LOCUS       NM_001105893            3903 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus interferon alpha and beta receptor subunit 1
            (Ifnar1), transcript variant 1, mRNA.
ACCESSION   NM_001105893 XM_001073651 XM_213649
VERSION     NM_001105893.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3903)
  AUTHORS   Huber,M., Suprunenko,T., Ashhurst,T., Marbach,F., Raifer,H.,
            Wolff,S., Strecker,T., Viengkhou,B., Jung,S.R., Obermann,H.L.,
            Bauer,S., Xu,H.C., Lang,P.A., Tom,A., Lang,K.S., King,N.J.C.,
            Campbell,I.L. and Hofer,M.J.
  TITLE     IRF9 Prevents CD8+ T Cell Exhaustion in an Extrinsic Manner during
            Acute Lymphocytic Choriomeningitis Virus Infection
  JOURNAL   J Virol 91 (22), e01219-17 (2017)
   PUBMED   28878077
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3903)
  AUTHORS   Lee,A.J., Chen,B., Chew,M.V., Barra,N.G., Shenouda,M.M., Nham,T.,
            van Rooijen,N., Jordana,M., Mossman,K.L., Schreiber,R.D., Mack,M.
            and Ashkar,A.A.
  TITLE     Inflammatory monocytes require type I interferon receptor signaling
            to activate NK cells via IL-18 during a mucosal viral infection
  JOURNAL   J Exp Med 214 (4), 1153-1167 (2017)
   PUBMED   28264883
REFERENCE   3  (bases 1 to 3903)
  AUTHORS   Qaisar,N., Lin,S., Ryan,G., Yang,C., Oikemus,S.R., Brodsky,M.H.,
            Bortell,R., Mordes,J.P. and Wang,J.P.
  TITLE     A Critical Role for the Type I Interferon Receptor in Virus-Induced
            Autoimmune Diabetes in Rats
  JOURNAL   Diabetes 66 (1), 145-157 (2017)
   PUBMED   27999109
  REMARK    GeneRIF: IFNAR1 deficiency significantly delayed the onset and
            frequency of diabetes and greatly reduced the intensity of
            insulitis after poly I:C treatment. The occurrence of Kilham rat
            virus-induced diabetes was also diminished in IFNAR1-deficient
            animals.
REFERENCE   4  (bases 1 to 3903)
  AUTHORS   Ren,Y., Zhao,Y., Lin,D., Xu,X., Zhu,Q., Yao,J., Shu,H.B. and
            Zhong,B.
  TITLE     The Type I Interferon-IRF7 Axis Mediates Transcriptional Expression
            of Usp25 Gene
  JOURNAL   J Biol Chem 291 (25), 13206-13215 (2016)
   PUBMED   27129230
REFERENCE   5  (bases 1 to 3903)
  AUTHORS   Li,W., Hofer,M.J., Jung,S.R., Lim,S.L. and Campbell,I.L.
  TITLE     IRF7-dependent type I interferon production induces lethal
            immune-mediated disease in STAT1 knockout mice infected with
            lymphocytic choriomeningitis virus
  JOURNAL   J Virol 88 (13), 7578-7588 (2014)
   PUBMED   24760883
REFERENCE   6  (bases 1 to 3903)
  AUTHORS   Giannakopoulos,N.V., Luo,J.K., Papov,V., Zou,W., Lenschow,D.J.,
            Jacobs,B.S., Borden,E.C., Li,J., Virgin,H.W. and Zhang,D.E.
  TITLE     Proteomic identification of proteins conjugated to ISG15 in mouse
            and human cells
  JOURNAL   Biochem Biophys Res Commun 336 (2), 496-506 (2005)
   PUBMED   16139798
REFERENCE   7  (bases 1 to 3903)
  AUTHORS   Honda,K., Yanai,H., Negishi,H., Asagiri,M., Sato,M., Mizutani,T.,
            Shimada,N., Ohba,Y., Takaoka,A., Yoshida,N. and Taniguchi,T.
  TITLE     IRF-7 is the master regulator of type-I interferon-dependent immune
            responses
  JOURNAL   Nature 434 (7034), 772-777 (2005)
   PUBMED   15800576
REFERENCE   8  (bases 1 to 3903)
  AUTHORS   Kumar,K.G., Tang,W., Ravindranath,A.K., Clark,W.A., Croze,E. and
            Fuchs,S.Y.
