LOCUS       NM_001419674            3409 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus indoleamine 2,3-dioxygenase 2 (Ido2), mRNA.
ACCESSION   NM_001419674 XM_008771375
VERSION     NM_001419674.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3409)
  AUTHORS   Maddison,D.C. and Giorgini,F.
  TITLE     The kynurenine pathway and neurodegenerative disease
  JOURNAL   Semin Cell Dev Biol 40, 134-141 (2015)
   PUBMED   25773161
  REMARK    Review article
REFERENCE   2  (bases 1 to 3409)
  AUTHORS   Bessede,A., Gargaro,M., Pallotta,M.T., Matino,D., Servillo,G.,
            Brunacci,C., Bicciato,S., Mazza,E.M., Macchiarulo,A., Vacca,C.,
            Iannitti,R., Tissi,L., Volpi,C., Belladonna,M.L., Orabona,C.,
            Bianchi,R., Lanz,T.V., Platten,M., Della Fazia,M.A., Piobbico,D.,
            Zelante,T., Funakoshi,H., Nakamura,T., Gilot,D., Denison,M.S.,
            Guillemin,G.J., DuHadaway,J.B., Prendergast,G.C., Metz,R.,
            Geffard,M., Boon,L., Pirro,M., Iorio,A., Veyret,B., Romani,L.,
            Grohmann,U., Fallarino,F. and Puccetti,P.
  TITLE     Aryl hydrocarbon receptor control of a disease tolerance defence
            pathway
  JOURNAL   Nature 511 (7508), 184-190 (2014)
   PUBMED   24930766
REFERENCE   3  (bases 1 to 3409)
  AUTHORS   Watts,S.W., Shaw,S., Burnett,R. and Dorrance,A.M.
  TITLE     Indoleamine 2,3-diooxygenase in periaortic fat: mechanisms of
            inhibition of contraction
  JOURNAL   Am J Physiol Heart Circ Physiol 301 (4), H1236-H1247 (2011)
   PUBMED   21841011
  REMARK    GeneRIF: We conclude that IDO is an enzyme active primarily in
            brown fat surrounding the thoracic aorta and depresses aortic
            contractility
REFERENCE   4  (bases 1 to 3409)
  AUTHORS   Metz,R., Duhadaway,J.B., Kamasani,U., Laury-Kleintop,L.,
            Muller,A.J. and Prendergast,G.C.
  TITLE     Novel tryptophan catabolic enzyme IDO2 is the preferred biochemical
            target of the antitumor indoleamine 2,3-dioxygenase inhibitory
            compound D-1-methyl-tryptophan
  JOURNAL   Cancer Res 67 (15), 7082-7087 (2007)
   PUBMED   17671174
REFERENCE   5  (bases 1 to 3409)
  AUTHORS   Ball,H.J., Sanchez-Perez,A., Weiser,S., Austin,C.J., Astelbauer,F.,
            Miu,J., McQuillan,J.A., Stocker,R., Jermiin,L.S. and Hunt,N.H.
  TITLE     Characterization of an indoleamine 2,3-dioxygenase-like protein
            found in humans and mice
  JOURNAL   Gene 396 (1), 203-213 (2007)
   PUBMED   17499941
  REMARK    Erratum:[Gene. 2010 Oct 1;465(1-2):66]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Apr 13, 2023 this sequence version replaced XM_008771375.2.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760400,
                              SAMEA5760476 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on manual assertion,
                                         conservation, expression, longest
                                         protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-193               JAXUCZ010000016.1  74161780-74161972
            194-289             JAXUCZ010000016.1  74173706-74173801
            290-409             JAXUCZ010000016.1  74178227-74178346
            410-528             JAXUCZ010000016.1  74180766-74180884
            529-543             JAXUCZ010000016.1  74182827-74182841
            544-643             JAXUCZ010000016.1  74184635-74184734
            644-761             JAXUCZ010000016.1  74185588-74185705
            762-813             JAXUCZ010000016.1  74191512-74191563
            814-962             JAXUCZ010000016.1  74196884-74197032
            963-3409            JAXUCZ010000016.1  74198205-74200651
FEATURES             Location/Qualifiers
     source          1..3409
