LOCUS       NM_001136124             604 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus interferon induced transmembrane protein 3
            (Ifitm3), mRNA.
ACCESSION   NM_001136124 XM_001059289 XM_341957
VERSION     NM_001136124.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 604)
  AUTHORS   Xiong,C., Li,B., Song,R., Ma,Z., Huber,S.A. and Liu,W.
  TITLE     IFITM3 mediates inflammation induced myocardial injury through
            JAK2/STAT3 signaling pathway
  JOURNAL   Mol Immunol 167, 1-15 (2024)
   PUBMED   38306778
  REMARK    GeneRIF: IFITM3 mediates inflammation induced myocardial injury
            through JAK2/STAT3 signaling pathway.
REFERENCE   2  (bases 1 to 604)
  AUTHORS   Zhang,Y., Qin,L., Zhao,Y., Zhang,P., Xu,B., Li,K., Liang,L.,
            Zhang,C., Dai,Y., Feng,Y., Sun,J., Hu,Z., Xiang,H., Knight,J.C.,
            Dong,T. and Jin,R.
  TITLE     Interferon-Induced Transmembrane Protein 3 Genetic Variant
            rs12252-C Associated With Disease Severity in Coronavirus Disease
            2019
  JOURNAL   J Infect Dis 222 (1), 34-37 (2020)
   PUBMED   32348495
REFERENCE   3  (bases 1 to 604)
  AUTHORS   Fu,B., Wang,L., Li,S. and Dorf,M.E.
  TITLE     ZMPSTE24 defends against influenza and other pathogenic viruses
  JOURNAL   J Exp Med 214 (4), 919-929 (2017)
   PUBMED   28246125
REFERENCE   4  (bases 1 to 604)
  AUTHORS   Rackham,O.J., Langley,S.R., Oates,T., Vradi,E., Harmston,N.,
            Srivastava,P.K., Behmoaras,J., Dellaportas,P., Bottolo,L. and
            Petretto,E.
  TITLE     A Bayesian Approach for Analysis of Whole-Genome Bisulfite
            Sequencing Data Identifies Disease-Associated Changes in DNA
            Methylation
  JOURNAL   Genetics 205 (4), 1443-1458 (2017)
   PUBMED   28213474
  REMARK    GeneRIF: Ifitm3 is involved in the pathogenesis of
            glomerulonephritis via promoter hypermethylation that is associated
            with Ifitm3 repression in the rat strain susceptible to
            glomerulonephritis.
REFERENCE   5  (bases 1 to 604)
  AUTHORS   Chesarino,N.M., McMichael,T.M., Hach,J.C. and Yount,J.S.
  TITLE     Phosphorylation of the antiviral protein interferon-inducible
            transmembrane protein 3 (IFITM3) dually regulates its endocytosis
            and ubiquitination
  JOURNAL   J Biol Chem 289 (17), 11986-11992 (2014)
   PUBMED   24627473
REFERENCE   6  (bases 1 to 604)
  AUTHORS   El-Tanani,M.K., Jin,D., Campbell,F.C. and Johnston,P.G.
  TITLE     Interferon-induced transmembrane 3 binds osteopontin in vitro:
            expressed in vivo IFITM3 reduced OPN expression
  JOURNAL   Oncogene 29 (5), 752-762 (2010)
   PUBMED   19901966
  REMARK    GeneRIF: This work has shown for the first time that IFITM3
            physically interacts with OPN and reduces OPN mRNA expression
REFERENCE   7  (bases 1 to 604)
  AUTHORS   Brass,A.L., Huang,I.C., Benita,Y., John,S.P., Krishnan,M.N.,
            Feeley,E.M., Ryan,B.J., Weyer,J.L., van der Weyden,L., Fikrig,E.,
            Adams,D.J., Xavier,R.J., Farzan,M. and Elledge,S.J.
  TITLE     The IFITM proteins mediate cellular resistance to influenza A H1N1
            virus, West Nile virus, and dengue virus
  JOURNAL   Cell 139 (7), 1243-1254 (2009)
   PUBMED   20064371
REFERENCE   8  (bases 1 to 604)
  AUTHORS   Ropolo,A., Tomasini,R., Grasso,D., Dusetti,N.J., Cerquetti,M.C.,
            Iovanna,J.L. and Vaccaro,M.I.
