LOCUS       NP_001388114             554 aa            linear   ROD 09-APR-2024
DEFINITION  iduronate 2-sulfatase precursor [Rattus norvegicus].
ACCESSION   NP_001388114 XP_038956467
VERSION     NP_001388114.1
DBSOURCE    REFSEQ: accession NM_001401185.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 554)
  AUTHORS   Demydchuk,M., Hill,C.H., Zhou,A., Bunkoczi,G., Stein,P.E.,
            Marchesan,D., Deane,J.E. and Read,R.J.
  TITLE     Insights into Hunter syndrome from the structure of
            iduronate-2-sulfatase
  JOURNAL   Nat Commun 8, 15786 (2017)
   PUBMED   28593992
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 554)
  AUTHORS   Uttarilli,A., Ranganath,P., Matta,D., Md Nurul Jain,J., Prasad,K.,
            Babu,A.S., Girisha,K.M., Verma,I.C., Phadke,S.R., Mandal,K.,
            Puri,R.D., Aggarwal,S., Danda,S., Sankar,V.H., Kapoor,S., Bhat,M.,
            Gowrishankar,K., Hasan,A.Q., Nair,M., Nampoothiri,S. and Dalal,A.
  TITLE     Identification and characterization of 20 novel pathogenic variants
            in 60 unrelated Indian patients with mucopolysaccharidoses type I
            and type II
  JOURNAL   Clin Genet 90 (6), 496-508 (2016)
   PUBMED   27146977
REFERENCE   3  (residues 1 to 554)
  AUTHORS   Sardiello,M., Annunziata,I., Roma,G. and Ballabio,A.
  TITLE     Sulfatases and sulfatase modifying factors: an exclusive and
            promiscuous relationship
  JOURNAL   Hum Mol Genet 14 (21), 3203-3217 (2005)
   PUBMED   16174644
REFERENCE   4  (residues 1 to 554)
  AUTHORS   Zito,E., Fraldi,A., Pepe,S., Annunziata,I., Kobinger,G., Di
            Natale,P., Ballabio,A. and Cosma,M.P.
  TITLE     Sulphatase activities are regulated by the interaction of
            sulphatase-modifying factor 1 with SUMF2
  JOURNAL   EMBO Rep 6 (7), 655-660 (2005)
   PUBMED   15962010
  REMARK    Erratum:[EMBO Rep. 2016 Dec;17 (12 ):1901. PMID: 27909074]
REFERENCE   5  (residues 1 to 554)
  AUTHORS   Coronado-Pons,I., Novials,A., Casas,S., Clark,A. and Gomis,R.
  TITLE     Identification of iduronate-2-sulfatase in mouse pancreatic islets
  JOURNAL   Am J Physiol Endocrinol Metab 287 (5), E983-E990 (2004)
   PUBMED   15149955
REFERENCE   6  (residues 1 to 554)
  AUTHORS   Villani,G.R., Daniele,A., Balzano,N. and Di Natale,P.
  TITLE     Expression of five iduronate-2-sulfatase site-directed mutations
  JOURNAL   Biochim Biophys Acta 1501 (2-3), 71-80 (2000)
   PUBMED   10838181
REFERENCE   7  (residues 1 to 554)
  AUTHORS   Sukegawa,K., Tomatsu,S., Tamai,K., Ikeda,M., Sasaki,T., Masue,M.,
            Fukuda,S., Yamada,Y. and Orii,T.
  TITLE     Intermediate form of mucopolysaccharidosis type II (Hunter
            disease): a C1327 to T substitution in the iduronate sulfatase gene
  JOURNAL   Biochem Biophys Res Commun 183 (2), 809-813 (1992)
   PUBMED   1550586
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000021.1.
            
            On Mar 2, 2022 this sequence version replaced XP_038956467.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643429.60127.1,
                                           SRR26643298.33528.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760393,
                                           SAMN12840105 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..554
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq37"
     Protein         1..554
                     /product="iduronate 2-sulfatase precursor"
                     /EC_number="3.1.6.13"
                     /calculated_mol_wt=59202
     sig_peptide     1..31
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=3372
     Region          42..545
                     /region_name="iduronate-2-sulfatase"
                     /note="cd16030"
                     /db_xref="CDD:293754"
     Site            order(49..50,88,139,141,233,338..339)
                     /site_type="active"
                     /note="putative active site [active]"
                     /db_xref="CDD:293754"
     Site            order(49..50,88,139,141,233,339)
                     /site_type="other"
                     /note="putative substrate binding site [chemical binding]"
                     /db_xref="CDD:293754"
     CDS             1..554
                     /gene="Ids"
                     /coded_by="NM_001401185.1:212..1876"
                     /db_xref="GeneID:363513"
                     /db_xref="RGD:1560491"
ORIGIN      
        1 mspppppppt twrqlsfsll lgffcialvs aaqgnsatda lnilliivdd lrpslgcygd
       61 klvrspnidq lashsivfen afaqqavcap srvsfltgrr pdttrlydfn sywrvhsgnf
      121 stipqyfken gyvtmsvgkv fhpgissnhs ddypyswsfp pyhpssekye ntktckgqdg
      181 klhtnllcpv dvadvpegtl pdkqsteeai rllekmktsv spfflavgyh kphipfrypk
      241 efqklyplen mtlapdphvp dslppvaynp wmdireredv qalnisvpyg pipvdfqrki
      301 rqsyfasvsy ldtqvghlls alddlrlahn tiiafmsdhg walgehgewa kysnfdvttr
      361 vplmfyvpgk tallpaagek lfpyqdpfdp aselmgagrr tedlvelvsl fptlaglagm
      421 pvppwcpips fhvelcregh nlqrylqlhd leedpylfgn preliaysqy prpadfpqwn
      481 sdkpslkdik vmgysirtid yrytvwvgfs pteflanfsd ihagelyfvd sdplqdhnvy
      541 ndsqhgglll slrp
//
