LOCUS       NM_001172084            2582 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus alpha-L-iduronidase (Idua), mRNA.
ACCESSION   NM_001172084
VERSION     NM_001172084.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2582)
  AUTHORS   Gonzalez,E.A., Tobar Leitao,S.A., Soares,D.D.S., Tavares,A.M.V.,
            Giugliani,R., Baldo,G. and Matte,U.
  TITLE     Cardiac pathology in mucopolysaccharidosis I mice: Losartan
            modifies ERK1/2 activation during cardiac remodeling
  JOURNAL   J Inherit Metab Dis 44 (3), 740-750 (2021)
   PUBMED   33145772
REFERENCE   2  (bases 1 to 2582)
  AUTHORS   Uttarilli,A., Ranganath,P., Matta,D., Md Nurul Jain,J., Prasad,K.,
            Babu,A.S., Girisha,K.M., Verma,I.C., Phadke,S.R., Mandal,K.,
            Puri,R.D., Aggarwal,S., Danda,S., Sankar,V.H., Kapoor,S., Bhat,M.,
            Gowrishankar,K., Hasan,A.Q., Nair,M., Nampoothiri,S. and Dalal,A.
  TITLE     Identification and characterization of 20 novel pathogenic variants
            in 60 unrelated Indian patients with mucopolysaccharidoses type I
            and type II
  JOURNAL   Clin Genet 90 (6), 496-508 (2016)
   PUBMED   27146977
REFERENCE   3  (bases 1 to 2582)
  AUTHORS   Heppner,J.M., Zaucke,F. and Clarke,L.A.
  TITLE     Extracellular matrix disruption is an early event in the
            pathogenesis of skeletal disease in mucopolysaccharidosis I
  JOURNAL   Mol Genet Metab 114 (2), 146-155 (2015)
   PUBMED   25410057
REFERENCE   4  (bases 1 to 2582)
  AUTHORS   Stilhano,R.S., Martin,P.K., de Melo,S.M., Samoto,V.Y., Peres,G.B.,
            da Silva Michelacci,Y.M., da Silva,F.H., Pereira,V.G.,
            D'Almeida,V., da Cruz,A.T., Jasiulionis,M.G. and Han,S.W.
  TITLE     alpha- L-iduronidase gene-based therapy using the phiC31 system to
            treat mucopolysaccharidose type I mice
  JOURNAL   J Gene Med 17 (1-2), 1-13 (2015)
   PUBMED   25597593
REFERENCE   5  (bases 1 to 2582)
  AUTHORS   Ou,L., Herzog,T., Koniar,B.L., Gunther,R. and Whitley,C.B.
  TITLE     High-dose enzyme replacement therapy in murine Hurler syndrome
  JOURNAL   Mol Genet Metab 111 (2), 116-122 (2014)
   PUBMED   24100243
REFERENCE   6  (bases 1 to 2582)
  AUTHORS   Scott,H.S., Litjens,T., Nelson,P.V., Brooks,D.A., Hopwood,J.J. and
            Morris,C.P.
  TITLE     alpha-L-iduronidase mutations (Q70X and P533R) associate with a
            severe Hurler phenotype
  JOURNAL   Hum Mutat 1 (4), 333-339 (1992)
   PUBMED   1301941
REFERENCE   7  (bases 1 to 2582)
  AUTHORS   Scott,H.S., Litjens,T., Hopwood,J.J. and Morris,C.P.
  TITLE     A common mutation for mucopolysaccharidosis type I associated with
            a severe Hurler syndrome phenotype
  JOURNAL   Hum Mutat 1 (2), 103-108 (1992)
   PUBMED   1301196
REFERENCE   8  (bases 1 to 2582)
  AUTHORS   Watanabe,K.
  TITLE     [Changes in the activities of lysosomal enzyme (glycosidase) in
            experimental acute gastric mucosal lesion]
  JOURNAL   Nihon Geka Gakkai Zasshi 87 (4), 395-402 (1986)
   PUBMED   3713687
REFERENCE   9  (bases 1 to 2582)
  AUTHORS   Campbell,C.H. and Rome,L.H.
  TITLE     Coated vesicles from rat liver and calf brain contain lysosomal
            enzymes bound to mannose 6-phosphate receptors
  JOURNAL   J Biol Chem 258 (21), 13347-13352 (1983)
   PUBMED   6138357
REFERENCE   10 (bases 1 to 2582)
  AUTHORS   Weber,W., Kehrer,T., Gressner,A.M., Stuhlsatz,H.W. and Greiling,H.
