LOCUS       NM_203410                940 bp    mRNA    linear   ROD 22-MAR-2023
DEFINITION  Rattus norvegicus interferon, alpha-inducible protein 27 (Ifi27),
            mRNA.
ACCESSION   NM_203410 NM_130743 XM_346773
VERSION     NM_203410.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 940)
  AUTHORS   Gytz H, Hansen MF, Skovbjerg S, Kristensen AC, Horlyck S, Jensen
            MB, Fredborg M, Markert LD, McMillan NA, Christensen EI and
            Martensen PM.
  TITLE     Apoptotic properties of the type 1 interferon induced family of
            human mitochondrial membrane ISG12 proteins
  JOURNAL   Biol Cell 109 (2), 94-112 (2017)
   PUBMED   27673746
REFERENCE   2  (bases 1 to 940)
  AUTHORS   Chen Y, Jiao B, Yao M, Shi X, Zheng Z, Li S and Chen L.
  TITLE     ISG12a inhibits HCV replication and potentiates the anti-HCV
            activity of IFN-alpha through activation of the Jak/STAT signaling
            pathway independent of autophagy and apoptosis
  JOURNAL   Virus Res 227, 231-239 (2017)
   PUBMED   27777077
REFERENCE   3  (bases 1 to 940)
  AUTHORS   Xue B, Yang D, Wang J, Xu Y, Wang X, Qin Y, Tian R, Chen S, Xie Q,
            Liu N and Zhu H.
  TITLE     ISG12a Restricts Hepatitis C Virus Infection through the
            Ubiquitination-Dependent Degradation Pathway
  JOURNAL   J Virol 90 (15), 6832-6845 (2016)
   PUBMED   27194766
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 940)
  AUTHORS   Liu N, Zuo C, Wang X, Chen T, Yang D, Wang J and Zhu H.
  TITLE     miR-942 decreases TRAIL-induced apoptosis through ISG12a
            downregulation and is regulated by AKT
  JOURNAL   Oncotarget 5 (13), 4959-4971 (2014)
   PUBMED   24970806
REFERENCE   5  (bases 1 to 940)
  AUTHORS   Papac-Milicevic N, Breuss JM, Zaujec J, Ryban L, Plyushch T, Wagner
            GA, Fenzl S, Dremsek P, Cabaravdic M, Steiner M, Glass CK, Binder
            CJ, Uhrin P and Binder BR.
  TITLE     The interferon stimulated gene 12 inactivates vasculoprotective
            functions of NR4A nuclear receptors
  JOURNAL   Circ Res 110 (8), e50-e63 (2012)
   PUBMED   22427340
REFERENCE   6  (bases 1 to 940)
  AUTHORS   Rosebeck S and Leaman DW.
  TITLE     Mitochondrial localization and pro-apoptotic effects of the
            interferon-inducible protein ISG12a
  JOURNAL   Apoptosis 13 (4), 562-572 (2008)
   PUBMED   18330707
REFERENCE   7  (bases 1 to 940)
  AUTHORS   Parker N and Porter AC.
  TITLE     Identification of a novel gene family that includes the
            interferon-inducible human genes 6-16 and ISG12
  JOURNAL   BMC Genomics 5 (1), 8 (2004)
   PUBMED   14728724
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 940)
  AUTHORS   Martensen PM, Sogaard TM, Gjermandsen IM, Buttenschon HN, Rossing
            AB, Bonnevie-Nielsen V, Rosada C, Simonsen JL and Justesen J.
  TITLE     The interferon alpha induced protein ISG12 is localized to the
            nuclear membrane
  JOURNAL   Eur J Biochem 268 (22), 5947-5954 (2001)
   PUBMED   11722583
REFERENCE   9  (bases 1 to 940)
  AUTHORS   Li Q, Zhang M, Kumar S, Zhu LJ, Chen D, Bagchi MK and Bagchi IC.
  TITLE     Identification and implantation stage-specific expression of an
            interferon-alpha-regulated gene in human and rat endometrium
  JOURNAL   Endocrinology 142 (6), 2390-2400 (2001)
   PUBMED   11356686
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC060548.1.
