid binding protein II
            expression
  JOURNAL   Eur J Neurosci 26 (12), 3358-3367 (2007)
   PUBMED   18052984
REFERENCE   3  (bases 1 to 1724)
  AUTHORS   Micheli,L., Leonardi,L., Conti,F., Buanne,P., Canu,N., Caruso,M.
            and Tirone,F.
  TITLE     PC4 coactivates MyoD by relieving the histone deacetylase
            4-mediated inhibition of myocyte enhancer factor 2C
  JOURNAL   Mol Cell Biol 25 (6), 2242-2259 (2005)
   PUBMED   15743821
  REMARK    GeneRIF: PC4 acts as a coactivator of MyoD and MEF2C by removing
            the inhibitory effect of HDAC4, thus exerting a pivotal function
            during myogenesis.
REFERENCE   4  (bases 1 to 1724)
  AUTHORS   Vadivelu,S.K., Kurzbauer,R., Dieplinger,B., Zweyer,M., Schafer,R.,
            Wernig,A., Vietor,I. and Huber,L.A.
  TITLE     Muscle regeneration and myogenic differentiation defects in mice
            lacking TIS7
  JOURNAL   Mol Cell Biol 24 (8), 3514-3525 (2004)
   PUBMED   15060170
  REMARK    Erratum:[Mol Cell Biol. 2005 Dec;25(24):11194]
REFERENCE   5  (bases 1 to 1724)
  AUTHORS   Roth,A., Gill,R. and Certa,U.
  TITLE     Temporal and spatial gene expression patterns after experimental
            stroke in a rat model and characterization of PC4, a potential
            regulator of transcription
  JOURNAL   Mol Cell Neurosci 22 (3), 353-364 (2003)
   PUBMED   12691737
  REMARK    GeneRIF: PC4 is a regulator of transcription involved in tissue
            regeneration after ischemic stroke.
REFERENCE   6  (bases 1 to 1724)
  AUTHORS   Buanne,P., Incerti,B., Guardavaccaro,D., Avvantaggiato,V.,
            Simeone,A. and Tirone,F.
  TITLE     Cloning of the human interferon-related developmental regulator
            (IFRD1) gene coding for the PC4 protein, a member of a novel family
            of developmentally regulated genes
  JOURNAL   Genomics 51 (2), 233-242 (1998)
   PUBMED   9722946
REFERENCE   7  (bases 1 to 1724)
  AUTHORS   Iacopetti,P., Barsacchi,G., Tirone,F. and Cremisi,F.
  TITLE     Expression of the PC4 gene in the developing rat nervous system
  JOURNAL   Brain Res 707 (2), 293-297 (1996)
   PUBMED   8919308
REFERENCE   8  (bases 1 to 1724)
  AUTHORS   Guardavaccaro,D., Ciotti,M.T., Schafer,B.W., Montagnoli,A. and
            Tirone,F.
  TITLE     Inhibition of differentiation in myoblasts deprived of the
            interferon-related protein PC4
  JOURNAL   Cell Growth Differ 6 (2), 159-169 (1995)
   PUBMED   7756174
REFERENCE   9  (bases 1 to 1724)
  AUTHORS   Guardavaccaro,D., Montagnoli,A., Ciotti,M.T., Gatti,A., Lotti,L.,
            Di Lazzaro,C., Torrisi,M.R. and Tirone,F.
  TITLE     Nerve growth factor regulates the subcellular localization of the
            nerve growth factor-inducible protein PC4 in PC12 cells
  JOURNAL   J Neurosci Res 37 (5), 660-674 (1994)
   PUBMED   8028043
REFERENCE   10 (bases 1 to 1724)
  AUTHORS   Tirone,F. and Shooter,E.M.
  TITLE     Early gene regulation by nerve growth factor in PC12 cells:
            induction of an interferon-related gene
  JOURNAL   Proc Natl Acad Sci U S A 86 (6), 2088-2092 (1989)
   PUBMED   2467301
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000006.1.
