LOCUS       NP_001406603             405 aa            linear   ROD 01-MAY-2025
DEFINITION  indoleamine 2,3-dioxygenase 2 [Rattus norvegicus].
ACCESSION   NP_001406603 XP_008769597
VERSION     NP_001406603.1
DBSOURCE    REFSEQ: accession NM_001419674.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 405)
  AUTHORS   Maddison,D.C. and Giorgini,F.
  TITLE     The kynurenine pathway and neurodegenerative disease
  JOURNAL   Semin Cell Dev Biol 40, 134-141 (2015)
   PUBMED   25773161
  REMARK    Review article
REFERENCE   2  (residues 1 to 405)
  AUTHORS   Bessede,A., Gargaro,M., Pallotta,M.T., Matino,D., Servillo,G.,
            Brunacci,C., Bicciato,S., Mazza,E.M., Macchiarulo,A., Vacca,C.,
            Iannitti,R., Tissi,L., Volpi,C., Belladonna,M.L., Orabona,C.,
            Bianchi,R., Lanz,T.V., Platten,M., Della Fazia,M.A., Piobbico,D.,
            Zelante,T., Funakoshi,H., Nakamura,T., Gilot,D., Denison,M.S.,
            Guillemin,G.J., DuHadaway,J.B., Prendergast,G.C., Metz,R.,
            Geffard,M., Boon,L., Pirro,M., Iorio,A., Veyret,B., Romani,L.,
            Grohmann,U., Fallarino,F. and Puccetti,P.
  TITLE     Aryl hydrocarbon receptor control of a disease tolerance defence
            pathway
  JOURNAL   Nature 511 (7508), 184-190 (2014)
   PUBMED   24930766
REFERENCE   3  (residues 1 to 405)
  AUTHORS   Watts,S.W., Shaw,S., Burnett,R. and Dorrance,A.M.
  TITLE     Indoleamine 2,3-diooxygenase in periaortic fat: mechanisms of
            inhibition of contraction
  JOURNAL   Am J Physiol Heart Circ Physiol 301 (4), H1236-H1247 (2011)
   PUBMED   21841011
  REMARK    GeneRIF: We conclude that IDO is an enzyme active primarily in
            brown fat surrounding the thoracic aorta and depresses aortic
            contractility
REFERENCE   4  (residues 1 to 405)
  AUTHORS   Metz,R., Duhadaway,J.B., Kamasani,U., Laury-Kleintop,L.,
            Muller,A.J. and Prendergast,G.C.
  TITLE     Novel tryptophan catabolic enzyme IDO2 is the preferred biochemical
            target of the antitumor indoleamine 2,3-dioxygenase inhibitory
            compound D-1-methyl-tryptophan
  JOURNAL   Cancer Res 67 (15), 7082-7087 (2007)
   PUBMED   17671174
REFERENCE   5  (residues 1 to 405)
  AUTHORS   Ball,H.J., Sanchez-Perez,A., Weiser,S., Austin,C.J., Astelbauer,F.,
            Miu,J., McQuillan,J.A., Stocker,R., Jermiin,L.S. and Hunt,N.H.
  TITLE     Characterization of an indoleamine 2,3-dioxygenase-like protein
            found in humans and mice
  JOURNAL   Gene 396 (1), 203-213 (2007)
   PUBMED   17499941
  REMARK    Erratum:[Gene. 2010 Oct 1;465(1-2):66]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Apr 13, 2023 this sequence version replaced XP_008769597.2.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760400,
                              SAMEA5760476 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on manual assertion,
                                         conservation, expression, longest
                                         protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..405
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16q12.5"
     Protein         1..405
                     /product="indoleamine 2,3-dioxygenase 2"
                     /EC_number="1.13.11.52"
                     /note="indoleamine-pyrrole 2,3 dioxygenase-like 1;
                     indoleamine 2,3-dioxygenase-like protein 1;
                     indoleamine-pyrrole 2,3-dioxygenase-like protein 1"
                     /calculated_mol_wt=45105
     Region          15..399
                     /region_name="IDO"
                     /note="Indoleamine 2,3-dioxygenase; pfam01231"
                     /db_xref="CDD:460123"
     CDS             1..405
                     /gene="Ido2"
                     /gene_synonym="IDO-2; Indol1"
                     /coded_by="NM_001419674.1:95..1312"
                     /db_xref="GeneID:681319"
                     /db_xref="RGD:1596771"
ORIGIN      
        1 meaqrqdgkl asslslgkyh iseeygfllp npleelpdhy kpwmeiahrl phlieshqlq
       61 ahvyemplld crfltsyreq rlahlvlaai tmgfvwqege aqpqkvlprt laipfvevsr
      121 slglppilvh sdlvltnwtk rnpegpleig nletiisfpg geslqgfilv tvlvekaavp
      181 gikalvlgve airqhsqdtl lealqqlrls iqditralaq mhdyvdpeif ylviriflsg
      241 wkdnpvmpvg lvyegvstep lkysggsaaq ssvlhafdef lgiqhckesv dflhrmrdym
      301 ppshkafled lhsapslrdy ildsgpggcl maynqcveal gelrsyhinm varyiisaas
      361 karsrmltrl sphaledrgt ggtavlsflk svrektmeai lcpga
//