  TITLE     Changes in the catalytic activities of proteoglycan-degrading
            lysosomal enzymes in parenchymal and non-parenchymal liver cells
            and in serum during the development of experimental liver fibrosis
  JOURNAL   J Clin Chem Clin Biochem 21 (5), 287-293 (1983)
   PUBMED   6875476
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000014.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643294.49227.1,
                                           SRR26643299.53654.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760433,
                                           SAMN12840105 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-235               JAXUCZ010000014.1  1190694-1190928     c
            236-376             JAXUCZ010000014.1  1189967-1190107     c
            377-462             JAXUCZ010000014.1  1180366-1180451     c
            463-570             JAXUCZ010000014.1  1180133-1180240     c
            571-666             JAXUCZ010000014.1  1179746-1179841     c
            667-869             JAXUCZ010000014.1  1179455-1179657     c
            870-1049            JAXUCZ010000014.1  1179201-1179380     c
            1050-1266           JAXUCZ010000014.1  1178874-1179090     c
            1267-1479           JAXUCZ010000014.1  1178353-1178565     c
            1480-1601           JAXUCZ010000014.1  1178152-1178273     c
            1602-1727           JAXUCZ010000014.1  1177929-1178054     c
            1728-1804           JAXUCZ010000014.1  1177780-1177856     c
            1805-1905           JAXUCZ010000014.1  1177370-1177470     c
            1906-2582           JAXUCZ010000014.1  1176577-1177253     c
FEATURES             Location/Qualifiers
     source          1..2582
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14p22"
     gene            1..2582
                     /gene="Idua"
                     /note="alpha-L-iduronidase"
                     /db_xref="GeneID:360904"
                     /db_xref="RGD:1310943"
     exon            1..235
                     /gene="Idua"
                     /inference="alignment:Splign:2.1.0"
     CDS             81..2012
                     /gene="Idua"
                     /EC_number="3.2.1.76"
                     /note="Idual; iduronidase, alpha-L-like"
                     /codon_start=1
                     /product="alpha-L-iduronidase precursor"
                     /protein_id="NP_001165555.1"
                     /db_xref="GeneID:360904"
                     /db_xref="RGD:1310943"
                     /translation="MRPPRPASAMLIFFAAFLASPLALAETPYLVRVDAARPLRPLLP
                     FWRSTGFCPPLPHDQADQYDLSWDQQLNLAYIGAVPHSGIEQVRIHWLLDLITARKSS
                     GQGLIYNFTHLDAFLDLLMENQLLPGFELMGSPSGYFTDFEDKQQVFEWKDLVSLLAR
                     RYIGKYGLTNVSKWNFETWNEPDHHDFDNVSMTTQGFLNYYDACSEGLRIASPTLRLG
                     GPGDSFHPLPRSPMCWSLLGHCANGTNFFTGEVGVRLDYISLHKKGAGSSIAILEQEV
                     AVVEQIQQLFPKFKDTPIYNDEADPLVGWSLPQPWRADVTYAALVVKVIAQHQNLLFA
                     NSSSSMRYILLSNDNAFLSYHPYPFSQRTLTARFQVNNTHPPHVQLLRKPVLTVMGLM
                     ALLDGEQLWAEVLKAGAVLDSNHTVGVLASTHHPEGPSEAWRTTVLIYTSDDTHIHPN
                     DSIPVILHLRGVPPGLELVYVVLYLDNQLSSPYSAWQHMGQPVFPSAEQFRQMRMVED
                     PVAEAPRPFPARGRLTLYRKLPVPSLMLVHLCARPLEPPGQVSRLRALPLTRGQLVLV
                     WSDEHVGSKCLWTYEIQFSQKGEVYAPINRRPSTFNLFVFSPDTAVVSGFYRVRAVDY
                     WARPGPFSDPVTYLDTPAS"
     exon            236..376
                     /gene="Idua"
                     /inference="alignment:Splign:2.1.0"
     exon            377..462
                     /gene="Idua"
                     /inference="alignment:Splign:2.1.0"
     exon            463..570
                     /gene="Idua"
                     /inference="alignment:Splign:2.1.0"
     exon            571..666
                     /gene="Idua"
                     /inference="alignment:Splign:2.1.0"
     exon            667..869
                     /gene="Idua"
                     /inference="alignment:Splign:2.1.0"
     exon            870..1049
                     /gene="Idua"
