LOCUS       NM_001024753            3433 bp    mRNA    linear   ROD 20-MAR-2023
DEFINITION  Rattus norvegicus interferon-induced protein with tetratricopeptide
            repeats 2 (Ifit2), mRNA.
ACCESSION   NM_001024753 XM_220060
VERSION     NM_001024753.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3433)
  AUTHORS   Fensterl V and Sen GC.
  TITLE     Interferon-induced Ifit proteins: their role in viral pathogenesis
  JOURNAL   J Virol 89 (5), 2462-2468 (2015)
   PUBMED   25428874
  REMARK    Review article
REFERENCE   2  (bases 1 to 3433)
  AUTHORS   Castello A, Fischer B, Eichelbaum K, Horos R, Beckmann BM, Strein
            C, Davey NE, Humphreys DT, Preiss T, Steinmetz LM, Krijgsveld J and
            Hentze MW.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   3  (bases 1 to 3433)
  AUTHORS   Pichlmair A, Lassnig C, Eberle CA, Gorna MW, Baumann CL, Burkard
            TR, Burckstummer T, Stefanovic A, Krieger S, Bennett KL, Rulicke T,
            Weber F, Colinge J, Muller M and Superti-Furga G.
  TITLE     IFIT1 is an antiviral protein that recognizes 5'-triphosphate RNA
  JOURNAL   Nat Immunol 12 (7), 624-630 (2011)
   PUBMED   21642987
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3433)
  AUTHORS   Stawowczyk M, Van Scoy S, Kumar KP and Reich NC.
  TITLE     The interferon stimulated gene 54 promotes apoptosis
  JOURNAL   J Biol Chem 286 (9), 7257-7266 (2011)
   PUBMED   21190939
REFERENCE   5  (bases 1 to 3433)
  AUTHORS   Daffis S, Szretter KJ, Schriewer J, Li J, Youn S, Errett J, Lin TY,
            Schneller S, Zust R, Dong H, Thiel V, Sen GC, Fensterl V, Klimstra
            WB, Pierson TC, Buller RM, Gale M Jr, Shi PY and Diamond MS.
  TITLE     2'-O methylation of the viral mRNA cap evades host restriction by
            IFIT family members
  JOURNAL   Nature 468 (7322), 452-456 (2010)
   PUBMED   21085181
REFERENCE   6  (bases 1 to 3433)
  AUTHORS   Li Y, Li C, Xue P, Zhong B, Mao AP, Ran Y, Chen H, Wang YY, Yang F
            and Shu HB.
  TITLE     ISG56 is a negative-feedback regulator of virus-triggered signaling
            and cellular antiviral response
  JOURNAL   Proc Natl Acad Sci U S A 106 (19), 7945-7950 (2009)
   PUBMED   19416887
REFERENCE   7  (bases 1 to 3433)
  AUTHORS   Bluyssen HA, Vlietstra RJ, Faber PW, Smit EM, Hagemeijer A and
            Trapman J.
  TITLE     Structure, chromosome localization, and regulation of expression of
            the interferon-regulated mouse Ifi54/Ifi56 gene family
  JOURNAL   Genomics 24 (1), 137-148 (1994)
   PUBMED   7896268
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC097384.1.
            
            On Jun 10, 2005 this sequence version replaced XM_220060.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC097384.1, CV111699.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3433
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q53"
     gene            1..3433
                     /gene="Ifit2"
                     /note="interferon-induced protein with tetratricopeptide
                     repeats 2"
                     /db_xref="GeneID:294091"
                     /db_xref="RGD:1307804"
     exon            1..216
                     /gene="Ifit2"
                     /inference="alignment:Splign:2.1.0"
     CDS             212..1606
                     /gene="Ifit2"
                     /codon_start=1
                     /product="interferon-induced protein with
                     tetratricopeptide repeats 2"
                     /protein_id="NP_001019924.1"
                     /db_xref="GeneID:294091"
                     /db_xref="RGD:1307804"
                     /translation="MSTASKESLESSLQQLKCHFTWNLRAEDESLDEFEDRVFNKDEF
                     QNSEFKATMCNLLAYVKHCRGLNEAALKCLGEAEDFIRQQHPDQIEIKSLVTWGNYAW
                     VYYHMGQLSKAQEYLDKVKQVCKKFSSPYRIENPVLDCEEGWARLKCTKNQNERMKVC
                     FEKALEKDPKNPESTSGWAIANYRLDDWPASNDYIDSLEQAISLSPDNTYVKVLLAMK
                     LEEVHENRAKELVEEALKKDPSAIDTMLGAAKFYVKVHDTDRAIQLLKKALESMPNNA
                     YVHYYLGCCYRSKVLHILNTEETTSNGNREKLEALIQPALNHLRKAEDIKEMIENSCS
                     HLAGLYVTTKQYEEADYYFQKEFNKDLRPLPKQLLHLRYGNFQFYERKCEDRAIYHYM
                     EGVKINRESKPKGKMRDKLRKLALRRLSRDESDPEALRILAFLREHREGQGADKASEG
                     EEDPGNRVPSASLE"
     exon            217..3410
