LOCUS       NM_001401185            5072 bp    mRNA    linear   ROD 09-APR-2024
DEFINITION  Rattus norvegicus iduronate 2-sulfatase (Ids), mRNA.
ACCESSION   NM_001401185 XM_039100539
VERSION     NM_001401185.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5072)
  AUTHORS   Demydchuk,M., Hill,C.H., Zhou,A., Bunkoczi,G., Stein,P.E.,
            Marchesan,D., Deane,J.E. and Read,R.J.
  TITLE     Insights into Hunter syndrome from the structure of
            iduronate-2-sulfatase
  JOURNAL   Nat Commun 8, 15786 (2017)
   PUBMED   28593992
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5072)
  AUTHORS   Uttarilli,A., Ranganath,P., Matta,D., Md Nurul Jain,J., Prasad,K.,
            Babu,A.S., Girisha,K.M., Verma,I.C., Phadke,S.R., Mandal,K.,
            Puri,R.D., Aggarwal,S., Danda,S., Sankar,V.H., Kapoor,S., Bhat,M.,
            Gowrishankar,K., Hasan,A.Q., Nair,M., Nampoothiri,S. and Dalal,A.
  TITLE     Identification and characterization of 20 novel pathogenic variants
            in 60 unrelated Indian patients with mucopolysaccharidoses type I
            and type II
  JOURNAL   Clin Genet 90 (6), 496-508 (2016)
   PUBMED   27146977
REFERENCE   3  (bases 1 to 5072)
  AUTHORS   Sardiello,M., Annunziata,I., Roma,G. and Ballabio,A.
  TITLE     Sulfatases and sulfatase modifying factors: an exclusive and
            promiscuous relationship
  JOURNAL   Hum Mol Genet 14 (21), 3203-3217 (2005)
   PUBMED   16174644
REFERENCE   4  (bases 1 to 5072)
  AUTHORS   Zito,E., Fraldi,A., Pepe,S., Annunziata,I., Kobinger,G., Di
            Natale,P., Ballabio,A. and Cosma,M.P.
  TITLE     Sulphatase activities are regulated by the interaction of
            sulphatase-modifying factor 1 with SUMF2
  JOURNAL   EMBO Rep 6 (7), 655-660 (2005)
   PUBMED   15962010
  REMARK    Erratum:[EMBO Rep. 2016 Dec;17 (12 ):1901. PMID: 27909074]
REFERENCE   5  (bases 1 to 5072)
  AUTHORS   Coronado-Pons,I., Novials,A., Casas,S., Clark,A. and Gomis,R.
  TITLE     Identification of iduronate-2-sulfatase in mouse pancreatic islets
  JOURNAL   Am J Physiol Endocrinol Metab 287 (5), E983-E990 (2004)
   PUBMED   15149955
REFERENCE   6  (bases 1 to 5072)
  AUTHORS   Villani,G.R., Daniele,A., Balzano,N. and Di Natale,P.
  TITLE     Expression of five iduronate-2-sulfatase site-directed mutations
  JOURNAL   Biochim Biophys Acta 1501 (2-3), 71-80 (2000)
   PUBMED   10838181
REFERENCE   7  (bases 1 to 5072)
  AUTHORS   Sukegawa,K., Tomatsu,S., Tamai,K., Ikeda,M., Sasaki,T., Masue,M.,
            Fukuda,S., Yamada,Y. and Orii,T.
  TITLE     Intermediate form of mucopolysaccharidosis type II (Hunter
            disease): a C1327 to T substitution in the iduronate sulfatase gene
  JOURNAL   Biochem Biophys Res Commun 183 (2), 809-813 (1992)
   PUBMED   1550586
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000021.1.
