LOCUS       NM_031551               1371 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus isocitrate dehydrogenase (NAD(+)) 3 non-catalytic
            subunit gamma (Idh3g), mRNA; nuclear gene for mitochondrial
            product.
ACCESSION   NM_031551 XM_215224
VERSION     NM_031551.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1371)
  AUTHORS   Ma,T., Peng,Y., Huang,W. and Ding,J.
  TITLE     Molecular mechanism of the allosteric regulation of the alphagamma
            heterodimer of human NAD-dependent isocitrate dehydrogenase
  JOURNAL   Sci Rep 7, 40921 (2017)
   PUBMED   28098230
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1371)
  AUTHORS   Soundar,S., Park,J.H., Huh,T.L. and Colman,R.F.
  TITLE     Evaluation by mutagenesis of the importance of 3 arginines in
            alpha, beta, and gamma subunits of human NAD-dependent isocitrate
            dehydrogenase
  JOURNAL   J Biol Chem 278 (52), 52146-52153 (2003)
   PUBMED   14555658
REFERENCE   3  (bases 1 to 1371)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   4  (bases 1 to 1371)
  AUTHORS   Brenner,V., Nyakatura,G., Rosenthal,A. and Platzer,M.
  TITLE     Genomic organization of two novel genes on human Xq28: compact head
            to head arrangement of IDH gamma and TRAP delta is conserved in rat
            and mouse
  JOURNAL   Genomics 44 (1), 8-14 (1997)
   PUBMED   9286695
REFERENCE   5  (bases 1 to 1371)
  AUTHORS   Yokoyama,S., Ohishi,N., Shamoto,M., Watanabe,Y. and Yagi,K.
  TITLE     Isolation and expression of rat interferon beta gene and
            growth-inhibitory effect of its expression on rat glioma cells
  JOURNAL   Biochem Biophys Res Commun 232 (3), 698-701 (1997)
   PUBMED   9126338
REFERENCE   6  (bases 1 to 1371)
  AUTHORS   Nichols,B.J., Hall,L., Perry,A.C. and Denton,R.M.
  TITLE     Molecular cloning and deduced amino acid sequences of the
            gamma-subunits of rat and monkey NAD(+)-isocitrate dehydrogenases
  JOURNAL   Biochem J 295 (Pt 2) (Pt 2), 347-350 (1993)
   PUBMED   8240232
REFERENCE   7  (bases 1 to 1371)
  AUTHORS   Saha,A., Huang,Y.C. and Colman,R.F.
  TITLE     Cysteinyl peptide labeled by 3-bromo-2-ketoglutarate in the active
            site of pig heart NAD+-dependent isocitrate dehydrogenase
  JOURNAL   Biochemistry 28 (21), 8425-8431 (1989)
   PUBMED   2605193
REFERENCE   8  (bases 1 to 1371)
  AUTHORS   Lai,J.C. and Clark,J.B.
  TITLE     Preparation and properties of mitochondria derived from
            synaptosomes
  JOURNAL   Biochem J 154 (2), 423-432 (1976)
   PUBMED   938457
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC083688.1.
            
            [WARNING] On Jul 18, 2024 this sequence was replaced by
            NM_031551.2.
            
            On Oct 11, 2004 this sequence version replaced XM_215224.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC083688.1, FQ224843.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760389, SAMEA5760396
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1371
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq37"
     gene            1..1371
                     /gene="Idh3g"
                     /gene_synonym="IDH"
                     /note="isocitrate dehydrogenase (NAD(+)) 3 non-catalytic
                     subunit gamma"
                     /db_xref="GeneID:25179"
                     /db_xref="RGD:2863"
     exon            1..140
                     /gene="Idh3g"
                     /gene_synonym="IDH"
                     /inference="alignment:Splign:2.1.0"
     CDS             60..1241
                     /gene="Idh3g"
                     /gene_synonym="IDH"
                     /EC_number="1.1.1.41"
                     /note="isocitrate dehydrogenase [NAD] subunit gamma,
                     mitochondrial; isocitrate dehydrogenase [NAD] subunit
                     gamma 1, mitochondrial; NAD(+)-specific ICDH subunit
                     gamma; isocitric dehydrogenase subunit gamma; NAD
                     (H)-specific isocitrate dehydrogenase gamma subunit;
                     isocitrate dehydrogenase 3, gamma; NAD+-isocitrate
                     dehydrogenase gamma subunit; isocitrate dehydrogenase 3
                     (NAD), gamma; isocitrate dehydrogenase (NAD(+)) 3 gamma"
                     /codon_start=1
                     /product="isocitrate dehydrogenase [NAD] subunit gamma 1,
