LOCUS       NM_001014161            1695 bp    mRNA    linear   ROD 02-APR-2024
DEFINITION  Rattus norvegicus isocitrate dehydrogenase (NADP(+)) 2 (Idh2),
            mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_001014161 XM_341875
VERSION     NM_001014161.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1695)
  AUTHORS   Adachi,T., Adachi,T., Nakagaki,T., Ono,S., Hidaka,M., Ito,S.,
            Kanetaka,K., Takatsuki,M., Nishida,N. and Eguchi,S.
  TITLE     Difference in driver gene expression patterns between perihilar and
            peripheral intrahepatic cholangiocarcinoma in an experimental mouse
            model
  JOURNAL   J Hepatobiliary Pancreat Sci 27 (8), 477-486 (2020)
   PUBMED   32463951
REFERENCE   2  (bases 1 to 1695)
  AUTHORS   Chen,X., Zhuo,S., Xu,W., Chen,X., Huang,D., Sun,X. and Cheng,Y.
  TITLE     Isocitrate dehydrogenase 2 contributes to radiation resistance of
            oesophageal squamous cell carcinoma via regulating mitochondrial
            function and ROS/pAKT signalling
  JOURNAL   Br J Cancer 123 (1), 126-136 (2020)
   PUBMED   32367071
REFERENCE   3  (bases 1 to 1695)
  AUTHORS   Kim,H., Lee,J.H. and Park,J.W.
  TITLE     IDH2 deficiency exacerbates acetaminophen hepatotoxicity in mice
            via mitochondrial dysfunction-induced apoptosis
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1865 (9), 2333-2341 (2019)
   PUBMED   31121248
REFERENCE   4  (bases 1 to 1695)
  AUTHORS   Gong,F., Gao,L. and Ding,T.
  TITLE     IDH2 protects against nonalcoholic steatohepatitis by alleviating
            dyslipidemia regulated by oxidative stress
  JOURNAL   Biochem Biophys Res Commun 514 (3), 593-600 (2019)
   PUBMED   31064654
REFERENCE   5  (bases 1 to 1695)
  AUTHORS   Li,J., He,Y., Tan,Z., Lu,J., Li,L., Song,X., Shi,F., Xie,L.,
            You,S., Luo,X., Li,N., Li,Y., Liu,X., Tang,M., Weng,X., Yi,W.,
            Fan,J., Zhou,J., Qiang,G., Qiu,S., Wu,W., Bode,A.M. and Cao,Y.
  TITLE     Wild-type IDH2 promotes the Warburg effect and tumor growth through
            HIF1alpha in lung cancer
  JOURNAL   Theranostics 8 (15), 4050-4061 (2018)
   PUBMED   30128035
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1695)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   7  (bases 1 to 1695)
  AUTHORS   Da Cruz,S., Xenarios,I., Langridge,J., Vilbois,F., Parone,P.A. and
            Martinou,J.C.
  TITLE     Proteomic analysis of the mouse liver mitochondrial inner membrane
  JOURNAL   J Biol Chem 278 (42), 41566-41571 (2003)
   PUBMED   12865426
REFERENCE   8  (bases 1 to 1695)
  AUTHORS   Jennings,G.T., Minard,K.I. and McAlister-Henn,L.
  TITLE     Expression and mutagenesis of mammalian cytosolic NADP+-specific
            isocitrate dehydrogenase
  JOURNAL   Biochemistry 36 (44), 13743-13747 (1997)
   PUBMED   9354646
REFERENCE   9  (bases 1 to 1695)
  AUTHORS   Yang,L., Luo,H., Vinay,P. and Wu,J.
  TITLE     Molecular cloning of the cDNA of mouse mitochondrial NADP-dependent
            isocitrate dehydrogenase and the expression of the gene during
            lymphocyte activation
  JOURNAL   J Cell Biochem 60 (3), 400-410 (1996)
   PUBMED   8867815
REFERENCE   10 (bases 1 to 1695)
  AUTHORS   Stallings,R.L. and Siciliano,M.J.
  TITLE     Confirmational, provisional, and/or regional assignment of 15
            enzyme loci onto Chinese hamster autosomes 1, 2, and 7
  JOURNAL   Somatic Cell Genet 7 (6), 683-698 (1981)
   PUBMED   7323947
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC076398.1.