  TITLE     SCF(HOS) ubiquitin ligase mediates the ligand-induced
            down-regulation of the interferon-alpha receptor
  JOURNAL   EMBO J 22 (20), 5480-5490 (2003)
   PUBMED   14532120
REFERENCE   9  (bases 1 to 3903)
  AUTHORS   Ledeboer,A., Wierinckx,A., Bol,J.G., Floris,S., Renardel de
            Lavalette,C., De Vries,H.E., van den Berg,T.K., Dijkstra,C.D.,
            Tilders,F.J. and van dam,A.M.
  TITLE     Regional and temporal expression patterns of interleukin-10,
            interleukin-10 receptor and adhesion molecules in the rat spinal
            cord during chronic relapsing EAE
  JOURNAL   J Neuroimmunol 136 (1-2), 94-103 (2003)
   PUBMED   12620647
REFERENCE   10 (bases 1 to 3903)
  AUTHORS   Domanski,P., Witte,M., Kellum,M., Rubinstein,M., Hackett,R.,
            Pitha,P. and Colamonici,O.R.
  TITLE     Cloning and expression of a long form of the beta subunit of the
            interferon alpha beta receptor that is required for signaling
  JOURNAL   J Biol Chem 270 (37), 21606-21611 (1995)
   PUBMED   7665574
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000011.1.
            
            On or before Oct 3, 2007 this sequence version replaced
            XM_213649.4, XM_001073651.1.
            
            Transcript Variant: This variant (1) encodes the functional
            protein.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643299.47416.1,
                                           SRR26643295.42810.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-348               JAXUCZ010000011.1  44211769-44212116
            349-472             JAXUCZ010000011.1  44217779-44217902
            473-651             JAXUCZ010000011.1  44221560-44221738
            652-806             JAXUCZ010000011.1  44224467-44224621
            807-945             JAXUCZ010000011.1  44224709-44224847
            946-1060            JAXUCZ010000011.1  44225433-44225547
            1061-1260           JAXUCZ010000011.1  44228200-44228399
            1261-1394           JAXUCZ010000011.1  44228649-44228782
            1395-1557           JAXUCZ010000011.1  44230648-44230810
            1558-1700           JAXUCZ010000011.1  44231403-44231545
            1701-3903           JAXUCZ010000011.1  44233227-44235429
FEATURES             Location/Qualifiers
     source          1..3903
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q11"
     gene            1..3903
                     /gene="Ifnar1"
                     /note="interferon alpha and beta receptor subunit 1"
                     /db_xref="GeneID:288264"
                     /db_xref="RGD:1305399"
     exon            1..348
                     /gene="Ifnar1"
                     /inference="alignment:Splign:2.1.0"
     CDS             276..2057
                     /gene="Ifnar1"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; interferon alpha/beta receptor 1; interferon
                     (alpha and beta) receptor 1; interferon (alpha, beta and
                     omega) receptor 1"
                     /codon_start=1
                     /product="interferon alpha/beta receptor 1 isoform 1
                     precursor"
                     /protein_id="NP_001099363.2"
                     /db_xref="GeneID:288264"
                     /db_xref="RGD:1305399"
                     /translation="MLAVVGAAALVLVAGAPWMLPVASGEDNLRPPEDVAIYIIDDNY
                     TLKWNHHRESMGNVTFSAEYQKGEGRIWLKVPKCQHITRTKCEFSLLGINVYSKTQFR