                     /inference="alignment:Splign:2.1.0"
     exon            1050..1266
                     /gene="Idua"
                     /inference="alignment:Splign:2.1.0"
     exon            1267..1479
                     /gene="Idua"
                     /inference="alignment:Splign:2.1.0"
     exon            1480..1601
                     /gene="Idua"
                     /inference="alignment:Splign:2.1.0"
     exon            1602..1727
                     /gene="Idua"
                     /inference="alignment:Splign:2.1.0"
     exon            1728..1804
                     /gene="Idua"
                     /inference="alignment:Splign:2.1.0"
     exon            1805..1905
                     /gene="Idua"
                     /inference="alignment:Splign:2.1.0"
     exon            1906..2582
                     /gene="Idua"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtggggcgtt acccggaggc ggaacactgc gaccgctgcc taaaagcttg ctgttttggg
       61 ggcgcctgga tatcccagcc atgcgccccc cgcgccccgc ctctgctatg ctgatatttt
      121 ttgcagcgtt cttggcctcg cccctggcgc tggctgagac accgtacctg gtgcgcgtgg
      181 acgcagcccg cccgctgagg cctctgctgc ccttctggag gagcaccggc ttctgccccc
      241 cactgcctca cgaccaggct gaccagtacg accttagttg ggaccagcaa ctgaaccttg
      301 cctacatagg tgctgtgcct cacagtggca ttgagcaggt ccggatacac tggctgctgg
      361 acctcatcac agccaggaag tcatcaggcc agggattgat ctacaacttc acccacttgg
      421 atgcattcct ggacctcctc atggaaaacc agcttctccc gggatttgag ctaatgggca
      481 gtccttctgg gtacttcacg gactttgagg acaagcagca ggtgtttgaa tggaaagacc
      541 tggtttctct cttggccagg agatacattg gtaagtatgg gctgacaaat gtttccaagt
      601 ggaactttga aacttggaac gaaccagacc accatgactt tgacaacgtg tccatgacca
      661 cacaaggctt cctgaattac tatgacgctt gctctgaggg gctgcgcatt gccagcccta
      721 ctttgaggct gggtggtcct ggggattcct tccaccccct gccaaggtca ccaatgtgct
      781 ggagcctcct gggacactgt gccaacggaa ccaacttctt cactggtgag gtgggcgtcc
      841 gcctagatta catctccctg cacaagaagg gtgcaggcag ctccatcgcc atcctggagc
      901 aggaggtggc agtcgtggag cagatccagc agctcttccc caagttcaag gacaccccta
      961 tttataatga cgaggcagac cctctggtag gctggtccct gccgcaacct tggagagccg
     1021 atgtgactta tgccgcccta gtggtgaagg tcatcgcaca gcaccagaac ctgctgtttg
     1081 ccaacagcag ctcctccatg cgctacatac tcctcagcaa tgacaatgcc ttcctgagct
     1141 accacccgta ccctttctcc cagcgtacac ttactgctcg cttccaggtc aacaatactc
     1201 acccacccca cgtgcagttg ctgcggaagc cagtactcac agtcatgggg ctgatggccc
     1261 tgttggatgg agagcaactc tgggcagagg tcttgaaggc tggggctgtg ttggacagca
     1321 accatacagt gggtgtcctg gccagcaccc atcaccctga aggtccctca gaggcctgga
     1381 gaaccactgt cctgatctac actagtgatg acacccacat acaccctaac gacagtatcc
     1441 ctgttattct tcatctgcgt ggagtacctc ctggcttgga gcttgtctac gtagtactct
     1501 acttagacaa tcaactcagc agcccctaca gtgcatggca gcacatgggc cagccagtct
     1561 tcccctctgc agagcagttc cgacaaatgc gcatggtgga ggacccagtg gctgaggcac
     1621 cgcgcccatt tcctgctagg ggccgcctga ccctgtaccg taaacttcca gtgccatctc
     1681 tcatgctggt tcatttatgc gcacgcccct tggagccacc agggcaggtc agccggctcc
     1741 gtgcactgcc cctgacacgt gggcagctgg ttctggtctg gtcggatgag catgtgggct
     1801 ccaagtgcct gtggacatat gagatccagt tttcccagaa gggtgaagta tatgccccaa
     1861 tcaacaggag gccgtctact tttaacctat ttgtgttcag ccccgacaca gctgtggtct
     1921 ctggcttcta ccgagtgcga gcagtggact actgggcccg gccgggcccc ttctccgacc
     1981 ctgtgactta cctggatacc cctgcctcct gaaaaccact gactcccaga gactggtgaa
     2041 aggagtcagc caggatgagc tagactgcca tcaactaagc agctgactag tagcttcttt
     2101 tgttgtcccc ctatttcctt taaggtgtct ttctctacct cagacttggg gtcagccttt
     2161 gtggatgagc actttactgg cccacttgga gtgacctttg cccaccttcc tcctggggag
     2221 atggctcagt gggtaaagtg cttgctgtgc aggcacgagg acttgtgttc agagatctag
     2281 cactcatgta aagtagggca tggcaatata tgcctagtgc cctagtgttg gtggaaggga
     2341 cagggacagg ccagagctca ctggccatct agtctacccg aaactgcaag ttccgggttc
     2401 agtaagaaac cctgttttag aaaaatcaag tagagagctt ggtgtacacg tgcgcacaca
     2461 cacgcacaca aacacacaca tgcacacaca tacatcacac catgcacgca gtctgaattc
     2521 tgtaattaaa aaataaatgc aaacacgtct ttctgaaata caattgcata gagtaaacat
     2581 tt
//