            
            On Mar 2, 2022 this sequence version replaced XM_039100539.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643429.60127.1,
                                           SRR26643298.33528.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760393,
                                           SAMN12840105 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-326               JAXUCZ010000021.1  154091119-154091444 c
            327-463             JAXUCZ010000021.1  154090170-154090306 c
            464-641             JAXUCZ010000021.1  154089376-154089553 c
            642-730             JAXUCZ010000021.1  154087661-154087749 c
            731-931             JAXUCZ010000021.1  154086468-154086668 c
            932-1102            JAXUCZ010000021.1  154084764-154084934 c
            1103-1229           JAXUCZ010000021.1  154079974-154080100 c
            1230-1403           JAXUCZ010000021.1  154077549-154077722 c
            1404-5072           JAXUCZ010000021.1  154070781-154074449 c
FEATURES             Location/Qualifiers
     source          1..5072
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq37"
     gene            1..5072
                     /gene="Ids"
                     /note="iduronate 2-sulfatase"
                     /db_xref="GeneID:363513"
                     /db_xref="RGD:1560491"
     exon            1..326
                     /gene="Ids"
                     /inference="alignment:Splign:2.1.0"
     CDS             212..1876
                     /gene="Ids"
                     /EC_number="3.1.6.13"
                     /codon_start=1
                     /product="iduronate 2-sulfatase precursor"
                     /protein_id="NP_001388114.1"
                     /db_xref="GeneID:363513"
                     /db_xref="RGD:1560491"
                     /translation="MSPPPPPPPTTWRQLSFSLLLGFFCIALVSAAQGNSATDALNIL
                     LIIVDDLRPSLGCYGDKLVRSPNIDQLASHSIVFENAFAQQAVCAPSRVSFLTGRRPD
                     TTRLYDFNSYWRVHSGNFSTIPQYFKENGYVTMSVGKVFHPGISSNHSDDYPYSWSFP
                     PYHPSSEKYENTKTCKGQDGKLHTNLLCPVDVADVPEGTLPDKQSTEEAIRLLEKMKT
                     SVSPFFLAVGYHKPHIPFRYPKEFQKLYPLENMTLAPDPHVPDSLPPVAYNPWMDIRE
                     REDVQALNISVPYGPIPVDFQRKIRQSYFASVSYLDTQVGHLLSALDDLRLAHNTIIA
                     FMSDHGWALGEHGEWAKYSNFDVTTRVPLMFYVPGKTALLPAAGEKLFPYQDPFDPAS
                     ELMGAGRRTEDLVELVSLFPTLAGLAGMPVPPWCPIPSFHVELCREGHNLQRYLQLHD
                     LEEDPYLFGNPRELIAYSQYPRPADFPQWNSDKPSLKDIKVMGYSIRTIDYRYTVWVG
                     FSPTEFLANFSDIHAGELYFVDSDPLQDHNVYNDSQHGGLLLSLRP"
     exon            327..463
                     /gene="Ids"
                     /inference="alignment:Splign:2.1.0"
     exon            464..641
                     /gene="Ids"
                     /inference="alignment:Splign:2.1.0"
     exon            642..730
                     /gene="Ids"
                     /inference="alignment:Splign:2.1.0"
     exon            731..931
                     /gene="Ids"
                     /inference="alignment:Splign:2.1.0"
     exon            932..1102
                     /gene="Ids"
                     /inference="alignment:Splign:2.1.0"
     exon            1103..1229
                     /gene="Ids"
                     /inference="alignment:Splign:2.1.0"
