LOCUS       NM_212505               1114 bp    mRNA    linear   ROD 20-MAR-2023
DEFINITION  Rattus norvegicus immediate early response 3 (Ier3), mRNA.
ACCESSION   NM_212505 XM_215304
VERSION     NM_212505.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1114)
  AUTHORS   Jin H, Won M, Shin E, Kim HM, Lee K and Bae J.
  TITLE     EGR2 is a gonadotropin-induced survival factor that controls the
            expression of IER3 in ovarian granulosa cells
  JOURNAL   Biochem Biophys Res Commun 482 (4), 877-882 (2017)
   PUBMED   27890615
  REMARK    GeneRIF: Analysis of consensus EGR-binding elements (EBEs) showed
            that the immediate early response 3 gene (IER3) is a novel
            transcriptional target gene of EGR2 as confirmed by the luciferase
            assay, electrophoretic mobility-shift assay (EMSA), chromatin
            immunoprecipitation (ChIP), and western blot analysis.
REFERENCE   2  (bases 1 to 1114)
  AUTHORS   Pawlikowska P, Leray I, de Laval B, Guihard S, Kumar R, Rosselli F
            and Porteu F.
  TITLE     ATM-dependent expression of IEX-1 controls nuclear accumulation of
            Mcl-1 and the DNA damage response
  JOURNAL   Cell Death Differ 17 (11), 1739-1750 (2010)
   PUBMED   20467439
REFERENCE   3  (bases 1 to 1114)
  AUTHORS   Akilov OE, Ustyugova IV, Zhi L, Hasan T and Wu MX.
  TITLE     Enhanced susceptibility to Leishmania infection in resistant mice
            in the absence of immediate early response gene X-1
  JOURNAL   J Immunol 183 (12), 7994-8003 (2009)
   PUBMED   19923449
REFERENCE   4  (bases 1 to 1114)
  AUTHORS   Shen L, Zhi L, Hu W and Wu MX.
  TITLE     IEX-1 targets mitochondrial F1Fo-ATPase inhibitor for degradation
  JOURNAL   Cell Death Differ 16 (4), 603-612 (2009)
   PUBMED   19096392
REFERENCE   5  (bases 1 to 1114)
  AUTHORS   Sommer SL, Berndt TJ, Frank E, Patel JB, Redfield MM, Dong X,
            Griffin MD, Grande JP, van Deursen JM, Sieck GC, Romero JC and
            Kumar R.
  TITLE     Elevated blood pressure and cardiac hypertrophy after ablation of
            the gly96/IEX-1 gene
  JOURNAL   J Appl Physiol (1985) 100 (2), 707-716 (2006)
   PUBMED   16166241
REFERENCE   6  (bases 1 to 1114)
  AUTHORS   Zhang Y, Finegold MJ, Porteu F, Kanteti P and Wu MX.
  TITLE     Development of T-cell lymphomas in Emu-IEX-1 mice
  JOURNAL   Oncogene 22 (44), 6845-6851 (2003)
   PUBMED   14534530
REFERENCE   7  (bases 1 to 1114)
  AUTHORS   Schilling D, Pittelkow MR and Kumar R.
  TITLE     IEX-1, an immediate early gene, increases the rate of apoptosis in
            keratinocytes
  JOURNAL   Oncogene 20 (55), 7992-7997 (2001)
   PUBMED   11753682
REFERENCE   8  (bases 1 to 1114)
  AUTHORS   Schafer H, Trauzold A, Siegel EG, Folsch UR and Schmidt WE.
  TITLE     PRG1: a novel early-response gene transcriptionally induced by
            pituitary adenylate cyclase activating polypeptide in a pancreatic
            carcinoma cell line
  JOURNAL   Cancer Res 56 (11), 2641-2648 (1996)
   PUBMED   8653710
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AW916683.1, FM066628.1 and BC099831.1.
            
            On Oct 15, 2009 this sequence version replaced NM_212505.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC099831.1, FN802958.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-405               AW916683.1         2-406
            406-518             FM066628.1         391-503
            519-1114            BC099831.1         495-1090
FEATURES             Location/Qualifiers
     source          1..1114
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20p12"
     gene            1..1114
                     /gene="Ier3"
                     /gene_synonym="Dif2; Iex1; Ler3; Prg1"
                     /note="immediate early response 3"
                     /db_xref="GeneID:294235"
                     /db_xref="RGD:1303321"
     exon            1..242
                     /gene="Ier3"
                     /gene_synonym="Dif2; Iex1; Ler3; Prg1"
                     /inference="alignment:Splign:2.1.0"
     CDS             33..515
                     /gene="Ier3"
                     /gene_synonym="Dif2; Iex1; Ler3; Prg1"
                     /codon_start=1
                     /product="radiation-inducible immediate-early gene IEX-1"
                     /protein_id="NP_997670.1"
                     /db_xref="GeneID:294235"
                     /db_xref="RGD:1303321"
                     /translation="MCHSRNHLHTMTGLRAPAPAPSTSPELRRGSGPEIFTFDPLPER
                     AVASAVRPNTSRGHRKRSRRVLYPRVVRRQLPTEEPNIAKRILFLLLAIIFCQILMAE
                     EGVSQALAPEDATSAISPEPISVPITAPPVLEPLNLTSESSDYALDLKAFLQQHPAAF
                     "
     exon            243..1098
                     /gene="Ier3"
                     /gene_synonym="Dif2; Iex1; Ler3; Prg1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctcctccgta ccctctgtac agcgcgcgaa ttatgtgcca ctcacgcaac catctccaca
       61 ccatgactgg cctgagggct ccggcgccag ctccctccac cagcccggaa ctccggcggg
      121 gctccggtcc cgagattttc accttcgacc ccctcccgga gcgggcggta gcgtccgccg
      181 tgcgtccgaa cacttctcgc gggcaccgaa aacgcagccg acgggtgctc taccctcgag
      241 tggtccggcg ccagctacca accgaggaac ccaacattgc caagaggatc ctctttctcc
      301 tgctcgccat catcttctgc cagattttga tggctgaaga aggtgtgtcg caggccctgg
      361 ctccggagga tgctaccagc gccatatcac ctgagcccat ctctgtgccc attactgcgc
      421 ctcctgtcct cgagcctttg aacctgacct cggagtcctc ggactatgct ctggatctca
      481 aagcttttct ccagcaacac ccggcggcat tctaaacgcg atgggtcaca gtccggaaaa
      541 aaaacccaaa gaggcaccag gggtacctgg tgcgcaagaa cgtatcccaa actgggactt
      601 ataaggcaac gctaactcag aacactaccg ccaagatgcc ggttcttggg gcgagcccga
      661 ggcaccgtgg gtcctggcta ggctcactgg tgacggacgg aggtcttctc ggtgtctaat
      721 taatatttat gtatttatgt atatcctcct aggtgaagga ggggtgtatg taatatttat
      781 tctaacttat gcaggggtgc gagatatgcc cccttgctgt gacacagata tttattacga
      841 tttatagggt ccgtgagaca gagttgtggg aggattagtt tagtcttggt cggggggcat
      901 aggtttaggg gtaacactcc attttccagc acttcgactc tgttgtaaga ctttggcaga
      961 cccttgggaa tacggtctgt ggcctttgat gtcttcctga ctggaagtct tgggtccatg
     1021 gattgtcaga gggcggctgt ctggggtcgc ctagtatgtt ctgtgaacac gaataaactt
     1081 gattgcctgt cattattaaa aaaaaaaaaa aaaa
//