                     /gene="Ifit2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtcagctgca cagaaacagg aaaagaaacc agcagctact gttatatatg ggtctgtagc
       61 atttcattag aaggcagagg aagagcttgc ctggagagtg cctgctgcca gccctgggct
      121 gagtgctttg acacagcgcg ccagtgacac agcagttgag tgtgcttcca gagacacaga
      181 caccgacacc acaaacagtc acacagcagt catgagtaca gccagtaagg aatcattgga
      241 gagcagtcta cagcagctca aatgccactt cacctggaac ctgagagcag aagacgagtc
      301 cttggatgag tttgaggaca gggtgtttaa caaagatgag tttcagaaca gtgagtttaa
      361 agccaccatg tgcaacctac tggcctatgt taagcattgc agaggtctaa atgaggcagc
      421 actgaaatgc ttaggggaag ccgaagactt catccggcaa caacatcctg atcaaataga
      481 aatcaaaagt ctggtcacct ggggaaacta tgcttgggtt tactatcaca tgggccagct
      541 gtccaaagct caggagtatc tggacaaggt gaaacaggtc tgtaagaagt tctccagtcc
      601 ctacaggatt gagaatcctg tgcttgactg tgaggagggg tgggcccgac taaagtgtac
      661 caagaaccaa aatgagagaa tgaaggtgtg cttcgagaag gctctggaaa aggacccaaa
      721 gaacccagaa tccacttctg gatgggccat tgcaaactac cgtctggatg actggccagc
      781 atccaatgac tatattgact ctctggagca agccattagc ctgtctcctg acaacacgta
      841 tgttaaagtc ctcttggcaa tgaaacttga ggaggtgcat gaaaaccgag caaaggagct
      901 agttgaagaa gccttgaaga aggacccaag tgcaatagat acaatgcttg gtgcagccaa
      961 gttttacgtc aaggtacatg acacagacag agcaatacag ttgcttaaaa aggctttgga
     1021 atccatgccc aacaatgctt atgtgcatta ctaccttggg tgctgttaca ggtcaaaagt
     1081 ccttcacata ctgaacaccg aagaaaccac atctaatgga aatagggaga agttagaggc
     1141 actgatacaa ccagcactga atcacttacg gaaagcagag gatatcaagg agatgatcga
     1201 aaattcctgt agtcacctcg ccggccttta tgtcacaaca aagcagtatg aagaagccga
     1261 ttattacttc cagaaagaat tcaacaagga cctccgtccc ctccctaaac agttactcca
     1321 tctacggtat ggcaactttc agttctacga aaggaagtgt gaagacagag ccatctacca
     1381 ctatatggag ggtgtgaaaa taaatcggga atcaaagcct aaaggaaaga tgagagacaa
     1441 acttcgaaaa cttgctctaa ggcggctttc tagagatgaa tctgatcctg aggccttgcg
     1501 catcttggca ttccttaggg agcatagaga aggtcaggga gctgataaag cctcggaggg
     1561 agaagaggac cctggaaacc gggtcccttc agcatctttg gaatgaaaac tagtgacaca
     1621 gtggcaggct tactgctaga aggaaaccgc aaacccttac caagctgcca tttaaaatac
     1681 ttaacaactc catggaccaa gcatggtctg tcattctgac taatagtatt cgtcagaatt
     1741 ttggggaatt ctgctgtcag gttttagcac ctgaattgct ggatcatggg gtgtctgaga
     1801 gagggaccaa acgcagggag agatgtagga tcttagcaaa cagcgtaggg ttctatttct
     1861 ttaaaatagt ttccacagta gtaattcttt aatcaccccc ccccagcttg cctggagttt
     1921 gatgctgtat ttattcaaag cagccaaatt cctcacatgg gtgagtgttc cacccttgaa
     1981 ttacttgaga tgttgcacag ccctgctcta caatgtccat caaaaggctg aggagccagg
     2041 gactgtggct cgggactgtg atcctagcac ttgggaactg agacaggagg attacagtaa
     2101 gcttgaggtc agcctgaaca tgacctggaa ggggtggtgg tggtgggtga tgggaattat
     2161 aaatgtaata cttaatgact acatatattt gccttgctag tttgagtgta gatatgtcta
     2221 tataaccact attaacacac acacacacac acacacacac acacacacac acacagagag
     2281 agagagagag agagagagag agagagagag agaaggtggt gattttgctt tattgaataa
     2341 atttgagact aacaaaataa tgtccaatat taattgagct caaaatagaa attcaatagt
     2401 gagtcccagg tctaaaaaca aacaaacaac aaaagctgtg gggccaaatc atttctccag
     2461 tttaccagcc actcctcaat ctatggcgtc tcacacacat gagtttaact gttccattag
     2521 ctcagaggca gacttccaga aggcagacaa ggagacttct tagccactct tttctcctat
     2581 gactatgttg ttatatgaaa agaaggggga ttctgtctcc catcctgaca attcatataa
     2641 acatttattt caagtgtgtg gaaacttcac tggggatgaa gggattgccg atttatactt
     2701 gctgattata aactcccaag ggaaatgttt atagtcactg ttaggaagct ttccctgtca
     2761 aatgaacact tattttattc caaaatgcta cattggaccc atattgcaga tgccaggaag
     2821 gcagctggct ggaagaataa cttggactga agcttaggtg gagagactta gaaatgacat
     2881 gggtattgga ggttgagttg ttttcttcca ttagaaatgt ggcacatgga ggaatataaa
     2941 aaattctctt aactctggaa aaaaaactat agaaacacca aaaatttgac aactgccatt
     3001 tcctaggcag atcttgaagg gcctaagtat tgaggttggt atgaatcaac agagtcaagt
     3061 ggcccagcct aagaactgtc agctacattc cgggatacaa aaatgtttct ctactggcat
     3121 tagcttgtct ttatgtatcc atgaacatct tatttagcaa ttaaaacata tatgagtctc
     3181 agattgttaa aactaaacat tccaacagct gtaataatgg tctatgatat tttaaaaatt
     3241 caaatattct ctatgcatta agtccattga tatttgccat ttgaatttct ggaaaaataa
     3301 caaatgttgt ttataaataa tgcatgatgg aacattaaac tatgctctgg aactgtactg
     3361 taccttcgct tttttagact caagtgcaga taataaagag taacattaca aaaaaaaaaa
     3421 aaaaaaaaaa aaa
//
