LOCUS       NM_031510               1719 bp    mRNA    linear   ROD 11-SEP-2024
DEFINITION  Rattus norvegicus isocitrate dehydrogenase (NADP(+)) 1 (Idh1),
            mRNA.
ACCESSION   NM_031510
VERSION     NM_031510.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1719)
  AUTHORS   Sei,H., Hirade,N., Kamiya,K., Nakashima,F., Yoshitake,J., Kano,K.,
            Mishiro-Sato,E., Kikuchi,R., Uchida,K. and Shibata,T.
  TITLE     Isocitrate dehydrogenase 1 upregulation in urinary extracellular
            vesicles from proximal tubules of type 2 diabetic rats
  JOURNAL   FASEB J 38 (10), e23688 (2024)
   PUBMED   38780519
  REMARK    GeneRIF: Isocitrate dehydrogenase 1 upregulation in urinary
            extracellular vesicles from proximal tubules of type 2 diabetic
            rats.
REFERENCE   2  (bases 1 to 1719)
  AUTHORS   Clement,A., Doyen,M., Fauvelle,F., Hossu,G., Chen,B.,
            Barberi-Heyob,M., Hirtz,A., Stupar,V., Lamiral,Z., Pouget,C.,
            Gauchotte,G., Karcher,G., Beaumont,M., Verger,A. and Lemasson,B.
  TITLE     In vivo characterization of physiological and metabolic changes
            related to isocitrate dehydrogenase 1 mutation expcression by
            multiparametric MRI and MRS in a rat model with orthotopically
            grafted human-derived glioblastoma cell lines
  JOURNAL   NMR Biomed 34 (6), e4490 (2021)
   PUBMED   33599048
  REMARK    GeneRIF: In vivo characterization of physiological and metabolic
            changes related to isocitrate dehydrogenase 1 mutation expcression
            by multiparametric MRI and MRS in a rat model with orthotopically
            grafted human-derived glioblastoma cell lines.
REFERENCE   3  (bases 1 to 1719)
  AUTHORS   Wang,T., Drill,E., Vakiani,E., Pak,L.M., Boerner,T., Askan,G.,
            Schvartzman,J.M., Simpson,A.L., Jarnagin,W.R. and Sigel,C.S.
  TITLE     Distinct histomorphological features are associated with IDH1
            mutation in intrahepatic cholangiocarcinoma
  JOURNAL   Hum Pathol 91, 19-25 (2019)
   PUBMED   31121195
REFERENCE   4  (bases 1 to 1719)
  AUTHORS   Al-Amodi,H.S.A.B., Nabih,E.S., Kamel,H.F.M., El Sayed,M.A. and
            Dwedar,I.A.M.
  TITLE     Wild-Type Isocitrate Dehydrogenase 1 Over-Expression is Related to
            Cancer Stem Cells Survival in Lung Adenocarcinoma
  JOURNAL   Cancer Invest 36 (3), 185-189 (2018)
   PUBMED   29537891
REFERENCE   5  (bases 1 to 1719)
  AUTHORS   Lee,J.H., Shin,D.H., Park,W.Y., Shin,N., Kim,A., Lee,H.J.,
            Kim,Y.K., Choi,K.U., Kim,J.Y., Yang,Y.I., Lee,C.H. and Sol,M.Y.
  TITLE     IDH1 R132C mutation is detected in clear cell hepatocellular
            carcinoma by pyrosequencing
  JOURNAL   World J Surg Oncol 15 (1), 82 (2017)
   PUBMED   28403884
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1719)
  AUTHORS   Jennings,G.T., Sechi,S., Stevenson,P.M., Tuckey,R.C., Parmelee,D.
            and McAlister-Henn,L.
  TITLE     Cytosolic NADP(+)-dependent isocitrate dehydrogenase. Isolation of
            rat cDNA and study of tissue-specific and developmental expression
            of mRNA
  JOURNAL   J Biol Chem 269 (37), 23128-23134 (1994)
   PUBMED   8083215
REFERENCE   7  (bases 1 to 1719)
  AUTHORS   Sechi,S., Parmelee,D., Roller,P.P. and Jennings,G.T.