            
            On Nov 26, 2020 this sequence version replaced NM_019242.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: J04511.1, BC083560.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760389,
                                           SAMEA5760400 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-233               JAXUCZ010000006.1  63015833-63016065   c
            234-338             JAXUCZ010000006.1  63010506-63010610   c
            339-423             JAXUCZ010000006.1  63010288-63010372   c
            424-548             JAXUCZ010000006.1  63009362-63009486   c
            549-706             JAXUCZ010000006.1  63007245-63007402   c
            707-757             JAXUCZ010000006.1  63006333-63006383   c
            758-936             JAXUCZ010000006.1  63006062-63006240   c
            937-1045            JAXUCZ010000006.1  63005435-63005543   c
            1046-1180           JAXUCZ010000006.1  63000449-63000583   c
            1181-1309           JAXUCZ010000006.1  62997770-62997898   c
            1310-1405           JAXUCZ010000006.1  62997311-62997406   c
            1406-1724           JAXUCZ010000006.1  62996562-62996880   c
FEATURES             Location/Qualifiers
     source          1..1724
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q21"
     gene            1..1724
                     /gene="Ifrd1"
                     /gene_synonym="Pc4"
                     /note="interferon-related developmental regulator 1"
                     /db_xref="GeneID:29596"
                     /db_xref="RGD:2867"
     exon            1..233
                     /gene="Ifrd1"
                     /gene_synonym="Pc4"
                     /inference="alignment:Splign:2.1.0"
     CDS             146..1495
                     /gene="Ifrd1"
                     /gene_synonym="Pc4"
                     /note="IRPR; nerve growth factor-inducible protein PC4"
                     /codon_start=1
                     /product="interferon-related developmental regulator 1"
                     /protein_id="NP_062115.2"
                     /db_xref="GeneID:29596"
                     /db_xref="RGD:2867"
                     /translation="MPKNKKRNAPHRGGGGGGGSGAATSAATTGGPHRTVQPFSDEDA
                     SIETMSHCSGYSDPSSFAEDGPEVLDEEGTQEDLEYKLKGLIDLTLDKSAKTRQAALE
                     GVKNALSSKVLYEFVLERRMTLTDSIERCLKKGKSDEQRAAAALASVLCIQLGPGLES
                     EEILKTLGPILKKIICDGTASIQARQTCATCFGVCCFIATDDITELYSTLECLESIFT
                     KSYLKEKDTNVPCSTPNTVLHISSLLAWTLLLTICPISEVKKKLELHFHKLPSLLSCD
                     DVNMRIAAGESLALLFELARGMESDFFYEDMDSLTQMLRALATDGNKHRAKVDKRKQR
                     SVFRDVLRAVEERDFPTETVKFGPERMYIDSWVKKHTYDTFKEALGSGMQYHLQTNEF
                     LRNVFELGPPVMLDAATLKTMKIPRFERHLYNSAAFKARTKARSKCRDKRADVGEFF"
     exon            234..338
                     /gene="Ifrd1"
                     /gene_synonym="Pc4"
                     /inference="alignment:Splign:2.1.0"
     exon            339..423
                     /gene="Ifrd1"
                     /gene_synonym="Pc4"
                     /inference="alignment:Splign:2.1.0"
     exon            424..548
                     /gene="Ifrd1"
                     /gene_synonym="Pc4"
                     /inference="alignment:Splign:2.1.0"
     exon            549..706
                     /gene="Ifrd1"
                     /gene_synonym="Pc4"