     exon            1230..1403
                     /gene="Ids"
                     /inference="alignment:Splign:2.1.0"
     exon            1404..5072
                     /gene="Ids"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtcgcgttc aagccagcgc ccgggccttc gggcccgagg cgtcgcgtcg gtgtcgcgca
       61 gtcttctctg agacagtcgc gggctgtgga ggccgcgacg acggcagcgg cggcggcggc
      121 ggcggcggcg gcggcggcgg cggcggcggc tacggctacc taatggtcct gatgtagccg
      181 taccttctcg caaggctgtg ctgaggaaga aatgtcgccg ccgccgccgc cgccaccaac
      241 tacctggcgc cagcttagct tcagcttgtt gctaggcttc ttctgtatcg ccctggtgtc
      301 cgcagcgcaa ggcaactctg ctacagatgc tctgaatatc cttctgatca tcgtggatga
      361 tctccgcccc tccctgggct gttatggaga taagctagtg aggtccccaa acattgacca
      421 actggcatcc catagcattg tctttgagaa tgcctttgct cagcaagcag tgtgtgcacc
      481 aagtcgagtt tccttcctca ccgggaggag gcctgacacc acccgcctgt atgacttcaa
      541 ttcctactgg agggtacact ctggaaattt ttccaccatc ccccaatact tcaaggagaa
      601 tggctacgtg accatgtcgg ttgggaaagt ctttcaccct ggtatatctt ccaatcacag
      661 tgatgattat ccatatagtt ggtcttttcc accttatcat ccatcctccg agaagtatga
      721 aaacactaag acatgtaagg gacaagatgg aaaactccac accaacctgc tttgtcctgt
      781 ggatgtggca gatgtgcctg agggtacctt gcctgacaaa cagagcacag aggaagccat
      841 tcgattgttg gaaaagatga aaacgtcagt cagtcctttc ttcctggcgg tcgggtatca
      901 caagccacac atccccttca gataccctaa ggaatttcag aagttgtatc ccctggaaaa
      961 catgaccctg gctcctgatc cccatgttcc tgatagccta ccacctgtag cctacaaccc
     1021 gtggatggac atcagggagc gggaagatgt ccaagcctta aacatcagtg ttccctatgg
     1081 accaattcct gtggattttc agcggaaaat ccgccagagc tactttgctt ctgtgtccta
     1141 tttggataca caggtcgggc atcttttgag tgctttggat gatctccgtc tggcccacaa
     1201 cacaattatt gctttcatgt ctgatcatgg atgggcccta ggtgaacacg gagaatgggc
     1261 caaatacagc aactttgatg tcactacccg tgtaccactg atgttttatg ttcctggaaa
     1321 gacagccctc cttcctgcag caggagagaa gctctttcct taccaggacc cttttgatcc
     1381 cgcttcagaa ttgatgggtg caggcaggcg cactgaggac ctcgtagaac ttgtgtctct
     1441 cttccccacg ctcgctggac ttgcaggaat gccagttcct ccttggtgcc ccatcccttc
     1501 ttttcatgtt gagctgtgca gagaaggcca taatctccag aggtatttgc agctccatga
     1561 cttggaagag gatccatact tgtttggtaa tccccgggag ttgattgcct acagccagta
     1621 tccccggcct gcagatttcc ctcagtggaa ttctgacaag ccaagcttaa aagatataaa
     1681 ggtcatggga tactccatac gcaccataga ctataggtat actgtgtggg ttggcttcag
     1741 tcctactgag tttctggcta acttttctga tatccatgct ggggaactct attttgtcga
     1801 ttctgaccca ctgcaggatc acaatgtata taatgactcc caacatggag gtcttctcct
     1861 ctcactgaga ccttgagttc tgccagcctc agagagcaga tatgcgtccc cttccccgtc
     1921 tttatggtga aaggaggcat tagagatggt atcttttcct acccgttgta ttagacataa
     1981 cctgagtggg aaacaatcaa aacatgaatc agcaatctgg cctatgagta ggtggcaatg
     2041 gatcttttcc tatagtcctt aagttagatt ttgccattgg atttgggcta agctaaaact
     2101 tccattttta aaagctccca tagctcatta ctatacaagt gcaaagtgaa ctaaagtaaa
     2161 atcatatctt tatatctaaa gaccatgcta accagacata atactttact caagaaattg
     2221 tttgcttatt gaatttaatg cttttcatat agtaaccata tgtcttaagt agcccagtgt
     2281 gtcaagcatg ttaacatgtg attcatttct ttctcatatg taaaattaaa gttgtttcta
     2341 gaattattac ttagttccta agactacaga tttcaaaatc aatggtaaaa tacccatgag
     2401 atgatcaatg cagtgttttg tcattaaata atgcttagta aattatagtt aaagctagga