  TITLE     Structural characterization of cytosolic NADP(+)-dependent
            isocitrate dehydrogenase from rat ovary
  JOURNAL   Enzyme Protein 48 (1), 27-36 (1994)
   PUBMED   7787968
REFERENCE   8  (bases 1 to 1719)
  AUTHORS   Bobyleva,V., Kneer,N., Bellei,M., Battelli,D. and Lardy,H.A.
  TITLE     Concerning the mechanism of increased thermogenesis in rats treated
            with dehydroepiandrosterone
  JOURNAL   J Bioenerg Biomembr 25 (3), 313-321 (1993)
   PUBMED   8349575
REFERENCE   9  (bases 1 to 1719)
  AUTHORS   Yasue,M., Serikawa,T. and Yamada,J.
  TITLE     Chromosomal assignments of 23 biochemical loci of the rat by using
            rat x mouse somatic cell hybrids
  JOURNAL   Cytogenet Cell Genet 57 (2-3), 142-148 (1991)
   PUBMED   1914521
REFERENCE   10 (bases 1 to 1719)
  AUTHORS   Nichols,E.A. and Ruddle,F.H.
  TITLE     Polymorphism and linkage of glutathione reductase in Mus musculus
  JOURNAL   Biochem Genet 13 (5-6), 323-329 (1975)
   PUBMED   1180875
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from L35317.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: L35317.1, FQ214242.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676785, SAMN16676786
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1719
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q32"
     gene            1..1719
                     /gene="Idh1"
                     /gene_synonym="IDPc"
                     /note="isocitrate dehydrogenase (NADP(+)) 1"
                     /db_xref="GeneID:24479"
                     /db_xref="RGD:2862"
     exon            1..13
                     /gene="Idh1"
                     /gene_synonym="IDPc"
                     /inference="alignment:Splign:2.1.0"
     exon            14..151
                     /gene="Idh1"
                     /gene_synonym="IDPc"
                     /inference="alignment:Splign:2.1.0"
     CDS             30..1274
                     /gene="Idh1"
                     /gene_synonym="IDPc"
                     /EC_number="1.1.1.42"
                     /note="IDH; IDP; NADP(+)-specific ICDH; oxalosuccinate
                     decarboxylase; cytosolic NADP-isocitrate dehydrogenase;
                     Isocitrate dehydrogenase 1, soluble; isocitrate
                     dehydrogenase 1 (NADP+), soluble; isocitrate dehydrogenase
                     (NADP(+)) 1, cytosolic"
                     /codon_start=1
                     /product="isocitrate dehydrogenase [NADP] cytoplasmic"
                     /protein_id="NP_113698.1"
                     /db_xref="GeneID:24479"
                     /db_xref="RGD:2862"
                     /translation="MSRKIHGGSVVEMQGDEMTRIIWELIKEKLILPYVELDLHSYDL
                     GIENRDATNDQVTKDAAEAIKKYNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNI
                     LGGTVFREAIICKNIPRLVTGWVKPIIIGRHAYGDQYRATDFVVPGPGKVEITYTPKD
                     GSQKVTYLVHDFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKK
                     YDGRFKDIFQEIYDKQYKSKFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDV
                     QSDSVAQGYGSLGMMTSVLICPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIF
                     AWSRGLAHRAKLDNNTELSFFANALEEVCIETIEAGFMTKDLAACIKGLPNVQRSDYL
                     NTFEFMDKLGENLKAKLAQAKL"
