LOCUS       NM_001009541            1564 bp    mRNA    linear   ROD 04-DEC-2024
DEFINITION  Rattus norvegicus immediate early response 2 (Ier2), mRNA.
ACCESSION   NM_001009541
VERSION     NM_001009541.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1564)
  AUTHORS   Izquierdo,A.G., Boughanem,H., Diaz-Lagares,A., Arranz-Salas,I.,
            Esteller,M., Tinahones,F.J., Casanueva,F.F., Macias-Gonzalez,M. and
            Crujeiras,A.B.
  TITLE     DNA methylome in visceral adipose tissue can discriminate patients
            with and without colorectal cancer
  JOURNAL   Epigenetics 17 (6), 665-676 (2022)
   PUBMED   34311674
REFERENCE   2  (bases 1 to 1564)
  AUTHORS   Kyjacova,L., Saup,R., Ronsch,K., Wallbaum,S., Dukowic-Schulze,S.,
            Foss,A., Scherer,S.D., Rothley,M., Neeb,A., Grau,N., Thiele,W.,
            Thaler,S., Cremers,N., Sticht,C., Gretz,N., Garvalov,B.K.,
            Utikal,J. and Sleeman,J.P.
  TITLE     IER2-induced senescence drives melanoma invasion through
            osteopontin
  JOURNAL   Oncogene 40 (47), 6494-6512 (2021)
   PUBMED   34611309
REFERENCE   3  (bases 1 to 1564)
  AUTHORS   Liu,X., Liu,X., Cai,M., Luo,A., He,Y., Liu,S., Zhang,X., Yang,X.,
            Xu,L. and Jiang,H.
  TITLE     CircRNF220, not its linear cognate gene RNF220, regulates cell
            growth and is associated with relapse in pediatric acute myeloid
            leukemia
  JOURNAL   Mol Cancer 20 (1), 139 (2021)
   PUBMED   34702297
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1564)
  AUTHORS   Xu,X., Zhou,W., Chen,Y., Wu,K., Wang,H., Zhang,J., Zhou,Y.,
            Zeng,J., Yang,J., Deng,Z., Zhang,Y. and Shen,W.
  TITLE     Immediate early response protein 2 promotes the migration and
            invasion of hepatocellular carcinoma cells via regulating the
            activity of Rho GTPases
  JOURNAL   Neoplasma 67 (3), 614-622 (2020)
   PUBMED   32009420
REFERENCE   5  (bases 1 to 1564)
  AUTHORS   Neeb,A., Wallbaum,S., Novac,N., Dukovic-Schulze,S., Scholl,I.,
            Schreiber,C., Schlag,P., Moll,J., Stein,U. and Sleeman,J.P.
  TITLE     The immediate early gene Ier2 promotes tumor cell motility and
            metastasis, and predicts poor survival of colorectal cancer
            patients
  JOURNAL   Oncogene 31 (33), 3796-3806 (2012)
   PUBMED   22120713
REFERENCE   6  (bases 1 to 1564)
  AUTHORS   Takaya,T., Kasatani,K., Noguchi,S. and Nikawa,J.
  TITLE     Functional analyses of immediate early gene ETR101 expressed in
            yeast
  JOURNAL   Biosci Biotechnol Biochem 73 (7), 1653-1660 (2009)
   PUBMED   19584537
REFERENCE   7  (bases 1 to 1564)
  AUTHORS   Park,J.B., Kim,E.J., Yang,E.J., Seo,S.R. and Chung,K.C.
  TITLE     JNK- and Rac1-dependent induction of immediate early gene pip92
            suppresses neuronal differentiation
  JOURNAL   J Neurochem 100 (2), 555-566 (2007)
   PUBMED   17156131
REFERENCE   8  (bases 1 to 1564)
  AUTHORS   Charles,C.H., Simske,J.S., O'Brien,T.P. and Lau,L.F.
