LOCUS       NM_053783               1948 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus interferon gamma receptor 1 (Ifngr1), mRNA.
ACCESSION   NM_053783 XM_346525
VERSION     NM_053783.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1948)
  AUTHORS   Balkan,E., Bilen,H., Eyerci,N., Keles,S., Kara,A., Akdeniz,N. and
            Dogan,H.
  TITLE     Cytokine, C-Reactive Protein, and Heat Shock Protein mRNA
            Expression Levels in Patients with Active Behcet's Uveitis
  JOURNAL   Med Sci Monit 24, 1511-1516 (2018)
   PUBMED   29534057
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1948)
  AUTHORS   Sonekatsu,M., Taniguchi,W., Yamanaka,M., Nishio,N., Tsutsui,S.,
            Yamada,H., Yoshida,M. and Nakatsuka,T.
  TITLE     Interferon-gamma potentiates NMDA receptor signaling in spinal
            dorsal horn neurons via microglia-neuron interaction
  JOURNAL   Mol Pain 12, 1744806916644927 (2016)
   PUBMED   27094552
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1948)
  AUTHORS   Rauch,I., Rosebrock,F., Hainzl,E., Heider,S., Majoros,A.,
            Wienerroither,S., Strobl,B., Stockinger,S., Kenner,L., Muller,M.
            and Decker,T.
  TITLE     Noncanonical Effects of IRF9 in Intestinal Inflammation: More than
            Type I and Type III Interferons
  JOURNAL   Mol Cell Biol 35 (13), 2332-2343 (2015)
   PUBMED   25918247
REFERENCE   4  (bases 1 to 1948)
  AUTHORS   Liao,J., Jijon,H.B., Kim,I.R., Goel,G., Doan,A., Sokol,H.,
            Bauer,H., Herrmann,B.G., Lassen,K.G. and Xavier,R.J.
  TITLE     An image-based genetic assay identifies genes in T1D susceptibility
            loci controlling cellular antiviral immunity in mouse
  JOURNAL   PLoS One 9 (9), e108777 (2014)
   PUBMED   25268627
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1948)
  AUTHORS   Hofer,M.J., Li,W., Manders,P., Terry,R., Lim,S.L., King,N.J. and
            Campbell,I.L.
  TITLE     Mice deficient in STAT1 but not STAT2 or IRF9 develop a lethal CD4+
            T-cell-mediated disease following infection with lymphocytic
            choriomeningitis virus
  JOURNAL   J Virol 86 (12), 6932-6946 (2012)
   PUBMED   22496215
REFERENCE   6  (bases 1 to 1948)
  AUTHORS   Dorman,S.E., Picard,C., Lammas,D., Heyne,K., van Dissel,J.T.,
            Baretto,R., Rosenzweig,S.D., Newport,M., Levin,M., Roesler,J.,
            Kumararatne,D., Casanova,J.L. and Holland,S.M.
  TITLE     Clinical features of dominant and recessive interferon gamma
            receptor 1 deficiencies
  JOURNAL   Lancet 364 (9451), 2113-2121 (2004)
   PUBMED   15589309
REFERENCE   7  (bases 1 to 1948)
  AUTHORS   Aoki,M., Matsui,E., Kaneko,H., Inoue,R., Fukao,T., Watanabe,M.,
            Teramoto,T., Kato,Z., Suzuki,K., Suzuki,Y., Kasahara,K. and
            Kondo,N.
  TITLE     A novel single-nucleotide substitution, Leu 467 Pro, in the
            interferon-gamma receptor 1 gene associated with allergic diseases
  JOURNAL   Int J Mol Med 12 (2), 185-191 (2003)
   PUBMED   12851715
REFERENCE   8  (bases 1 to 1948)
  AUTHORS   Vikman,K., Robertson,B., Grant,G., Liljeborg,A. and Kristensson,K.