                     mitochondrial precursor"
                     /protein_id="NP_113739.1"
                     /db_xref="GeneID:25179"
                     /db_xref="RGD:2863"
                     /translation="MALKVAIAAGSAAKAIFKPALLCRPWEVLAAHEAPRRSISSQQT
                     IPPSAKYGGRHTVTMIPGDGIGPELMLHVKSVFRHACVPVDFEEVHVSSNADEEDIRN
                     AIMAIRRNRVALKGNIETNHNLPPSHKSRNNILRTSLDLYANVIHCKSLPGVVTRHKD
                     IDILIVRENTEGEYSSLEHESVAGVVESLKIITKAKSLRIAEYAFKLAQESGRKKVTA
                     VHKANIMKLGDGLFLQCCREVAARYPQITFDSMIVDNTTMQLVSRPQQFDVMVMPNLY
                     GNIVNNVCAGLVGGPGLVAGANYGHVYAVFETATRNTGKSIANKNIANPTATLLASCM
                     MLDHLKLHSYATSIRKAVLASMDNENMHTPDIGGQGTTSQAIQDIIRHIRIINGRAVE
                     A"
     exon            141..182
                     /gene="Idh3g"
                     /gene_synonym="IDH"
                     /inference="alignment:Splign:2.1.0"
     exon            183..194
                     /gene="Idh3g"
                     /gene_synonym="IDH"
                     /inference="alignment:Splign:2.1.0"
     exon            195..292
                     /gene="Idh3g"
                     /gene_synonym="IDH"
                     /inference="alignment:Splign:2.1.0"
     exon            293..405
                     /gene="Idh3g"
                     /gene_synonym="IDH"
                     /inference="alignment:Splign:2.1.0"
     exon            406..466
                     /gene="Idh3g"
                     /gene_synonym="IDH"
                     /inference="alignment:Splign:2.1.0"
     exon            467..599
                     /gene="Idh3g"
                     /gene_synonym="IDH"
                     /inference="alignment:Splign:2.1.0"
     exon            600..733
                     /gene="Idh3g"
                     /gene_synonym="IDH"
                     /inference="alignment:Splign:2.1.0"
     exon            734..836
                     /gene="Idh3g"
                     /gene_synonym="IDH"
                     /inference="alignment:Splign:2.1.0"
     exon            837..983
                     /gene="Idh3g"
                     /gene_synonym="IDH"
                     /inference="alignment:Splign:2.1.0"
     exon            984..1078
                     /gene="Idh3g"
                     /gene_synonym="IDH"
                     /inference="alignment:Splign:2.1.0"
     exon            1079..1139
                     /gene="Idh3g"
                     /gene_synonym="IDH"
                     /inference="alignment:Splign:2.1.0"
     exon            1140..1347
                     /gene="Idh3g"
                     /gene_synonym="IDH"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgaagtgtcg cgagaacggt gcttaacgtt ttgacctgta gaggtcctca cttttcgtta
       61 tggcgctgaa ggtggcgata gctgctggca gtgctgcaaa ggcaatattc aagccagctc
      121 tcctctgccg tccttgggag gttctggctg cccatgaggc cccccgaagg agcatttcct
      181 cacaacaaac aattcctccg tctgctaagt atggtgggcg gcatacagtg actatgattc
      241 caggggatgg catcggcccg gagctcatgt tgcatgttaa gtcggtattc aggcatgcat
      301 gtgtgccagt ggactttgaa gaggtgcatg taagctccaa cgctgatgag gaggacatcc
      361 gcaatgccat catggccatc cgccggaacc gtgtggctct aaagggcaac atcgaaacaa
      421 atcataactt gccaccatcc cacaaatccc ggaacaacat ccttcgtacc agcctagacc
      481 tctatgccaa cgtcatccac tgtaagagtc tgccaggagt ggtgacccgg cacaaggaca
      541 tagacatcct cattgtgcgg gaaaacacag aaggcgagta cagcagcctg gagcatgaga
      601 gtgtagcagg agtggtggag agcttgaaga ttatcaccaa agccaagtcc ctgcgcattg
      661 ctgaatatgc tttcaagctg gcccaggaga gtgggcgtaa gaaagtgacg gctgtgcaca
      721 aggccaacat catgaaactg ggtgatggac tcttcctcca gtgttgcagg gaagtggcag
      781 cccgctaccc tcagatcacc tttgatagca tgattgtgga caacacaaca atgcagctgg
      841 tatcccggcc tcagcagttt gatgtcatgg tgatgcctaa tctctatggt aacattgtca
      901 acaacgtctg tgcagggcta gttggaggcc caggccttgt ggctggggcc aactatggcc
      961 atgtgtatgc agtattcgag acagctacaa ggaacacagg caaaagtatt gccaataaga
     1021 acattgctaa ccctactgcc acattgctag caagttgcat gatgctagac cacctcaagc
     1081 tccattccta tgccacctcc atccgaaaag ctgtcttagc atccatggac aatgaaaata
     1141 tgcatacccc agacattgga ggccagggca ccacatccca agccatccag gacatcattc
     1201 gtcacatccg catcattaat ggacgggctg tggaggccta gctatccctg cagtttgctc
     1261 agtttgtctg taggactccc ttctcatttt agcactccag ctagctttgg ggacaggctc
     1321 cagaataaag ccacttgtgt tccagaaaaa aaaaaaaaaa aaaaaaaaaa a
//
