LOCUS       NM_030833                630 bp    mRNA    linear   ROD 20-MAR-2023
DEFINITION  Rattus norvegicus interferon induced transmembrane protein 2
            (Ifitm2), mRNA.
ACCESSION   NM_030833
VERSION     NM_030833.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 630)
  AUTHORS   Fu B, Wang L, Li S and Dorf ME.
  TITLE     ZMPSTE24 defends against influenza and other pathogenic viruses
  JOURNAL   J Exp Med 214 (4), 919-929 (2017)
   PUBMED   28246125
REFERENCE   2  (bases 1 to 630)
  AUTHORS   Li K, Markosyan RM, Zheng YM, Golfetto O, Bungart B, Li M, Ding S,
            He Y, Liang C, Lee JC, Gratton E, Cohen FS and Liu SL.
  TITLE     IFITM proteins restrict viral membrane hemifusion
  JOURNAL   PLoS Pathog 9 (1), e1003124 (2013)
   PUBMED   23358889
REFERENCE   3  (bases 1 to 630)
  AUTHORS   Lau SL, Yuen ML, Kou CY, Au KW, Zhou J and Tsui SK.
  TITLE     Interferons induce the expression of IFITM1 and IFITM3 and suppress
            the proliferation of rat neonatal cardiomyocytes
  JOURNAL   J Cell Biochem 113 (3), 841-847 (2012)
   PUBMED   22021094
REFERENCE   4  (bases 1 to 630)
  AUTHORS   Zhang Z, Liu J, Li M, Yang H and Zhang C.
  TITLE     Evolutionary dynamics of the interferon-induced transmembrane gene
            family in vertebrates
  JOURNAL   PLoS One 7 (11), e49265 (2012)
   PUBMED   23166625
REFERENCE   5  (bases 1 to 630)
  AUTHORS   Chan YK, Huang IC and Farzan M.
  TITLE     IFITM proteins restrict antibody-dependent enhancement of dengue
            virus infection
  JOURNAL   PLoS One 7 (3), e34508 (2012)
   PUBMED   22479637
REFERENCE   6  (bases 1 to 630)
  AUTHORS   Huang IC, Bailey CC, Weyer JL, Radoshitzky SR, Becker MM, Chiang
            JJ, Brass AL, Ahmed AA, Chi X, Dong L, Longobardi LE, Boltz D, Kuhn
            JH, Elledge SJ, Bavari S, Denison MR, Choe H and Farzan M.
  TITLE     Distinct patterns of IFITM-mediated restriction of filoviruses,
            SARS coronavirus, and influenza A virus
  JOURNAL   PLoS Pathog 7 (1), e1001258 (2011)
   PUBMED   21253575
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 630)
  AUTHORS   Weidner JM, Jiang D, Pan XB, Chang J, Block TM and Guo JT.
  TITLE     Interferon-induced cell membrane proteins, IFITM3 and tetherin,
            inhibit vesicular stomatitis virus infection via distinct
            mechanisms
  JOURNAL   J Virol 84 (24), 12646-12657 (2010)
   PUBMED   20943977
REFERENCE   8  (bases 1 to 630)
  AUTHORS   Brass AL, Huang IC, Benita Y, John SP, Krishnan MN, Feeley EM, Ryan
            BJ, Weyer JL, van der Weyden L, Fikrig E, Adams DJ, Xavier RJ,
            Farzan M and Elledge SJ.
  TITLE     The IFITM proteins mediate cellular resistance to influenza A H1N1
            virus, West Nile virus, and dengue virus
  JOURNAL   Cell 139 (7), 1243-1254 (2009)
   PUBMED   20064371
REFERENCE   9  (bases 1 to 630)
  AUTHORS   Daido H, Zhou MY, Gomez-Sanchez EP and Gomez-Sanchez CE.
  TITLE     Interferon-inducible genes in the rat adrenal gland and vascular
            smooth muscle cells
  JOURNAL   Mol Cell Endocrinol 200 (1-2), 81-87 (2003)
   PUBMED   12644301
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF164040.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF164040.1, FM086251.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132273
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..630
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q41"
     gene            1..630
                     /gene="Ifitm2"
                     /gene_synonym="Ifitm3l; Ifitml"
                     /note="interferon induced transmembrane protein 2"
                     /db_xref="GeneID:114709"
                     /db_xref="RGD:69332"
     exon            1..305
                     /gene="Ifitm2"
                     /gene_synonym="Ifitm3l; Ifitml"
                     /inference="alignment:Splign:2.1.0"
     CDS             60..494
                     /gene="Ifitm2"
                     /gene_synonym="Ifitm3l; Ifitml"
                     /note="interferon-inducible protein 16; interferon induced
                     transmembrane protein, like; interferon induced
                     transmembrane protein 2 (1-8D)"
                     /codon_start=1
                     /product="interferon-induced transmembrane protein 2"
                     /protein_id="NP_110460.1"
                     /db_xref="GeneID:114709"
                     /db_xref="RGD:69332"
                     /translation="MSHNSQAFLPANAGLPPSYETIKEEYGVTELGEPNNSAVVRTTV
                     INMPREVSVPDHVVWSLFNTLFFNACCLGFIAYAYSVKSRDRKMVGDVIGAQAYASTA
                     KCLNISSLIFSVLMVIICIIIFSTTSAVVFQSLSQRTPHSGF"
     exon            306..630
                     /gene="Ifitm2"
                     /gene_synonym="Ifitm3l; Ifitml"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cagaaccagg gtagcagcag ccatcctcca gacggtgcga ttgttccaga gtcaatacca
       61 tgagccacaa ttcccaagcc ttcttgcccg ccaatgccgg gcttcctcca agctatgaga
      121 caatcaaaga ggagtacggg gtgactgagc tgggggaacc caacaactca gctgtcgtga
      181 ggaccaccgt gatcaacatg cccagagagg tctctgtgcc tgaccatgtg gtctggtccc
      241 tgttcaatac gctcttcttc aatgcctgct gcctgggctt cattgcctat gcctactctg
      301 tgaagtccag ggacaggaag atggtgggcg atgtgattgg agcccaggcc tacgcctcca
      361 ctgccaagtg cctgaacatc agctccctga tcttcagtgt cctcatggtc attatctgca
      421 tcatcatttt ctctaccacc tctgcggtag tctttcagtc gctttcacaa agaacgccac
      481 attctggatt ctagctgccc tgtgtcccac ggtccacatc tggccctccc cctgcctgag
      541 gctgagggct tgacccttta ccctatgtgt atgcaaatgt taccttcgta tatctgtcca
      601 cagtggagtc aataaagtac acttggtggc
//
