LOCUS       NM_001109199            3897 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus interferon induced with helicase C domain 1
            (Ifih1), mRNA.
ACCESSION   NM_001109199 XM_001055482 XM_575141
VERSION     NM_001109199.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3897)
  AUTHORS   Sarmiento L, Frisk G, Anagandula M, Hodik M, Barchetta I, Netanyah
            E, Cabrera-Rode E and Cilio CM.
  TITLE     Echovirus 6 Infects Human Exocrine and Endocrine Pancreatic Cells
            and Induces Pro-Inflammatory Innate Immune Response
  JOURNAL   Viruses 9 (2), 25 (2017)
   PUBMED   28146100
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3897)
  AUTHORS   Takashima,K., Oshiumi,H., Takaki,H., Matsumoto,M. and Seya,T.
  TITLE     RIOK3-mediated phosphorylation of MDA5 interferes with its assembly
            and attenuates the innate immune response
  JOURNAL   Cell Rep 11 (2), 192-200 (2015)
   PUBMED   25865883
REFERENCE   3  (bases 1 to 3897)
  AUTHORS   Nocon AL, Ip JP, Terry R, Lim SL, Getts DR, Muller M, Hofer MJ,
            King NJ and Campbell IL.
  TITLE     The bacteriostatic protein lipocalin 2 is induced in the central
            nervous system of mice with west Nile virus encephalitis
  JOURNAL   J Virol 88 (1), 679-689 (2014)
   PUBMED   24173226
REFERENCE   4  (bases 1 to 3897)
  AUTHORS   Peisley A, Lin C, Wu B, Orme-Johnson M, Liu M, Walz T and Hur S.
  TITLE     Cooperative assembly and dynamic disassembly of MDA5 filaments for
            viral dsRNA recognition
  JOURNAL   Proc Natl Acad Sci U S A 108 (52), 21010-21015 (2011)
   PUBMED   22160685
REFERENCE   5  (bases 1 to 3897)
  AUTHORS   Zhang Z, Yuan B, Lu N, Facchinetti V and Liu YJ.
  TITLE     DHX9 pairs with IPS-1 to sense double-stranded RNA in myeloid
            dendritic cells
  JOURNAL   J Immunol 187 (9), 4501-4508 (2011)
   PUBMED   21957149
REFERENCE   6  (bases 1 to 3897)
  AUTHORS   Li X, Lu C, Stewart M, Xu H, Strong RK, Igumenova T and Li P.
  TITLE     Structural basis of double-stranded RNA recognition by the RIG-I
            like receptor MDA5
  JOURNAL   Arch Biochem Biophys 488 (1), 23-33 (2009)
   PUBMED   19531363
REFERENCE   7  (bases 1 to 3897)
  AUTHORS   Takahasi K, Kumeta H, Tsuduki N, Narita R, Shigemoto T, Hirai R,
            Yoneyama M, Horiuchi M, Ogura K, Fujita T and Inagaki F.
  TITLE     Solution structures of cytosolic RNA sensor MDA5 and LGP2
            C-terminal domains: identification of the RNA recognition loop in
            RIG-I-like receptors
  JOURNAL   J Biol Chem 284 (26), 17465-17474 (2009)
   PUBMED   19380577
REFERENCE   8  (bases 1 to 3897)
  AUTHORS   Bamming D and Horvath CM.
  TITLE     Regulation of signal transduction by enzymatically inactive
            antiviral RNA helicase proteins MDA5, RIG-I, and LGP2
  JOURNAL   J Biol Chem 284 (15), 9700-9712 (2009)
   PUBMED   19211564
REFERENCE   9  (bases 1 to 3897)
  AUTHORS   Loo YM, Fornek J, Crochet N, Bajwa G, Perwitasari O,
            Martinez-Sobrido L, Akira S, Gill MA, Garcia-Sastre A, Katze MG and
            Gale M Jr.
  TITLE     Distinct RIG-I and MDA5 signaling by RNA viruses in innate immunity
  JOURNAL   J Virol 82 (1), 335-345 (2008)
   PUBMED   17942531
REFERENCE   10 (bases 1 to 3897)
  AUTHORS   Diao F, Li S, Tian Y, Zhang M, Xu LG, Zhang Y, Wang RP, Chen D,
            Zhai Z, Zhong B, Tien P and Shu HB.