                     VRAEEGNSTSSWNEADSFIPFYKAHVSPPRVHLKAEDKAILVYISPPGEDGTMWAQEK
                     RCFNYTIRIWGRSFPVREIKPMYFPKKISKLLPETTYCLEVRAVHTSLQRHSNYSSAR
                     CINTTVANKIPVPENLEVDVQGDSYVLKWDHAFANMTFKAQWIPVYSKSSPGNHSDKW
                     KPIPTCANVQTTHCVSPRETFHTGTFFLRVQASDGNNTSFWSEEKLIDSQKYTLLPPP
                     VIAVTPTGDSLLVYVSCKDSKCNGLIYEVIFWENTSNTEKRQHPQSMIKEHPEFNVVN
                     LRPLTVYCVQARVLSTGVWNKTSKFSDKLCKKTHPGNSSVTWIITGFGALLFSAMAFY
                     AGRSLQKYLYYVFSPPLKPPCSIDEFFSELPSKSLLLLTAEEHTERCFVIENTGVVAG
                     EENRAPEEELRKYSSQSSQDSGNYSNEEEESVGPESGQDMLSTAPSGSPWSLPCPAGT
                     LEDGACFPGKEKHLQSPVLRTQPALHG"
     exon            349..472
                     /gene="Ifnar1"
                     /inference="alignment:Splign:2.1.0"
     exon            473..651
                     /gene="Ifnar1"
                     /inference="alignment:Splign:2.1.0"
     exon            652..806
                     /gene="Ifnar1"
                     /inference="alignment:Splign:2.1.0"
     exon            807..945
                     /gene="Ifnar1"
                     /inference="alignment:Splign:2.1.0"
     exon            946..1060
                     /gene="Ifnar1"
                     /inference="alignment:Splign:2.1.0"
     exon            1061..1260
                     /gene="Ifnar1"
                     /inference="alignment:Splign:2.1.0"
     exon            1261..1394
                     /gene="Ifnar1"
                     /inference="alignment:Splign:2.1.0"
     exon            1395..1557
                     /gene="Ifnar1"
                     /inference="alignment:Splign:2.1.0"
     exon            1558..1700
                     /gene="Ifnar1"
                     /inference="alignment:Splign:2.1.0"
     exon            1701..3903
                     /gene="Ifnar1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctgtcgggtg cggtctttcc ggaagtgtgg gtagagcgtg gcaggggcct tcagggtccg
       61 agctcagagc accaggactg gaccgcgccc ggtactttcc gagccgctcg ctcgcggaga
      121 gggcggggcg ttggtagagg aggagtaccg ggcggagggg gcggggcaga ggggcggggc
      181 gtcaggaaga gggcctagct accctggagt catcttcagc tccgctgtac tgctgaagag
      241 gaagatgtga gcaacgggtc cggcctccca agacgatgct cgctgtcgta ggcgctgcgg
      301 ccctggtgct ggtggcaggg gcgccttgga tgctgcccgt agcctcaggt gaagacaatc
      361 taaggcctcc tgaggatgta gccatctaca ttatagacga caactatacc ctaaagtgga
      421 accaccacag agaatcaatg ggcaacgtga ctttttcagc agaatatcaa aaaggagaag
      481 gaaggatctg gttaaaagtg cccaaatgtc aacatattac aaggaccaaa tgtgaattct
      541 ctttactggg cataaatgtt tacagcaaga cacagtttcg tgtaagagca gaagaaggga
      601 atagcacttc ttcatggaat gaggctgatt catttattcc attctacaaa gctcacgtca
      661 gccccccaag agtacattta aaagctgaag ataaagccat actagtctac atctctcctc
      721 ccggagaaga cggaaccatg tgggcacagg agaaacgctg cttcaattac acgatacgga
      781 tctgggggag gtcttttcct gtcagagaaa ttaaacctat gtattttcca aaaaagatat
      841 caaagctctt gccagagact acctactgtt tagaagtcag agcagtgcac acatcgcttc
      901 agagacacag caactatagc tcagcgcggt gtataaacac cacagtggca aataaaatac
      961 ctgtgccaga aaatctagaa gtggatgtcc aaggtgacag ctatgttctg aaatgggacc
     1021 acgcatttgc aaacatgacc ttcaaagcac agtggatccc tgtctattca aaaagtagtc
     1081 ctggaaacca ttcagacaaa tggaaaccaa tacctacctg tgcaaatgtg cagactacac
     1141 actgtgtatc tcctcgagag actttccaca caggaacttt ctttctccgt gtacaagcct
