LOCUS       NM_053581               1532 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus isocitrate dehydrogenase (NAD(+)) 3 non-catalytic
            subunit beta (Idh3b), mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_053581 XM_342518
VERSION     NM_053581.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1532)
  AUTHORS   de Mateo,S., Castillo,J., Estanyol,J.M., Ballesca,J.L. and Oliva,R.
  TITLE     Proteomic characterization of the human sperm nucleus
  JOURNAL   Proteomics 11 (13), 2714-2726 (2011)
   PUBMED   21630459
REFERENCE   2  (bases 1 to 1532)
  AUTHORS   Soundar,S., Park,J.H., Huh,T.L. and Colman,R.F.
  TITLE     Evaluation by mutagenesis of the importance of 3 arginines in
            alpha, beta, and gamma subunits of human NAD-dependent isocitrate
            dehydrogenase
  JOURNAL   J Biol Chem 278 (52), 52146-52153 (2003)
   PUBMED   14555658
REFERENCE   3  (bases 1 to 1532)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   4  (bases 1 to 1532)
  AUTHORS   Shinohara,Y., Daikoku,T., Kajimoto,K., Shima,A., Yamazaki,N. and
            Terada,H.
  TITLE     Expression of NAD(+)-dependent isocitrate dehydrogenase in brown
            adipose tissue
  JOURNAL   Biochem Biophys Res Commun 281 (3), 634-638 (2001)
   PUBMED   11237704
REFERENCE   5  (bases 1 to 1532)
  AUTHORS   Lai,J.C. and Clark,J.B.
  TITLE     Preparation and properties of mitochondria derived from
            synaptosomes
  JOURNAL   Biochem J 154 (2), 423-432 (1976)
   PUBMED   938457
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC079113.1.
            
            [WARNING] On Apr 23, 2024 this sequence was replaced by
            NM_053581.2.
            
            On Nov 26, 2004 this sequence version replaced XM_342518.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC079113.1, SRR8487227.48217.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1532
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q36"
     gene            1..1532
                     /gene="Idh3b"
                     /note="isocitrate dehydrogenase (NAD(+)) 3 non-catalytic
                     subunit beta"
                     /db_xref="GeneID:94173"
                     /db_xref="RGD:621881"
     exon            1..49
                     /gene="Idh3b"
                     /inference="alignment:Splign:2.1.0"
     CDS             14..1171
                     /gene="Idh3b"
                     /EC_number="1.1.1.41"
                     /note="isocitrate dehydrogenase [NAD] subunit beta,
                     mitochondrial; NAD(+)-specific ICDH subunit beta;
                     isocitric dehydrogenase subunit beta; NAD+-specific
                     isocitrate dehydrogenase b subunit; isocitrate
                     dehydrogenase 3 (NAD+) beta; isocitrate dehydrogenase
                     (NAD(+)) 3 beta"
                     /codon_start=1
                     /product="isocitrate dehydrogenase [NAD] subunit beta,
                     mitochondrial precursor"
                     /protein_id="NP_446033.1"
                     /db_xref="GeneID:94173"
                     /db_xref="RGD:621881"
                     /translation="MAALSNVRWLTRAVLGARNSGAWRGLRTAASAQAASQSQAQDVR
                     VEGAFPVTMLPGDGVGPELMHAVKEVFKAAAVPVEFKEHHLSEVQNMASEEKLEQVLS
                     SMKENKVAIIGKIYTPMEYKGELASYDMQLRRKLDLFANVVHVKSLPGYKTRHNNLDL
                     VIIREQTEGEYSSLEHESARGVIECLKIVTRTKSQRIAKFAFDYATKKGRSKVTAVHK
