LOCUS       NM_138880                508 bp    mRNA    linear   ROD 13-FEB-2025
DEFINITION  Rattus norvegicus interferon gamma (Ifng), mRNA.
ACCESSION   NM_138880
VERSION     NM_138880.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 508)
  AUTHORS   Tong,L., Chen,G., Liu,T., Wang,L., Zhang,H., Chen,F., Zhang,S. and
            Du,D.
  TITLE     IFN-gamma deficiency in the rostral ventrolateral medulla
            contributes to stress-induced hypertension by impairing microglial
            synaptic engulfment
  JOURNAL   J Hypertens 41 (8), 1323-1332 (2023)
   PUBMED   37260264
  REMARK    GeneRIF: IFN-gamma deficiency in the rostral ventrolateral medulla
            contributes to stress-induced hypertension by impairing microglial
            synaptic engulfment.
REFERENCE   2  (bases 1 to 508)
  AUTHORS   Ren,Y.S., Li,H.H., Yao,J.C., Tan,Y.J., Pan,L.H., Peng,T.,
            Zhao,L.L., Zhang,G.M., Yue,J., Hu,X.M., Liu,Z. and Li,J.
  TITLE     Application quantitative proteomics approach to identify
            differentially expressed proteins associated with cardiac
            protection mediated by cycloastragenol in acute myocardial
            infarction rats
  JOURNAL   J Proteomics 222, 103691 (2020)
   PUBMED   32068187
REFERENCE   3  (bases 1 to 508)
  AUTHORS   Fraser,D.D., Cepinskas,G., Slessarev,M., Martin,C., Daley,M.,
            Miller,M.R., O'Gorman,D.B., Gill,S.E., Patterson,E.K. and Dos
            Santos,C.C.
  TITLE     Inflammation Profiling of Critically Ill Coronavirus Disease 2019
            Patients
  JOURNAL   Crit Care Explor 2 (6), e0144 (2020)
   PUBMED   32696007
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 508)
  AUTHORS   Gangisetty,O., Palagani,A. and Sarkar,D.K.
  TITLE     Transgenerational inheritance of fetal alcohol exposure adverse
            effects on immune gene interferon-Upsilon
  JOURNAL   Clin Epigenetics 12 (1), 70 (2020)
   PUBMED   32448218
  REMARK    GeneRIF: Transgenerational inheritance of fetal alcohol exposure
            adverse effects on immune gene interferon-Upsilon.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 508)
  AUTHORS   Huang,C., Wang,Y., Li,X., Ren,L., Zhao,J., Hu,Y., Zhang,L., Fan,G.,
            Xu,J., Gu,X., Cheng,Z., Yu,T., Xia,J., Wei,Y., Wu,W., Xie,X.,
            Yin,W., Li,H., Liu,M., Xiao,Y., Gao,H., Guo,L., Xie,J., Wang,G.,
            Jiang,R., Gao,Z., Jin,Q., Wang,J. and Cao,B.
  TITLE     Clinical features of patients infected with 2019 novel coronavirus
            in Wuhan, China
  JOURNAL   Lancet 395 (10223), 497-506 (2020)
   PUBMED   31986264
  REMARK    Erratum:[Lancet. 2020 Feb 15;395(10223):496. doi:
            10.1016/S0140-6736(20)30252-X.. PMID: 32007144]
REFERENCE   6  (bases 1 to 508)
  AUTHORS   Freundlich,B., Jimenez,S.A., Steen,V.D., Medsger,T.A. Jr.,
            Szkolnicki,M. and Jaffe,H.S.
  TITLE     Treatment of systemic sclerosis with recombinant interferon-gamma.
            A phase I/II clinical trial
  JOURNAL   Arthritis Rheum 35 (10), 1134-1142 (1992)
   PUBMED   1418004
REFERENCE   7  (bases 1 to 508)
  AUTHORS   Machold,K.P., Neumann,K. and Smolen,J.S.