  TITLE     Interferon-gamma receptors are expressed at synapses in the rat
            superficial dorsal horn and lateral spinal nucleus
  JOURNAL   J Neurocytol 27 (10), 749-759 (1998)
   PUBMED   10640190
REFERENCE   9  (bases 1 to 1948)
  AUTHORS   Newport,M.J., Huxley,C.M., Huston,S., Hawrylowicz,C.M.,
            Oostra,B.A., Williamson,R. and Levin,M.
  TITLE     A mutation in the interferon-gamma-receptor gene and susceptibility
            to mycobacterial infection
  JOURNAL   N Engl J Med 335 (26), 1941-1949 (1996)
   PUBMED   8960473
REFERENCE   10 (bases 1 to 1948)
  AUTHORS   Gray,P.W., Leong,S., Fennie,E.H., Farrar,M.A., Pingel,J.T.,
            Fernandez-Luna,J. and Schreiber,R.D.
  TITLE     Cloning and expression of the cDNA for the murine interferon gamma
            receptor
  JOURNAL   Proc Natl Acad Sci U S A 86 (21), 8497-8501 (1989)
   PUBMED   2530582
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Feb 26, 2021 this sequence version replaced NM_053783.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC062039.1, AF201901.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-157               JAXUCZ010000001.1  16152910-16153066
            158-272             JAXUCZ010000001.1  16157484-16157598
            273-436             JAXUCZ010000001.1  16161491-16161654
            437-603             JAXUCZ010000001.1  16164821-16164987
            604-790             JAXUCZ010000001.1  16167405-16167591
            791-915             JAXUCZ010000001.1  16169442-16169566
            916-1948            JAXUCZ010000001.1  16170407-16171439
FEATURES             Location/Qualifiers
     source          1..1948
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1p12"
     gene            1..1948
                     /gene="Ifngr1"
                     /gene_synonym="Ifngr"
                     /note="interferon gamma receptor 1"
                     /db_xref="GeneID:116465"
                     /db_xref="RGD:620570"
     exon            1..157
                     /gene="Ifngr1"
                     /gene_synonym="Ifngr"
                     /inference="alignment:Splign:2.1.0"
     CDS             46..1467
                     /gene="Ifngr1"
                     /gene_synonym="Ifngr"
                     /codon_start=1
                     /product="interferon gamma receptor 1 precursor"
                     /protein_id="NP_446235.3"
                     /db_xref="GeneID:116465"
                     /db_xref="RGD:620570"
                     /translation="MGPQAAVGRMILLVVLMLSAEIGSGALMSTEDPKPPSVPAPTNV
                     LITSYDLNPVVHWKHQNVSQAAVFTVQVKMYPDNWTDACTNIAHHYCNIYKHISYPDS
                     SAWARVKAKVGQRESAYAQSEEFIMCRKGKVGPPGLDIGRKEDQLIVHIFHPKVNVSQ
                     ETMFGDGNTCYTFDYTVFVKHYRSGEILHTEHSVLKEDCSETLCELNISVSTLNSNYC
                     VSVVGKSSFWQVNTETSKDACIPFLHDDREESIWMLLVAPLLFLTIVVPALVCCYIKK
                     NPFKRKSIMLPKSLLSVVKNATSETKPESKYSLVTSCQPAVLENETVICEEHLSTVTT
                     PDSLEAPEQEELSKGTVATVAEGNTSPETTDSPPTPVQSGHFSLSSSNQSGSCSLTTY
                     HSRDGSDSGLVGTGSSISDSDFLPNNDSETKMADPAPTPVRKALTFSGYDKPHVLVDV
                     PVDGEGKESLIGYRLTGDTQELS"
     exon            158..272
                     /gene="Ifngr1"
                     /gene_synonym="Ifngr"
                     /inference="alignment:Splign:2.1.0"
