LOCUS       NM_001030026            1142 bp    mRNA    linear   ROD 29-MAR-2024
DEFINITION  Rattus norvegicus IFI30, lysosomal thiol reductase (Ifi30), mRNA.
ACCESSION   NM_001030026 XM_214298
VERSION     NM_001030026.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1142)
  AUTHORS   Singh,R. and Cresswell,P.
  TITLE     Defective cross-presentation of viral antigens in GILT-free mice
  JOURNAL   Science 328 (5984), 1394-1398 (2010)
   PUBMED   20538950
REFERENCE   2  (bases 1 to 1142)
  AUTHORS   Bogunovic,B., Stojakovic,M., Chen,L. and Maric,M.
  TITLE     An unexpected functional link between lysosomal thiol reductase and
            mitochondrial manganese superoxide dismutase
  JOURNAL   J Biol Chem 283 (14), 8855-8862 (2008)
   PUBMED   18218638
REFERENCE   3  (bases 1 to 1142)
  AUTHORS   Hastings,K.T., Lackman,R.L. and Cresswell,P.
  TITLE     Functional requirements for the lysosomal thiol reductase GILT in
            MHC class II-restricted antigen processing
  JOURNAL   J Immunol 177 (12), 8569-8577 (2006)
   PUBMED   17142755
REFERENCE   4  (bases 1 to 1142)
  AUTHORS   Maric,M., Arunachalam,B., Phan,U.T., Dong,C., Garrett,W.S.,
            Cannon,K.S., Alfonso,C., Karlsson,L., Flavell,R.A. and Cresswell,P.
  TITLE     Defective antigen processing in GILT-free mice
  JOURNAL   Science 294 (5545), 1361-1365 (2001)
   PUBMED   11701933
REFERENCE   5  (bases 1 to 1142)
  AUTHORS   Arunachalam,B., Phan,U.T., Geuze,H.J. and Cresswell,P.
  TITLE     Enzymatic reduction of disulfide bonds in lysosomes:
            characterization of a gamma-interferon-inducible lysosomal thiol
            reductase (GILT)
  JOURNAL   Proc Natl Acad Sci U S A 97 (2), 745-750 (2000)
   PUBMED   10639150
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Apr 22, 2021 this sequence version replaced NM_001030026.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ225096.1, BC099774.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-318               JAXUCZ010000016.1  18709570-18709887
            319-501             JAXUCZ010000016.1  18711105-18711287
            502-576             JAXUCZ010000016.1  18711388-18711462
            577-669             JAXUCZ010000016.1  18711542-18711634
            670-822             JAXUCZ010000016.1  18712280-18712432
            823-876             JAXUCZ010000016.1  18713229-18713282
            877-1142            JAXUCZ010000016.1  18713370-18713635
FEATURES             Location/Qualifiers
     source          1..1142
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p14"
     gene            1..1142
                     /gene="Ifi30"
                     /note="IFI30, lysosomal thiol reductase"
                     /db_xref="GeneID:290644"
                     /db_xref="RGD:1310758"
     exon            1..318
                     /gene="Ifi30"
                     /inference="alignment:Splign:2.1.0"
     CDS             196..942
                     /gene="Ifi30"
                     /note="gamma-interferon-inducible lysosomal thiol
                     reductase; interferon gamma inducible protein 30"
                     /codon_start=1
                     /product="gamma-interferon-inducible lysosomal thiol
                     reductase precursor"
                     /protein_id="NP_001025197.1"
                     /db_xref="GeneID:290644"
                     /db_xref="RGD:1310758"
                     /translation="MSCSPLVPFLSLLLLLFLPEVPRAATASLPQGSSEGAATCKAHD
                     LCLFGPRRLLSAPPVNVSLYYESLCGACRYFLVRNLFPTWLMVMEIMNITLVPYGNAQ
                     ERNVSGTWEFTCQHGELECKLNKVEACLLDKLEKEAAFLTIVCMEEMEDMEKKLGPCL
                     QLYVPEVSPESIMECATGKRGTELMHENAQLTDALQPPHEYVPWVLVNEKPLTDPSQL
                     LSSVCELYQGTEKPDICSSMADAPREVCYK"
     exon            319..501
                     /gene="Ifi30"
                     /inference="alignment:Splign:2.1.0"
     exon            502..576
                     /gene="Ifi30"
                     /inference="alignment:Splign:2.1.0"
     exon            577..669
                     /gene="Ifi30"
                     /inference="alignment:Splign:2.1.0"
     exon            670..822
                     /gene="Ifi30"
                     /inference="alignment:Splign:2.1.0"
     exon            823..876
                     /gene="Ifi30"
                     /inference="alignment:Splign:2.1.0"
     exon            877..1142
                     /gene="Ifi30"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctgcggagaa cacaaggcta gacagagtcc tgtggcctcg tgatttgggg ctagcacctg
       61 gctggagcgg agccttgagg aaagggggcc cagagttagg aggaacctgt gtgggcgtgg
      121 tctcagtggg tggagcatcc acttgcttaa agtctcccgc ctccccggcc tggccaagct
      181 tttttctcct cagccatgtc ctgttctccg ctcgtaccat tcttgtccct tttgcttctg
      241 ctgttcctac ccgaggttcc cagagcagcc actgcgtccc tgccgcaagg atcctccgag
      301 ggcgcagcca cctgcaaggc ccacgacctg tgcctcttcg ggccacgccg gttgctctct
      361 gcaccacctg tcaatgtcag cctctattat gagtccctgt gtggagcttg tcgctacttc
      421 ctcgtccgaa atttgttccc aacctggctg atggttatgg aaatcatgaa catcactctg
      481 gtgccctacg ggaacgcaca ggagagaaat gtcagcggta catgggagtt cacgtgccag
      541 cacggggagc tggagtgtaa actgaacaag gtggaggcct gtctgctgga caagctggaa
      601 aaggaggcgg cattcctaac catcgtctgt atggaggaga tggaggacat ggagaagaaa
      661 ctgggcccgt gcctgcagct gtatgttcca gaggtgtcac cagaaagcat catggagtgt
      721 gccaccggaa aacgaggcac agagctgatg catgagaacg cccagctcac agatgcccta
      781 cagccacccc atgagtatgt gccctgggtc ctggtcaacg agaaaccgtt gacggacccc
      841 agccagctcc tgagctccgt ttgtgagctg taccagggga cagagaagcc agacatctgc
      901 tcctccatgg ctgatgcccc cagggaggtc tgctataagt gaaggtcatt gtcccaagaa
      961 aaactactca gcttgaagtg gaggagtctg ccagagctgc tgaccagcca tggagtcctg
     1021 cacgtgtccc acaaaaccca gatgcaaaac tcggagtcaa gaatcttgcc ttattttcaa
     1081 atggtgctaa attcaaatcc acacaataca tcatccacat tgctgtgatt cccttttcct
     1141 ga
//