            
            On Apr 20, 2005 this sequence version replaced XM_341875.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC076398.1, SRR8487227.39155.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06621351, SAMN11044071
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1695
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q31"
     gene            1..1695
                     /gene="Idh2"
                     /note="isocitrate dehydrogenase (NADP(+)) 2"
                     /db_xref="GeneID:361596"
                     /db_xref="RGD:1597139"
     exon            1..144
                     /gene="Idh2"
                     /inference="alignment:Splign:2.1.0"
     CDS             30..1388
                     /gene="Idh2"
                     /EC_number="1.1.1.42"
                     /note="isocitrate dehydrogenase [NADP], mitochondrial;
                     IDH; IDP; ICD-M; NADP(+)-specific ICDH; oxalosuccinate
                     decarboxylase; isocitrate dehydrogenase 2 (NADP+),
                     mitochondrial; isocitrate dehydrogenase (NADP(+)) 2,
                     mitochondrial"
                     /codon_start=1
                     /product="isocitrate dehydrogenase [NADP], mitochondrial
                     precursor"
                     /protein_id="NP_001014183.1"
                     /db_xref="GeneID:361596"
                     /db_xref="RGD:1597139"
                     /translation="MAGYLRAVSSLCRASGSTRTWAPAALNVPSWPEQPRRHYAEKRI
                     KVEKPVVEMDGDEMTRIIWQFIKEKLILPHVDVQLKYFDLGLPNRDQTNDQVTIDSAL
                     ATQKYSVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPIICKNIPRL
                     VPGWTKPITIGRHAHGDQYKATDFVVDRAGMFKLVFTPKDGSGAKEWEVYNFPAGGVG
                     MGMYNTDESISGFAHSCFQYSIQKKWPLYLSTKNTIMKAYDGRFKDIFQEIFDKHYKT
                     DFDKNKIWYEHRLIDDMVAQVLKSSGGFVWACKNYDGDVQSDILAQGFGSLGLMTSVL
                     VCPDGKTIEAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHRGKLDGNQDLI
                     RFAQTLEKVCVQTVESGAMTKDLAGCIHGLSNVKLNEHFLNTTDFLDTIKSNLDRALG
                     KQ"
     exon            145..236
                     /gene="Idh2"
                     /inference="alignment:Splign:2.1.0"
     exon            237..402
                     /gene="Idh2"
                     /inference="alignment:Splign:2.1.0"
     exon            403..563
                     /gene="Idh2"
                     /inference="alignment:Splign:2.1.0"
     exon            564..707
                     /gene="Idh2"
                     /inference="alignment:Splign:2.1.0"
     exon            708..844
                     /gene="Idh2"
                     /inference="alignment:Splign:2.1.0"
     exon            845..996
                     /gene="Idh2"
                     /inference="alignment:Splign:2.1.0"
     exon            997..1109
                     /gene="Idh2"
                     /inference="alignment:Splign:2.1.0"
     exon            1110..1207
                     /gene="Idh2"
                     /inference="alignment:Splign:2.1.0"
     exon            1208..1300
                     /gene="Idh2"
                     /inference="alignment:Splign:2.1.0"
     exon            1301..1672
                     /gene="Idh2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcggcgcgct cggacctcgt gtgctcggga tggccggcta tctgcgggcc gtgagctcgc
       61 tctgcagagc ctcgggctca acacggacct gggcaccggc tgcactgaat gtccccagct
      121 ggccggagca gccgcggcgc cactatgctg agaagagaat caaggtggag aagccggtgg
      181 tggagatgga tggcgatgag atgacccgga tcatctggca gttcatcaag gagaagctca
      241 tcctgcctca cgtggatgtc cagctcaagt attttgacct tgggcttcca aaccgtgacc
      301 agaccaatga ccaggtcacc atcgactctg cgctggccac tcagaagtac agtgtggctg
      361 ttaagtgtgc tacaatcacc cccgatgagg cccgtgtgga agagttcaag ctgaagaaaa
      421 tgtggaagag ccctaacgga actatccgta acatccttgg gggaacggtc ttcagagagc
      481 caattatctg caaaaatatc ccccgccttg tccctggctg gaccaagccc atcaccattg
      541 gcagacacgc ccatggcgac cagtacaagg ccacagattt tgtggtagat cgagctggca
      601 tgttcaagtt ggtcttcacc ccaaaggatg gcagtggtgc caaggagtgg gaggtgtata
      661 acttccctgc cggaggcgtt ggtatgggga tgtacaacac cgacgagtcc atttcgggct
      721 tcgcgcacag ctgcttccag tactctatcc agaagaaatg gccgctctac ttgagcacca
      781 agaacaccat tatgaaggcc tatgacgggc gtttcaagga catcttccag gagatctttg
      841 acaagcacta taagactgac tttgacaaga ataagatctg gtacgagcat cggctcattg
      901 acgacatggt ggctcaggtg ctcaagtctt ccggtggctt tgtgtgggcc tgcaagaact
      961 atgacggaga tgtacagtct gacatcctgg ctcaaggatt tggctccctt ggcctgatga
     1021 catctgtgct ggtctgccct gacgggaaga ccattgaagc tgaggctgct cacgggacag
     1081 tcacccgcca ctaccgagaa caccagaagg gccggcccac cagtaccaac cctattgcca
     1141 gcatctttgc ctggacacgg ggtctggagc atcgagggaa gctggatggg aaccaggacc
     1201 tcatcaggtt tgcacagact ctggagaagg tgtgcgtgca gactgtggag agcggagcta
     1261 tgaccaagga cctggctggc tgcatccatg gcctcagcaa tgtgaagctg aatgagcact
     1321 tcctgaacac cacagacttc ctggacacca ttaagagcaa cctggacaga gctctgggca
     1381 agcagtaggg gtggacacta cactacccag ctccagtggg tgctccgtac atggtagagg
     1441 gtgggcgttg tagcccccct ctctggtggc ctttctaggg gattattttt ttacatatat
     1501 atatatatga tggagatgtt ttttaaagca tgtgagcaat ttccctcaca gtggacacga
     1561 ggcaggaacg gtgcgcttta cctcagccag tcagtgtgtt ttgcatactg taatttatat
     1621 tgccctgagt cacgtggtgc catatttagc tactaaaaag ctcttcacaa aaaaaaaaaa
     1681 aaaaaaaaaa aaaaa
//