     exon            152..443
                     /gene="Idh1"
                     /gene_synonym="IDPc"
                     /inference="alignment:Splign:2.1.0"
     exon            444..549
                     /gene="Idh1"
                     /gene_synonym="IDPc"
                     /inference="alignment:Splign:2.1.0"
     exon            550..727
                     /gene="Idh1"
                     /gene_synonym="IDPc"
                     /inference="alignment:Splign:2.1.0"
     exon            728..879
                     /gene="Idh1"
                     /gene_synonym="IDPc"
                     /inference="alignment:Splign:2.1.0"
     exon            880..1020
                     /gene="Idh1"
                     /gene_synonym="IDPc"
                     /inference="alignment:Splign:2.1.0"
     exon            1021..1183
                     /gene="Idh1"
                     /gene_synonym="IDPc"
                     /inference="alignment:Splign:2.1.0"
     exon            1184..1719
                     /gene="Idh1"
                     /gene_synonym="IDPc"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgggtgtgag cggggttatt gaagtaaaaa tgtccagaaa aatccatggc ggttctgtgg
       61 tggaaatgca aggagatgaa atgacacgga tcatctggga attgattaaa gaaaagctca
      121 ttcttcccta cgtggaactg gatctgcata gctatgactt aggcatagag aatcgggatg
      181 ccaccaatga ccaggtcacc aaggatgctg cggaggctat aaagaaatac aacgtcggcg
      241 tcaagtgtgc taccatcacc cccgatgaga agagggttga ggagttcaag ttgaaacaaa
      301 tgtggaaatc acccaacggt accatccgga acattctggg cggcactgtc ttcagagaag
      361 ctattatctg caaaaatatc ccccggctag tgacaggctg ggtaaaaccc atcatcattg
      421 gccgacacgc ctatggggac caatacagag caacagattt cgttgttcct gggcctggaa
      481 aagtagagat aacctacaca ccaaaagatg ggtcgcagaa agtgacatac ctggtgcatg
      541 actttgaaga aggtggtggt gttgccatgg gtatgtacaa ccaggataag tcaattgaag
      601 attttgcaca cagttccttc caaatggctc tgtcgaaggg ctggcctttg tatctaagca
      661 ccaagaacac tattctgaag aagtatgatg gacgcttcaa agacatcttc caggagatct
      721 atgacaagca atacaagtcc aagtttgaag ctcagaagat ctggtatgaa cacaggctca
      781 tagatgacat ggtggcccag gctatgaaat cagaaggagg cttcatctgg gcctgtaaga
      841 actatgatgg tgatgtgcag tcagactcag tagcccaagg ttatggctcc cttggcatga
      901 tgaccagtgt gctgatttgt ccagatggta agacggtaga agcagaggct gcccatggca
      961 ctgtcacacg tcactaccgc atgtaccaga aaggacagga gacgtccacc aatcccattg
     1021 cttccatttt tgcctggtcc cgagggttag cccacagagc aaagcttgac aacaatactg
     1081 agctcagctt ctttgcaaat gctttggaag aagtctgcat tgagaccatt gaggctggct
     1141 ttatgactaa ggacttggct gcttgcatta aaggcttacc caatgtacag cgttctgact
     1201 acttgaatac atttgagttt atggacaaac ttggagaaaa cttgaaggcc aaactagctc
     1261 aggccaaact ttaaggtcaa acctgggctt agggcaaatc tttgtggtaa ctaagtccac
     1321 agtttacata tttccttttt gttttaataa cactcaaggt taaaaacaag aatcattttg
     1381 taatttgttt agaagacgaa gttgaacttt tctatatgtt tacagcctat tttctttttc
     1441 atacagttat tgccacctta atgaatgtgg tggggaaggt ttttttaatt gtattttact
     1501 gtgtaatagc agtctaggaa ttgtgttagt atctgttcac aattaactgt cactttttat
     1561 ttgctctaat gtaaatgacc aaaatcagaa atgctccaag ggtgaacaat cactacacta
     1621 tgtttccccg taaaggtgaa ggagaggctc acctccccta ctgtccatga gtgtgaacac
     1681 agggagcaaa agtgtgcaaa tgttgcactg tgtgtggaa
//