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16q12.5"
     gene            1..3409
                     /gene="Ido2"
                     /gene_synonym="IDO-2; Indol1"
                     /note="indoleamine 2,3-dioxygenase 2"
                     /db_xref="GeneID:681319"
                     /db_xref="RGD:1596771"
     exon            1..193
                     /gene="Ido2"
                     /gene_synonym="IDO-2; Indol1"
                     /inference="alignment:Splign:2.1.0"
     CDS             95..1312
                     /gene="Ido2"
                     /gene_synonym="IDO-2; Indol1"
                     /EC_number="1.13.11.52"
                     /note="indoleamine-pyrrole 2,3 dioxygenase-like 1;
                     indoleamine 2,3-dioxygenase-like protein 1;
                     indoleamine-pyrrole 2,3-dioxygenase-like protein 1"
                     /codon_start=1
                     /product="indoleamine 2,3-dioxygenase 2"
                     /protein_id="NP_001406603.1"
                     /db_xref="GeneID:681319"
                     /db_xref="RGD:1596771"
                     /translation="MEAQRQDGKLASSLSLGKYHISEEYGFLLPNPLEELPDHYKPWM
                     EIAHRLPHLIESHQLQAHVYEMPLLDCRFLTSYREQRLAHLVLAAITMGFVWQEGEAQ
                     PQKVLPRTLAIPFVEVSRSLGLPPILVHSDLVLTNWTKRNPEGPLEIGNLETIISFPG
                     GESLQGFILVTVLVEKAAVPGIKALVLGVEAIRQHSQDTLLEALQQLRLSIQDITRAL
                     AQMHDYVDPEIFYLVIRIFLSGWKDNPVMPVGLVYEGVSTEPLKYSGGSAAQSSVLHA
                     FDEFLGIQHCKESVDFLHRMRDYMPPSHKAFLEDLHSAPSLRDYILDSGPGGCLMAYN
                     QCVEALGELRSYHINMVARYIISAASKARSRMLTRLSPHALEDRGTGGTAVLSFLKSV
                     REKTMEAILCPGA"
     exon            194..289
                     /gene="Ido2"
                     /gene_synonym="IDO-2; Indol1"
                     /inference="alignment:Splign:2.1.0"
     exon            290..409
                     /gene="Ido2"
                     /gene_synonym="IDO-2; Indol1"
                     /inference="alignment:Splign:2.1.0"
     exon            410..528
                     /gene="Ido2"
                     /gene_synonym="IDO-2; Indol1"
                     /inference="alignment:Splign:2.1.0"
     exon            529..543
                     /gene="Ido2"
                     /gene_synonym="IDO-2; Indol1"
                     /inference="alignment:Splign:2.1.0"
     exon            544..643
                     /gene="Ido2"
                     /gene_synonym="IDO-2; Indol1"
                     /inference="alignment:Splign:2.1.0"
     exon            644..761
                     /gene="Ido2"
                     /gene_synonym="IDO-2; Indol1"
                     /inference="alignment:Splign:2.1.0"
     exon            762..813
                     /gene="Ido2"
                     /gene_synonym="IDO-2; Indol1"
                     /inference="alignment:Splign:2.1.0"
     exon            814..962
                     /gene="Ido2"
                     /gene_synonym="IDO-2; Indol1"
                     /inference="alignment:Splign:2.1.0"
     exon            963..3409
                     /gene="Ido2"
                     /gene_synonym="IDO-2; Indol1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaagcactgt gcaaccacaa ccaccacaga agacacagct gggtagctcc ccgaacctgg
       61 gcgttcctcc agtgcagaga ccgcaagcga aaatatggaa gctcaaagac aggatgggaa
      121 gctggcatcg tcgttatcct tgggaaaata ccacatttct gaggagtatg gctttctcct
      181 tccaaatcct ctggaagaac ttcccgacca ttacaagcct tggatggaaa ttgcccacag
      241 acttcctcac ttaatcgaga gccaccagct ccaagctcat gtgtacgaga tgcctctcct
      301 ggactgcagg ttcctaacga gttaccgcga gcagcgcctg gcacacctgg tgctggccgc
      361 tatcactatg ggattcgtct ggcaggaagg ggaggcccaa ccccaaaagg tgctgccaag