  TITLE     Pip92: a short-lived, growth factor-inducible protein in BALB/c 3T3
            and PC12 cells
  JOURNAL   Mol Cell Biol 10 (12), 6769-6774 (1990)
   PUBMED   2247083
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC061717.1.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC061717.1, CK366536.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1564
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19q11"
     gene            1..1564
                     /gene="Ier2"
                     /note="immediate early response 2"
                     /db_xref="GeneID:494344"
                     /db_xref="RGD:1359581"
     exon            1..1525
                     /gene="Ier2"
                     /inference="alignment:Splign:2.1.0"
     CDS             89..754
                     /gene="Ier2"
                     /codon_start=1
                     /product="immediate early response gene 2 protein"
                     /protein_id="NP_001009541.1"
                     /db_xref="GeneID:494344"
                     /db_xref="RGD:1359581"
                     /translation="MEVQKEAQRIMTLSVWKMYHSRMQRGGLRLHRSLQLSLVMRSAR
                     ELYLSAKVETHQPEFPPSRRALDPRLHPPREPEAAMEAATPDVEQPPEPMDTQEEVLR
                     VQETPALCDPPPARVSRKRRSSSDLSDGSDAGLVPSKKARLEEVEGEATSEVSNRLQL
                     PPAQTEGAFPNLARVLQRRFSSLLNCGPAVPPPTPPTCEAKPACRPADNMLNVLVRTV
                     VAF"
ORIGIN      
        1 agtacctgca actgtaagtg agtcgtctag gcagcaacgc cggtcttaat ccattgtcgg
       61 cttaactcta cacagtcgtc gaacaagcat ggaagtacag aaagaagcgc agcgcatcat
      121 gacactgtcc gtgtggaaga tgtaccactc tcgcatgcag cgcggtggct tgcgcctcca
      181 ccggagtctg cagctgtccc tcgttatgcg cagcgctcgg gagctctacc tctcagccaa
      241 ggtagaaacc caccagcccg agttcccgcc atcccgcagg gcccttgacc ctcgcctgca
      301 cccgccgcga gaacccgaag ctgcaatgga agcagcgacc cctgacgtcg agcagcctcc
      361 ggagcccatg gacacgcaag aggaagtgct gcgagtccag gagacccccg cgctctgtga
      421 cccgcccccc gctagagtca gccgcaagcg ccggagtagc agcgacttga gcgacggtag
      481 tgatgccgga ctggtaccaa gcaagaaggc ccgtctggaa gaggtggagg gggaggcgac
      541 gtcggaggtc tccaatcgcc tgcagcttcc tcccgcacaa accgaaggtg ccttccctaa
      601 cctcgcccgc gtcctccaaa ggcgcttctc cagtctcttg aactgtgggc ccgccgtgcc
      661 cccgccgacg ccccccacgt gcgaggccaa gccagcctgc cgcccggccg acaatatgct
      721 caacgtgctg gtgcgaaccg tggtggcctt ctgaggatta cgagcggcgc caccggagcg
      781 gagaacgcac acccgaggcg aaggccggcg gggggccgta aagaagagcc gcggcccgag
      841 ctgccgagag gccaggggaa ggactgagga gctaggagct aggggcgcgg gcgccttctc
      901 ccagacgtac gtccacaggt gctattaaag gactgtccct tccttggttt ggagaaggga
      961 cacctggatc ttgaatctca gggtcggact ctctagggcc caggctgccc tttcaaggcc
     1021 gtttcactag cattcgcgtt tcggccccta caagtgggca cgcttgtgca agcggtcaga
     1081 gttgcgtcat gggacagacg cgggtgcttc ctgttgcctt gcgtgggtgt ggggcctggg
     1141 aggaggccag ggtgtggacc cgccctaggg actgggaagt gacttgagtc acctcgcccc
     1201 cacaggctgc tgtgggcgag ccggccttcg gctgagatcc agaactgaac aaatcaaatc
     1261 ttgctgcgat cagagttgat tgaagtggct ggagaccccg ggactggtca gcctagactg
     1321 atcgcctggc gtggactacc gcggaaaggg tgggtgggtg gtctcatttg ctgtcttaga
     1381 cacgacctct tcgggcaaga tagaattttt taccagcgaa tttaagaaag tctgtttact
     1441 tttcccacgg tgggttgtgt ttaactccca actacctgga gttttacaat gtcagctagg
     1501 aaaataaaag tccatcggtg taaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     1561 aaaa
//
