LOCUS       NM_001191868            4231 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus interferon, lambda receptor 1 (Ifnlr1), mRNA.
ACCESSION   NM_001191868 XM_342946
VERSION     NM_001191868.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4231)
  AUTHORS   Pott,J., Mahlakoiv,T., Mordstein,M., Duerr,C.U., Michiels,T.,
            Stockinger,S., Staeheli,P. and Hornef,M.W.
  TITLE     IFN-lambda determines the intestinal epithelial antiviral host
            defense
  JOURNAL   Proc Natl Acad Sci U S A 108 (19), 7944-7949 (2011)
   PUBMED   21518880
REFERENCE   2  (bases 1 to 4231)
  AUTHORS   Ank,N., Iversen,M.B., Bartholdy,C., Staeheli,P., Hartmann,R.,
            Jensen,U.B., Dagnaes-Hansen,F., Thomsen,A.R., Chen,Z., Haugen,H.,
            Klucher,K. and Paludan,S.R.
  TITLE     An important role for type III interferon (IFN-lambda/IL-28) in
            TLR-induced antiviral activity
  JOURNAL   J Immunol 180 (4), 2474-2485 (2008)
   PUBMED   18250457
REFERENCE   3  (bases 1 to 4231)
  AUTHORS   Sheppard,P., Kindsvogel,W., Xu,W., Henderson,K., Schlutsmeyer,S.,
            Whitmore,T.E., Kuestner,R., Garrigues,U., Birks,C., Roraback,J.,
            Ostrander,C., Dong,D., Shin,J., Presnell,S., Fox,B., Haldeman,B.,
            Cooper,E., Taft,D., Gilbert,T., Grant,F.J., Tackett,M., Krivan,W.,
            McKnight,G., Clegg,C., Foster,D. and Klucher,K.M.
  TITLE     IL-28, IL-29 and their class II cytokine receptor IL-28R
  JOURNAL   Nat Immunol 4 (1), 63-68 (2003)
   PUBMED   12469119
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Sep 7, 2022 this sequence version replaced NM_001191868.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643289.16616.1,
                                           SRR26643288.24311.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-397               JAXUCZ010000005.1  153203597-153203993
            398-521             JAXUCZ010000005.1  153207792-153207915
            522-700             JAXUCZ010000005.1  153215643-153215821
            701-846             JAXUCZ010000005.1  153218107-153218252
            847-1006            JAXUCZ010000005.1  153221508-153221667
            1007-1137           JAXUCZ010000005.1  153221958-153222088
            1138-4231           JAXUCZ010000005.1  153222818-153225911
FEATURES             Location/Qualifiers
     source          1..4231
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..4231
                     /gene="Ifnlr1"
                     /gene_synonym="Il28ra; RGD1562689"
                     /note="interferon, lambda receptor 1"
                     /db_xref="GeneID:362628"
                     /db_xref="RGD:1562689"
     exon            1..397
                     /gene="Ifnlr1"
                     /gene_synonym="Il28ra; RGD1562689"
                     /inference="alignment:Splign:2.1.0"
     CDS             340..1932
                     /gene="Ifnlr1"
                     /gene_synonym="Il28ra; RGD1562689"
                     /note="interleukin-28 receptor subunit alpha; interleukin
                     28 receptor alpha"
                     /codon_start=1
                     /product="interferon lambda receptor 1 precursor"
                     /protein_id="NP_001178797.1"
                     /db_xref="GeneID:362628"
                     /db_xref="RGD:1562689"
                     /translation="MWRAGRWAPLLLFLMQSALGRPRLAPPRNVTLLSQNFTVYLTWL
                     PGLGSPPNVTYFVTYKSYNNHWRRVEHCAGISTLVCPMMCLKKQDLYIKFKGRVQAAS