     1201 cagatggaaa taacacgtcc ttttggtctg aagagaaact tattgattct caaaaataca
     1261 ctctccttcc tcctccggtc attgctgtca cccccacggg ggactccttg cttgtttatg
     1321 tcagctgtaa ggacagcaaa tgtaatggac tcatttacga agtcatcttt tgggaaaaca
     1381 cttccaatac tgagaaaaga caacacccac aaagcatgat taaagaacac ccagagttca
     1441 acgttgtgaa cctgcggccg ctgactgtgt actgtgtcca ggctagagtg ctctccactg
     1501 gcgtgtggaa taagaccagt aaattcagtg ataagctgtg taagaaaaca catccaggaa
     1561 actcttctgt gacctggatt ataactggat ttggtgctct actcttctct gccatggcct
     1621 tttatgctgg gaggagcctc caaaaatacc tgtattacgt gttctcccca ccactcaagc
     1681 ctccctgcag tatcgacgag tttttctcag agctgccttc caaaagcctt ctgcttctga
     1741 ctgctgaaga gcacaccgag aggtgcttcg tcattgagaa cacaggtgtg gttgctggag
     1801 aggagaatcg cgcacctgag gaggagctca ggaagtacag ttcccagagc agccaggact
     1861 cagggaacta ctccaacgaa gaggaggaga gtgtggggcc tgagagtggc caggatatgc
     1921 tttccacagc tcccagtggg tctccatgga gcctgccctg ccctgctggc accttggaag
     1981 atggtgcctg cttcccggga aaagaaaagc accttcagag cccagtcctg aggacacagc
     2041 cagctctcca cggctgacac aggctcgccg tagtctggag tacatgtgga tgagacaggc
     2101 ttaactgaag gtgactgccc gtctctctct gctggcagcc taaaccccag ggcgccattt
     2161 ggagccacag atgaggctca ctgctgcaag gctgcctggt ggttctgtct tcctgttctt
     2221 accctagcag acagcagttt agaacatccg ctttttaatc ctgctgtaac ctctcagtgt
     2281 tgcaaaggtg ctgttgtcta cagtagtgct tcccagccat aactccgcac agcagtggct
     2341 tccgaccaga cgtcactgaa ccgcggggaa aggggacttg gactagagga gccaacattg
     2401 ctctaaggtc tcagcatggc ctgggtatgc acgttgcact ctagtacttg gggaagtaga
     2461 aaatggcagg gacaaaatgc agacgtgaag tcattcagga agagagaagc tagtgagtct
     2521 gatgagagaa gaccatgtac actcagtgtt tgtatgaatg tctctgtatc tttcctgtga
     2581 ttctttataa agccagacag accctctctc ctccagccag cactcttcag gtccccttct
     2641 cagctccatg tacttaacaa aaaccagtgt tggatactag gggaagggat agtgctgcct
     2701 ggcggtgcct ctaagtaacc ttaaattgac gctctgtgag tctgttttgt gggcaggata
     2761 cctagcaatc ctgggggctg cagggcagac tctcagtctc aggccagaaa ggaagagata
     2821 ggactgatgg atcctagcca tggctcactc ccctgagcca ttttaaggat tctccccagg
     2881 actgcccatc ctgtgctcac cacaggaaaa gtaccttttg ccaggatggc ctgcaaagaa
     2941 acaagacctg tcaggatggg ggcggggggt gaagggaagg cccgggcgtt aacactaagt
     3001 tgtcacttgg cgttgtatcc tccctcacaa gtgcgagcga gcgcaggtct tcaggctaag
     3061 gcagtggcag gtgaggaggc gacttcacct gagcctggcc ttctaggcaa gcaaaggcag
     3121 ttccattgca tgcttcatga cagcctcgtg aagcctccca cagggcactg cctgcctgtg
     3181 tgacaaggtt ttcctgaaca gacacatgtt cttaaggaat gccatgcacg tggcctgaag
     3241 aactggccca gtgggtaaga gcactgaatg ctcttctaca ggatctgagt tcagtcccct
     3301 gcacccactg gatacttcac agctgactgg agctttagcc acagaggata cagcactgac
     3361 ttctggttgc ttcagacacc agggtgcaca tatgtgtaag caagatactt gtacacagag
     3421 aagcaaaacc ttttttaaaa aaaagaaaca ctgtgcactt gagggcacca accgcctaat
     3481 ccttgttcac tgatagttct tggggaagct gagccgtcta agaaccgtgt aaaagacaag
     3541 agtgaggtgc tttcacatac acatgaaata gtaacgggcc catgaacaca cctacctggg
     3601 agctggctgc actccattag acttgccaca aggcaccgtt acagaaaagc ctacaattag
     3661 aaatgctgtt tagacaagga tcacttaaag cttgggcaga aatctgaaac ctgtgggaat
     3721 tgtcatttaa aactaggtca ggagctggag agatggctca gcagttaata gcactgaatg
     3781 ctcttccaga ggtcctgagt tcaaatccca gcaaccacgt gatggctcac aaccatctgt
     3841 aatgagatct gatccccttt tctggtgtgt ctgaagacag cgacagtgta cttacttaat
     3901 aaa
//