      421 aacacttgct attccttttg ttgaggtatc caggagcctg ggactcccac ctatcctggt
      481 ccactctgat ctggttctga caaactggac caaaaggaac ccagaaggac cactggaaat
      541 cggtaacctg gagaccatca tctcttttcc gggtggagag agcctgcagg gcttcatact
      601 ggtgacagtc ttggtggaga aggcggcagt acctggcatt aaggccctag ttctgggagt
      661 ggaggccatt cggcaacaca gccaggacac cctgctagag gccctgcagc agctgagact
      721 ctccattcag gacattacca gagccttggc ccaaatgcac gattatgtag acccagaaat
      781 attttacttg gtcatccgga tcttcctctc tgggtggaag gacaacccag tcatgcccgt
      841 ggggctggtc tatgagggtg tttccacaga gcctctgaag tactctggcg gaagtgcagc
      901 ccagagctcc gtgcttcatg cctttgatga gttcctgggc attcagcatt gcaaggaaag
      961 tgttgacttt ctacacagaa tgagggacta catgccgcct tcccataagg ccttcctgga
     1021 ggacctccac tcagcccctt cactgagaga ctacatactg gactctggcc ctgggggctg
     1081 cctgatggcc tataaccagt gtgtggaggc cctgggagag ctgcgcagtt accacatcaa
     1141 catggtggcc agatacatta tttccgctgc cagcaaggcc aggagcagga tgctgactcg
     1201 tctctcaccc catgccttgg aagacagggg cactgggggc actgctgtgc tgagcttctt
     1261 gaagagtgtc agggagaaga ccatggaggc catcctgtgt cctggcgctt agcagtcacg
     1321 tcctgcatcc tagtgcttag ctgttctcac cctgcatcct ggaacttagc tgttctcatc
     1381 ctgcatccta gtgcttacct gttcttaccc tgcatcctgg aacttagctg ttctcatcct
     1441 gcatcctaat gcttagctgt tctcatcctg catcctagtg cttagctgtt ctcatcctgc
     1501 atcctagtgc ttacctgttc ttatcctgca tcctagtgct tagctgttct catcctgcat
     1561 cctagtgctt agctgttctc atcctgcatc ctagtgctta gctgttctca tcctgcatcc
     1621 tagtgcttag ctgttctcat cctgcatcct ggaacttagc tgttctcatc ctgcatccta
     1681 gtgcttagct gttctcatcc tgcatcctag tgcttagctg ttctcatcct gcatcctagt
     1741 gcttagctgt tctcatcctg catcctagtg cttacctgtt ctcatcctgc atcctagtgc
     1801 ttagctgttc tcatcctgca tcctagtgct tagctgttct catcctgcat cctagaactt
     1861 cactgttctc atcctgtatc cttgtgctta gctgttctca tcctgcatcc tagtgcttag
     1921 ctgttctcat cctgcatcct aatgcttagc ttctcatcct gcatcctaga acttcactgt
     1981 tctcatcctg catccttgtg cttagctgtt ctcatcctgc atcctggaac tttgctgttc
     2041 tcatcctgca tcctagtgct tagctgttct catcctgcat ccttgtgctt agctgttctc
     2101 atcctgcatc cttgtgctta gctgttctca tcctgcatcc ttgtgcttag catcctgtgg
     2161 gagccagaac cagggtctct gcttagactc aagcatagtt ttgccacaaa gaacaccatg
     2221 tcctttgtta gtaaactgtg gctcccaccc caaccctacc ccagccagtt tgcttgctag
     2281 gaacctttct gccctgccca atccccctgc ctcacagcag agagctgcca ccgtgtcttc
     2341 attctgtggg caagtcagag atacccaagc tcaatctaaa aagaatcaag ttgcttttgg
     2401 acgtgtcact ggttcttctc ccagacctct tcccttcctc cctccctgcc tcttctctcc
     2461 gggcctcaaa ctgtgatccc cctgcctcac ccttcagagc ttatgtgtat gcgccatgtg
     2521 tgagtagctt ggtatgaagc tttgtttctt ttgttttgcc ttcctggagg ttacacccaa
     2581 cgctctgcac acgttggcca attgctccac catacgcttc ctgctctctg tgtccctggc
     2641 tttgagagaa agtctcgatg agtcacttag gctggagctg tacaggggtg agacactgag
     2701 ccatgctgct gctgctgctg ctgttggtga tgacgatgat gatgatgaca acgacgacga
     2761 cgacgatgat gataatgacg atgatgatga cgacgacgat gatgataatg acaatgtggc
     2821 cacaatgatg acagagatgg tattgacggc tgtctctttc tttttgttta tttttggtat
     2881 tttttgtttt gttttttgag acagtatctt actatccttc agcccaggtt gccttgaact
     2941 acttgagcct cccgagtgct tgtattacac acatgcaacc accatggccg gctctagatt
     3001 ctttcagttc accaaggccc tactgtgctc ttgtccgtga cctgggccag ccttctcctc
     3061 cctgcccagg ttggattcag cacagggtgg ggaggagggg tcagatgctc agtggagatt
     3121 tgtgaggtga ggttgctctc catgcagacc tggaagtcac cagcatggga gcgaccggct
     3181 actgacttgg aaccgatgtg actcccccac agggtgtaga catcgccgat tctattttaa
     3241 ttctctctgc tctattttta ggactgtgtt tttctttccc cctggtgaca ctggaaattt
     3301 gtatgtgaaa aatgctttaa ttgacccctt gaaagcaaga gagccaaacc agaataaata
     3361 gtaagcccac atgtttagga taaaaataaa tgtggctttt tatattgga
//