                     AHVKSPWVESRYLEYIFDVELAPPTLVLSQKEKILNVNATYQLPPCMPRSLELKYQVE
                     FWKEDLRSKTLFPDTPYGQPVKIPLQQDARGRHCFSARTVYTLTHTKYSLFSEPSCIF
                     LAAPGANRAVLAVPLLLLLLIAAAAAGTAWKKMDGNPWFQWVKMPQALDFSENRHPVA
                     TFQPSGPEFSGDLILCPQKELTIRTRPVPRVRGPATLQAGSEKDSTEDEDEDTDDDGD
                     SIQPYLERPLFVREKLQVTEHSEADESGVDSVGSEGSSAWDSSGGSWSSTGVSSGDSS
                     YKDEAGSSSCLDQKKPDQEPHGDGHQGPLPCLEFSEDLGTVEELLKDDLSGWRIWGTL
                     SPKRDLAPVEPPVSLQTLTFCWDSNPEEEEEEEEEEEEEEEEEEEDWESDLKDSNTSC
                     WDASSPQRTDVRGGMLGDYMVR"
     exon            398..521
                     /gene="Ifnlr1"
                     /gene_synonym="Il28ra; RGD1562689"
                     /inference="alignment:Splign:2.1.0"
     exon            522..700
                     /gene="Ifnlr1"
                     /gene_synonym="Il28ra; RGD1562689"
                     /inference="alignment:Splign:2.1.0"
     exon            701..846
                     /gene="Ifnlr1"
                     /gene_synonym="Il28ra; RGD1562689"
                     /inference="alignment:Splign:2.1.0"
     exon            847..1006
                     /gene="Ifnlr1"
                     /gene_synonym="Il28ra; RGD1562689"
                     /inference="alignment:Splign:2.1.0"
     exon            1007..1137
                     /gene="Ifnlr1"
                     /gene_synonym="Il28ra; RGD1562689"
                     /inference="alignment:Splign:2.1.0"
     exon            1138..4231
                     /gene="Ifnlr1"
                     /gene_synonym="Il28ra; RGD1562689"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aagcctgccc ggaattccag cagaaactct ggtgagaaac tcgcaagaca ggctgggtgc
       61 cttcctccat ctccaaaaca ggagacctgc cggtgacctc gaactctacc ctgggtgctg
      121 attacttact cctcatcgga accccagagc tggatttctt gtctgattta cagaaaatgt
      181 tactgagagc cccgccccca cccacggcgg cgacgcgagg cggccctagg tgaatccccg
      241 ccgttggcac cgccggaggc tcctcctccc tgggccgccg cccttgtcac ctgccgccca
      301 ggggcctggc agcgggcggc cgggaccctc gggaccgaaa tgtggcgggc tggccggtgg
      361 gcgcccctac tcctgttcct gatgcaaagc gccctaggaa ggccccgtct agccccaccc
      421 agaaacgtga cactgctctc ccagaatttc actgtttacc tgacatggct cccagggcta
      481 ggtagccccc cgaatgtgac ctactttgtg acctacaaaa gctataacaa tcattggcga
      541 agagtagagc attgtgcggg catcagtact ctggtgtgtc ccatgatgtg cctgaagaaa
      601 caggacctgt acatcaagtt caaaggtcga gtacaggcag cttctgccca tgtgaagtcc
      661 ccatgggtgg agtccaggta cctggaatac atttttgatg tggagctagc cccacccacc
      721 ctggtgctct cccagaagga gaagatccta aatgtcaacg ctacctacca gctgccaccc
      781 tgcatgcctc ggtcactgga actgaagtac caggtggagt tctggaagga ggacctgaga
      841 agcaagaccc tgtttccaga cactccatat ggccagccag tgaagattcc tctccagcaa
      901 gatgctcgtg gacgccactg cttcagcgcc agaaccgtct ataccttaac ccacacgaag
      961 tacagcctgt tctctgagcc cagctgcatc ttcctagcgg ccccaggggc caacagggct
     1021 gtcctggcgg tgcccttact cttgcttcta ctgatagcag cggctgcagc gggtacggca
     1081 tggaagaaaa tggatgggaa cccctggttt cagtgggtga agatgcccca ggcactggac
     1141 ttttctgaaa acagacaccc agtggcgacc tttcagccca gtggacctga gttctcaggt
     1201 gacttgatcc tctgtcccca gaaggaactg accataagga ccagaccagt ccctcgggtc
     1261 agaggcccag ccacactgca ggcaggatca gaaaaagaca gtactgagga tgaagacgag
     1321 gacacagacg acgacggtga cagcatccag ccctacctgg aacggcccct cttcgtgagg
     1381 gagaagctcc aggttacgga gcactcagag gcagatgaat ctggggtgga ttcagttggg