     exon            273..436
                     /gene="Ifngr1"
                     /gene_synonym="Ifngr"
                     /inference="alignment:Splign:2.1.0"
     exon            437..603
                     /gene="Ifngr1"
                     /gene_synonym="Ifngr"
                     /inference="alignment:Splign:2.1.0"
     exon            604..790
                     /gene="Ifngr1"
                     /gene_synonym="Ifngr"
                     /inference="alignment:Splign:2.1.0"
     exon            791..915
                     /gene="Ifngr1"
                     /gene_synonym="Ifngr"
                     /inference="alignment:Splign:2.1.0"
     exon            916..1948
                     /gene="Ifngr1"
                     /gene_synonym="Ifngr"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctcgggcggc gcgggtaccc tgtctagggt gtcctttgct caggaatggg cccgcaggct
       61 gcagtcggca ggatgattct gctggtggtc ctgatgctgt ctgcggagat cgggagtgga
      121 gctttgatga gcaccgagga tcctaagccg ccctcggtgc ctgcgccaac aaatgttcta
      181 attacgtcct atgacttgaa ccctgtcgta cattggaagc accagaacgt gtcgcaggct
      241 gccgtcttca ctgtacaggt aaagatgtat ccggataact ggactgatgc ctgcaccaac
      301 attgcccatc attattgtaa tatctacaaa cacatttcct atcctgactc atctgcctgg
      361 gccagagtta aggccaaggt tggacaaaga gaatctgcct atgcacagtc agaagagttt
      421 attatgtgcc gaaaggggaa ggttggaccg cctggcctgg acatcggaag gaaggaagat
      481 cagctgattg tccacatatt tcaccctaag gtcaatgtga gtcaggaaac catgtttggt
      541 gacggaaata cctgttacac attcgactac actgtgtttg tgaaacatta caggagtggg
      601 gagatcctac atacagaaca tagcgtccta aaagaagatt gtagcgaaac tctgtgtgag
      661 ttaaacatct cagtgtccac gctgaattcc aattactgtg tttcagtagt tggaaagtcg
      721 tctttctggc aagttaatac agaaacatca aaagacgcct gtatcccctt tctccatgat
      781 gacagagaag aatcaatttg gatgctgctt gttgctcctc ttctcttcct tacaatagtt
      841 gtcccggcac ttgtgtgttg ttacattaag aagaatccat ttaagagaaa aagcataatg
      901 ttacctaagt ccttgctctc tgtggtaaaa aatgccacgt ccgagaccaa acctgaatca
      961 aagtactccc ttgtcacgtc gtgccagcca gctgtcctag agaacgagac agtgatctgt
     1021 gaggagcact tgtccacagt gacaactcca gacagcctag aagcaccaga gcaggaagaa
     1081 ctttctaaag gaaccgtggc tacggttgct gaaggaaaca cttcccccga gaccaccgac
     1141 agccctccaa ctccggtaca aagtggccat ttttccctgt caagtagtaa ccagtcaggc
     1201 tcctgtagcc tcaccaccta tcactccagg gacggctctg acagtggcct cgtgggcaca
     1261 ggcagctcca tatctgactc tgactttctc ccaaacaacg actcggaaac aaagatggca
     1321 gacccagccc ctacacctgt gaggaaggcc ctgactttct ccggttatga caaaccacac
     1381 gtgttggtgg acgtgcccgt ggatggggag ggcaaggagt ctttgattgg gtatagactc
     1441 acgggtgata cccaggaact gtcctaaggc cgccgagtcc tgacggtgct gaaggatctg
     1501 cctctaggca gttttcctgc tttgttctcg tgaaagactt tgcacgttag ccgattctga
     1561 ccgcagcgtc cctaatgtga cacccggata aggagtctgt gtgagcgcac tgcccggtct
     1621 actccgcaaa tgccaagact gccagaggga tgaacagtca cctatgagct cctgcctggg
     1681 tgggctggtt ctcctcctct agccttgctt cctccagccg ctgctcctcc acctcactgc
     1741 ctcacgggac acgggggacc tgtcctcaca cacctttgta tctgtaagtc cgtgtatata
     1801 gtgtgtttgc agtttcactt aagggaaagc tgaaagccac tgcaggtgga ctccgttcgt
     1861 gacaagtttg gtaggacatt tgtgggcgca tacgtttttt tatggggcat cacttatgat
     1921 ttttaagtaa aatgttttga aaccagaa
//