  TITLE     Negative regulation of MDA5- but not RIG-I-mediated innate
            antiviral signaling by the dihydroxyacetone kinase
  JOURNAL   Proc Natl Acad Sci U S A 104 (28), 11706-11711 (2007)
   PUBMED   17600090
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473949.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_575141.2, XM_001055482.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMD00132261, SAMD00132262
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3897
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q21"
     gene            1..3897
                     /gene="Ifih1"
                     /gene_synonym="RGD1560496"
                     /note="interferon induced with helicase C domain 1"
                     /db_xref="GeneID:499801"
                     /db_xref="RGD:1560496"
     exon            1..674
                     /gene="Ifih1"
                     /gene_synonym="RGD1560496"
                     /inference="alignment:Splign:2.1.0"
     CDS             222..3305
                     /gene="Ifih1"
                     /gene_synonym="RGD1560496"
                     /EC_number="3.6.4.13"
                     /codon_start=1
                     /product="interferon-induced helicase C domain-containing
                     protein 1"
                     /protein_id="NP_001102669.1"
                     /db_xref="GeneID:499801"
                     /db_xref="RGD:1560496"
                     /translation="MSTVCSAEDSFRNLISIFRPRVKMNIQVEPVLDYLVFLPAETKE
                     QILRKVTTCGNTSAAELLLSTLEQGQWPLGWTQMFVEALEHSGNPLAARYVKPSLTDL
                     PSPSSETAHDECLHLLNLLQPTLVGKLLINDVLDTCSEKGLVTVEDRNRISAAGNSGN
                     ESGVRELLRRIVQKENWFSTFLDVLRQTGNDALVQELTGVSCPEESTDLDNASHKDRP
                     AANEPLLPAIDALSLETEAWTIEDTSPEASFADSSVTTESDTSLAEGSVSCFDESLGH
                     NSNMGRDSGTMGSDSDEDTIMGTKRASPKPELQLRPYQMEVAQPALDGKNIIICLPTG
                     SGKTRVAVYITKDHLDKKKQACESGKVIVLVNKVMLAEQLFRKEFNPFLKKWYRIIGL
                     SGDTQLKISFPEVVKSYDVIISTAQILENSLLNLESGEDDGVQLSDFSLIIIDECHHT
                     NKEAVYNNIMRRYLKQKLKNHKLKKQNKPTIHLPQILGLTASPGVGAAKKQSEAEKHI
                     LNICANLDAFTIKTVKENLSQLKHQIKEPCKKFVIADDTRENPFKEKLLEIMASIQTY
                     CQKSPLSDFGTQHYEQWAIQMEKKAAKDGNRRDRVCAEHLRKYNEALQINDTIRMIDA
                     YSHLETFYTDEKEKKFAALNDSDESDDDEASSCHDQLKGNVKKSLKLDETDEFLMNLF
                     FDNKKMLKKLAENPKYENEKLIKLRNTILEQFTRSEESSRGIIFTKTRQSTYALSQWI
                     MENEKFAEVGVKAHHLIGAGHSSEVKPMTQTEQKEVISKFRTGEINLLIATTVAEEGL
                     DIKECNIVIRYGLVTNEIAMVQARGRARADESTYVLVTSSGSGVTEREIVNDFREKMM
                     YKAINRVQNMKPEEYAHKILELQVQSILEKKMKVKRSIARQYNSDPSLITLLCKNCST
                     LVCSGENIHVIEKMHHVNMTPEFKGLYIVRENKALQMKFADYQTNGEIICKCGQAWGT
                     MMVHKGLDLPCLKIRNFVVNFKNNSSKKQYKKWVELPIRFPDLDCSEYCLYSDED"
     exon            675..843
                     /gene="Ifih1"
                     /gene_synonym="RGD1560496"
                     /inference="alignment:Splign:2.1.0"
     exon            844..990
                     /gene="Ifih1"
                     /gene_synonym="RGD1560496"
                     /inference="alignment:Splign:2.1.0"
     exon            991..1095
                     /gene="Ifih1"
                     /gene_synonym="RGD1560496"
                     /inference="alignment:Splign:2.1.0"
     exon            1096..1322
                     /gene="Ifih1"
