LOCUS       NM_019127                838 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus interferon beta 1 (Ifnb1), mRNA.
ACCESSION   NM_019127
VERSION     NM_019127.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 838)
  AUTHORS   Bolivar,S., Espitia-Corredor,J.A., Olivares-Silva,F.,
            Valenzuela,P., Humeres,C., Anfossi,R., Castro,E., Vivar,R.,
            Salas-Hernandez,A., Pardo-Jimenez,V. and Diaz-Araya,G.
  TITLE     In cardiac fibroblasts, interferon-beta attenuates differentiation,
            collagen synthesis, and TGF-beta1-induced collagen gel contraction
  JOURNAL   Cytokine 138, 155359 (2021)
   PUBMED   33160814
  REMARK    GeneRIF: In cardiac fibroblasts, interferon-beta attenuates
            differentiation, collagen synthesis, and TGF-beta1-induced collagen
            gel contraction.
REFERENCE   2  (bases 1 to 838)
  AUTHORS   Guo,Y., Gu,R., Gan,D., Hu,F., Li,G. and Xu,G.
  TITLE     Mitochondrial DNA drives noncanonical inflammation activation via
            cGAS-STING signaling pathway in retinal microvascular endothelial
            cells
  JOURNAL   Cell Commun Signal 18 (1), 172 (2020)
   PUBMED   33115500
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 838)
  AUTHORS   Hassan,A.O., Case,J.B., Winkler,E.S., Thackray,L.B., Kafai,N.M.,
            Bailey,A.L., McCune,B.T., Fox,J.M., Chen,R.E., Alsoussi,W.B.,
            Turner,J.S., Schmitz,A.J., Lei,T., Shrihari,S., Keeler,S.P.,
            Fremont,D.H., Greco,S., McCray,P.B. Jr., Perlman,S., Holtzman,M.J.,
            Ellebedy,A.H. and Diamond,M.S.
  TITLE     A SARS-CoV-2 Infection Model in Mice Demonstrates Protection by
            Neutralizing Antibodies
  JOURNAL   Cell 182 (3), 744-753 (2020)
   PUBMED   32553273
REFERENCE   4  (bases 1 to 838)
  AUTHORS   Hung,I.F., Lung,K.C., Tso,E.Y., Liu,R., Chung,T.W., Chu,M.Y.,
            Ng,Y.Y., Lo,J., Chan,J., Tam,A.R., Shum,H.P., Chan,V., Wu,A.K.,
            Sin,K.M., Leung,W.S., Law,W.L., Lung,D.C., Sin,S., Yeung,P.,
            Yip,C.C., Zhang,R.R., Fung,A.Y., Yan,E.Y., Leung,K.H., Ip,J.D.,
            Chu,A.W., Chan,W.M., Ng,A.C., Lee,R., Fung,K., Yeung,A., Wu,T.C.,
            Chan,J.W., Yan,W.W., Chan,W.M., Chan,J.F., Lie,A.K., Tsang,O.T.,
            Cheng,V.C., Que,T.L., Lau,C.S., Chan,K.H., To,K.K. and Yuen,K.Y.
  TITLE     Triple combination of interferon beta-1b, lopinavir-ritonavir, and
            ribavirin in the treatment of patients admitted to hospital with
            COVID-19: an open-label, randomised, phase 2 trial
  JOURNAL   Lancet 395 (10238), 1695-1704 (2020)
   PUBMED   32401715
REFERENCE   5  (bases 1 to 838)
  AUTHORS   Han,X., Wang,C., Tang,D., Shi,Y. and Gao,M.
  TITLE     Association of genetic polymorphisms in chromosome 9p21 with risk
            of ischemic stroke
  JOURNAL   Cytokine 127, 154921 (2020)
   PUBMED   31810024
REFERENCE   6  (bases 1 to 838)
  AUTHORS   Hiemstra,P.S., van den Barselaar,M.T., Roest,M., Nibbering,P.H. and
            van Furth,R.
  TITLE     Ubiquicidin, a novel murine microbicidal protein present in the
            cytosolic fraction of macrophages
  JOURNAL   J Leukoc Biol 66 (3), 423-428 (1999)
   PUBMED   10496312
REFERENCE   7  (bases 1 to 838)
  AUTHORS   Zou,L.P., Ma,D.H., Wei,L., van der Meide,P.H., Mix,E. and Zhu,J.