     1441 agcgaaggct cgtctgcatg ggactcttca ggtgggagct ggtccagcac aggggtctcc
     1501 tcaggggact cctcttataa agatgaagct ggatcttcca gctgtttgga ccagaagaag
     1561 ccagaccagg agcctcatgg ggatgggcac caggggcctc tcccatgcct ggaattttct
     1621 gaggacttgg gcactgtgga agagcttctg aaagatgacc tctccggttg gagaatatgg
     1681 ggtaccttat ccccaaagag agatctggct cctgtggagc ccccagtttc tcttcagaca
     1741 ctgactttct gctgggacag caatccagag gaagaggaag aggaagagga ggaggaggag
     1801 gaagaggaag aggaagagga agaagactgg gaatcagacc ttaaggacag caacaccagc
     1861 tgttgggatg cttcaagccc gcagaggaca gacgtcaggg gtgggatgct gggagattac
     1921 atggtcaggt gagatggccc cggtggtcca tccatggacc agaggcacct ccaagagctg
     1981 tgtccctttg aatggtagcc aaggtcctgg cccttcttta tggatcttta tggcaccttg
     2041 tcattttgta agatgccacc tgctgtaggt gacctgtgag caggatggag ctgtggtcag
     2101 agactagttg aattccagtc tgcccactgt ccctgggatg acaggtctaa tggaaaaatc
     2161 accctcggac aaaatgaagc aggtgaagcc gggtggctgt ggacaccaag gactgacacg
     2221 ccctagtcca taagtcacac acagcattgc acaaaacagg ccttggtcca aatcactgct
     2281 ctgccgtttc tggcagtcac tgagcaagag actcttaacc tctgcgcctc agtttcccct
     2341 tctgcagctg tcacatggat atggtgaggg ttcgaggagt tttcaggtaa tgggtgacag
     2401 ggggccacca atgtcatgtg tactgactac gcactaaaac tcatcagtcc agactcctga
     2461 gagaccccag gcacctctca ccagcaaccc ctaagccagg agtaacaaaa tacctaccct
     2521 ccaacctgtc caccctctag gtcaccccat ttcttccttg tcaccttcta gtcaggagct
     2581 ccctgaaact acagcctgac caactttgct tctttctcaa acatagttca ccttccaggg
     2641 tcgacattgg tcagggcaga aattgcactc ctggcccggt gtccttttcg aatgccattg
     2701 taacagggtt taagtttttt gggtgtttga ttgtttgttt gtttatttgt ttttatctgt
     2761 tttggtcatg atgaggtcct agtatctgag aagctagtgt cttttagaaa tagacgactg
     2821 tccttttggg ggtgcgcgcg cgatatgtgt ccttggtctg caggtgtcac tcagaaccaa
     2881 tgtgtttgtg gctgaggacc tcaacagtcc atgatgcaga agagagctca caaccgcttt
     2941 actcacggag ctgtgcggct ctgaggctgg tacaaagcca caaccttaca gaactcgtgt
     3001 gagggtaccc cataaggcag aagttttcaa ccttcctaac actgccagcc ataaacagtt
     3061 cttcatggta tggtgacccc ccccagtcat aaaattattt cattaatact tcatacctgg
     3121 agttttgcta ctgttatgaa tcacaatgta aatatctgtg ttttccagtg gtcttaggtg
     3181 accactgtga aaagatcatt ggacccctaa aggggtcatg acctacatgg aggttgagaa
     3241 acaccatctt aagggcatct gattcgaggg ttctctagct cattctcaaa ggcctttggg
     3301 gctccaggat cttccccctt cagtgggagt ggcctcactg agttaataca cagacaatgg
     3361 ctttgcacag atggtgtctt gagtggggtt cacaggtaac aaaaccctaa agcactgtcc
     3421 tcaatacata cctgtatcat ttcaaacaaa cctttaagtc acctggcaag gcagccctag
     3481 tgacttaata tgtgtgtccc caagagttcc cacagtcatc aaactgacag gaggtctttg
     3541 tgacacacac acacacacac acctacctcc tacctcactg gggtttccct gcaatgatgc
     3601 ttgaccacat ccctgagccc agaagcagac caaatgcaca tgcttgagga cggtcatagc
     3661 actggagcag ctccaggaaa tgtcccagcc cagccagtgg cctttctgag acccagctga
     3721 gctgcgccac agaggctttg tcagaaatcc ttccaactgt gacagccttg gcctcgcctt
     3781 ccaagcttac tctccgatag ttcaccttac tgtttacaat gtttcccaaa gtttactttc
     3841 tgatcgagcc ttcttgtcat tctaaatccc agctcctttc agccattagg tcattgacaa
     3901 aagactgtgg gaagcccatg gaaagggcag gaggaacaac ccagaagttc ctagtgtgtg
     3961 ctcagcactt aacttatatg taagcagccc tgggcgacag tctctgggca cctcaaggat
     4021 aacaaggtca aagtgactga ctggatttgc agtggtgggc agcatcagta cactgaggcc
     4081 atacatcttt cttacttgtt tatattacct ttcttgcata tttgtatttt tgttgaattt
     4141 tgcactgtat tttataccct atttaaacaa taatatcagc tggcatataa tacccaaaac
     4201 cttaaataaa gagatctatt tttagagaaa a
//