                     /gene_synonym="RGD1560496"
                     /inference="alignment:Splign:2.1.0"
     exon            1323..1533
                     /gene="Ifih1"
                     /gene_synonym="RGD1560496"
                     /inference="alignment:Splign:2.1.0"
     exon            1534..1751
                     /gene="Ifih1"
                     /gene_synonym="RGD1560496"
                     /inference="alignment:Splign:2.1.0"
     exon            1752..1868
                     /gene="Ifih1"
                     /gene_synonym="RGD1560496"
                     /inference="alignment:Splign:2.1.0"
     exon            1869..1992
                     /gene="Ifih1"
                     /gene_synonym="RGD1560496"
                     /inference="alignment:Splign:2.1.0"
     exon            1993..2271
                     /gene="Ifih1"
                     /gene_synonym="RGD1560496"
                     /inference="alignment:Splign:2.1.0"
     exon            2272..2531
                     /gene="Ifih1"
                     /gene_synonym="RGD1560496"
                     /inference="alignment:Splign:2.1.0"
     exon            2532..2681
                     /gene="Ifih1"
                     /gene_synonym="RGD1560496"
                     /inference="alignment:Splign:2.1.0"
     exon            2682..2843
                     /gene="Ifih1"
                     /gene_synonym="RGD1560496"
                     /inference="alignment:Splign:2.1.0"
     exon            2844..3034
                     /gene="Ifih1"
                     /gene_synonym="RGD1560496"
                     /inference="alignment:Splign:2.1.0"
     exon            3035..3125
                     /gene="Ifih1"
                     /gene_synonym="RGD1560496"
                     /inference="alignment:Splign:2.1.0"
     exon            3126..3897
                     /gene="Ifih1"
                     /gene_synonym="RGD1560496"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggccggcgg tggcagtgag agtagtccgg ggtctatgac cacctgctgc agcgcattcc
       61 tggctcgtct gccaccttcc gggtgccacc gatcaatccg gtgctcagag gctacccggt
      121 acctgcgact cccaggcagc ggaggcgggg actcattcac tcccacctgt ggatcgtccg
      181 cctgcccagg agactcctct cccattccct gagaacccag gatgtcgacc gtctgttctg
      241 cagaggacag cttcaggaat ctcatctcaa tcttcaggcc cagggtgaaa atgaacattc
      301 aggtggagcc ggtgctggac tacctcgtct ttctgccggc agaaaccaaa gagcagattc
      361 ttagaaaggt caccacctgt ggtaacacca gcgccgcaga actgctgctg agcaccttgg
      421 agcagggaca gtggccgctg ggatggacgc agatgttcgt cgaggccctg gagcacagtg
      481 gcaaccctct agccgcgcgc tatgtcaaac ccagtcttac tgatctgccc tctccttcct
      541 ctgagaccgc ccatgatgag tgtctccact tgctgaacct cctccagccc actttagtgg
      601 gcaagctcct gattaatgat gtcttggata cttgctccga gaagggactg gtgacagtcg
      661 aggacagaaa tcggatttct gctgcgggaa atagtgggaa tgagtcagga gtaagagaac
      721 tgctgagaag gatagtgcag aaagaaaact ggttttctac cttcctggat gttcttcgcc
      781 aaactggaaa cgatgcgcta gtccaagagc taacaggtgt gagctgccca gaagagagca
      841 cagacttgga taacgcatct cacaaagaca ggcctgcagc taacgagccc cttctgcccg
      901 ccatcgatgc attaagtctg gagacagagg cctggaccat agaggacacc tcaccagagg
      961 cttcctttgc agattcttct gtgaccacag aatcagacac aagtttggca gaaggaagtg
     1021 tcagctgctt cgatgaaagt cttggacata acagcaacat gggcagggat tcaggcacca
     1081 tgggaagtga ttcagatgaa gataccatca tggggacaaa aagagcatcc cccaagccag