     2461 aattcagtta actattttga tattctctgg cctaaataat aatttattag taaatagtac
     2521 aactattgaa ctcagaggct atctgccaaa aattctatta ttcacaatga aaagcattta
     2581 aaatggaagt attaccatga tttgaatcat tcagaattgt attcatattc ctatttagag
     2641 aattgcagat atctatgtat cctggaggca ggaggtattc tactttttgc taaagaaaac
     2701 atgtttatga aatgtaaatt atcttgaggc ttatggaaac ttttcactaa taaggtataa
     2761 gtaatgtcca gaatgtagtt ctaaattcgc aagtacaaaa gtaagtagaa gggtatgtag
     2821 tgaggataaa gttatttcat tgctgtcatc aaagagaagc cctttgtcta acatggtgag
     2881 aactgctcca ttaccagctg tccacagctt tctaaatcaa cattctttgt atttgctttt
     2941 gtatttaaat gagtaatttc aataattttc ttaaaaatgc ccgtgttcaa ggcaaatgtt
     3001 tttaaaacaa aaatacaaca aatagctagt taaattattg acatgtatta aattgtaacc
     3061 aaaaagtcaa ggtattactt tgaacagtgt aaaatttcag agacagcgtt gtttttccca
     3121 gttgcctgta gaagactggt agctgacaat ccattgtttt cccctgagca attaagtagc
     3181 tgtcttggca acagcagttt gcattgctgg tttgggattg atggtcccat tcatctctcc
     3241 tgatccccag attggtctgt tgtctagaaa ctgactgttg caccgtcttt tcttgttctt
     3301 gatctttatg gctctcatga tgtccactca gcatcagttt tacaatttag tttagaaatt
     3361 tctcacagca tgctttcatt ttgtttagct ctgtttgttt ctcctacttg atggttagag
     3421 ggacagattt tgacacaagt ttttatcttt tatctattta ttatttctgt ttgatcatag
     3481 tatatatact tcattttttt taatgtccca aagcacagtt ttagtgttaa actcacctga
     3541 attctgtttt cattgtagtt ataaggccag tggtggccac atgatatata tggctattta
     3601 aatttaaatt agttgacaca aaataacatt tgaaaagatt tctggtatgt tataatttac
     3661 acttagaacc ttcccatcat agcagactgg acagagatgc cctggattcg agctagaagt
     3721 gttcaccgtg attggcaggt tcctactgtc gtgtatttgc ccacagtgag caaactctat
     3781 ttggtttagg cagagtcggc ctagagtgtg ttgtggccat cagcttcttc cttccactct
     3841 catcaccatt gcttttgtcc ttctttcttt ccttcccaag aaatttacct cccttccttt
     3901 ttcctccccc gttcctgaag gaatccatgt gtcttcctaa aatccctctt gacccctgcc
     3961 ctttaagaac accgtcagtg cctactaagg gtctagcaag acctccgctg agcagtcaga
     4021 gtcttccctg gctccacaat gccccttccc ttggctgact ctccttgcca atccttacct
     4081 ccctggtcct tccagccttt gtcccttctt ctttgctcca accccttcat tgccattctt
     4141 cataacctgg ctcccttacc cccctgctta gaggctgagg ctgtcaggac tctctagact
     4201 gtatgagggg ggaatttgag tacatcttaa aaaatgtggt atttgcttca ctttttaaaa
     4261 ggcatttttc tctcattatg agtttgatat gttaattata caacaattgg aaagcagaaa
     4321 tgcatttaaa ggcaagaaaa tgtctgagtg ctttatacta agattgccat atcttgtcct
     4381 ttttggggta tgaatgtttt acatttattg atcctctatg tttttttata atacaacttc
     4441 tgctcttact ttctctctaa acatcatgta tggctactag tgatttttgc agatatttca
     4501 tattgctggt aatatatgtt attgcattga tttattgtaa ttttctcaac cttctttcag
     4561 ttgttagaaa tttaggttat ttccaagttt tcagtattac gaatagtgct gtgatcaatt
     4621 ttgtgaatac agtgttttta tatattttaa agtattccca tacgctaatt tctcagtacc
     4681 aagtcatcaa aaacagctct gttttctctt tgcttgctat gatagcatat taaacttaga
     4741 aaagaaactc aaaagaccta tattaaaaaa ctataatacc aaaaaagaaa ctctgtagtc
     4801 ccataataat aagtgaaagt tgtattctgt tttgacgtct gattctttgt tgattaataa
     4861 catgaaccat tattctctct gtatggtagt tgtgcagttg catttccagt tgtgtgactg
     4921 tgtggaaatg ttatgagtct tattaccttt tagtgtaata aagtaaattt cttttttcct
     4981 gtgtgatagt ttttcctgta tatttgttct aagcacagaa caactccatt tgcgttgaat
     5041 aaaaatgaat aaatactcat tttcctttga aa
//