            
            [WARNING] On Aug 13, 2024 this sequence was replaced by
            NM_203410.2.
            
            On or before Feb 9, 2007 this sequence version replaced
            NM_130743.1, XM_346773.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC060548.1, CF976008.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..940
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q32"
     gene            1..940
                     /gene="Ifi27"
                     /gene_synonym="Ifi27l; Ifi27l1; IRG1; isg12(a)"
                     /note="interferon, alpha-inducible protein 27"
                     /db_xref="GeneID:170512"
                     /db_xref="RGD:69404"
     exon            1..42
                     /gene="Ifi27"
                     /gene_synonym="Ifi27l; Ifi27l1; IRG1; isg12(a)"
                     /inference="alignment:Splign:2.1.0"
     exon            43..194
                     /gene="Ifi27"
                     /gene_synonym="Ifi27l; Ifi27l1; IRG1; isg12(a)"
                     /inference="alignment:Splign:2.1.0"
     CDS             77..625
                     /gene="Ifi27"
                     /gene_synonym="Ifi27l; Ifi27l1; IRG1; isg12(a)"
                     /note="putative ISG12(a) protein; interferon,
                     alpha-inducible protein 27 like 1"
                     /codon_start=1
                     /product="interferon alpha-inducible protein 27"
                     /protein_id="NP_981955.1"
                     /db_xref="GeneID:170512"
                     /db_xref="RGD:69404"
                     /translation="MALSGTGTLVASIASKVASSVAVVKAGGAVSSTILASSQGLNLL
                     AQTALGSGASALGSALGALKAGTVLSSLPASALAVCPIGVKTAVAMLGGAVTVAAVPP
                     VLSAVGFTGSGIAASSLAAKLMSVSAIANGGGVPAGGLVATLQSAGAAGLSMTSKVLV
                     GSTGSAVVASVMGVCKHLYSFL"
     exon            195..326
                     /gene="Ifi27"
                     /gene_synonym="Ifi27l; Ifi27l1; IRG1; isg12(a)"
                     /inference="alignment:Splign:2.1.0"
     exon            327..356
                     /gene="Ifi27"
                     /gene_synonym="Ifi27l; Ifi27l1; IRG1; isg12(a)"
                     /inference="alignment:Splign:2.1.0"
     exon            357..518
                     /gene="Ifi27"
                     /gene_synonym="Ifi27l; Ifi27l1; IRG1; isg12(a)"
                     /inference="alignment:Splign:2.1.0"
     exon            519..800
                     /gene="Ifi27"
                     /gene_synonym="Ifi27l; Ifi27l1; IRG1; isg12(a)"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggacaccaa aacctatctc atcctctcac ttacatcact gggtttggct cctatctgga
       61 acgcacaccg gtccccatgg cattgtctgg cacaggtacg ctggtggctt ctattgcctc
      121 caaggtggca tcttcagtgg ccgtggtcaa agccggaggg gcggtatcca gcaccatcct
      181 agctagctca caggggctca acttgttagc ccagactgca ctgggctctg gagcttctgc
      241 acttggatct gcattgggag cactgaaggc tggcaccgtt ttatccagcc tccctgcctc
      301 cgccttggct gtttgcccca ttggagtcaa gactgctgtc gccatgcttg ggggagccgt
      361 gacagtagct gcggttccac ctgtgctgag tgccgtgggc ttcactgggt caggcattgc
      421 agcctcctct ctagcagcca agctgatgtc tgtgtcagcc attgctaatg ggggcggagt
      481 cccagctggt ggcctggtgg ccactctgca gtctgctgga gctgctggac tctccatgac
      541 atctaaggtc ctcgtgggct ctacagggtc tgccgttgtg gccagtgtga tgggtgtctg
      601 taagcatttg tactccttcc tctgataatt gtacttggaa accaaggtgg ctgacatggc
      661 aagagaggag gcagacatgg gaacagaggt gtcgccactc agcttgtcta atccggagag
      721 ggattaatta gccccagggg acaatttact atcacagatt gcctacgtgg aaataagaaa
      781 taaaaccaag tgcttgccaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
      841 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
      901 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
//