     1141 aactgcagct caggccttac caaatggaag tggcccagcc tgccctggat gggaagaata
     1201 ttattatctg cctccccacg gggagcggga aaaccagagt ggcagtttac atcaccaaag
     1261 atcacttaga caagaagaag caggcgtgtg aatccgggaa ggttatcgtc cttgtcaata
     1321 aggtaatgtt agcagaacaa cttttccgca aagagttcaa cccgttcttg aagaaatggt
     1381 atcgcattat tggattaagc ggcgataccc agctgaaaat atcttttcca gaagttgtca
     1441 aatcttacga tgttattatc agcacagctc aaatccttga aaactccctc ttaaatctgg
     1501 agagtgggga agatgatggt gtgcagctgt cagacttttc ccttattatc attgacgagt
     1561 gtcatcatac caacaaggag gcagtctata acaacatcat gagacggtat ttgaagcaga
     1621 agttgaaaaa ccataaactc aagaaacaaa acaaaccaac aattcacctg cctcagatac
     1681 taggactgac agcttcaccg ggtgttggag cagccaaaaa gcaatctgag gctgaaaaac
     1741 atattttaaa tatatgtgcc aatctcgatg cctttaccat taaaacagtg aaagagaatc
     1801 tcagtcaact caaacaccaa ataaaggaac catgcaagaa gtttgtgatt gctgatgaca
     1861 ccagagagaa tccatttaaa gagaaacttc tagaaattat ggcaagcatt caaacttact
     1921 gccaaaagag tccattgtca gattttggaa cccaacatta tgagcagtgg gctattcaaa
     1981 tggaaaaaaa agctgctaaa gacggaaatc gcagagatcg tgtctgtgca gaacatttga
     2041 ggaagtacaa cgaagcccta caaatcaatg acacgatccg aatgattgac gcgtacagcc
     2101 acctggaaac gttctacacc gacgagaaag aaaagaagtt tgcagccctc aatgacagcg
     2161 atgagagtga cgacgacgag gccagcagtt gccatgacca acttaagggc aatgtaaaga
     2221 aatctttgaa actggacgaa acggatgaat ttctcatgaa tttgttcttc gataacaaga
     2281 aaatgttgaa aaaactagct gaaaacccaa agtacgagaa cgaaaaactc attaaattaa
     2341 gaaacacgat cctggaacag ttcacaaggt ctgaggagtc ctcccgagga attattttca
     2401 caaaaacgcg gcagagcacc tatgcgcttt cccagtggat tatggagaat gaaaagtttg
     2461 cggaagttgg agtcaaagcg catcacctga ttggcgcggg acacagcagc gaggtcaagc
     2521 ccatgactca gactgaacaa aaagaagtca ttagtaaatt tcgcactggg gaaataaatc
     2581 tgcttatcgc tactacggtg gcagaggaag gcctggatat caaagaatgc aatatcgtta
     2641 tccggtatgg ccttgtcacg aacgagatag ccatggtcca ggcccggggt cgagctagag
     2701 ccgatgagag cacctacgtc ctggttacca gcagtggctc gggagttact gaacgggaga
     2761 ttgttaatga tttccgagag aagatgatgt ataaagctat taaccgtgtt caaaatatga
     2821 aaccagagga gtatgcacat aagattttgg aattacaagt gcaaagtatc ttggaaaaga
     2881 agatgaaagt caagagaagt attgcgaggc agtacaacag cgatccatcg ttaataacac
     2941 ttctctgcaa aaactgtagt acgctggtct gctcaggaga aaacatccac gtaattgaga
     3001 agatgcatca tgtcaacatg acaccagagt tcaagggact ctacattgtg agagagaaca
     3061 aagcactaca aatgaaattt gctgattatc agacaaatgg agagattatc tgcaaatgtg
     3121 gccaagcttg gggaacaatg atggtgcaca aaggtttaga tttgccttgt cttaaaataa
     3181 ggaattttgt agtcaatttc aaaaataact catcaaagaa acagtacaag aagtgggtgg
     3241 aattgcctat cagatttcct gatctcgatt gctcagagta ctgcttgtat agtgatgaag
     3301 actagctctt gagtcatgaa tgttgtaaaa ttgttgccaa ctcagcattg agtttgattt
     3361 tgattgacgt tttcattaac accactgaac taactctaga atatgtaaat gatggttttg
     3421 ttttgctttt agtgatgtaa agaaatacca caaaatgcat acatgctatt ggttgataaa
     3481 tgtaattatt aatcaaaatt gtcaatttga tgagttctaa attcacctgg gttcagggaa
     3541 taccaaggag ggattgattg tcttaaatta attaaggaag tcctgtccac tctgggtggt
     3601 cccattctcc aggcttgggt cctggactgt ataaaactga gaaaactacg tgagcccaca
     3661 tttgctctca tagctctgct cttgactgtg caatgcaatg tgacaagcta cctcaagctc
     3721 ctgtggttgt gacttccgca cagtaatgga ttataacctc ataccgtgag ctgcagttaa
     3781 atcattcctt ccaaagttgt tatgggcgtt tcatcacagc aacagaagag taactaaaac
     3841 agcaggggta agggaaacct accaacagta ctcattactg cagtgttcta cagaatt
//
