LOCUS       NM_001408791             570 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus interferon, alpha 1 (Ifna1), mRNA.
ACCESSION   NM_001408791 XM_001076062
VERSION     NM_001408791.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 570)
  AUTHORS   Yang,D.W., Zhang,X., Qian,G.B., Jiang,M.J., Wang,P. and Wang,K.Z.
  TITLE     Downregulation of long noncoding RNA LOC101928134 inhibits the
            synovial hyperplasia and cartilage destruction of osteoarthritis
            rats through the activation of the Janus kinase/signal transducers
            and activators of transcription signaling pathway by upregulating
            IFNA1
  JOURNAL   J Cell Physiol 234 (7), 10523-10534 (2019)
   PUBMED   30456844
  REMARK    GeneRIF: These results demonstrate that downregulation of
            LOC101928134 suppresses the synovial hyperplasia and cartilage
            destruction of Osteoarthritis (OA) rats via activation of JAK/STAT
            signaling pathway by upregulating IFNA1, providing a new candidate
            for the treatment of OA.
REFERENCE   2  (bases 1 to 570)
  AUTHORS   Doan,H.Q., Nguyen,H.P., Rady,P. and Tyring,S.K.
  TITLE     Expression patterns of immune-associated genes in external genital
            and perianal warts treated with sinecatechins
  JOURNAL   Viral Immunol 28 (4), 236-240 (2015)
   PUBMED   25774455
REFERENCE   3  (bases 1 to 570)
  AUTHORS   Fan,W., Xu,L., Ren,L., Qu,H., Li,J., Liang,J., Liu,W., Yang,L. and
            Luo,T.
  TITLE     Functional characterization of canine interferon-lambda
  JOURNAL   J Interferon Cytokine Res 34 (11), 848-857 (2014)
   PUBMED   24950142
REFERENCE   4  (bases 1 to 570)
  AUTHORS   Marchant,D.J., Bellac,C.L., Moraes,T.J., Wadsworth,S.J., Dufour,A.,
            Butler,G.S., Bilawchuk,L.M., Hendry,R.G., Robertson,A.G.,
            Cheung,C.T., Ng,J., Ang,L., Luo,Z., Heilbron,K., Norris,M.J.,
            Duan,W., Bucyk,T., Karpov,A., Devel,L., Georgiadis,D., Hegele,R.G.,
            Luo,H., Granville,D.J., Dive,V., McManus,B.M. and Overall,C.M.
  TITLE     A new transcriptional role for matrix metalloproteinase-12 in
            antiviral immunity
  JOURNAL   Nat Med 20 (5), 493-502 (2014)
   PUBMED   24784232
REFERENCE   5  (bases 1 to 570)
  AUTHORS   Yang,L., Xu,L., Li,Y., Li,J., Bi,Y. and Liu,W.
  TITLE     Molecular and functional characterization of canine
            interferon-epsilon
  JOURNAL   J Interferon Cytokine Res 33 (12), 760-768 (2013)
   PUBMED   23964570
REFERENCE   6  (bases 1 to 570)
  AUTHORS   Gerlach,N., Gibbert,K., Alter,C., Nair,S., Zelinskyy,G., James,C.M.
            and Dittmer,U.
  TITLE     Anti-retroviral effects of type I IFN subtypes in vivo
  JOURNAL   Eur J Immunol 39 (1), 136-146 (2009)
   PUBMED   19130550
REFERENCE   7  (bases 1 to 570)
  AUTHORS   Schiavoni,G., Mauri,C., Carlei,D., Belardelli,F., Pastoris,M.C. and
            Proietti,E.
  TITLE     Type I IFN protects permissive macrophages from Legionella
            pneumophila infection through an IFN-gamma-independent pathway
  JOURNAL   J Immunol 173 (2), 1266-1275 (2004)
   PUBMED   15240719
REFERENCE   8  (bases 1 to 570)
  AUTHORS   Kubo,S., Nishiguchi,S., Hirohashi,K., Tanaka,H., Shuto,T.,
            Yamazaki,O., Shiomi,S., Tamori,A., Oka,H., Igawa,S., Kuroki,T. and
            Kinoshita,H.
  TITLE     Effects of long-term postoperative interferon-alpha therapy on
            intrahepatic recurrence after resection of hepatitis C
            virus-related hepatocellular carcinoma. A randomized, controlled
            trial
  JOURNAL   Ann Intern Med 134 (10), 963-967 (2001)
   PUBMED   11352697
REFERENCE   9  (bases 1 to 570)
  AUTHORS   Spanjaard,R.A., van Himbergen,J.A. and van Duin,J.
  TITLE     The cysteines in position 1 and 86 of rat interferon-alpha 1 are
            indispensable for antiviral activity
  JOURNAL   FEBS Lett 249 (2), 186-188 (1989)
   PUBMED   2737278
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Jun 27, 2022 this sequence version replaced XM_001076062.4.
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on single protein-coding
                                         transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-570               JAXUCZ010000005.1  108143240-108143809
FEATURES             Location/Qualifiers
     source          1..570
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q32"
     gene            1..570
                     /gene="Ifna1"
                     /gene_synonym="If1ai3; Ifna5"
                     /note="interferon, alpha 1"
                     /db_xref="GeneID:690894"
                     /db_xref="RGD:1306135"
     CDS             1..570
                     /gene="Ifna1"
                     /gene_synonym="If1ai3; Ifna5"
                     /note="interferon alpha 6-like; interferon alpha family,
                     gene 5; interferon alpha-5; interferon 1ai3"
                     /codon_start=1
                     /product="interferon alpha family, gene 5 precursor"
                     /protein_id="NP_001395720.1"
                     /db_xref="GeneID:690894"
                     /db_xref="RGD:1306135"
                     /translation="MARPCAFLIALVVMMYWSTCSLGCALLQQQSLRNKRALTFLTQI
                     RRFSPVSCLKDRKDFGFPLEKMDAQQIQKTQAIPILYELTQQVLNIFTSKDSSAAWDA
                     TLLDSFCNNLHQQLNDLKACLMQQSGVQEPPLTQEDSLLYVKEYFHRISVYLREKKHS
                     PCAWEVVRAEVWRALSSSAKLLTRQSKEE"
     exon            1..570
                     /gene="Ifna1"
                     /gene_synonym="If1ai3; Ifna5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggctaggc cctgtgcttt cctgattgcc ctggtggtga tgatgtactg gtcaacctgc
       61 tctctaggat gtgccctgct tcagcaacaa agcctcagga acaagagagc cttaacattc
      121 ctgactcaaa taaggagatt ttcccctgtc tcttgcttga aagacagaaa ggactttgga
      181 ttccctttgg agaagatgga tgcccagcag atccagaaga ctcaagcgat ccctattcta
      241 tatgagctga cccagcaggt cctgaacatc ttcacatcaa aggactcatc tgctgcttgg
      301 gatgcaaccc tccttgactc attctgcaat aatctccacc agcagctcaa tgacctcaaa
      361 gcctgtttga tgcagcagag tggggtgcag gaacctccct tgactcagga agactccctg
      421 ctgtatgtga aggaatactt ccacaggatc tctgtgtacc tgagagagaa gaaacacagc
      481 ccctgtgcct gggaggtggt cagagcagaa gtctggagag ccctgtcttc ctcagccaaa
      541 ttgctgacaa gacagagtaa ggaggagtga
//