                     /inference="alignment:Splign:2.1.0"
     exon            707..757
                     /gene="Ifrd1"
                     /gene_synonym="Pc4"
                     /inference="alignment:Splign:2.1.0"
     exon            758..936
                     /gene="Ifrd1"
                     /gene_synonym="Pc4"
                     /inference="alignment:Splign:2.1.0"
     exon            937..1045
                     /gene="Ifrd1"
                     /gene_synonym="Pc4"
                     /inference="alignment:Splign:2.1.0"
     exon            1046..1180
                     /gene="Ifrd1"
                     /gene_synonym="Pc4"
                     /inference="alignment:Splign:2.1.0"
     exon            1181..1309
                     /gene="Ifrd1"
                     /gene_synonym="Pc4"
                     /inference="alignment:Splign:2.1.0"
     exon            1310..1405
                     /gene="Ifrd1"
                     /gene_synonym="Pc4"
                     /inference="alignment:Splign:2.1.0"
     exon            1406..1724
                     /gene="Ifrd1"
                     /gene_synonym="Pc4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tctcacccgc gccgctcctc gcctctcttg ttagccggag actcgcctct cagccgcccg
       61 ccgcacagac gcacgagtag acagtgcagc tccatcggct gatccttgct gagctccaag
      121 tgtaggcggc accgggcggc ccacgatgcc gaagaacaag aagcggaacg ctccccaccg
      181 cggtggcggg ggtggcggcg gctccggggc agcgacgtcg gcggccacga caggtggccc
      241 gcatcggact gttcaacctt tcagtgatga agacgcatcc attgaaacaa tgagccactg
      301 cagtggctat agcgatcctt ccagtttcgc ggaggacgga ccagaagttc ttgatgagga
      361 aggaactcag gaagacttag agtacaagtt gaagggatta attgacctaa cccttgataa
      421 gagtgcgaag acaagacagg cagctcttga aggtgttaaa aatgcgctgt cttcaaaagt
      481 gctgtatgag tttgttctcg agagaagaat gactttaact gatagcattg agcgctgtct
      541 gaaaaaagga aagagtgatg agcagcgcgc agctgcagcg ctcgcgtccg ttctttgtat
      601 tcagttgggc cctggattgg aaagtgaaga gattttaaag actcttggac caatcctaaa
      661 aaaaataatt tgtgatggaa cagcgagtat ccaggctagg cagacttgtg caacttgctt
      721 tggtgtttgc tgttttattg ccacagatga catcactgag ctgtattcaa ctctggagtg
      781 cttggaaagt atcttcacca agtcctacct taaagagaaa gacacgaacg ttccttgcag
      841 cactcctaat acagtgcttc acatcagctc gcttctcgcg tggacgctac tgctgaccat
      901 atgcccaatc agtgaagtga agaaaaagct ggagctgcat ttccataaac ttccaagcct
      961 cctttcttgt gatgatgtaa acatgagaat tgctgctggc gaatctttgg cacttctgtt
     1021 tgaattggcc agaggaatgg agagtgactt tttttatgaa gatatggatt ctttgaccca
     1081 gatgctccgg gctctggcta cagatggaaa taaacaccgt gccaaagtgg acaagagaaa
     1141 gcagcgctct gtcttcagag acgtcctgag ggctgtggag gaacgggatt ttccaacaga
     1201 aactgttaaa ttcggtcctg agcgcatgta tattgatagc tgggtcaaaa agcacaccta
     1261 tgacacgttt aaagaggctc ttggatcagg gatgcagtac cacttgcaga caaatgaatt
     1321 ccttcgcaat gtatttgagc tgggaccccc tgtgatgctc gatgctgcaa cacttaaaac
     1381 catgaagatt cctcgttttg aaaggcattt atataactct gcagctttca aagctcgaac
     1441 aaaagcccga agcaaatgcc gagataagag agcagatgtt ggagaattct tctagatgtc
     1501 tgactttgat gtctgttttc taatttcttc ctttattatt atttttgcta cttctaatgt
     1561 atataagctt ttagagactt tttttatctt ggtcaactta gataattttt gatgtaggga
     1621 tgggttatat tttaatttaa tgtacagtgt tacaaattaa tgagttcttt attctgtaaa
     1681 aataactgat aaccacaaat aaaagtgttt gtgatgcttg gtca
//