  TITLE     IFN-beta suppresses experimental autoimmune neuritis in Lewis rats
            by inhibiting the migration of inflammatory cells into peripheral
            nervous tissue
  JOURNAL   J Neurosci Res 56 (2), 123-130 (1999)
   PUBMED   10494101
REFERENCE   8  (bases 1 to 838)
  AUTHORS   Triantaphyllopoulos,K., Croxford,J., Baker,D. and Chernajovsky,Y.
  TITLE     Cloning and expression of murine IFN beta and a TNF antagonist for
            gene therapy of experimental allergic encephalomyelitis
  JOURNAL   Gene Ther 5 (2), 253-263 (1998)
   PUBMED   9578846
REFERENCE   9  (bases 1 to 838)
  AUTHORS   Yokoyama,S., Ohishi,N., Shamoto,M., Watanabe,Y. and Yagi,K.
  TITLE     Isolation and expression of rat interferon beta gene and
            growth-inhibitory effect of its expression on rat glioma cells
  JOURNAL   Biochem Biophys Res Commun 232 (3), 698-701 (1997)
   PUBMED   9126338
REFERENCE   10 (bases 1 to 838)
  AUTHORS   Ruuls,S.R., de Labie,M.C., Weber,K.S., Botman,C.A.,
            Groenestein,R.J., Dijkstra,C.D., Olsson,T. and van der Meide,P.H.
  TITLE     The length of treatment determines whether IFN-beta prevents or
            aggravates experimental autoimmune encephalomyelitis in Lewis rats
  JOURNAL   J Immunol 157 (12), 5721-5731 (1996)
   PUBMED   8955226
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Sep 13, 2022 this sequence version replaced NM_019127.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-838               JAXUCZ010000005.1  108066650-108067487 c
FEATURES             Location/Qualifiers
     source          1..838
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q32"
     gene            1..838
                     /gene="Ifnb1"
                     /gene_synonym="If1da1; Ifnb"
                     /note="interferon beta 1"
                     /db_xref="GeneID:24481"
                     /db_xref="RGD:2865"
     exon            1..838
                     /gene="Ifnb1"
                     /gene_synonym="If1da1; Ifnb"
                     /inference="alignment:Splign:2.1.0"
     CDS             73..627
                     /gene="Ifnb1"
                     /gene_synonym="If1da1; Ifnb"
                     /note="IFN-beta; interferon beta 1, fibroblast; interferon
                     1da1"
                     /codon_start=1
                     /product="interferon beta precursor"
                     /protein_id="NP_062000.1"
                     /db_xref="GeneID:24481"
                     /db_xref="RGD:2865"
                     /translation="MANRWTLHIAFLLCFSTTALSIDYKQLQFRQSTSIRTCQKLLRQ
                     LNGRLNLSYRTDFKIPMEVMHPSQMEKSYTAFAIQVMLQNVFLVFRSNFSSTGWNETI
                     VESLLDELHQQTELLEIILKEKQEERLTWVTSTTTLGLKSYYWRVQRYLKDKKYNSYA
                     WMVVRAEVFRNFSIILRLNRNFQN"
ORIGIN      
        1 attctcactg cagcctttgg cagcctttgc ctcatcgtgc aggtagcagc caacaccagc
       61 ccagcttcca tcatggccaa caggtggacc ctccacattg cgttcctgct gtgcttctcc
      121 accactgccc tctccatcga ctacaagcag ctccagttcc gacaaagcac tagcattcgg
      181 acatgtcaga agctcctgag gcagctgaat ggaaggctca acctcagcta caggacggac
      241 ttcaagatcc ctatggaggt gatgcacccg tcacagatgg agaagagtta cactgccttt
      301 gccattcaag tgatgctcca gaatgtcttt cttgtcttca gaagcaattt ctccagcact
      361 gggtggaatg agactattgt tgaaagtctc ttggatgaac tacatcagca gacagagctt
      421 ctggagataa tactaaagga aaagcaagag gaaagattga cttgggtgac atccacgact
      481 actttaggct tgaagagcta ttactggagg gtacaaaggt accttaaaga caagaagtac
      541 aacagctatg cctggatggt ggtccgagca gaagtcttca ggaacttttc cattattcta
      601 agacttaata gaaacttcca gaactgaaga cctgtcagcc aatgcctcca agagcaggtg
      661 atggttgcag gcaatcttaa aacattagag actgactctg tgactggtag tgaatctact
      721 gcatttgaaa ggtcaaagga aaacactgaa tttttattaa tttataattt aaattatttt
      781 ctactcttta tttaaacttt taacctcaaa aataaaatat ttataataca aaagtcaa
//