  TITLE     Recombinant human interferon gamma in the treatment of rheumatoid
            arthritis: double blind placebo controlled study
  JOURNAL   Ann Rheum Dis 51 (9), 1039-1043 (1992)
   PUBMED   1417133
REFERENCE   8  (bases 1 to 508)
  AUTHORS   Charteris,D.G. and Lightman,S.L.
  TITLE     Interferon-gamma (IFN-gamma) production in vivo in experimental
            autoimmune uveoretinitis
  JOURNAL   Immunology 75 (3), 463-467 (1992)
   PUBMED   1572694
REFERENCE   9  (bases 1 to 508)
  AUTHORS   Borda,E., Leiros,C.P., Sterin-Borda,L. and de Bracco,M.M.
  TITLE     Cholinergic response of isolated rat atria to recombinant rat
            interferon-gamma
  JOURNAL   J Neuroimmunol 32 (1), 53-59 (1991)
   PUBMED   1900518
REFERENCE   10 (bases 1 to 508)
  AUTHORS   Celada,A. and Maki,R.A.
  TITLE     IFN-gamma induces the expression of the genes for MHC class II I-A
            beta and tumor necrosis factor through a protein kinase
            C-independent pathway
  JOURNAL   J Immunol 146 (1), 114-120 (1991)
   PUBMED   1845803
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Nov 27, 2020 this sequence version replaced NM_138880.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF010466.1, SRR26643292.29446.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676810 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-111               JAXUCZ010000007.1  55789180-55789290
            112-180             JAXUCZ010000007.1  55790431-55790499
            181-363             JAXUCZ010000007.1  55790603-55790785
            364-508             JAXUCZ010000007.1  55793072-55793216
FEATURES             Location/Qualifiers
     source          1..508
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q22"
     gene            1..508
                     /gene="Ifng"
                     /gene_synonym="If2f; IFNG2"
                     /note="interferon gamma"
                     /db_xref="GeneID:25712"
                     /db_xref="RGD:2866"
     CDS             1..471
                     /gene="Ifng"
                     /gene_synonym="If2f; IFNG2"
                     /note="IFN-gamma; interferon 2f"
                     /codon_start=1
                     /product="interferon gamma precursor"
                     /protein_id="NP_620235.1"
                     /db_xref="GeneID:25712"
                     /db_xref="RGD:2866"
                     /translation="MSATRRVLVLQLCLMALSGCYCQGTLIESLESLKNYFNSSSMDA
                     MEGKSLLLDIWRNWQKDGNTKILESQIISFYLRLFEVLKDNQAISNNISVIESHLITN
                     FFSNSKAKKDAFMSIAKFEVNNPQIQHKAVNELIRVIHQLSPESSLRKRKRSRC"
     exon            1..111
                     /gene="Ifng"
                     /gene_synonym="If2f; IFNG2"
                     /inference="alignment:Splign:2.1.0"
     exon            112..180
                     /gene="Ifng"
                     /gene_synonym="If2f; IFNG2"
                     /inference="alignment:Splign:2.1.0"
     exon            181..363
                     /gene="Ifng"
                     /gene_synonym="If2f; IFNG2"
                     /inference="alignment:Splign:2.1.0"
     exon            364..508
                     /gene="Ifng"
                     /gene_synonym="If2f; IFNG2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgagtgcta cacgccgcgt cttggttttg cagctctgcc tcatggccct ctctggctgt
       61 tactgccaag gcacactcat tgaaagccta gaaagtctga agaactattt taactcaagt
      121 agcatggatg ctatggaagg aaagagcctc ctcttggata tctggaggaa ctggcaaaag
      181 gacggtaaca cgaaaatact tgagagccag attatctctt tctacctcag actctttgaa
      241 gtcttgaaag acaaccaggc catcagcaac aacataagtg tcatcgaatc gcacctgatc
      301 actaacttct tcagcaacag taaagcaaaa aaggatgcat tcatgagcat cgccaagttc
      361 gaggtgaaca acccacagat ccagcacaaa gctgtcaatg aactcatcag agtgattcac
      421 cagctgtcac cagaatctag cctaaggaag cggaaaagga gtcggtgctg attctggggt
      481 agagagtgtg ccaataagaa gaattctg
//