  TITLE     Cloning of IP15, a pancreatitis-induced gene whose expression
            inhibits cell growth
  JOURNAL   Biochem Biophys Res Commun 319 (3), 1001-1009 (2004)
   PUBMED   15184081
REFERENCE   9  (bases 1 to 604)
  AUTHORS   Zucchi,I., Prinetti,A., Scotti,M., Valsecchi,V., Valaperta,R.,
            Mento,E., Reinbold,R., Vezzoni,P., Sonnino,S., Albertini,A. and
            Dulbecco,R.
  TITLE     Association of rat8 with Fyn protein kinase via lipid rafts is
            required for rat mammary cell differentiation in vitro
  JOURNAL   Proc Natl Acad Sci U S A 101 (7), 1880-1885 (2004)
   PUBMED   14766990
  REMARK    GeneRIF: recruitment of rat8 to lipid membrane domains is a
            necessary step in mammary epithelial cell differentiation.
REFERENCE   10 (bases 1 to 604)
  AUTHORS   Daido,H., Zhou,M.Y., Gomez-Sanchez,E.P. and Gomez-Sanchez,C.E.
  TITLE     Interferon-inducible genes in the rat adrenal gland and vascular
            smooth muscle cells
  JOURNAL   Mol Cell Endocrinol 200 (1-2), 81-87 (2003)
   PUBMED   12644301
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Nov 27, 2020 this sequence version replaced NM_001136124.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC168774.1, DV726117.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760476, SAMN12840106
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-301               JAXUCZ010000001.1  205541458-205541758 c
            302-604             JAXUCZ010000001.1  205540649-205540951 c
FEATURES             Location/Qualifiers
     source          1..604
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q41"
     gene            1..604
                     /gene="Ifitm3"
                     /gene_synonym="DSPA2b; rat8"
                     /note="interferon induced transmembrane protein 3"
                     /db_xref="GeneID:361673"
                     /db_xref="RGD:1595844"
     exon            1..301
                     /gene="Ifitm3"
                     /gene_synonym="DSPA2b; rat8"
                     /inference="alignment:Splign:2.1.0"
     CDS             53..466
                     /gene="Ifitm3"
                     /gene_synonym="DSPA2b; rat8"
                     /note="dispanin subfamily A member 2b;
                     interferon-inducible protein"
                     /codon_start=1
                     /product="interferon-induced transmembrane protein 3"
                     /protein_id="NP_001129596.1"
                     /db_xref="GeneID:361673"
                     /db_xref="RGD:1595844"
                     /translation="MNHTSQAFVNAATGGQPPNYERIKEEYEVSELGAPHGSASVRTT
                     VINMPREVSVPDHVVWSLFNTLFMNFCCLGFIAYAYSVKSRDRKMVGDMTGAQAYAST
                     AKCLNISSLVLSILMVIITIVTVVIIALNAPRLQT"
     exon            302..604
                     /gene="Ifitm3"
                     /gene_synonym="DSPA2b; rat8"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acagagccac agaactctcc tctacctttc gctgctgctt ttgctcggta ccatgaacca
       61 cacttctcaa gccttcgtga acgctgccac tgggggacaa cccccaaact acgaaagaat
      121 caaggaagaa tatgaggtgt ctgaactggg ggcaccccac ggatcggctt ctgtcagaac
      181 taccgtgatc aacatgccca gagaggtctc tgtgcctgac catgtggtct ggtccctgtt
      241 caatacgctc ttcatgaact tctgctgcct gggcttcatt gcctatgcct actctgtgaa
      301 gtctagggat cggaagatgg tgggtgatat gactggagcc caggcctacg catccactgc
      361 caaatgcctg aacatcagct ccctggtcct cagcatcctc atggtcatta tcactattgt
      421 tactgtcgtc atcattgctc ttaatgctcc tcgtctccag acttgataga ggattctggt
      481 ttctgatcct gacgtgctcc accatctgca gctgcatccc tccttgcccc tctgcccctc
      541 ccgacacgca ggtgtaacac tcatctatcc acaatggatt caataaaacg cacttgatag
      601 ccat
//