                     ANIMKLGDGLFLQCCEEVAELYPKIKFETMIIDNCCMQLVQNPYQFDVLVMPNLYGNI
                     IDNLAAGLVGGAGVVPGESYSAEYAVFETGARHPFAQAVGRNIANPTAMLLSASNMLR
                     HLNLEYHSSMIADAVKKVIKVGKVRTRDMGGYSTTTDFIKSVIGHLHPHGG"
     exon            50..130
                     /gene="Idh3b"
                     /inference="alignment:Splign:2.1.0"
     exon            131..229
                     /gene="Idh3b"
                     /inference="alignment:Splign:2.1.0"
     exon            230..350
                     /gene="Idh3b"
                     /inference="alignment:Splign:2.1.0"
     exon            351..411
                     /gene="Idh3b"
                     /inference="alignment:Splign:2.1.0"
     exon            412..544
                     /gene="Idh3b"
                     /inference="alignment:Splign:2.1.0"
     exon            545..678
                     /gene="Idh3b"
                     /inference="alignment:Splign:2.1.0"
     exon            679..781
                     /gene="Idh3b"
                     /inference="alignment:Splign:2.1.0"
     exon            782..928
                     /gene="Idh3b"
                     /inference="alignment:Splign:2.1.0"
     exon            929..1023
                     /gene="Idh3b"
                     /inference="alignment:Splign:2.1.0"
     exon            1024..1084
                     /gene="Idh3b"
                     /inference="alignment:Splign:2.1.0"
     exon            1085..1506
                     /gene="Idh3b"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccctcggcag aacatggcag cgctgagcaa tgtccgctgg ctgacccgag cggtgctcgg
       61 cgctcggaac tccggggcat ggagaggtct ccgaacagca gcttcggctc aagccgcttc
      121 acagagtcag gcacaagatg tgagggtgga gggtgccttt cctgtgacaa tgctacctgg
      181 agacggtgtg gggccagagc tcatgcatgc tgtcaaggaa gtgttcaagg ctgctgctgt
      241 ccctgtggaa ttcaaggagc accacctaag tgaggtgcag aatatggctt ctgaggagaa
      301 gctggagcag gtgctgagtt ccatgaagga gaacaaagtt gccatcattg gaaagatcta
      361 caccccaatg gagtataagg gtgaactagc ctcctatgat atgcaactga ggcgtaagtt
      421 ggatttgttt gccaacgtgg tccatgtgaa gtcacttcct ggatataaga ctcggcacaa
      481 caatctagac ctggtgatca ttcgagaaca gacagaaggg gagtatagct ctctggaaca
      541 tgagagtgca aggggtgtca ttgagtgcct gaagatcgtc actcgaacca agtctcagag
      601 gattgcaaag tttgcctttg actatgccac caaaaaaggg cggagcaagg tcacagctgt
      661 ccataaagcc aacatcatga aacttggaga tgggctgttc ttgcagtgct gtgaggaagt
      721 tgctgaactg taccctaaaa tcaagtttga aacaatgatc atagacaact gttgcatgca
      781 gctggtgcag aatccttacc agtttgatgt gcttgtgatg cccaatctct atgggaacat
      841 tatcgacaat ctggctgctg gccttgttgg gggagctggt gtggttcctg gtgagagcta
      901 cagtgcagag tatgcagttt ttgagacggg cgctcggcac ccatttgccc aggcagtggg
      961 caggaatata gccaatccca cagccatgct gctgtcagct tccaacatgc tacggcatct
     1021 caaccttgag tatcactcca gcatgattgc agatgcagtg aagaaggtga tcaaggttgg
     1081 caaggtccgg actcgagaca tgggaggcta cagcaccaca actgacttca tcaagtccgt
     1141 catcggccat ctgcaccccc atgggggcta gagcccttta cttcctcctt caaaaggatc
     1201 atgcttcgaa tacatccctt cagtacagtg gaccagaaga gaccatctag acagtagaca
     1261 ataaataact gcttttctgg cagaggctag gttgtcctgg gggctggctt taagggtacc
     1321 acctcacagg atgggctgtt gagacagggc ccagactgta agattatcac tttttcccac
     1381 aggttcgaac ctcagatatg ggtggttatg ccacatgtca tgacttcact gaagctgtta
     1441 ttactgccct atcataaatc ctatatgccc atgtaaaaat aaaaataaat atagacaaac
     1501 acatgtaaaa aaaaaaaaaa aaaaaaaaaa aa
//
